• What is less clear is the evidence for a role of macrolides in the treatment of other chronic inflammatory airway diseases, e.g. cystic fibrosis, bronchiectasis, asthma, obliterative bronchiolitis, chronic obstructive pulmonary disease (COPD) and chronic rhinosinusitis. (ersjournals.com)
  • Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. (ersjournals.com)
  • In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular. (ersjournals.com)
  • These changes in mucin production in the peripheral airways may contribute to the pathophysiology of COPD. (nih.gov)
  • In the United States, about 16 million people have chronic obstructive pulmonary disease (COPD). (msdmanuals.com)
  • COPD leads to a persistent decrease in the rate of airflow from the lungs when the person breathes out (exhales), which is called chronic airflow obstruction. (msdmanuals.com)
  • COPD includes the diagnoses of chronic obstructive bronchitis and emphysema. (msdmanuals.com)
  • In some cases, the distinction between chronic obstructive bronchitis and chronic asthmatic bronchitis is unclear, and then the condition may be referred to as asthma COPD overlap. (msdmanuals.com)
  • Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. (e-trd.org)
  • Therapies such as inhaled corticosteroids and azithromycin may modulate the airway microbiome or its metabolites in patients with COPD. (e-trd.org)
  • This paper provides an up-to-date overview of the airway microbiome and its importance in the pathophysiology of COPD and as potential therapeutic target in the future. (e-trd.org)
  • Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality, responsible for 3.23 million deaths per year worldwide [ 1 ]. (e-trd.org)
  • Interestingly, even in patients with stable disease (i.e., free of exacerbations for at least a month), use of antibiotics, especially macrolides, leads to better outcomes, reducing the frequency of COPD exacerbations by approximately 25% [ 6 ]. (e-trd.org)
  • however, modern genomic technology has unveiled a rich and diverse microbial communities in the airways from the nose to the alveoli, which become perturbed in COPD, causing dysbiosis. (e-trd.org)
  • In this review, we will review our current understanding of the airway microbiome (microbiota) in health and disease and discuss the impact of dysbiosis on morbidity and mortality of patients with COPD. (e-trd.org)
  • Using search terms "COPD," "chronic obstructive pulmonary disease," "microbiome," and "bacteria," PubMed was interrogated to January 1, 2023 to identify relevant papers on this topic. (e-trd.org)
  • For this review, we will use the Global initiative for chronic Obstructive Lung Disease (GOLD)'s definition of COPD, which is based on forced expiratory volume in 1 second/forced vital capacity (FEV 1 /FVC) ratio of less than 0.70 in the presence of chronic respiratory symptoms such as dyspnea, cough, or sputum production [ 8 ]. (e-trd.org)
  • Methods: The degree of depression and anxiety in 84 outpatients with chronic obstructive pulmonary disease (COPD), 37 with asthma, 33 with bronchiectasis, and 73 healthy controls were evaluated by the Beck Depression Inventory (BDI) and the State-Trait Anxiety Inventory (STAI). (ewha.ac.kr)
  • Medical aerosols are key elements of current chronic obstructive pulmonary disease (COPD) therapy. (mdpi.com)
  • Dr. Long Clinical question: How did GOLD revise its prior recommendations for the diagnosis and management of chronic obstructive pulmonary disease (COPD)? (the-hospitalist.org)
  • Dr. Sundararaghavan Clinical question: Can magnesium sulfate be used as an efficacious adjunct therapy in the treatment of chronic obstructive pulmonary disease (COPD). (the-hospitalist.org)
  • The Global Initiative for Obstructive Lung Disease (GOLD) staging approach is frequently used to classify the severity of COPD by using spirometry. (springeropen.com)
  • Chronic obstructive pulmonary disease (COPD) is defined by the Global Initiative for Obstructive Lung Disease (GOLD) group as a common preventable and treatable disease which is characterized by airflow limitation that is progressive usually and combined by an enhanced chronic inflammatory response in the airways and lung to gases and noxious particles [ 2 ]. (springeropen.com)
  • Main outcome measures Primary outcome was a change in symptom severity from baseline to day 30, as assessed by the self-reported COPD (chronic obstructive pulmonary disease) assessment test (CAT), which was adjusted for baseline values and stratification factors. (bmj.com)
  • Ginsenoside Rg1 may suppress cigarette smoke-induced airway fibrosis in pulmonary fibroblasts and COPD rats. (greenmedinfo.com)
  • Lung problems such as asthma or chronic obstructive pulmonary diseases (COPD). (healthlinkbc.ca)
  • Quick-relief medicines for chronic obstructive pulmonary disease (COPD) work quickly to help you breathe better. (medlineplus.gov)
  • Health Care Guideline: Diagnosis and Management of Chronic Obstructive Pulmonary Disease (COPD). (medlineplus.gov)
  • Chronic obstructive pulmonary disease (COPD) is a group of lung diseases involving limited airflow and varying degrees of air sac enlargement, airway inflammation, and lung tissue destruction. (health.am)
  • Emphysema and chronic bronchitis are the most common forms of COPD. (health.am)
  • The leading cause of COPD is smoking, which can lead to the two most common forms of this disease, emphysema and chronic bronchitis. (health.am)
  • Treatment for COPD includes inhalers that dilate the airways (bronchodilators) and sometimes theophylline. (health.am)
  • In Germany, 13.2% of the population older than 40 are affected by chronic obstructive pulmonary disease (COPD). (medindia.net)
  • By 2020, chronic obstructive pulmonary disease (COPD) will be the third most common cause of morbidity and mortality worldwide. (medindia.net)
  • Childhood measles was found to be associated to increase the risk of chronic obstructive pulmonary disease (COPD) later in life, especially in middle age. (medindia.net)
  • ML could be the next step of personalized medicine in chronic obstructive pulmonary disease (COPD) by giving the exact risk (risk for exacerbation, death, etc.) of every patient (based on his/her parameters like lung function, clinical data, demographics, previous exacerbations, etc.), thus providing a prognosis/risk for the specific patient based on individual characteristics (individu-al approach). (imperial.ac.uk)
  • COPD is a composite term encompassing several diseases including chronic bronchitis and emphysema. (nottingham.ac.uk)
  • Asthma and COPD are complex diseases involving both genetic and environmental factors resulting in disease expression. (nottingham.ac.uk)
  • There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. (nottingham.ac.uk)
  • Chronic obstructive pulmonary disease (COPD) is a group of conditions that affect how well a person breathes. (medicalnewstoday.com)
  • You might also have bronchiectasis, emphysema, chronic bronchitis, or chronic obstructive pulmonary disease (COPD) to name a few. (asthma.org.au)
  • DEFINITION COPD is a disease state characterized by increase in resistance to airflow due to partial or complete obstruction of airway at any level from the trachea to respiratory bronchiole. (slideserve.com)
  • Chronic obstructive pulmonary disease (COPD) is estimated to affect 32 million persons in the United States and is the third leading cause of death in this country. (medscape.com)
  • The sensitivity of physical examination in detecting mild to moderate COPD is relatively poor, but physical signs are quite specific and sensitive for severe disease. (medscape.com)
  • Chronic Airway-Digestive Inflammatory Disease" (CAID) is a phrase which has been coined by Dr. Jordan S. Josephson, M.D., F.A.C.S. and Dr. Jens Ponikeau, M.D. to describe this very complex set of problems which are caused by inflammation. (wikipedia.org)
  • Reflux can be set off by sinus problems and reflux can also send acids up to the upper airway and worsen the inflammation already occurring secondary to infection. (wikipedia.org)
  • This study will test the hypothesis that persistent symptoms in WTC "Survivors" are associated with abnormal small airways whose dysfunction is amplified during exercise and is associated with biologic evidence of inflammation and remodeling. (cdc.gov)
  • Macrolides are postulated to reduce airway inflammation via several mechanisms. (ersjournals.com)
  • The relationship between airway inflammation and structural changes of airway remodeling, and their relative effects on airway function, are poorly understood. (monash.edu)
  • The relationship between inflammation, remodeling changes, and airway hyperresponsiveness (AHR) were examined. (monash.edu)
  • The acute and subacute models exhibited marked airway inflammation, whereas the chronic model had very modest inflammation. (monash.edu)
  • Inflammation also causes swelling of the airway passages and secretions in them, further limiting airflow. (msdmanuals.com)
  • To model acute and chronic phases of the disease , we infected wild-type C57BL/6 and toll-like receptor 7 knockout (TLR7 KO) mice with RSV and temporally assessed nasal, airway and lung inflammation for up to 42 days post- infection . (bvsalud.org)
  • We show that TLR7 reduced viral titers in the URT during acute infection but promoted pronounced pathogenic and chronic airway inflammation and hyperreactivity in the LRT. (bvsalud.org)
  • Researchers have revealed in an animal model that ImmuBalance, a fermented soybean product, is effective in suppressing airway inflammation caused by asthma. (sciencedaily.com)
  • Bronchial asthma causes symptoms such as wheezing and cough due to chronic airway inflammation, but there is no fundamental treatment for it, leaving a desire for new prevention and treatment methods. (sciencedaily.com)
  • Now a new study reveals that a fermented soy product called ImmuBalance suppresses airway inflammation in animal models of asthma. (sciencedaily.com)
  • 6, 2022 Researchers evaluated whether dietary fiber intake was associated with a decrease in inflammation in older adults and if fiber was inversely related to cardiovascular disease. (sciencedaily.com)
  • Feb. 6, 2020 Eosinophilic chronic rhinosinusitis (ECRS) is a type of airway disease that involves nasal inflammation. (sciencedaily.com)
  • Asthma is a heterogeneous disease characterized by airway chronic inflammation together with airway hyperresponsiveness 1 . (nature.com)
  • These are medications that can reduce inflammation in the airways, making it easier to breathe. (medicalnewstoday.com)
  • Increased size of submucosal glands in large airways (Reid index: ratio of thickness of mucosal glands to thickness of wall between epithelium and cartilage) -Peribronchiolar chronic inflammation. (slideserve.com)
  • Bronchiectasis - Permanent abnormal dilation of bronchi and bronchioles, - Usually associated with chronic necrotizing inflammation - Patients have fever, cough, foul-smelling sputum. (slideserve.com)
  • Many "Survivors" in the WTC clinical program have a clinical syndrome characterized by chronic obstruction in small airways and persistence of lower respiratory symptoms despite therapy. (cdc.gov)
  • Chronic obstructive pulmonary disease is persistent narrowing (blocking, or obstruction) of the airways occurring with emphysema, chronic obstructive bronchitis, or both disorders. (msdmanuals.com)
  • When chronic bronchitis involves airflow obstruction, it qualifies as chronic obstructive bronchitis. (msdmanuals.com)
  • A decentralized rehabilitation program for chronic airway obstruction disease patients in small urban and rural areas of Wisconsin: a preliminary report. (cdc.gov)
  • Exposures of 50 to 100 ppm may be tolerated for more than 30 to 60 minutes, but higher or longer exposures can cause death from airway obstruction. (cdc.gov)
  • Can occur with or without evidence of airway obstruction - Smoking is the most important cause. (slideserve.com)
  • As of May 1, 2020, a total of 193 of 195 evacuees completed exposure surveys and 3,175,207 coronavirus disease (COVID-19) cases had submitted upper respiratory or serum specimens or both been confirmed and 224,172 persons had died world- at arrival in the United States. (cdc.gov)
  • This strategic plan has considered the successes already achieved in the health sector, the global focus on non-communicable diseases, the Brazzaville declaration on prevention and control of Noncommunicable diseases in the WHO African region, the political declaration on NCDs, World Health Assembly resolutions on NCDs, the WHO Global NCD Action Plan 2013-2020 and the global NCD monitor. (who.int)
  • A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. (ersjournals.com)
  • The Laboratory of Chronic Airway Infection, led by Dr. Kenneth Olivier, focuses on bronchiectasis, a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • Dr. Olivier's research focuses on bronchiectasis , a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • Bronchiectasis and chronic lung infections caused by NTM in the United States are steadily on the rise but difficult to diagnose and treat. (nih.gov)
  • Dr. Olivier's studies of respiratory ciliary function, conducted through the NIH Rare Diseases Clinical Research Network, led to the discovery of potential defects in nitric oxide synthesis as well as Toll-like receptor signaling associated with altered ciliary beat frequency in patients with idiopathic bronchiectasis and chronic NTM infection. (nih.gov)
  • Dr. Olivier's experiences in evaluating and managing large patient cohorts enrolled in bronchiectasis and mycobacterial natural history protocols, as well as his efforts to foster research partnerships with industry, have allowed assessment of novel therapeutic approaches for treating refractory NTM lung disease, such aerosolized liposomal amikacin for inhalation. (nih.gov)
  • CAID directly affects the upper respiratory system (the nose and the sinuses), the lower airway (the lungs) and the GI tract and these areas are intimately connected. (wikipedia.org)
  • The small airways (bronchioles) of the lungs contain smooth muscles and are normally held open by their attachments to alveolar walls. (msdmanuals.com)
  • In chronic bronchitis, the glands lining the larger airways (bronchi) of the lungs enlarge and increase their secretion of mucus. (msdmanuals.com)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Asthma is a chronic disease that affects the airways of the lungs. (cdc.gov)
  • During an asthma attack, airways (tubes that carry air to your lungs) become swollen, making it hard to breathe. (cdc.gov)
  • 1, 2 As the walls of the airways swell, they narrow, and less air gets in and out of the lungs. (cdc.gov)
  • Postmortem examination verified that the lungs in patients died of COVID-19 are indeed filled with sticky mucus, suggesting a great need to improve airway mucus clearance in critically ill COVID-19 patients. (techscience.com)
  • These factors can damage the air sacs and airways in the lungs. (medicalnewstoday.com)
  • These are medicines a person inhales that act on the tissues in the lungs to dilate, or widen, the airways. (medicalnewstoday.com)
  • Asthma is a chronic disease that affects your lungs, making your airways inflamed and irritated. (yahoo.com)
  • These effects include reduced airway mucus secretion 17 and anti-inflammatory properties, including decreased airway neutrophil accumulation through a reduction in expression of pro-inflammatory cytokines, e.g. interleukin (IL)-8, and adhesion molecule production, e.g. macrophage adhesion molecule-1 18 - 20 . (ersjournals.com)
  • Cells in the airways can make more mucus (a sticky, thick liquid) than usual, which can make breathing even harder. (cdc.gov)
  • However, both the virus infection and MV disrupt the balance between secretion and elimination of airway mucus and lead to mucus accumulation in the lung. (techscience.com)
  • Therefore, it may be helpful to comprehensively review the current understanding regarding the changes of biochemical and rheological features of airway mucus associated with the disease, as well as the physiological principles and algorithm to decide airway clearance techniques suitable for the critically ill COVID-19 patients. (techscience.com)
  • Based on these considerations, optimized strategies may be developed to eliminate the airway mucus accumulated in the airways of critically ill COVID-19 patients. (techscience.com)
  • Early recognition and treatment of small airway disease in people who smoke, combined with smoking cessation, may prevent progression of the disease. (health.am)
  • These are chronic bronchitis, emphysema and small airway disease. (medindia.net)
  • Given the contribution of airway remodeling to the development and persistence of symptoms in airways disease, targeting remodeling is an important. (lu.se)
  • Although asthma is a chronic illness, symptoms can be prevented with medications and avoidance of triggers. (cdc.gov)
  • Consecutive adult patients aged 18 and above with chronic respiratory symptoms (lasting more than 8 weeks) and no evidence of active tuberculosis were recruited. (who.int)
  • Conclusion: This study demonstrated a high burden of abnormal lung function in patients attending clinics due to chronic respiratory symptoms. (who.int)
  • 4 ings highlight the critical need for spirometry services to identify lung abnormalities in patients with chronic res- piratory symptoms. (who.int)
  • Patients typically present with a combination of signs and symptoms of chronic bronchitis, emphysema, and reactive airway disease. (medscape.com)
  • Moreover, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease (LPRD) and/or snoring or sleep apnea are often present as well. (wikipedia.org)
  • In patients with sleep apnea, does using positive airway pressure (PAP) treatment prevent adverse cardiovascular events and death? (the-hospitalist.org)
  • Positive airway pressure treatment for patients with sleep apnea is not an intervention to prevent cardiovascular morbidity. (the-hospitalist.org)
  • Association of positive airway pressure with cardiovascular events and death in adults with sleep apnea. (the-hospitalist.org)
  • The chance finding that erythromycin treatment radically improved the clinical outcome of a patient with diffuse panbronchiolitis rekindled interest in the use of macrolides as a potential treatment in other inflammatory airway disorders, e.g. cystic fibrosis 8 . (ersjournals.com)
  • Conversely, airway fibrosis was only evident in the chronic model. (monash.edu)
  • People with inflammatory lung disease such as cystic fibrosis are particularly vulnerable to this condition. (nih.gov)
  • They also identified environmental and atmospheric factors associated with NTM disease in high-risk populations such as people with cystic fibrosis and people age 65 years and older. (nih.gov)
  • Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. (imperial.ac.uk)
  • Physiological consequences associated with eosinophil-driven remodeling include impaired lung function and reduced bronchodilator reversibility in asthma, and obstructed airflow in chronic rhinosinusitis with nasal polyps. (lu.se)
  • Conclusions: Chronic airway lung diseases are associated with depression and/or anxiety, particularly in those with a higher airflow limitation and/or history of smoking. (ewha.ac.kr)
  • In conclusion, our results suggest that intraepithelial and alveolar mast cell release of proteases plays a crucial role in epithelial homeostasis, and that an inbalance of the protease release may be involved in respiratory disease progression and in disruption of critical epithelial functions. (phiab.com)
  • Stratified medicine in respiratory disease. (nottingham.ac.uk)
  • This review provides an overview of tissue remodeling in both health and airway disease with a particular focus on eosinophilic asthma and chronic rhinosinusitis with nasal polyps, as well as the role of eosinophils in these processes and the implications for therapeutic interventions. (lu.se)
  • Early intubation versus use of conventional or high-flow nasal cannula oxygen therapy (COT/HFNC), continuous positive airway pressure (CPAP), and non-invasive ventilation (NIV) has been debated throughout the COVID-19 pandemic. (karger.com)
  • Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. (imperial.ac.uk)
  • The Council of State and Territorial Epidemiologists (CSTE) has recommended that state health departments report cases of selected diseases ( Table 1 ) to CDC's National Notifiable Diseases Surveillance System (NNDSS). (cdc.gov)
  • They also seek to better define host susceptibility and disease pathogenesis through candidate gene analysis coupled with whole exome and whole genome analyses of carefully phenotyped populations. (nih.gov)
  • Despite this, little is know about the molecular mechanisms underpinning disease pathogenesis. (phiab.com)
  • Specific pathogen may play a critical role in the allergic airway diseases (AAD) pathogenesis by affecting the immune system 5 . (nature.com)
  • Infection in the pathogenesis and course of chronic obstructive pulmonary disease. (medscape.com)
  • Objectives: In a cohort of rescue/recovery workers exposed to the dust that resulted from the collapse of the World Trade Center (WTC), we assessed how a diagnosis of obstructive airways disease (OAD) affected the likelihood of a subsequent diagnosis of chronic rhinosinusitis (CRS) or gastroesophageal reflux disease (GERD). (elsevierpure.com)
  • Chronic obstructive pulmonary disease which encompasses two main disorders-emphysema and chronic bronchitis-is the third greatest cause of disability and the fourth most prevalent cause of death in the USA, according to the Centers for Disease Control and Prevention (CDC) [ 3 ]. (springeropen.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • According to the Centers for Disease Control and Prevention (CDC), over 37 million Americans have diabetes, and nearly 100 million have prediabetes. (yahoo.com)
  • Effects of regular salmeterol on lung function and exercise capacity in patients with chronic obstructive airways disease. (bmj.com)
  • BACKGROUND: The aim of this study was to evaluate the effects of single and chronic dosing with salmeterol on exercise capacity and lung function in patients with chronic obstructive pulmonary disease. (bmj.com)
  • Patients reported a significantly lower Borg score for perceived exertion following the six minute walk after chronic treatment with salmeterol compared with placebo. (bmj.com)
  • If the process is secondary to an underlying condition, patients should be treated for the underlying disease. (medscape.com)
  • More specific systemic disease treatments, such as immunomodulatory and immunosuppressive medications, are appropriate in patients with chILD related to vasculitis and connective tissue diseases. (medscape.com)
  • Background/Aims: Patients with chronic airway lung diseases often experience depression and anxiety, but little information is available regarding Koreans with these conditions. (ewha.ac.kr)
  • We thus assessed depression and anxiety in Korean patients with chronic airway lung diseases. (ewha.ac.kr)
  • p = 0.018) were independent risk factors for depression in patients with chronic airway lung diseases. (ewha.ac.kr)
  • Magnetic Resonance Imaging (MRI) is occasionally used for more advanced problem solving and mediastinal diseases or in younger patients with radiation exposure issues. (ohsu.edu)
  • We perform detailed anatomic, functional, and physiologic imaging of the coronary arteries, myocardium, cardiac chambers, valves, aorta, pulmonary arteries, and pericardium using cardiac magnetic resonance imaging (MRI) and computed tomography (CT) in adults and pediatric patients suffering from a broad range of congenital and acquired cardiac diseases. (ohsu.edu)
  • Patients with chronic bronchitis are often overweight and cyanotic. (medscape.com)
  • In the area of non-communicable diseases, although lots remain to be done, the Ministry of Health is exerting its efforts in the provision of care to patients, with the establishment of dedicated NCD services including NCD corners in all health facilities & NCD clinics in health centers and above levels in all Zones. (who.int)
  • This study aimed to characterize the common chronic respiratory diseases, along with their lung function and possible determinants in symptomatic patients attending clinics at Bishoftu General Hospital, Ethiopia. (who.int)
  • The medical name of these drugs is bronchodilators, meaning medicines that open the airways (bronchi). (medlineplus.gov)
  • Bronchodilators work by relaxing the airways, making it easier to breathe, but they come with side effects like headache , restlessness, stomach pain, and irritability. (yahoo.com)
  • Clinical improvement has been reported independent of the presence or absence of chronic airway infection 11 and with antibiotic levels below the minimum inhibitory concentrations of several pathogenic bacteria 15 . (ersjournals.com)
  • A better understanding of how an acute RSV infection transitions to a LRT chronic inflammatory disease is critically important to improve patient care and long-term health outcomes. (bvsalud.org)
  • The aim of this review is to examine the current literature for the most recent updates on health effects of specific air pollutants and their impact on asthma, chronic obstructive pulmonary disease, lung cancer, and respiratory infection. (cdc.gov)
  • Vitamin A supplement after neonatal S. pneumoniae pneumonia significantly promoted Foxp3 + Treg and Th1 productions, decreased Th2 and Th17 cells expressions, alleviated airway hyperresponsiveness (AHR) and inflammatory cells infiltration during AAD. (nature.com)
  • Eosinophils play a cardinal role in airway remodeling both in health and disease, driving epithelial homeostasis and extracellular matrix turnover. (lu.se)
  • Bronchial and alveolar remodeling and impaired epithelial function are typical characteristics of chronic respiratory diseases. (phiab.com)
  • Of the 2,639 classifiable adults over 20 years of age, 274 (10 percent) had chronic bronchitis and 48 (1.8 percent) chronic obstructive pulmonary disease. (rand.org)
  • Healthy adults experience increased airway resistance at 5 ppm, sneezing and coughing at 10 ppm, and bronchospasm at 20 ppm. (cdc.gov)
  • Dyspnea and cyanosis are not observed in adults unless the patient has underlying chronic obstructive pulmonary disease or another condition that impairs lung function. (medscape.com)
  • Diffuse panbronchiolitis is a progressive inflammatory disorder of lung airways found almost exclusively in Japan. (ersjournals.com)
  • Interstitial lung diseases (ILDs) in childhood are a diverse group of conditions that primarily involve the alveoli and perialveolar tissues, leading to derangement of gas exchange and diffuse infiltrates on radiographs. (medscape.com)
  • Because ILDs can involve the distal airspaces as well as the interstitium, the terms diffuse lung disease or diffuse infiltrative lung disease have been suggested. (medscape.com)
  • People who have severe disease may need to take other drugs, use oxygen, have pulmonary rehabilitation, or rarely lung volume reduction surgery. (msdmanuals.com)
  • However, in infants and the elderly , severe disease of the lower respiratory tract (LRT) often occurs and can develop into chronic airway disease . (bvsalud.org)
  • This makes them a good choice for young children and for people with severe lung disease. (medlineplus.gov)
  • We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. (imperial.ac.uk)
  • Areas for future research are also noted, to help improve our understanding of the homeostatic and pathological roles of eosinophils in tissue remodeling, which should aid the development of targeted and effective treatments for eosinophilic diseases of the airways. (lu.se)
  • We examined the sequence of events in remodeling using three commonly used mouse models of allergic airways disease in which mice are exposed to nebulized ovalbumin for four consecutive days (acute), seven consecutive days (subacute), or three times a week for 6 wk (chronic). (monash.edu)
  • It was reported that imbalances in the gut microbiota may be involved in immune system and allergic diseases, and fermented dietary fiber, like that found in soy, might have beneficial effects in allergic asthma models. (sciencedaily.com)
  • Four weeks after pneumonia, mice were sensitized and challenged with OVA to induce allergic airway disease (AAD). (nature.com)
  • CAID begins when bacteria, virus, fungus (mold), pollutants or other irritants, or an allergen initiate an inflammatory response in the airway (both upper and lower). (wikipedia.org)
  • The successes are mainly attributed to efforts of Ministry of Health (MOH) and its partners in the areas of malaria control, control of vaccine preventable diseases and improvement in prevention and case management of the main childhood killer diseases. (who.int)
  • Many of the childhood vaccine-preventable diseases include epidemiologic criteria (e.g., exposure to probable or confirmed cases of disease) in the case definitions. (cdc.gov)
  • Tuberculosis and Respiratory Diseases 2023;86(3):166-175. (e-trd.org)
  • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2023 report. (medlineplus.gov)
  • Coronavirus disease 2019 (COVID-19) caused by acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is still threatening the human life and society throughout the world. (techscience.com)
  • The information should not be used for either diagnosis or treatment or both for any health related problem or disease. (medindia.net)
  • Other diseases (e.g., mumps) have such a characteristic clinical presentation that, even in the absence of confirmatory laboratory testing, a diagnosis may be based only on clinical findings. (cdc.gov)
  • Some diseases require laboratory confirmation for diagnosis, regardless of clinical symptomatology, and some are diagnosed on the basis of epidemiologic data. (cdc.gov)
  • Although this nomenclature may be more accurate than ILD, childhood interstitial lung disease (chILD) has become the preferred term. (medscape.com)
  • The results from this study will have important treatment implications for our WTC population with potential applicability to larger populations with inhalational lung injury and/or airway diseases such as asthma and chronic obstructive pulmonary disease. (cdc.gov)
  • Asthma and chronic obstructive pulmonary disease. (medlineplus.gov)
  • This volume reviews pertinent medical literature, details the HIS definitions for three chronic obstructive airway diseases, describes HIS methods for measuring their presence and impact on people's lives, presents and discusses the enrollment data from the six HIS sites, and outlines quality of care criteria. (rand.org)
  • They likely represent a continuum of different diseases that may share biological mechanisms ( i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed ( i.e. phenotypes) which require individualised treatment. (ersjournals.com)
  • Both are ideally suited for precision medicine because they likely represent a continuum of different diseases that may share biological mechanisms (often referred to as "endotypes") and present similar clinical features (often referred to as "phenotypes") that require "individualised" treatment [ 1 , 10 - 12 ]. (ersjournals.com)
  • Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
  • This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease. (nottingham.ac.uk)
  • Childhood ILD is not a single disease but a large and diverse group of disorders. (medscape.com)
  • Dr. Chocano emphasizes the importance of nutrition, exercise, sleep and mental hygiene in the prevention and management of chronic respiratory disorders. (chkd.org)
  • By monitoring migratory properties of airway smooth muscle cells in the presence of albuterol isomers, the different effect of albuterol on proliferation and migration of airway smooth muscle cells is probed. (scirp.org)
  • As a kind of well mature pharmaceutical for asthma treatment, it would be very important to distinguish the effect of two different isomers of albuterol on proliferation and migration activities of airway smooth muscle cells. (scirp.org)
  • third, whole tissue culture was also performed to further demonstrate the different effect of R- and S-albuterol on migration of airway smooth muscle cells. (scirp.org)
  • Primary culture of rat airway smooth muscle cells was performed by enzyme digestion. (scirp.org)
  • Chronic obstructive pulmonary disease affects millions of people worldwide and is responsible for numerous deaths due to complications. (medindia.net)
  • These diseases and their related complications generate a real and significant threat globally and to Eritrea. (who.int)
  • Although they are leading causes of morbidity and mortality globally, chronic respiratory diseases have received relatively little public attention. (who.int)
  • If you have asthma, an asthma attack can occur when something irritates your airways and "triggers" an attack. (cdc.gov)