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  • synaptic
  • However, no studies have so far examined the role of CREB family transcription factors in dorsal striatum-dependent synaptic plasticity and procedural memory formation. (jneurosci.org)
  • Mice
  • We examined procedural memory and plasticity in transgenic mice reversibly expressing a dominant-negative cAMP response element-binding protein (CREB) mutant in the dorsal striatum. (jneurosci.org)
  • Histopathological analysis revealed that prominent atrophic changes occurred in the striatum of MCAO mice and that these changes were reduced following APZ treatment. (spandidos-publications.com)
  • basal ganglia
  • In the present study, we sought to determine the effects of chronic dopamine (DA) depletion on responses mediated by stimulation of serotonergic 2C (5-HT(2C)) receptors, a serotonergic receptor subtype present in discrete regions of the basal ganglia. (mendeley.com)
  • manipulations
  • Many chronic manipulations of neural circuits (both permanent genetic changes and physical lesions) do actually produce major behavioural changes. (blogspot.dk)
  • One response that often occurs after long-term manipulations of DA transmission in the striatum is an alteration in dye coupling. (jneurosci.org)
  • selective
  • We are continuing with more mechanistic studies in rat models using selective lesions, local infusions and neurotransmitter interaction studies. (duke.edu)
  • correlation
  • MR imaging studies were performed for all patients, and both MR imaging and MRA were performed for 42 patients, who formed the cohort for review of the presence and correlation of lesions. (ajnr.org)
  • alterations
  • Importantly, CREB-deficient animals show reversible alterations in several forms of striatum-dependent memory, including footshock avoidance learning and "response" learning in the cross maze. (jneurosci.org)
  • secondary
  • Previous studies have demonstrated that APZ exhibits benefits in patients with post-stroke depression, including the protection of primary lesions and secondary extrafocal sites following ischemic stroke ( 8 , 9 ). (spandidos-publications.com)
  • effects
  • Although such an approach is seemingly straightforward, there have been a large number of contradictory reports, with "decreases", "no effects", and "increases" in sensitivity to amphetamine sometimes reported to follow lesions in the same brain region. (springer.com)
  • In this study we examined the effects of altering striatal dopamine levels on the neurotoxicity induced by chronic 3-NP treatment. (jneurosci.org)
  • B12, sodium, methionine intake) human case studies and epidemiological studies of the chronic toxicological effects have shown very variable results and were not conclusive. (inchem.org)
  • monkey
  • Carpenter MB, Carpenter CS (1951) Analysis of somatotopic relations of the corpus Luysii in man and monkey. (springer.com)
  • Changes
  • Voxelwise diffusional kurtosis imaging analysis was performed to detect global WM changes in the patients with and without WM lesions. (ajnr.org)
  • In voxelwise analysis, progressive WM changes were detected in patients with WM lesions. (ajnr.org)
  • diagnosis
  • The primary aim of this study was to determine the distribution of parenchymal and vascular lesions of cPACNS on MR imaging and MRA at diagnosis. (ajnr.org)
  • animals
  • This action, it will be proposed, may be responsible for normal variations among animals in drug sensitivity before as well as after lesions. (springer.com)
  • Our data strongly support the suggestion of a central role for dopamine in the formation of striatal lesions in 3-NP-intoxicated animals. (jneurosci.org)
  • patients
  • However, no significant WM change was noted in patients without WM lesions during the 9 months after CO intoxication. (ajnr.org)
  • Figure 2 Proposed referral criteria to palliative care for patients with Chronic Heart Failure. (gabapathway.com)
  • large
  • Although there are a large number of neuroactive substances in the striatum that might be involved in 3-NP toxicity, one of the best candidates is dopamine. (jneurosci.org)
  • The large majority (75 percent or more) of neural cells in a particular area of the brain are killed before any clinical symptoms of a chronic illness are noticed. (merliannews.com)
  • mouse
  • Inversely, pharmacological inhibition of neuroinflammation in a 6-hydroxydopamine mouse model led to increased neural progenitor cell proliferation in the subventricular zone and neuroblast migration into the lesioned striatum. (biomedsearch.com)
  • clinical
  • Over the past decade there has been great clinical interest in improving bone healing by altering the mechanical environment through the fixation stability around the lesion. (jove.com)
  • The otolaryngologist diagnosed chronic sinusitis based on the clinical exam and CT imaging. (biomedcentral.com)
  • studies
  • Bj√∂rklund A, Lindvall O, Isacson O, Brundin P, Wictorin K, Strecker RE, Clarke DJ, Dunnett SB (1987) Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum. (springer.com)