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  • pathways
  • Patients with CFS showed abnormalities in 20 metabolic pathways. (pnas.org)
  • Measurements of gene expression were assessed by blood samples taken before, during and after exercise challenge using peripheral blood mononuclear cells (PBMC), Our preliminary data using gene expression Affymetrix U133 plus 2 microarrays showed that genes mapped to 132 metabolic pathways, including energy metabolism and immune system signaling genes, are differentially expressed in CFS/ME patients. (nova.edu)
  • Assessment of altered metabolites against the Kyoto Encyclopedia of Genes and Genomes revealed distinct non-overlapping metabolic pathways and revealed phenylalanine-tyrosine and associated metabolism being the most impacted. (springer.com)
  • Metaboanalyst analysis of these common metabolites revealed that phenylalanine metabolism and Valine, leucine, and isoleucine biosynthetic pathways are central metabolic pathways in both bio-fluids and could be analyzed further, either for the discovery of therapeutics or biomarker development. (springer.com)
  • Eight common metabolites were identified when we combined urinary and plasma metabolic signature, which revealed a perturbation of Phenylalanine metabolism and valine, leucine & isoleucine metabolic pathways, involved in CNS dysfunction during diseases. (springer.com)
  • diseases
  • One important pathway that may link these metabolic diseases to sugar consumption is hepatic conversion of sugar to fat, a process known as de novo lipogenesis (DNL). (jaoa.org)
  • Although the sugar and beverage industries continue to question the scientific evidence linking high-sugar diets to metabolic diseases, major health organizations now make evidence-based recommendations to limit consumption of simple sugars to no more than 5% to 10% of daily intake. (jaoa.org)
  • Although the sugar and beverage industries still try to question the scientific evidence linking high-sugar diets to metabolic diseases, health organizations, including the World Health Organization, 1 the American Heart Association, 2 and the US Department of Agriculture, 3 have recently published evidence-based recommendations to limit the consumption of simple sugars to no more than 5% to 10% of daily caloric intake. (jaoa.org)
  • Data from the US Department of Health and Human Services indicate that chronic diseases accounted for 86% of all health care spending in 2010. (jaoa.org)
  • Investigating role of diets, nutraceuticals and pharmaceuticals for prevention and treatment of diabetes and related chronic diseases. (monash.edu)
  • Evaluating models of care for treatment of diabetes and related chronic diseases. (monash.edu)
  • This metal is not considered by international agencies for the study of metabolic diseases. (mdpi.com)
  • Overall, our study suggests that urine and plasma metabolomics may contribute to the identification of a distinct metabolic fingerprint of EAE disease discriminating from the healthy control which may aid in the development of an objective non-invasive monitoring method for progressive autoimmune diseases like MS. (springer.com)
  • complications
  • It is our goal to help children and adolescents reach and maintain a healthy weight and establish healthy habits that will reduce their risk of metabolic complications throughout the teen years and into adulthood," Dr. Moerschel said. (wvu.edu)
  • 2017
  • Bhargava P, Fitzgerald KC, Calabresi PA, Mowry EM (2017) Metabolic alterations in multiple sclerosis and the impact of vitamin D supplementation. (springer.com)
  • Acute
  • Moore L.G., Brewer G.J., Oelshlegel F.J. (1972) Red Cell Metabolic Changes in Acute and Chronic Exposure to High Altitude. (springer.com)
  • In this study, metabolic profiles from the pancreas of Wistar rats were examined using high-resolution proton magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to investigate the metabolite indicator(s) of acute necrotizing pancreatitis (ANP) and chronic pancreatitis (CP). (spandidos-publications.com)
  • Metabolic consequences of acute and chronic empagliflozin administration in treatment-naive and metformin pretreated patients with type 2 diabetes. (nih.gov)
  • alterations
  • Bruhn H, Frahm J, Merboldt KD, Hanicke W, Hanefeld F, Christen HJ, Kruse B, Bauer HJ (1992) Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. (springer.com)
  • infection
  • Hepatocellular carcinoma (HCC) is another complication, however, and, particularly interestingly, it can occur not only in patients with advanced liver fibrosis or cirrhosis, but also in patients with chronic hepatitis B infection and high viremia. (hindawi.com)
  • hepatitis
  • Chronic viral hepatitis B and C can lead to liver cirrhosis. (hindawi.com)
  • Interestingly, SVR achievement after interferon based treatment in patients with chronic hepatitis C reduced T2DM incidence in the future. (hindawi.com)
  • DAA therapy leads to both significant decrease in fasting glucose (FG) levels and significant decrease in glycated hemoglobin levels (HbA1C) in diabetic patients with chronic hepatitis C and is thus requiring reduction of antidiabetic therapy in certain part of patients [ 9 ]. (hindawi.com)
  • Natural history of HCV related chronic hepatitis is influenced and modified by many factors: virus features, coinfections and host characteristics. (hindawi.com)
  • An association between chronic hepatitis C (CHC) and uric acid levels has been poorly investigated. (wiley.com)
  • pathway
  • Untargeted urinary metabolomics of a chronic mouse model of multiple sclerosis identified Phenylalanine, tyrosine & tryptophan metabolism as the significantly altered metabolic pathway. (springer.com)
  • pancreatitis
  • Retrospective analysis of outpatient coding for "chronic pancreatitis" was performed over a 2 year period. (ovid.com)
  • Patient demographics, aetiology of chronic pancreatitis, prescription of pancreatic enzyme replacement therapy (PERT), vitamin D levels, DEXA scan result, history of fractures and bone protection medications were noted. (ovid.com)
  • 134 chronic pancreatitis patients (mean age 57.6 years, 88 males) were included with aetiology recorded as alcohol (n=68), idiopathic (n=52), hypertriglyceridaemia (n=5), autoimmune (n=4), hereditary (n=3), anatomical (n=1) and biliary (n=1). (ovid.com)
  • risk
  • Investigating related risk factor measures may elucidate the biological burden of chronic pain. (hindawi.com)
  • In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. (hindawi.com)
  • More metabolic risk factors have increased the risk of high ABI. (medsci.org)
  • bone
  • Whether a standardised proforma would improve rates of metabolic bone assessments needs to be studied. (ovid.com)
  • duration
  • In conclusion, metformin as a first-line pharmacological therapy must take into consideration the origin and duration of metabolic disruption, because in this work the NOAEL dose of metformin (200 mg/kg/day) showed a limited efficiency in the metabolic disruption caused by chronic Cd exposure. (mdpi.com)
  • study
  • In the present study, we investigated the metabolic fate of strawberry polyphenols after chronic (90 days) supplementation of freeze-dried strawberry (24 g d −1 , equivalent to 2 cups of fresh strawberries) vs. control powder in 19 healthy older adults. (rsc.org)