Time FactorsToxicity Tests, ChronicBlood PressureDose-Response Relationship, DrugRats, Sprague-DawleyOrgan SizeBody WeightRats, WistarDrug ToleranceChronic DiseaseInsulinRespiratory Tract DiseasesHeart RateEnvironmental ExposureHemodynamicsHypertensionMotor ActivityVascular ResistanceOccupational DiseasesGrowth HormoneBlood GlucoseDrug Administration ScheduleBrainKidneyDisease Models, AnimalOccupational ExposureDouble-Blind MethodRats, Inbred SHRAnalysis of VarianceBehavior, AnimalOxygen ConsumptionCross-Over StudiesAntihypertensive AgentsRats, Inbred StrainsRegional Blood FlowMuscle, SkeletalVasodilator AgentsHippocampusNorepinephrineGlucoseLiverHeart FailureMice, Inbred C57BLNeuronsSmokingCells, CulturedRNA, MessengerCalcium