Chronic lymphoid lymphoproliferative disorders. Medical search. Frequent questions

The purpose of this study is to assess the safety and tolerability of zilovertamab vedotin as monotherapy and in combination in participants with select B-cell lymphomas including mantle cell lymphoma (MCL), Richter's transformation lymphoma (RTL), follicular lymphoma (FL), and chronic lymphocytic leukemia (CLL). (clinicaltrials.gov)
Conversely, HCL-like disorders including HCL-Variant (vHCL) and Splenic Diffuse Red Pulp Lymphoma (SDRPL) remain provisional entities. (fortuneonline.org)
Splenic marginal zone lymphoma with circulating villous lymphoid cells (SMZL) is a distinct and very different pathological entity since the WHO 2008 classification: it is characterized by an expansion of the splenic white pulp with the infiltration of the red pulp. (fortuneonline.org)
ABSTRACT In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). (who.int)
The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia. (who.int)
To avoid immunosuppression in chronic lymphocytic leukaemia (CLL), there is an association between pesti- these patients all cases were selected non-Hodgkin lymphoma (NHL), cide exposure and lymphoproliferative before initiation of chemotherapy. (who.int)
The Hodgkin lymphoma, Waldenström disorders or not. (who.int)
In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
The investigators compiled a list of key genomic biomarkers in chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia (ALL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and mantle cell lymphoma (MCL) from published and publicly available resources and established a comprehensive NGS panel for their analysis both in routine clinical practice and in biomedical research. (ceitec.eu)
Caption: A schematic presentation of genomic targets and molecular markers integrated within the LYmphoid NeXt-generation sequencing (LYNX) panel design for the most common lymphoid malignant tumors (1 chronic lymphocytic leukemia, 2 mantle cell lymphoma, 3 follicular lymphoma, 4 diffuse large B-cell lymphoma, 5 acute lymphoblastic leukemia, and 6 Philadelphia chromosome-like acute lymphoblastic leukemia). (ceitec.eu)
Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Forty-eight patients were treated and were assessable for response (32 with chronic lymphocytic leukemia [CLL], 9 with CLL/prolymphocytic leukemia [PLL], 1 with PLL, 4 with mantle cell leukemia/lymphoma, 2 with Richter transformation). (ashpublications.org)
hodgkin lymphoma in a case of chronic myeloid leukemia treated with tyrosine kinase inhibitors. (liverpool.ac.uk)
novel mutations in sh2d1a gene in x-linked lymphoproliferative syndrome, diagnosed after b-cell non-hodgkin lymphoma. (liverpool.ac.uk)
x-linked lymphoproliferative disease type i (xlp i) is caused by mutations in the sh2d1a gene and characterized mainly by hypogammaglobulinemia and abnormal response to epstein-barr virus with a high predisposition to b-cell non-hodgkin lymphoma development. (liverpool.ac.uk)
The term non-Hodgkin lymphoma (NHL) encompasses a heterogeneous mix of lymphomas, which are either of a B- or T-cell phenotype and that meet the diagnostic criteria for one of the subtypes detailed in the 2008 World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues. (medscape.com)
Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ: Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. (karger.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
Subsequent studies revealed that EBV caused a number of different human malignancies, such as nasopharyngeal carcinoma (NPC), Hodgkin's lymphoma, extranodal NK/T-cell lymphoma, nasal type and lymphoproliferative disorders of immunocompromised hosts ( 2 ). (spandidos-publications.com)
Persistent infection with H. pylori induces atrophic gastritis and intestinal metaplasia, and subsequently leads to gastric malignancies including gastric carcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). (spandidos-publications.com)

HCL is a well-defined entity in the 2017 revision of the World Health Organization (WHO) classification of the tumours of haematopoietic and lymphoid tissues. (fortuneonline.org)
Swerdlow SH, International Agency for Research on Cancer, World Health Organization: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. (karger.com)

Foucar K: chronic lymphoid leukemias and lymphoproliferative disorders. (wikipedia.org)
B-cell disorders are divided into defects of B-cell development/immunoglobulin production ( immunodeficiencies ) and excessive/uncontrolled proliferation ( lymphomas , leukemias ). (medscape.com)
Latest genomic analyses of leukemias of another lymphoid lineage T cell severe lymphoblastic leukemia (T-ALL) uncovered that a particular subset of T-ALL is normally highly similar on track and myeloid leukemic HSCs in gene appearance and mutational profile (25). (academicediting.org)
Confirmation of diagnosis and immunophenotype in acute and chronic leukemias and lymphomas. (umich.edu)

Treatment of post-transplantation lymphoproliferative disorders after kidney transplant with rituximab and conversion to m-TOR inhibitor. (univalle.edu.co)
Post-transplantation lymphoproliferative disorders are serious complications of organ transplantation which treatment is not yet standardized. (univalle.edu.co)
Draoua HY, Tsao L, Mancini DM, Addonizio LJ, Bhagat G, Alobeid B: T-cell post-transplantation lymphoproliferative disorders after cardiac transplantation: a single institutional experience. (karger.com)

Even though stem cell source for myeloid malignancies such as myeloproliferative neoplasms myelodysplastic syndromes and acute myeloid leukemia (AML) is definitely well established a link between aberrations in HSPCs and development of mature lymphoid malignancies has been less thoroughly investigated. (academicediting.org)
A new integrative, capture-based, next-generation sequencing (NGS) panel, LYmphoid NeXt-Generation Sequencing (LYNX), can detect and analyze standard and novel biomarkers in the most common lymphoid neoplasms simultaneously. (ceitec.eu)

Therefore the paradigm of linking B cell malignancies to counterparts in normal B cell development has been a predominant model to describe the cell of source for these disorders and could have got obscured the id of a far more primitive cell of origins. (academicediting.org)
Collectively these results claim that genomic and useful analyses of lymphoid malignancies may reveal unforeseen alterations in much less differentiated HSPC populations. (academicediting.org)
The research team believes that the LYNX panel is suitable for routine testing with research and clinical applicability and may assist in personalized management of patients with lymphoid malignancies. (ceitec.eu)
Individuals with immune deficiency disorders also have an increased risk of malignancies and of having autoimmune disorders. (ssa.gov)
We explored the safety and efficacy of rituximab plus alemtuzumab in patients with relapsed or refractory lymphoid malignancies. (ashpublications.org)

Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
Tsao L, Hsi ED: The clinicopathologic spectrum of posttransplantation lymphoproliferative disorders. (karger.com)

Posttransplant lymphoproliferative disorders (PTLD) are a potentially life-threatening complication of immunosuppression in transplant recipients. (karger.com)
Morovic A, Jaffe ES, Raffeld M, Schrager JA: Metachronous EBV-associated B-cell and T-cell posttransplant lymphoproliferative disorders in a heart transplant recipient. (karger.com)

Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (merckmanuals.com)
In a similar way, HCV infection may also be involved in the pathogenesis of other autoimmune (glomerulonephritis, thyroiditis, lung fibrosis, autoimmune hepatitis, porphyria cutanea tarda) and lymphoproliferative disorders (monoclonal gammopathies, B-cell lymphomas). (unimore.it)

Immune system disorders may result in recurrent and unusual infections, or inflammation and dysfunction of the body's own tissues. (ssa.gov)
2. Autoimmune disorders (14.00D) . Autoimmune disorders are caused by dysfunctional immune responses directed against the body's own tissues, resulting in chronic, multisystem impairments that differ in clinical manifestations, course, and outcome. (ssa.gov)
But cancers can also originate outside the lymphatic system and then make their way into lymphoid tissues and glands. (newworldencyclopedia.org)
The HCV infection of lymphoid tissues may represent the remote event leading to B-lymphocyte proliferation responsible for autoantibodies and immune-complex production. (unimore.it)

B and T cells, type 2 dendritic cells, and natural killer (NK) cells share a common ancestor: common lymphoid progenitor (CLP). (medscape.com)

Ideal as a quick, easy-to-use reference in the laboratory or clinical setting, Atlas of Diagnostic Hematology is an abundantly illustrated guide to the vast range of malignant and non-malignant disorders of the blood. (physioshop.co.uk)
More than 1,200 vibrant, full-color images enable you to identify and compare the unique clinical and histologic features of various blood disorders and confidently reach a diagnosis. (physioshop.co.uk)
Because this assay is straightforward and can also be used in research, it warrants further prospective testing in close cooperation among researchers, clinical hemato-oncologists, and hematopathologists to demonstrate its clinical utility and benefit for patients with lymphoid malignant tumors. (ceitec.eu)
The typical clinical course is chronic and relapsing, and therapy is generally progressive and of poor outcome. (medscape.com)
The precise meaning will depend on the specific immune system disorder, the usual course of the disorder, and the other circumstances of your clinical course. (ssa.gov)
MC is characterised by a typical clinical triad (purpura, weakness, arthralgias) and by one or more organ involvement: chronic hepatitis, glomerulonephritis, peripheral neuropathy, skin ulcers and diffuse vasculitis. (unimore.it)
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. (lookformedical.com)

If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)
They are sometimes referred to as rheumatic diseases, connective tissue disorders, or collagen vascular disorders. (ssa.gov)
Gastrointestinal disorders such as chronic or acute diarrhea, malabsorption, abdominal pain, and inflammatory bowel diseases can indicate immune deficiency. (medscape.com)
The gastrointestinal tract is the largest lymphoid organ in the body, so it is not surprising that intestinal diseases are common among immunodeficient patients. (medscape.com)
This review highlights the GI manifestations of the more common primary immunodeficiency disorders, focusing on the recognition of these diseases, appropriate diagnostic testing, and therapy. (medscape.com)
However, EBV has been linked to several refractory diseases such as EBV-associated hemophagocytic syndrome(EBV-AHS) and chronic active EBV infection (CAEBV). (researchgate.net)
A general term for various neoplastic diseases of the lymphoid tissue. (lookformedical.com)
Flow cytometry is an important methodology for the diagnosis of chronic B-cell lymphoproliferative diseases (B-CLPD), however, sometimes the cytometrist does not find sufficient elements for the exact definition of the pathological entity involved. (bvsalud.org)
The results emphasize that even though flow cytometry is important for the characterization of B-CLPD, sometimes the cytometrist needs to include the category "other chronic B-cell lymphoproliferative diseases not classified by flow cytometry" in the report to induce the prescriber to request additional complementary exams. (bvsalud.org)

Chronic active Epstein-Barr virus (CAEBV) disease is a rare disorder in which persons are unable to control infection with the virus. (frontiersin.org)
EBV infection is also associated with lymphoid interstitial pneumonia (LIP). (e-cep.org)
3. Immune deficiency disorders, excluding HIV infection (14.00E) . Immune deficiency disorders are characterized by recurrent or unusual infections that respond poorly to treatment, and are often associated with complications affecting other parts of the body. (ssa.gov)
Chronic active Epstein-Barr virus (EBV) infection is a severe systemic disease associated with high rates of mortality and morbidity. (researchgate.net)
Recent studies suggest that the clonal expansion of EBV-infected T or natural killer cells plays a crucial role in the pathogenesis of chronic active EBV infection. (researchgate.net)

Defects occurring at the CLP stage or those affecting processes common to B- and T-cell development result in combined immunodeficiency involving B, T, and NK cells (see Combined B-Cell and T-Cell Disorders ). (medscape.com)
Chronic active Epstein-Barr virus disease is usually defined as a chronic illness lasting at least 6 months, an increased EBV level in either the tissue or the blood, and lack of evidence of a known underlying immunodeficiency ( 15 ). (frontiersin.org)
Many of these disorders mimic classic forms of disease (in the absence of immunodeficiency) such as celiac sprue, inflammatory bowel disease (IBD), and pernicious anemia but differ in pathogenesis and are often unresponsive to conventional therapies. (medscape.com)

Pulmonary involvement in pSS includes interstitial lung disease (ILD) and airway disease, together with lymphoproliferative disorders. (ersjournals.com)

After myeloma, macroglobulinemia is the 2nd most common malignant disorder associated with a monoclonal gammopathy. (merckmanuals.com)
Excessive amounts of IgM M-proteins (monoclonal immunoglobulin protein, which may consist of both heavy and light chains or of only one type of chain) can also accumulate in other disorders, causing manifestations similar to macroglobulinemia. (merckmanuals.com)

For ITD-1 instance multiple myeloma a problem regarded as a malignancy of late-stage immunoglobulin-secreting plasma cells was lately present to contain subpopulations of pre-plasmablasts and Compact disc20+ B cell progenitors which propagate the disorder and mediate treatment level of resistance (23). (academicediting.org)

Immune system disorders can cause a deficit in a single organ or body system that results in extreme (that is, very serious) loss of function. (ssa.gov)
This is in part because the gut is the largest lymphoid organ in the body, containing the majority of lymphocytes and producing large amounts of immunoglobulin (Ig). (medscape.com)
Blaes AH, Morrison VA: Post-transplant lymphoproliferative disorders following solid-organ transplantation. (karger.com)
Lundell R, Elenitoba-Johnson KS, Lim MS: T-cell posttransplant lymphoproliferative disorder occurring in a pediatric solid-organ transplant patient. (karger.com)
Yang F, Li Y, Braylan R, Hunger SP, Yang LJ: Pediatric T-cell post-transplant lymphoproliferative disorder after solid organ transplantation. (karger.com)

Lemole (2001) claims that the key to health is a healthy lymphatic system, specifically stating "you can eliminate 70 percent of the chronic illnesses that are in part the result of that system being clogged. (newworldencyclopedia.org)

Determine the frequency and duration of complete and partial response rates for patients with relapsed or refractory indolent lymphoproliferative disorders treated with ixabepilone. (knowcancer.com)

Similarly, only a trephine biopsy shows the architecture of the bone marrow and permits the detection of an abnormal distribution of cells, bone marrow granulomas, and focal lymphoid infiltrates. (bmj.com)
[ 1 , 2 ] They can be defined as lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, which primarily occur in and remain confined to the skin in most patients, without detectable extracutaneous manifestations at diagnosis. (medscape.com)

This entity is referred to as chronic active EBV (CAEBV) disease. (frontiersin.org)
This course presents the disease processes leading to abnormal white and red cell morphology, and white blood cell disorders, including both benign and malignant states. (iowacentral.edu)
[ 10 ] Several cases of Evans syndrome have also been reported in association with the group of lymphoproliferative disorders known as Castleman disease. (medscape.com)
In 1991, Glenn Sabin was a 28-year-old newlywed diagnosed with chronic lymphocytic leukemia (CLL)-a disease doctors called "uniformly fatal. (scienceblogs.com)
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. (lookformedical.com)

Secondary lymphopoiesis (SL) begins when mature B cells enter the extrafollicular area of lymphoid tissue and differentiate into short-lived plasma cells and memory cells after being stimulated by antigen-presenting cells. (medscape.com)
Trephine biopsy sections should be examined and reported in a systematic manner, assessment being made of the bones, the vessels and stroma, and the haemopoietic and any lymphoid or other tissue. (bmj.com)
Generally, we need your medical history, a report(s) of a physical examination, a report(s) of laboratory findings, and in some instances, appropriate medically acceptable imaging or tissue biopsy reports to show that you have an immune system disorder. (ssa.gov)
White blood cells formed in the body's lymphoid tissue. (lookformedical.com)

Secondary B lymphopoiesis is an antigen-dependent process and occurs in the germinal center of peripheral lymphoid organs with specific antibody production. (medscape.com)
chronic myeloid leukemia (cml) is characterized by increased and unregulated proliferation of granulocytic lineage in the bone marrow and presence of these immature myeloid cells in the peripheral blood with presence of philadelphia (ph) chromosome. (liverpool.ac.uk)

Hairy cell leukemia (HCL) is certainly a chronic lymphoproliferative disorder seen as a somatic recently discovered somatic inhibition in hematopoiesis inside our murine choices aswell as in individuals with in HCL individuals we performed quantitative sequencing of the spot of ITD-1 p. (academicediting.org)
Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is characterized by progressive accumulation of phenotypically mature malignant B lymphocytes. (merckmanuals.com)
Classical Hairy Cell Leukemia (HCL) and HCL-like disorders are a very heterogeneous group of mature B-cell Chronic Lympho proliferative Disorders (B-CLPD). (fortuneonline.org)
Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. (nih.gov)
Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)

Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
1976. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. (cdc.gov)

Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
Cause is unknown, although certain gene mutations have been associated with the disorder. (merckmanuals.com)
The type 1 of Waardenburg Syndrome usually inherited as an autosomal dominant pattern or where a copy of the altered gene is enough to cause the disorder. (illnessopedia.org)
It is also said to be an autosomal recessive inasmuch as it need two copies of altered gene to make a person affected with the disorder. (illnessopedia.org)
Type 2B of Waardenburg Syndrome is usually inherited as an autosomal recessive pattern where two copies of the altered gene is needed in order that a person may be said to be affected with the disorder. (illnessopedia.org)
It is usually inherited as an autosomal dominant pattern where only one copy of the damaged or altered gene is needed in order to make the person affected with the disorder. (illnessopedia.org)

1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)

Lymphoproliferative disorders are a ported in studies from the USA (11) , mainly with the help of the surgeons heterogeneous group of malignant Israel (12) and Australia (13) . (who.int)

Therefore, it is not surprising that GI disorders are common manifestations, and often the initial presenting symptom, in patients with dysfunction in humoral immunity or cell-mediated immunity ( Table 1 ). (medscape.com)

In a hospital-based, retrospective, case-control study in 20112012, adult cases of lymphoproliferative disorders (n = 130) were recruited from outpatient clinics in Menoufia, Egypt, while controls (n = 130) were age- and sex-matched fracture patients. (who.int)
2012, adult cases of lymphoproliferative disorders ( n = 130) were recruited from outpatient clinics in Menoufia, Egypt, while controls ( n = 130) were age- and sex-matched fracture patients. (who.int)
Savasan et al observed that more than half of the patients with Evans syndrome had evidence of lymphoid hyperactivity. (medscape.com)
[ 9 ] Teachey et al demonstrated that more than half (58%) of patients with Evans syndrome might have autoimmune lymphoproliferative syndrome (ALPS), a novel finding with potentially important therapeutic implications. (medscape.com)
Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. (ottawaheart.ca)
Gastrointestinal (GI) disorders present in 5% to 50% of patients with primary immunodeficiencies. (medscape.com)
Retrospective study, which included patients, diagnosed with post-transplant lymphoproliferative disorders after kidney transplantation from January 2011 to July 2014. (univalle.edu.co)
There are no standardized treatment regimens for lymphoproliferative disorders after kidney transplantation, but these patients can be managed successfully with reduction of immunosuppression, conversion to m-TOR and rituximab-based schemes. (univalle.edu.co)

Hairy cells are small to medium-sized lymphoid cells with an oval or indented nucleus with homogeneous and spongy chromatin. (fortuneonline.org)

Overview of Plasma Cell Disorders Plasma cell disorders are a diverse group of disorders of unknown etiology characterized by Disproportionate proliferation of a single clone of B cells Presence of a structurally and electrophoretically. (merckmanuals.com)

Discuss and differentiate the different benign disorders of leukocytes. (iowacentral.edu)

Although Evans syndrome seems to be a disorder of immune regulation, the exact pathophysiology is unknown, and the underlying etiology is unclear. (medscape.com)

Some of the features of autoimmune disorders in adults differ from the features of the same disorders in children. (ssa.gov)

It is associated with various congenital disorders such as defects in the intestine and spine, elevated scapula and the cleft lip palate. (illnessopedia.org)
Primary immunodeficiencies are a group of more than 150 disorders, often inherited, that are caused by intrinsic defects in the immune system. (medscape.com)

Macroglobulinemia is a malignant plasma cell disorder in which B cells produce excessive amounts of IgM M-proteins. (merckmanuals.com)

Immune deficiency disorders are classified as either primary (congenital) or acquired. (ssa.gov)

X-linked adrenoleukodystrophy (X-ALD) is a rare peroxisomal disorder, that is rapidly progressive, neurodegenerative, and recessive, and characteristically primary affects the central nervous system white matter and the adrenal cortex. (e-cep.org)

Family history of cancer, exposure to X-rays, smoking and use of hair dyes were not risk factors for lymphoproliferative disorders in univariate analysis. (who.int)
Hematotoxicity, leukemogenicity, and carcinogenicity of chronic exposure to benzene. (cdc.gov)

NF1 is also a multisystem disorder that primarily affects the skin and nervous system. (e-cep.org)

Usually a person affected with this type of disorder has one parent affected with the condition. (illnessopedia.org)

Anatomy14

Organisms3

Diseases58

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology10

Phenomena and Processes16

Disciplines and Occupations1

Information Science3

Health Care5

Lymphoma20

Tumours of haematopoietic and lymphoid tissues2

Leukemias4

Post-transplantation lymphoproliferative disorders3

Neoplasms2

Malignancies5

Posttransplantation lymphoproliferative disorders2

Posttransplant Lymphoproliferative Disorders2

Lymphomas2

Tissues4

Common lymphoid1

Clinical7

Diseases9

Infection5

Immunodeficiency3

Interstitial1

Monoclonal2

Malignancy1

Organ5

Lymphatic1

Indolent1

Infiltrates2

Disease5

Tissue4

Peripheral2

Leukemia6

Leukaemia2

Gene6

Antibody1

Heterogeneous1

Manifestations1

Patients8

Hairy1

Proliferation1

Differentiate1

Syndrome1

Autoimmune disorders1

Defects2

Cells1

Congenital1

Primary1

Exposure2

Multisystem1

Type1