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  • allogeneic
  • 1 Frequent neurological sequelae in the early period after allogeneic BMT include encephalopathy, cerebrovascular accidents, central nervous system (CNS) infections, and recurrence of the malignant disease. (ahajournals.org)
  • age range, 19 to 53 years) had had allogeneic BMT from HLA-matched family or nonrelated donors for treatment of chronic myelogenous leukemia (n=3), acute myelogenous leukemia (n=1), and acute lymphoblastic leukemia (n=1). (ahajournals.org)
  • cytokine
  • We asked whether IVIg can induce interleukin-10 (IL-10) and reduce pro-inflammatory cytokine production in human monocytes, and whether this response is reduced in monocytes from people with an Fcγ receptor IIA (FcγRIIA) gene variant, which is associated with increased risk of inflammatory diseases and poor response to antibody-based biological therapy. (frontiersin.org)
  • IVIg increased IL-10 production and reduced pro-inflammatory cytokine production in response to bacterial lipopolysaccharide (LPS), which required FcγRI and FcγRIIB and activation of MAPKs, extracellular signal-regulated kinase 1/2 (ERK1/2), and p38. (frontiersin.org)
  • IL-10 production was lower and pro-inflammatory cytokine production was higher in monocytes from people with the FcγRIIA risk variant and the risk variant prevented IL-10 production in response to (IVIg+LPS). (frontiersin.org)
  • IL-10 is a potent, non-redundant anti-inflammatory cytokine, which can limit inflammatory signaling from innate and adaptive immune cells ( 3 ). (frontiersin.org)
  • Zoreh Tatari-Calderone, PhD, Ross Fasano, MD, and Edward Wong, MD, have expanded patient enrollment, evaluated serial cytokine profiles, and abstracted patient-specific data on more than 300 SCD patients to correlate the development of RBC allo antibodies with B cell activation due to RBC antigen exposure during the inflammatory response associated with vaso-occlusive crises. (childrensnational.org)
  • systemic
  • Standard parameters for systemic vasculitis (eg, erythrocyte sedimentation rate), underlying collagen vascular disease (eg, antinuclear antibodies), or coagulopathy (lupus anticoagulant, cardiolipin antibodies) were either absent or normal. (ahajournals.org)
  • The seven categories are as follows: Gingivitis Chronic periodontitis Aggressive periodontitis Periodontitis as a manifestation of systemic disease Necrotizing ulcerative gingivitis/periodontitis Abscesses of the periodontium Combined periodontic-endodontic lesions Moreover, terminology expressing both the extent and severity of periodontal diseases are appended to the terms above to denote the specific diagnosis of a particular patient or group of patients. (wikipedia.org)
  • In addition to poor circulation, neuropathy, and difficulty moving, factors that contribute to chronic wounds include systemic illnesses, age, and repeated trauma. (wikipedia.org)
  • Macrophages
  • Some researchers posit that it must not be macrophages that are involved, as they could not appropriately discriminate between the varied array of opsonized entities as necessary, and that, in reality, the properties ascribed to the macrophage in the initiation phase of the inflammatory response actually belong to the lymphatic dendritic cell. (wikipedia.org)
  • donor
  • Alloimmunity is caused by the difference between products of highly polymorphic genes, primarily genes of the major histocompatibility complex, of the donor and graft recipient. (wikipedia.org)
  • severe
  • Adequate pulmonary function with no evidence of chronic obstructive or severe restrictive pulmonary disease. (clinicaltrials.gov)
  • Mesoblast's investigational product candidate MPC-06-ID is being developed to target the population of patients suffering from moderate to severe chronic low back pain due to moderately degenerated discs. (wikipedia.org)
  • According to the American Academy of Periodontology, the classification of severity is as follows: Mild: 1-2 mm (0.039-0.079 in) of attachment loss Moderate: 3-4 mm (0.12-0.16 in) of attachment loss Severe: ≥ 5 mm (0.20 in) of attachment loss In the early stages, periodontitis has very few symptoms, and in many individuals the disease has progressed significantly before they seek treatment. (wikipedia.org)
  • For instance, OHL with HIV/AIDS is a predictor of bad prognosis, (i.e. severe immunosuppression and advanced disease). (wikipedia.org)
  • Cyclophosphamide decreases the immune system's response, and although concerns about toxicity restrict its use to patients with severe disease, it remains an important treatment for life-threatening autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. (wikipedia.org)
  • recipient
  • CNV is more likely to occur in those with active blepharitis, those who receive sutured knots in their host stromas, and those with a large recipient area. (wikipedia.org)
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • After bone marrow transplantation, T cells present in the graft, either as contaminants or intentionally introduced into the host, attack the tissues of the transplant recipient after perceiving host tissues as antigenically foreign. (wikipedia.org)
  • treatments
  • Lichen planopilaris is considered an orphan disease with no definitive prevalence data and no proven effective treatments. (wikipedia.org)
  • It seeks to provide treatments for inflammatory ailments, cardiovascular disease and back pain. (wikipedia.org)
  • In addition to traditional Breast cancer treatments, Dr. Silva advocates for the prevention of cancer occurrence and/or recurrence through nutrition, anti-inflammatory, and immune system boosting treatments. (wikipedia.org)
  • These advantages have established autologous HSCT as one of the standard second-line treatments for such diseases as lymphoma. (wikipedia.org)
  • This distinction is important because the eosinophil-based disorder is due to a particular set of underlying diseases and preferred treatments that differ from those for non-eosinophilic myocarditis. (wikipedia.org)
  • receptors
  • 12. The device of claim 2, wherein the one or more binding agents include one or more of antibodies, receptors, or cognates and binds to at least one of the one or more inflammatory mediators. (patentsencyclopedia.com)
  • When LCMV attacks a cell, the process of replication starts by attachment of the virus to host receptors through its surface glycoproteins. (wikipedia.org)
  • It depends on the balance of activating and inhibitory NK cell receptors and on their ligands expressed by the graft. (wikipedia.org)
  • antibodies
  • Hemolytic disease of the fetus and newborn is similar to a transfusion reaction in that the mother's antibodies cannot tolerate the fetus's antigens, which happens when the immune tolerance of pregnancy is impaired. (wikipedia.org)
  • immune cells
  • An immuno-competent graft is administered, with viable and functional immune cells. (wikipedia.org)
  • Such components include: Microenvironmental factors like tonicity, pH, oxygen pressure and the redox status of immune cells Mechanical factors, such as tissue pressure, cellular stiffness and cell motility Cell membrane physics such as membrane composition and particles The research field of immunophysics aims to investigate the influence of these physicochemical parameters on the function of the immune system in health and disease. (wikipedia.org)
  • organ
  • Particular organ problems (e.g. diseases involving the skin, heart, facial development and skeletal system) may be present in certain conditions. (wikipedia.org)
  • periodontal disease
  • The 1999 classification system for periodontal diseases and conditions listed seven major categories of periodontal diseases, of which 2-6 are termed destructive periodontal disease, because the damage is essentially irreversible. (wikipedia.org)
  • In fact, the bacteria present within endodontic infections are thoroughly similar to the bacteria that are involved in periodontal disease. (wikipedia.org)
  • tissue damage
  • While primarily mobilized to kill the invading microorganisms, the neutrophils actually cause a significant amount of host tissue damage as well. (wikipedia.org)
  • Cancer, especially squamous cell carcinoma, may also form as the result of chronic wounds, probably due to repetitive tissue damage that stimulates rapid cell proliferation. (wikipedia.org)
  • peripheral
  • Extracorporeal devices, systems, and methods are provided that alter the functional structure of one or more inflammatory mediators in the peripheral blood of the subject. (patentsencyclopedia.com)
  • 14. The device of claim 1, further including a sensor configured to detect the one or more inflammatory mediators in the peripheral blood. (patentsencyclopedia.com)
  • 15. The device of claim 14, further including a controller in communication with the sensor and configured to adjust the one or more reactive biological or chemical compounds to achieve a target value of the detected one or more inflammatory mediators in the peripheral blood of the subject. (patentsencyclopedia.com)
  • neurological
  • At the time of neurological disease, bacterial or fungal infections were excluded by routine monitoring and cerebrospinal fluid (CSF) examinations. (ahajournals.org)
  • chemotherapy
  • Dehydration, radiotherapy involving the salivary glands, chemotherapy and several diseases can cause hyposalivation or a change in saliva consistency and hence a complaint of xerostomia. (wikipedia.org)
  • defense
  • Primary among the members of the host defense mechanism is the polymorphonuclear leukocyte, otherwise known as the neutrophil. (wikipedia.org)
  • Viral
  • The virion's outer portion consists of a lipid bilayer membrane that contains viral glycoproteins and is derived from that of the host. (wikipedia.org)
  • Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. (wikipedia.org)