• The recently exposed relationships between collagen fibers, applied mechanical stimuli, tissue micro-damage, acute and chronic inflammation and neuromuscular disorders are delineated with special reference to sports and occupational stressors such as load duration, rest duration, work/rest ratio, number of repetitions of activity and velocity of movement. (cdc.gov)
  • Andrew N. Wilner, MD, did not differentiate between the evidence levels and recommendations for acute and chronic TBI, which were clearly delineated. (medscape.com)
  • Acute/chronic pain management: Proposals should explore the osteopathic approaches to acute and chronic pain management, emphasizing treatments and patient outcomes. (osteopathic.org)
  • He has authored 20 original peer-reviewed papers relating to the use of osteopathic manipulation for pneumonia, chronic obstructive lung disease, influenza vaccine, improving immune function, applications of osteopathic philosophy, falls prevention, leg length discrepancies and, most recently, leg edema. (osteopathic.org)
  • Other types of respiratory diseases potentially impacted by workplace exposures include chronic obstructive pulmonary disease (or COPD), hypersensitivity pneumonitis, silicosis, lung cancer, and bronchiolitis obliterans. (cdc.gov)
  • Chronic paronychia is characterized by acute exacerbations of self-limiting inflammation and infection followed by remissions. (medscape.com)
  • After exposure to cocaine adulterated with the immunomodulator levasimole, a 48-year-old patient developed acute inflammation and ulcers that were expected to require long-term home nursing care. (bcmj.org)
  • The acute inflammation was resolved, but her chronic ulcers were expected to cause further debilitating pain and require long-term home nursing care. (bcmj.org)
  • We therefore investigated the effects of PM2.5 exposure on insulin resistance and the disorders of hepatic glucose and lipid metabolism via hypothalamic inflammation. (deepdyve.com)
  • Therefore, our current finding indicates an important role of hypothalamic inflammation in PM2.5 exposure-mediated hepatic glucose and lipid metabolism disorder. (deepdyve.com)
  • 2012). Our previous study demonstrated that PM2.5 exposure led to hyperglycemia and IR, which were accompanied by hypothalamic inflammation evidenced by increased mRNA levels of Interleukin-6 (IL-6), tumor necrosis factor α (TNFα), Inhibitor kappa B kinase 2 (IKK2), and enhanced microglial/astrocyte reactivity (Song et al. (deepdyve.com)
  • 2017). The inhibition of hypothalamic inflammation by intracerebroventricular (ICV) administration of IKK2 inhibitor (IMD-0354) rectified PM2.5-induced glucose intolerance, IR, energy metabolism dysfunction, and attenuated peripheral inflammation in response to PM2.5 exposure (Song et al. (deepdyve.com)
  • Bronchiectasis Bronchiectasis is dilation and destruction of larger bronchi caused by chronic infection and inflammation. (msdmanuals.com)
  • The disease is characterized by chronic inflammation extending through all layers of the intestinal wall and involving mesentery as well as regional lymph nodes. (medscape.com)
  • With chronic inflammation, the bowel walls become thickened, fibrotic, and stenotic in Crohn disease, and an extension of inflammation and fistula formation often occurs as a result of a transmural fissure. (medscape.com)
  • considerable importance as a cause of death and morbidity communicable chronic respiratory and this has in the past and diseases increases with Westernization . (who.int)
  • 3. Goal of the WHO strategy against CRDs is for Prevention and Control of to support Member States in their efforts to Chronic Respiratory Diseases reduce the toll of morbidity, disability and (CRDs)1 that was drafted after the expert consultation premature mortality related to chronic held in January 20012. (who.int)
  • The advisory meeting in Montpellier, France on 11-12 February 2002 comprised the next step in the process of developing a comprehensive implementation programme of the WHO strategy against chronic respiratory diseases. (who.int)
  • Populations affected by disasters may carry a large and measurable burden of disabilities and chronic diseases, especially heart disease, cancer, stroke, diabetes, and chronic respiratory disorders (4). (cdc.gov)
  • The aftermath of Hurricane Katrina is a reminder of the urgent need for developing and implementing recommendations for the control of chronic diseases during disasters. (cdc.gov)
  • A limited needs assessment among individuals staying in evacuation centers, conducted in the field and reported to the Centers for Disease Control and Prevention (CDC), demonstrated that five of the top six conditions were all chronic diseases and that, other than injuries, the majority of medical and health visits were for medication refills, oral health issues, and other chronic health conditions (16). (cdc.gov)
  • Clusters of health events, such as chronic diseases, injuries, and birth defects, are often reported to health agencies. (cdc.gov)
  • These guidelines focus on noninfectious health events such as chronic diseases, injuries, and birth defects. (cdc.gov)
  • Even though cardiovascular diseases (CVDs) are the main of cause of the global burden of diseases attributable to PM exposure, it remains difficult to show reliable associations between exposure to wildland fire smoke and cardiovascular disease risk in population-based studies. (frontiersin.org)
  • We found that chronic renal failure/impairment (adjusted odds ratio [aOR] 4.09), chronic pulmonary diseases (aOR 3.22), malignancy (aOR 3.04), and heart diseases (aOR 2.15) were independently associated with a higher risk for severe Legionnaires' disease. (cdc.gov)
  • Interestingly, however, tobacco use is modeled by clinicians and investigators differently from that of other chronic diseases. (biomedcentral.com)
  • A peculiar feature of the medical assessment of tobacco use is that it differs markedly from the assessment of other chronic diseases. (biomedcentral.com)
  • Specifically: unlike tobacco use, the assessment of control of most chronic diseases centers around the routine measurement of a validated biomarker or biomarkers. (biomedcentral.com)
  • Indeed, there are multiple lines of evidence that suggest that exposure to various environmental variables in utero and during early childhood may play a major role in susceptibility to allergic diseases. (biomedcentral.com)
  • In addition to their separate complexity, existing research has shown important multi-morbidity between these diseases, where multi-morbidity is defined as the co-occurrence of two or more chronic conditions [ 5 ]. (plos.org)
  • IMPACT: Given the significant intake of nicotine and carcinogens, chronic water pipe use could place users at increased risk of cancer and other chronic diseases. (who.int)
  • Which exposures and associated respiratory diseases should we focus on in creating the NORA research goals? (cdc.gov)
  • Although some believe that the difference between those who have addiction, and those who do not, is the quantity or frequency of alcohol/drug use, engagement in addictive behaviors (such as gambling or spending)3, or exposure to other external rewards (such as food or sex), a characteristic aspect of addiction is the qualitative way in which the individual responds to such exposures, stressors and environmental cues. (drugprevent.org.uk)
  • WBSPM exposure increases people's susceptibility to respiratory infections, exacerbates asthma, and causes emphysema and COPD. (grantome.com)
  • However, controlled exposure studies are more suitable for detecting acute or subacute responses of exposure, while panel studies using occupational populations suffer from exposure to a complex mixture of air pollutants such as various mine dust, gasoline emission, etc. that may confound the associations between DE exposure and health outcomes. (biomedcentral.com)
  • Exposure of human populations to smoke emitted by these fires increases, thereby contributing to airborne pollution through the emission of gas and particulate matter (PM). The adverse health outcomes associated with wildland fire exposure represent an important burden on the economies and health systems of societies. (frontiersin.org)
  • Here, we critically review the literature on this topic as it pertains to the rhizosphere microbiome of crop plants and gut microbiome of pollinator insects (namely managed populations of the western honey bee, Apis mellifera), since both are frequent recipients of chronic pesticide exposure. (researchgate.net)
  • and ultrasonography and MRI are adjuncts that provide alternative cross-sectional images in populations in whom radiation exposure is a concern. (medscape.com)
  • Many populations reside at high altitude and are exposed to chronic low oxygen levels. (hopkinsmedicine.org)
  • The mechanical and neurological properties of ligaments are reviewed and updated with recent development from the perspective which evaluates their role as a source of neuromusculoskeletal disorders resulting from exposure to sports and occupational activities. (cdc.gov)
  • Prev Chronic Dis [serial online] 2005 Nov [ date cited ]. (cdc.gov)
  • and Cochrane library and search engines ScienceDirect and Prev Chronic Dis 2022;19:210231. (cdc.gov)
  • www.cdc.gov/pcd/issues/2022/21_0231.htm Preventing Chronic Disease. (cdc.gov)
  • Numerous related issues--such as the epidemiologic workup of infectious disease outbreaks, the assessment of the health effects of environmental exposures, the prospective detection of clusters, and the investigation of interpersonal networks--are not addressed. (cdc.gov)
  • Addiction is a primary, chronic disease of brain reward, motivation, memory and related circuitry. (drugprevent.org.uk)
  • Tobacco use is a chronic relapsing disease, and remains the leading cause of preventable death in much of the world. (biomedcentral.com)
  • Increasingly, tobacco use, chiefly cigarette smoking, is being framed as a chronic disease, with periods of use and periods of abstinence. (biomedcentral.com)
  • Nevertheless, imaging remains of particular importance in IIM because it provides an assessment of structural abnormalities in muscle tissue, which can help confirm the presence of disease, delineate the type and pattern of its involvement and, ultimately, help guide treatment. (the-rheumatologist.org)
  • On the other hand, intensification of the largely irreversible markers of chronicity and damage, such as fatty replacement and atrophy (increased signal intensity and decreased muscle mass, respectively, on T1W), warrant reevaluation of the drug regimen to balance out the need to prevent both disease progression and unnecessary exposure to potentially harmful medications. (the-rheumatologist.org)
  • Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. (stanford.edu)
  • Dietary intake is an important environmental exposure to consider when evaluating an individual's or population's risk for chronic disease. (jmir.org)
  • Endometriosis, a chronic disease of heterogeneous etiopathology affects 10% of young women and is characterized by ectopic implantation of endometrial cells. (endometriosi.it)
  • The COCOA data collection schedule includes 11 routine standardized follow-up assessments of all children at 6 months and every year until 10 years of age, regardless of allergic-disease development. (biomedcentral.com)
  • The impact of the osteopathic approach on chronic disease and elderly care: Proposals should explore the impact of the osteopathic approach on chronic disease and elderly care through clinical, translational or basic science research. (osteopathic.org)
  • Too few samples were analyzed for pesticides toallow a more certain conclusion as to whether exposures to pesticides are occurring. (cdc.gov)
  • PURPOSE: To describe the clinical features of a unique pigmentary maculopathy noted in the setting of chronic exposure to pentosan polysulfate sodium (PPS), a therapy for interstitial cystitis (IC). (bvsalud.org)
  • We interviewed patients or their proxies and their attending doctors to obtain clinical and exposure history. (cdc.gov)
  • This is particularly important when discordance exists between the patients' symptoms and providers' assessments and when routine serologic markers of muscle breakdown fail to correlate with clinical findings. (the-rheumatologist.org)
  • I will present case studies of risk assessment, including application of in silico and in vitro methods to contribute to protein engineering and the selection of clinical candidates. (pegsummit.com)
  • The clinical latency period between asbestos exposure and mesothelioma development is 35-40 years, and as a result, the number of mesothelioma patients has continued to rise despite decreased asbestos production. (medscape.com)
  • A clinical history of asbestos exposure and radiologic findings that are consistent with mesothelioma warrant inclusion of mesothelioma in the differential diagnosis, but it is important to stress that a diagnosis of mesothelioma cannot be made exclusively with imaging studies. (medscape.com)
  • The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. (bvsalud.org)
  • Although many perceive water pipe smoking to be relatively safe, clinical experimental studies indicate significant exposures to tobacco smoke carcinogens following water pipe use. (who.int)
  • Compared with other pregnant women, women in the early stages of pregnancy may be at higher risk for adverse pregnancy outcomes because of exposure during organogenesis to toxins or infectious agents. (cdc.gov)
  • Our results further delineate the role ERK plays in regulating mood-related behaviors across the lifespan. (jneurosci.org)
  • Addiction also affects neurotransmission and interactions between cortical and hippocampal circuits and brain reward structures, such that the memory of previous exposures to rewards (such as food, sex, alcohol and other drugs) leads to a biological and behavioral response to external cues, in turn triggering craving and/or engagement in addictive behaviors. (drugprevent.org.uk)
  • 2007). Emerging evidence from both epidemiological and experimental studies indicates the adverse consequences of PM2.5 exposure on diabetes, including worsening of whole-body insulin sensitivity, glucose tolerance impairment, lipid accumulation, and glucose metabolism dysfunction (Hwang et al. (deepdyve.com)
  • A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment. (rivm.nl)
  • Options for prevention include avoiding exposure to carcinogens, for example by smoking cessation, as well as vaccination, screening, monitoring those at high genetic risk, using therapeutics to reduce cancer risk, and emerging molecular technology for early diagnosis. (who.int)
  • Calcified pleural plaques are present in 20% of patients with mesothelioma and are usually related to the previous asbestos exposure. (medscape.com)
  • We propose that clinicians move away from the dichotomous categorization of tobacco use, and adopt methods used to categorize the status of other chronic conditions. (biomedcentral.com)
  • Specifically, biomarkers such as carbon monoxide, cotinine, and anabasine, measured at regular intervals, can provide clinicians with much clearer, clinically relevant and actionable assessments of current tobacco use by their patients. (biomedcentral.com)
  • Because of the ubiquity of tobacco use, and its associated burden of morbidity and mortality, numerous practice guidelines, professional associations and regulatory bodies recommend routine assessment of tobacco use, often at every medical visit, with identified smokers then referred for treatment by quitlines, specialty clinics or groups, and offered prescriptions of approved tobacco treatment medications. (biomedcentral.com)
  • Cognitive-behavioral therapy using the techniques of exposure and response prevention has helped countless individuals with obsessive-compulsive disorder (OCD) overcome debilitating symptoms and live fuller, more satisfying lives. (hogrefe.com)
  • Based on how cancer is distributed worldwide, and differences between and within particular countries, this new assessment offers a comprehensive overview of the global cancer burden as a starting point for documenting all known options for cancer prevention through the latest research. (who.int)
  • Thus, radon exposure represents a readily preventable cause of the most lethal and common cancer type, and is a priority area of public health intervention and cancer prevention. (nature.com)
  • In addition to lung cancer, chronic DE exposure has also been linked to many non-malignant pulmonary and extra-pulmonary health effects. (biomedcentral.com)
  • After a quality assessment, the monthly numbers of newly diagnosed cancer cases were extracted for six cancer types: colorectal, female breast, lung, pancreas, prostate, and thyroid. (cdc.gov)
  • A comparison of associations with childhood lung function between air pollution exposure assessment methods with and without accounting for time-activity patterns. (rivm.nl)
  • We therefore systematically investigated this issue in a genetic diabetic model subjected to air pollution exposure along with ICV treatment of IKK2 inhibitor. (deepdyve.com)
  • Competitive athletes and nonathletes should follow appropriate general public health agency recommendations for screening for BBPs, considering their individual risk factors and exposures. (lww.com)
  • Exposure to WBSPM is often unavoidable even in modern society and specific molecular and chemical interactions that link exposure to the established acute and long term effects of WBSPM are not fully understood. (grantome.com)
  • Methodological issues with dietary assessment, however, have limited the ability to identify gene-nutrient interactions. (jmir.org)
  • The development of a mobile telephone food record has the potential to ameliorate much of the burden associated with current methods of dietary assessment. (jmir.org)
  • Assessments of retinal function and morphology as well as measurement of specific proteins expression level were conducted. (bvsalud.org)
  • Frontal lobe morphology, connectivity and functioning are still in the process of maturation during adolescence and young adulthood, and early exposure to substance use is another significant factor in the development of addiction. (drugprevent.org.uk)
  • Many neuroscientists believe that developmental morphology is the basis that makes early-life exposure to substances such an important factor. (drugprevent.org.uk)
  • Sample soil to assess whether average exposure point concentrations exceed levels of health concern for persons living at residences likely to be contaminated. (cdc.gov)
  • Additionally, a NOS (Newcastle-Ottawa Scale) assessment and an evaluation of the OCEM (Oxford Center for Evidence-Based Medicine) level of evidence for each study was conducted to assess each study's individual risk of bias, and the risk of bias across all studies. (aap.org)
  • Dr. Garry has worked extensively on projects involving petroleum, pulp and paper, and mining sites developing and applying scientifically-based methods to assess ecological and human exposure and toxicity. (exponent.com)
  • The mothers will complete multiple questionnaires to assess the baseline characteristics, the child's exposure to environmental factors, maternal pre- and post-natal psychological stress, and the child's neurodevelopment, nutritional status, and development of allergic and respiratory illnesses. (biomedcentral.com)
  • Human health risk assessments (HHRAs) use the dose- at Stephen B. Thacker CDC Library on August 19, 2014 models and the supporting computer code is necessary for their response relationship to characterize and quantify potential health consideration for use in HHRAs. (cdc.gov)
  • This includes insecticides, herbicides, and fungicides commonly used in agriculture that are known to produce broad ranging, off-target effects on beneficial wildlife, even at seemingly non-toxic low dose exposures. (researchgate.net)
  • Dale Hattis, PhD, of Clarke University has published a number of papers about the role of susceptibility factors in assessing neurotoxicity risks in accord with low levels of exposure. (whale.to)
  • Also use these analyses to help determine the need for exposure investigations (in coordination with the development of any studies of health effects) and to describe the size and geographic spread of the population with elevated blood PCBs. (cdc.gov)
  • This volume opens with an overview of the diagnosis and assessment of OCD in adults and delineates an evidence-based conceptual framework for understanding the development, maintenance, and treatment of obsessions and compulsions. (hogrefe.com)
  • Incorporating immunogenicity and developability risk assessment into the early stages of development is important for optimal lead selection. (pegsummit.com)
  • Some exposures in the first 1,000 days (from conception to two years of age) impact child development and can favour excess weight [ 14 ]. (biomedcentral.com)
  • He has also collaborated with U.S. EPA Region 10 on several projects, including the development of streamlined, risk-based screening software for indirect exposure to incinerator emissions, and compilation of seafood arsenic speciation and toxicity data. (exponent.com)
  • These results will inform age-specific development of the mobile telephone food record that may translate to a more accurate method of dietary assessment. (jmir.org)
  • The ATSDR approach to assessing the public health implications of exposure to TPH is presented in Section 2.3. (cdc.gov)
  • We investigated biomarkers of nicotine intake and carcinogen exposure from water pipe smoking in the naturalistic setting of hookah bars. (who.int)
  • Chronic leg edema and related lymphedema is a common chronic problem in the elderly refractory to conventional treatments that leads to significant morbidity. (osteopathic.org)
  • A class of actions which either individually or cumulatively would not have a significant effect on the human environment and therefore would not require preparation of an environmental assessment or environmental impact statement under the National Environmental Policy Act (NEPA). (frtr.gov)
  • derive (i) from ignoring susceptibility factors and their influence upon neurotoxic risks at low levels of exposure, and thereby (ii) from interpreting HMO data in accord with an artificially high and unsafe level for ingested methylmercury (EPA, 1997). (whale.to)
  • Each of these summaries contains major errors in the science of neurotoxic susceptibility-risk at low-level exposures. (whale.to)
  • The pattern of changes in small airway dimensions, i.e., thicker airway wall without lumen narrowing caused by occupational DE exposure was different to that (i.e., thicker airway wall with lumen narrowing) seen in our previous study of workers exposed to nano-scale carbon black aerosol, suggesting constituents other than carbon cores may contribute to such differences. (biomedcentral.com)
  • CONCLUSION: Water pipe smoking in a hookah bar is associated with significant nicotine intake and carcinogen exposure. (who.int)
  • Method We analysed, in a prospective, observational, monocentric, open label cohort, the effect of chronic non-motor STN-DBS in 19 patients with treatment-resistant OCD consecutively operated in a single centre. (bmj.com)
  • Chronic illnesses are exacerbated by the conditions caused by a disaster (e.g., lack of food, lack of clean water, extremes of cold or heat, physical and mental stress, injury, exposure to infection). (cdc.gov)
  • ATSDR's evaluation of the health hazard potential, particularly with regard to the size of the exposed population and the levels and duration of exposure, is limited by data gaps. (cdc.gov)
  • Successful completion of this CME activity, which includes participation in the evaluation component, enables the learner to earn credit toward the CME and/or Self-Assessment requirements of the American Board of Surgery's Continuous Certification program. (netce.com)
  • 25 reviewing LCIA research on PM, suggest the need for consistency in fate, exposure, and effect evaluation. (docecity.com)
  • ABSTRACT: In the case reported here, cocaine abuse led to levasimole-induced vasculitis and chronic ulcers. (bcmj.org)
  • The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure during adolescence are poorly understood. (jneurosci.org)
  • This and subsequent chapters are designed to aid the reader in understanding what TPH is, what we know about it, the chance of significant exposure, and possible health consequences. (cdc.gov)
  • The possible consequences of an immune response are also evaluated when completing a risk assessment. (pegsummit.com)
  • Assessment of the proposed TRPV3-dependent mechanistic paradigm will provide fundamental data to potentially predict human risks for respiratory conditions associated with WBSPM exposure by establishing new mechanisms for toxicity. (grantome.com)
  • The symptoms can be acute or chronic, and diagnosis is usually based on radiographic findings, typically a CT pulmonary angiogram. (lecturio.com)
  • In addition, indirect effects (e.g., loss of electricity) can lead to exposure to extreme heat or cold or interruption of supplemental oxygen supplies. (cdc.gov)
  • Here, we assessed the long-term effects of exposure to fluoxetine (FLX), a selective serotonin reuptake inhibitor, during adolescence on behavioral reactivity to emotion-eliciting stimuli. (jneurosci.org)
  • PCBs in soil in some areas of Anniston present a public health hazard based on the potential for chronic cancerous and noncancerous health effects. (cdc.gov)
  • Furthermore, residential soils in some areas of Anniston with higher levels of PCBsmay present a public health hazard for thyroid and neurodevelopmental effects forintermediate exposure durations (less than 1 year of exposure). (cdc.gov)
  • d) recommend research studies to be undertaken in India on the long-term effects of the gas exposure, and e) assure the wide circulation of its experience and findings in the professional literature. (wikipedia.org)
  • Purpose: To systematically review published literature to examine if a lack of sleep is associated with sports injuries in adolescents and to delineate the effects of chronic versus acute lack of sleep. (aap.org)
  • Traditional self-report methods of dietary assessment, including the 24-hour dietary recall, food record, and food frequency questionnaire [ 6 ], rely on the respondent's memory and ability to estimate portion sizes. (jmir.org)
  • Several life cycle impact assessment (LCIA) methods evaluate the human health damage per mass of PM emitted.12 15 Hofstetter12 generated one of the first LCIA approaches evaluating damage factors for PM, based on a consistent integration of data from existing models and epidemiological studies. (docecity.com)
  • Which methods for assessing exposure and health should be highlighted? (cdc.gov)
  • This would mirror the treatment of other chronic conditions, such as diabetes, hypertension, or hyperlipidemia. (biomedcentral.com)
  • Most chronic conditions, such as hypertension or diabetes, are considered to be in "good control" or not. (biomedcentral.com)
  • KKAy mice, a genetically susceptible model of type II diabetes mellitus, were administered intra-cerebroventricularly with IKK2 inhibitor (IMD-0354) and were exposed to either concentrated PM2.5 or filtered air (FA) for 4 weeks simultaneously via a versatile aerosol concentration exposure system. (deepdyve.com)
  • These findings demonstrate that exposure to FLX during adolescence modulates responsiveness to emotion-eliciting stimuli in adulthood, at least partially, via long-lasting adaptations in ERK-related signaling within the VTA. (jneurosci.org)
  • The present work aims to fill this gap by reviewing intake fraction estimates for PM-related emissions and then recommending a set of intake fraction values that are internally consistent, account for regional differences in fate and exposure ("regionalization"), and facilitate LCIA comparisons with nonparticle pollutants (e.g., organic pollutants). (docecity.com)
  • The magnitude of PCB levels in blood in older persons (i.e., 41 of the persons aged 38 years or older had levels greater than 100 g/L) suggests that PCB exposures may have been more severe in the past. (cdc.gov)
  • Conclusion Chronic DBS of the non-motor STN is an effective and relatively safe procedure to treat severe OCD resistant to conventional management. (bmj.com)
  • Conclusions: Chronic lack of sleep in adolescents is associated with greater risk of sports and musculoskeletal injuries. (aap.org)
  • Persons with elevated blood PCB levels (greater than 20 µ g/L) for whom there is evidence of current exposure to soil contamination should be a focus of particular attention in future environmental characterization and public health actions. (cdc.gov)
  • This lack of information has caused us to make estimates of PCB exposure that may overestimate or underestimate health risk. (cdc.gov)
  • For this reason, our estimates of exposure magnitude and our public health conclusions might change. (cdc.gov)
  • Exposures to PCBs in air present an indeterminate public health hazard. (cdc.gov)
  • Uncertainty about the levels of PCBs in the air near Solutia over chronic exposure durations, combined with uncertainty regarding air levels to which persons would be exposed at their homes precludes a determination of whether PCBs in air presents a health hazard. (cdc.gov)
  • Use blood PCB levels in conjunction with residential history information to help define areas where exposure point concentrations exceed levels of health concern. (cdc.gov)
  • In many instances, the health agency will not be able to demonstrate an excess of the condition in question or establish an etiologic linkage to an exposure. (cdc.gov)
  • When an excess is confirmed, the likelihood of establishing a definitive cause-and-effect relationship between the health event and an exposure is slight. (cdc.gov)
  • The medical community was often frustrated in its attempts to understand the links between gas exposure and health and devise appropriate treatment strategies. (wikipedia.org)
  • In these instances, EPA uses conservative assumptions and default values in its quantitative risk assessments to ensure the assessment protects human health and the environment. (americanbar.org)
  • Wildland fire, air pollution and cardiovascular health: is it time to focus on the microvasculature as a risk assessment tool? (frontiersin.org)
  • Thus, hazardous radon exposure is largely an anthropogenic environmental health issue. (nature.com)
  • Adolescent FLX exposure suppressed depression-like behavior, as measured by the social interaction and forced swim tests, while enhancing anxiety-like responses in the elevated plus maze in adulthood. (jneurosci.org)
  • Platforms include Epibase™ In Silico for the prediction of T cell epitopes and Epibase™ In Vitro for the assessment of T cell and B cell responses in human donor PBMC. (pegsummit.com)
  • Adjustments to the POD are made to account for uncertainties and to protect the most sensitive human population at risk of exposure to the chemical(s). (cdc.gov)
  • This presentation will focus on the human immunogenicity risk assessment platforms and other developability assessment tools at Lonza to aid the selection and optimization of lead candidates. (pegsummit.com)
  • This paper summarizes the work of an international expert group on the integration of human exposure to PM into life cycle impact assessment (LCIA), within the UNEP/SETAC Life Cycle Initiative. (docecity.com)
  • He is able to translate advances in basic science and technology into the practice of risk assessment and risk communication. (exponent.com)
  • NOS assessment was conducted for all six cohort studies to investigate each study's individual risk of bias. (aap.org)
  • OCEM criteria assessment showed that all but one study (a case-series) were of 2b level of evidence-which is the highest level of evidence possible for studies which were not randomized control trials or systematic reviews. (aap.org)
  • NOS assessment revealed that the most consistent source of bias was in ascertainment of exposure: all studies relied on self-reported data regarding sleep hours rather than a medical or lab record of sleep hours. (aap.org)
  • In the field of regulatory toxicology, Dr. Garry has designed and overseen laboratory-testing programs aimed at understanding the mechanisms of toxicity and developing safe exposure levels for industrial chemicals. (exponent.com)
  • The IMCB publicly condemned Union Carbide and reiterated the company's full liability not only for responsibility in causing the deadly gas leak, but also for the confounding role of its behaviour with respect to pre-accident preventive and exposure mitigating efforts, and the timely and effective application of the appropriate medical measures at the time of the accident. (wikipedia.org)
  • We examined how North American residential radon exposure varies by modern environmental design, occupant behaviour and season. (nature.com)
  • Regression analyses indicates that the modern North American Prairie residential environment displays exceptionally high and worsening radon exposure, with more recent construction year, greater square footage, fewer storeys, greater ceiling height, and reduced window opening behaviour all associated with increased radon. (nature.com)
  • Prolonged exposure to hypoxia strongly up-regulated CXCL12 expression in multiple myeloma plasma cells and hypoxia-inducible factor-2 was found to play a key role in this response. (haematologica.org)
  • 13] Factors to consider when assessing management options include etiology, duration, extent of paronychial involvement, and associated risk factors present such as contact with oral secretions or exposure to animals. (medscape.com)