Testing the hypothesisHyperbaric oxygenHypoxemiaObstructive pulmonary diseaseApneaExposureArousalsRatsInhibitionModulationArterialNocturnalObstructionMiceResponsesGenesInhibitsSevereRenalGene ExpressionAcute and chronicOxygenAffectsSpinalEffectsRegulationInflammatoryTreatmentObesityRespiratoryProteinMultiplePersistentStagesOccursStrokeResultsEvidenceMotorFoundAsthmaBloodLower
Testing the hypothesis1
- In this project, we are testing the hypothesis that chronic intermittent hypoxia exacerbates WTC dust exposure induced oxidative stress, lung injury, and alterations in lung function in a mouse model of WTC dust exposure. (cdc.gov)
Hyperbaric oxygen1
- In the current case report, we used both task-based and resting state functional MRI (fMRI) tools to investigate the neural response mechanisms and functional reorganization underlying hyperbaric oxygen therapy (HBOT)-induced motor rehabilitation in a chronic post-stroke patient suffering from severe upper-limb motor impairment. (frontiersin.org)
Hypoxemia3
- OSA is characterized by the quintessential triad of intermittent apnea, hypoxia, and hypoxemia due to pharyngeal collapse. (hindawi.com)
- One of the major physiologic perturbations of OSA is the development of repetitive, acute cycles of intermittent hypoxemia (IH) resulting from periodic collapse of the upper airway during sleep. (atsjournals.org)
- Currently, my work focuses on understanding the mechanisms that regulate the synthesis and release of angiotensin II within the brain in response to chronic intermittent hypoxia, an animal model that simulates the hypoxemia associated with sleep apnea. (unthsc.edu)
Obstructive pulmonary disease3
- The combined therapy of Bufei Yishen granules (BY) and electroacupuncture (EA) has shown good effects clinically in treating chronic obstructive pulmonary disease (COPD). (hindawi.com)
- Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and airflow limitation [ 1 ]. (hindawi.com)
- The aim of the present study was to compare the evolution of pulmonary haemodynamics and of arterial blood gases in chronic obstructive pulmonary disease (COPD) patients with mild-to-moderate hypoxaemia, with or without sleep-related oxygen desaturation. (ersjournals.com)
Apnea1
- Dr. David Gozal, a professor of Paediatrics at the University of Louisville, says that the link between the two conditions can be due to the chronic intermittent hypoxia (CIH)-oxygen deprivation-that sleep apnea sufferers often exerience during episodes of obstructed breathing. (medindia.net)
Exposure6
- Conclusions: Chronic HBO and CIH exposure causes only minor changes in the architecture of the tracheal mucosa of the rat. (um.es)
- To test this, we pre-exposed immortalized N9 and primary microglia to hypoxia (1% O 2 ) for 16 h and then challenged them with pro-inflammatory lipopolysaccharide (LPS) either immediately or 3-6 days following hypoxic exposure. (frontiersin.org)
- Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
- These findings provide evidence that hypoxia pre-exposure could lead to persistent and aberrant inflammatory responses in the context of CNS disorders. (frontiersin.org)
- A number of animal studies by Gozal and colleagues have suggested that it is the chronic exposure to IH that leads to oxidant stress, inflammation and related structural and pharmacometabolic changes of the central nervous system (CNS) (for review see Gozal, 2009 ). (wiley.com)
- Exposure to acute intermittent hypoxia augments somatic motor function in humans with incomplete spinal cord injury. (spauldingrehab.org)
Arousals2
- Intermittent hypoxia and multiple arousals resulting from obstructive events contribute to the well-described cardiovascular, neurocognitive, and behavioral consequences in pediatric patients with OSAS. (scielo.br)
- Obstructive sleep apnoea (OSA) is defined by repeated nocturnal episodes of pharyngeal obstruction with resultant intermittent hypoxia (IH), reoxygenation and arousals from sleep. (wiley.com)
Rats2
- The increased levels of the inflammatory cytokines interleukin (IL)-1 β and IL-6 indicated a chronic inflammatory state in the COPD rats. (hindawi.com)
- Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. (uchicago.edu)
Inhibition1
- We investigated whether inhibition of hypoxia-inducible factor prolyl 4-hydroxylase-2 (HIF-P4H-2), a key cellular oxygen sensor whose inhibition stabilizes HIF, would protect from NAFLD by subjecting HIF-P4H-2-deficient ( Hif-p4h-2 gt/gt ) mice to a high-fat, high-fructose (HFHF) or high-fat, methionine-choline-deficient (HF-MCD) diet. (springer.com)
Modulation1
- Modulation of autonomic cardiovascular function in Andean high-altitude natives with and without chronic mountain sickness. (wikipedia.org)
Arterial1
- We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). (unl.pt)
Nocturnal1
- Nocturnal hypoxia in OSA is a major pathological factor associated with cardiorespiratory diseases [ 3 , 7 ]. (hindawi.com)
Obstruction1
- The physical examination should assess growth status, signs of chronic upper airway obstruction, and craniofacial malformations. (scielo.br)
Mice2
- Banxia-Houpu decoction inhibits iron overload and chronic intermittent hypoxia-induced neuroinflammation in mice. (bvsalud.org)
- Intermittent hypoxia produces insulin resistance in lean mice. (atsjournals.org)
Responses3
- Gamboa, A., F. León-Velarde, M. Rivera-Ch, M. Vargas, J-A. Palacios and C. Monge C. Ventilatory and cardiovascular responses to hypoxia in Andean natives living at sea level. (wikipedia.org)
- Gamboa A, León-Velarde F, Rivera-Ch M, Palacios J-A, Pragnell T.R, O'Connor D. and Robbins P.A. Acute and sustained ventilatory responses to hypoxia in high altitude natives living at sea level. (wikipedia.org)
- We found that microglia exhibited enhanced responses to LPS 3 days and 6 days post-hypoxia. (frontiersin.org)
Genes1
- In: Hypoxia from Genes to the Bedside, Advances in Exp. (wikipedia.org)
Inhibits1
- In addition, chronic ethanol ingestion inhibits oxidation of fatty acids in the liver and the release of VLDL into the blood. (medscape.com)
Severe1
- However, there is a paucity of data on severe typhoid fever and its associated acute and chronic host immune response and carriage. (cdc.gov)
Renal1
- The first-in-class small-molecule HIF-P4H inhibitor that activates the hypoxia response has been approved for treatment of renal anemia and several others are in clinical trials [ 10 , 11 ]. (springer.com)
Gene Expression1
- We, therefore, tested the hypothesis that hypoxia would enhance or "prime" microglial pro-inflammatory gene expression in response to a later inflammatory challenge without programmatically increasing basal levels of pro-inflammatory cytokine expression. (frontiersin.org)
Acute and chronic1
- We found that acute and chronic IH had opposite effects on Cyp1a1 and the thiolome. (unl.pt)
Oxygen3
- Objective: This paper is aimed at identifying putative morphological changes induced in the rat's tracheal mucosa by chronic hyperbaric oxygen (HBO) treatment or chronic intermittent hypoxia (CIH). (um.es)
- The term hypoxia is used to describe biological situations where insufficient levels of oxygen exist. (mdpi.com)
- Furthermore, because VEGFA-165 expression is hypoxia sensitive, it may play a role in respiratory plasticity after prolonged exposures to low oxygen. (jneurosci.org)
Affects2
- However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)
- Chronic venous insufficiency affects up to 5% of people in the US. (msdmanuals.com)
Spinal5
- Here, we use phrenic motor facilitation (pMF) as a general term, including pLTF after acute intermittent hypoxia and other forms induced, for example, by spinal administration of receptor agonists. (jneurosci.org)
- Acute Intermittent Hypoxia as a Potential Adjuvant to Improve Walking Following Spinal Cord Injury: Evidence, Challenges, and Future Directions. (spauldingrehab.org)
- Daily acute intermittent hypoxia to improve walking function in persons with subacute spinal cord injury: a randomized clinical trial study protocol. (spauldingrehab.org)
- Hayes HB, Chvatal S, French MA, Ting LH, Trumbower RD. Neuromuscular constraints on muscle coordination during overground walking in persons with chronic incomplete spinal cord injury. (spauldingrehab.org)
- Hayes HB, Jayaraman A, Hermmann M, Rymer WZ, Mitchell GS, Trumbower RD. Daily acute intermittent hypoxia improves overground walking ability in persons with chronic incomplete spinal cord injury: a randomised, double-blind, placebo-controlled, crossover trial. (spauldingrehab.org)
Effects5
- While much research is, and has been, carried out to investigate the effects of hypoxia, this is usually done using experimental models which employ stable levels of hypoxia. (mdpi.com)
- Further studies are needed to explore the effects of sleep disruption and episodic hypoxia during sleep on the central nervous system that mediates sexual drive. (medindia.net)
- Although this study was performed in research animals, chronic intermittent hypoxia has profound effects on multiple organ systems and a strong biologic plausibility exists that similar findings will be observed in humans. (medindia.net)
- Although there is conflicting data on the effects of short-term training, it is possible that relatively long periods of walking, jogging, or intermittent running for over half a year can increase leg muscle size among older adults. (researchgate.net)
- Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. (uchicago.edu)
Regulation1
- Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. (uchicago.edu)
Inflammatory1
- Obesity is a chronic low-grade pro-inflammatory condition, with adipose tissue exhibiting both paracrine and endocrine functions. (peerj.com)
Treatment1
- Therefore, formal rehabilitation protocols are focused on the acute-sub-acute phase (up to 6 months), and long-term disability treatment is less frequent in the late chronic phase ( 9 ). (frontiersin.org)
Obesity1
- The purpose of the current study was to determine if the intermittent hypoxia (IH) stimulus that characterizes OSA causes insulin resistance in the absence of obesity. (atsjournals.org)
Respiratory1
- In 2017, 3.91 million all-age deaths worldwide were due to chronic respiratory diseases, including 3.19 million deaths from COPD [ 4 ]. (hindawi.com)
Protein1
- Using a rat model of CIH-HTN, we investigated the impact of short-term (1 and 7 days), mid-term (14 and 21 days, pre-HTN), and long-term intermittent hypoxia (IH) (up to 60 days, established HTN) on Cyp1a1 protein level (a sensitive hallmark of AhR activation) and cysteine-related thiol pools. (unl.pt)
Multiple2
- Hypoxia (Hx) is a component of multiple disorders, including stroke and sleep-disordered breathing, which often precede or are comorbid with neurodegenerative diseases. (frontiersin.org)
- CONCLUSION: Multiple clinical and molecular biomarkers are upregulated in Fontan patients, suggesting a state of chronic systemic dysregulation. (cdc.gov)
Persistent1
- Stroke is the second leading cause of long-term disability worldwide, where ~80% of individuals with acute stroke present upper-limb motor impairment, and 50-60% of them will have persistent disability or weakness at the chronic phase ( 1 , 2 ). (frontiersin.org)
Stages1
- Importantly, HBOT was found to induce neuroplasticity in chronic stages, even years after brain injury ( 11 - 15 ). (frontiersin.org)
Occurs1
- Causes of chronic venous insufficiency are disorders that result in venous hypertension, usually through venous damage or incompetence of venous valves, as occurs (for example) after DVT. (msdmanuals.com)
Stroke1
- This study provides additional insights into HBOT-induced brain plasticity and functional improvement in chronic post-stroke patients. (frontiersin.org)
Results1
- Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
Evidence1
- As to the cause of the headaches, while straps and pressure from the mask could be causative, the bulk of the evidence points toward hypoxia and/or hypercapnia as the cause. (openontario.ca)
Motor1
- Intermittent hypoxia-induced pLTF is associated with greater ERK phosphorylation (activation) in the region of the phrenic motor nucleus ( Wilkerson and Mitchell, 2009 ), and pLTF requires ERK (not Akt) activation in its underlying mechanism (M. S. Hoffman and G. S. Mitchell, unpublished observation). (jneurosci.org)
Found1
- Researchers have understood for numerous years that the hypoxia found in tumors leads to more aggressive and harder to treat disease and ultimately, poor patient outcome. (mdpi.com)
Asthma1
- Asthma is one of the most common chronic diseases of childhood, affecting about 6 million children in the US. (msdmanuals.com)
Blood1
- That is, a reduction in blood oxygenation (hypoxia) or an elevation in blood C02 (hypercapnia). (openontario.ca)
Lower1
- Chronic venous insufficiency is impaired venous return, sometimes causing lower extremity discomfort, edema, and skin changes. (msdmanuals.com)