Chromosomes on telomere length. Medical search. Frequent questions

Leukocyte telomere length Shorten Time a cell divides Change in telomere length Leucocyte telomere length Sequences Eukaryotic Shorter telomere lengths Senescence Ends Replication Structures Changes in telomere length Oxidative Shortens Activity and resultin Average telomere length Relative telomere length Maintain telomere length Determine telomere length Chromosomal Genomic Genetics Analysis of telomere Protective caps Genome Rate of telomere Role of telomere Researchers Mutations Quantitative Telomeric Cell's chromosomes Progressive telomere Abnormally Dysfunction Biomarker Longer telomeres Protects telomeres Lengthen telomeres Protect Short Homeostasis Stem cells Telomerase activity Enzyme called telomerase Gene Organismal Genes Biological age Naturally Elongation Cell division Observational studies 2019 Findings Significantly associated with shorter Protein Chronic Nucleoprotein Genetic Divisions Mutation Cells

Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999-2000. (cdc.gov)
Relative leukocyte telomere length (L. (nel.edu)
The researchers measured patients' leukocyte telomere length at the start of the study and again five years later, and then examined whether the difference between these measurements predicted which patients were most likely to die over the next four years. (scienceblog.com)
Our study shows that smoking status and cigarette quantity can result in the shortening of leukocyte telomere length, which is an indicator of tissue self-repair, regeneration and ageing. (morungexpress.com)
They found that current smoking status was statistically significantly associated with shorter leukocyte telomere length, whereas previous smokers and people who had never smoked didn't show significantly shorter leukocyte telomere length. (morungexpress.com)
People who smoked the greater number of cigarettes had significantly shorter leukocyte telomere length. (morungexpress.com)
In summary, smoking may cause the shortening of leukocyte telomere length, and the more cigarettes smoked, the stronger the shortening effect," said Dai. (morungexpress.com)
In recent years, observational studies have linked shortened leukocyte telomere length with many diseases, such as cardiovascular disease, diabetes and muscle loss. (morungexpress.com)
Purpose: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. (aacrjournals.org)
We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. (aacrjournals.org)
Methods: Average leukocyte telomere length was estimated by quantitative PCR on a sample of 677 women selected for a study of biomarkers and perceived stress in the NIEHS Sister Study cohort (median age 55, range 35-75). (cdc.gov)

The telomeres shorten each time a cell divides to make new cells, until they reach a critical short length and the cells enter an inactive state and then die. (medindia.net)
Therefore telomeres shorten as an individual gets older. (medindia.net)
But, individuals are born with different telomere lengths and the rate at which they subsequently shorten can also vary. (medindia.net)
Telomere length can also impact overall health, as shorter telomeres can increase our risk for age-related diseases like cancer and heart disease [ 2 ] and even shorten our lifespan. (antiaging-systems.com)
Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes, which shorten with age in all replicating somatic cells 3 , 4 . (ersjournals.com)
Among barnacle geese, the telomeres thus shorten more quickly in females, which in birds is the sex with two different gender chromosomes. (health.am)
Telomeres naturally shorten with age. (cdc.gov)
As a cell divides, telomeres shorten and some of these genetic instructions are lost. (stress.org)
Telomeres shrink as a person ages, explains Rae Paoletta for Gizmodo , and scientists had previously believed that the stresses of spaceflight caused them to shorten at a faster speed. (smithsonianmag.com)
Since genetics remain unchanged even as telomeres physically shorten, this measurement allowed for unbiased comparisons to cancer risk. (ascopost.com)
Telomeres are the protective end caps on our chromosomes that shorten as we age. (vermontrepublic.org)
The passing of time means that telomeres shorten naturally, but experts believe other factors might influence this process as well. (inverse.com)
In normal adult cells, telomerase is turned off and telomeres shorten with every cell division until they reach a critical length. (sciencedaily.com)
Furthermore, in addition, it demonstrates the intricacy of the task: telomere duration depends upon systems that elongate (telomerase) or shorten (nucleases) telomeres (each which may be favorably and negatively governed). (bioskinrevive.com)
Telomeres have been implicated in senescence and mortality because they tend to shorten with stress, growth and age. (datadryad.org)
Objectives: Telomeres are protective DNA sequences on the ends of chromosomes, which can shorten with repeated cell replication and contribute to senescence. (cdc.gov)
Enzymes remove the T-circles and therefore shorten the telomere. (medscape.com)
For example, recent data suggest that the lengths of telomeres, the DNA sequences at the ends of our chromosomes that shorten with aging, might be associated with COPD. (medlineplus.gov)

Each time a cell divides the protective telomere 'cap' gets shorter. (sciencedaily.com)
Telomeres start off at a certain length, become shorter each time a cell divides, decline as the years pass by until the telomeres can no longer protect the chromosomes, and the cell dies. (health.am)
Each time a cell divides, the telomeres become slightly shorter, eventually becoming so short that the cell can no longer divide successfully, and it dies. (morungexpress.com)
Telomeres provide a buffer that grows shorter every time a cell divides. (cdc.gov)

One striking result was that the change in telomere length varied according to gender. (health.am)
Now, research by scientists at UC San Francisco and the Veterans Affairs Medical Center in San Francisco has found that change in telomere length over time is also important: heart disease patients whose telomeres shrank over time had a worse short-term prognosis than those whose telomeres stayed stable, and those whose average telomere length grew over the course of the study had a higher chance of survival. (scienceblog.com)

Researchers studied the link between a person's walking pace and leucocyte telomere length (LTL) - an indicator of biological age. (ktvu.com)
They went on to evaluate potential correlations between leucocyte telomere length and dementia risk, including Alzheimer's disease and vascular dementia, as well as total and regional brain volumes, using data from the UK Biobank. (nepalnews.com)
The data analysis found a substantial link between leucocyte telomere length and the risk of dementia. (nepalnews.com)
Nevertheless, the researchers conclude, "We found that leucocyte telomere length acts as an aging biomarker associated with the risk of dementia. (nepalnews.com)
Furthermore, we also observed linear associations of leucocyte telomere length with total and regional brain structure. (nepalnews.com)
The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. (frontiersin.org)

The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment. (bmj.com)
Telomeres are repetitive non-coding DNA sequences on the ends of eukaryotic chromosomes. (nel.edu)
Telomere, a complex of guanine-rich repeat sequences and associated proteins, caps and protects every eukaryotic chromosome end against chromosomal fusion, recombination, and terminal DNA degradation ( Blackburn, 2001 ). (nature.com)
Telomeric DNA consists of short guanine-rich repeat sequences in all eukaryotes with linear chromosomes, and its length in human somatic cells is remarkably heterogeneous among individuals ranging from 5 to 20 kb, according to age, organ, and the proliferative history of each cell ( Wright and Shay, 2005 ). (nature.com)
Telomeres are lengths of repetitive DNA sequences that protect the ends of chromosomes. (morungexpress.com)
Telomeres refer to the repetitive sequences found at the end of human chromosomes that protect them from damage. (naturalnews.com)
These are short sequences of DNA that cap the end of chromosomes and protect cells. (inverse.com)
Telomerase is the enzyme synthesizing the specific DNA sequences found at the telomeres and is thus responsible for maintaining their lengths. (lu.se)

Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. (ersjournals.com)
Telomeres are specialized DNA-protein structures on the ends of eukaryotic chromosomes. (bioskinrevive.com)

We had previous evidence that shorter telomere lengths are associated with increased risk of coronary artery disease but were not sure whether this association was causal or not. (medindia.net)
Family members within kindreds who do not inherit the TERT mutation have shorter telomere lengths than controls, demonstrating epigenetic inheritance of a shortened parental telomere length set-point. (nih.gov)

Telomere length in white blood cells has been a subject of interest because telomere length in these cell types (and also of other somatic tissues) declines gradually over the human lifespan, resulting in cell senescence, apoptosis, or transformation. (wikipedia.org)
In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
In the later generations, when telomeres are short, cells die via apoptosis or senescence. (hopkinsmedicine.org)
Telomere length is, therefore, a marker of cell ageing and senescence 5 . (ersjournals.com)
In somatic cells, the activity of telomerase, a reverse transcriptase that can elongate telomeric repeats, is usually diminished after birth so that the telomere length is gradually shortened with cell divisions, and triggers cellular senescence. (nature.com)
Telomerase can add telomeric repeats onto the chromosome ends, and prevents the replication-dependent loss of telomere and cellular senescence in highly proliferative cells of the germline and in the majority of cancers ( Blasco, 2005 ). (nature.com)
A critical length of telomere repeats is required to ensure proper telomere function and avoid the activation of DNA damage pathways that result in replicative senescence or cell death. (nature.com)
Because telomeres function to maintain chromosomal stability, telomerase has a critical role in preventing cellular senescence and cancer progression. (medscape.com)

Flow-FISH is most commonly used to quantify the length of telomeres, which are stretches of repetitious DNA (hexameric TTAGGG repeats) at the distal ends of chromosomes in human white blood cells, and a semi-automated method for doing so was published in Nature Protocols. (wikipedia.org)
Dr Aboobaker predicted that planarian worms actively maintain the ends of their chromosomes in adult stem cells, leading to theoretical immortality. (sciencedaily.com)
In collaboration with the rest of the team, he also went some way to understanding the clever molecular trick that enabled cells to go on dividing indefinitely without suffering from shortened chromosome ends. (sciencedaily.com)
Telomeres are cap- like structures at chromosome ends that play an important role in ageing and in the initiation and progression of various diseases. (medindia.net)
Telomerase is an enzyme that catalyzes the addition of nucleotides on the ends of chromosomes. (nih.gov)
Telomeres protect chromosome ends from being recognized as DNA damage and chromosomal rearrangements. (hopkinsmedicine.org)
which are found at the ends of chromosomes. (medlineplus.gov)
Shorter telomeres on the ends of white blood cell chromosomes were discovered to be associated with an increased risk of dementia. (nepalnews.com)
Telomeres are areas of genetic material on the ends of a cell's chromosomes that provide protection. (stress.org)
Short telomeres - the protective caps on the ends of chromosomes - have been previously linked to increased risk of death from heart disease. (scienceblog.com)
Telomeres are the tips at the ends of chromosomes that protect our DNA. (enzymedica.com)
While Scott was in space, his telomeres-the caps on the ends of chromosomes-grew longer than Mark's. (smithsonianmag.com)
Telomeres are protective caps at the ends of chromosomes that become shorter with each cell division. (mpg.de)
Telomeres are protective caps of DNA that prevent damage to the ends of chromosomes. (ascopost.com)
More specifically, researchers studied the effect that soda has on telomeres, which are the protective units of DNA that cap the ends of chromosomes inside human cells. (scienceblogs.com)
Telomeres are the protective caps at the ends of chromosomes. (yang-sheng.com)
A bit like those plastic tips on the ends of your shoelaces, telomeres prevent the ends of the chromosomes from fraying. (glycemicindex.com)
Telomeres are tandem nucleotide repeats that protect the ends of chromosomes from erosion during cell division. (datadryad.org)
all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)
Telomeres are structures at the ends of chromosomes that contain repetitive stretches of DNA. (cdc.gov)
Chromosomes need functional caps at their ends. (lu.se)

Conventional replication leads to telomere shortening, but telomere length is maintained by the enzyme telomerase. (hopkinsmedicine.org)
As we age, our telomeres naturally get shorter due to cell replication and the natural wear and tear of everyday life. (antiaging-systems.com)
A telomere, which looks like a shoelace cap, is intended to keep chromosomes from fraying or unravelling during replication. (nepalnews.com)
Thus, telomere length is a basic indicator of cellular aging and telomerase activity is a measure of cellular capacity for ongoing replication. (stress.org)
Telomeres, guanine-rich tandem DNA repeats of the chromosomal end, provide chromosomal stability, and cellular replication causes their loss. (nature.com)
The events of meiotic prophase follow a specialized round of DNA replication when the meiotic chromosome axis is formed. (biorxiv.org)
however, RPA can also be recognized at telomeres, and is probably practical during DNA replication 48,49,50. (bioskinrevive.com)
Therefore, a division of work between the KU-55933 supplier CST and RPA must exist, which is probably intricately linked to the mechanism of replication of telomeres. (bioskinrevive.com)
In addition to the mutations that directly effect telomere length, recent studies also indicate that a DKC diagnosis should not be based solely on the length of the telomere, but also the fact that there are defects in telomere replication and protection. (medscape.com)

Telomeres are specialized structures that evolved to protect the end of linear chromosomes from the action of the cell DNA damage machinery. (nih.gov)
Chromosomes are protein structures found within the nucleus of each cell that contain DNA. (glycemicindex.com)

The above results suggest that even short-term changes in telomere length over just three months might reflect general fluctuations in the body's health- and aging status. (mpg.de)
Very few studies have actually followed people over time to see how changes in telomere length correlated with survival. (cdc.gov)

Oxidative stress plays an important part in telomere shortening in people with diabetes. (glycemicindex.com)
This increased oxidative stress level speeds up telomere shortening. (glycemicindex.com)
The good news is that healthy eating guidelines for preventing and managing type 2 diabetes that help people to optimise their blood glucose levels, like consuming a moderate amount of low GI carbohydrate at main meals, and eating plenty of non-starchy vegetables and low GI fruit, will also help slow the shortening of telomeres, in-part by reducing oxidative stress. (glycemicindex.com)
[ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)
Telomere shortening and chronic diseases could be caused by the same cell-damaging processes, such as oxidative stress and inflammation. (cdc.gov)

Telomere length shortens with age in all replicating somatic cells. (ersjournals.com)
In most human somatic cells except for stem cells and lymphocytes, telomerase activity is diminished after birth so that telomere length shortens with each cell division. (nature.com)
The study, presented at the European Respiratory Society International Congress in Milan, Italy, showed that smoking shortens the end fragments of chromosomes in the white blood cells of our immune systems. (morungexpress.com)

They were then able to confidently measure its activity and resulting telomere length and found that asexual worms dramatically increase the activity of this gene when they regenerate, allowing stem cells to maintain their telomeres as they divide to replace missing tissues. (sciencedaily.com)

The slower growth was associated with an average telomere length that was 147 base pairs longer at hatching. (biologists.com)

Telomere length was determined as relative telomere length (RTL) by comparison with an internal cell line control (1301 cells) 4 . (ersjournals.com)
Comparison of relative telomere length measured in aortic tissue and leukocytes in patients with end stage heart failure. (nel.edu)

In an immortal animal we would therefore expect cells to be able to maintain telomere length indefinitely so that they can continue to replicate. (sciencedaily.com)
However, what puzzled the team is that sexually reproducing planarian worms do not appear to maintain telomere length in the same way. (sciencedaily.com)
TA65® capsules - plant based compound to help maintain telomere length, or rebuild where necessary. (antiaging-systems.com)

Using the DNA of leukocytes from the blood, the scientists were able to determine telomere length using a polymerase chain reaction. (mpg.de)
We investigated this prediction using skeletochronology to determine the ages of individuals and qPCR to determine telomere length in a cross-sectional study. (datadryad.org)

Nevertheless, although ring chromosome 22 has been described in over 50 cases, 13 it remains uncertain whether the variable phenotype is caused by the loss of a variable amount of chromosomal material or by a cellular mosaicism arising from instability of the ring. (bmj.com)
When telomeres are not properly controlled, the resulting chromosomal alterations can induce genomic instability and ultimately the development of human diseases, such as cancer. (nih.gov)
During successive cellular divisions, telomeres prevent base pair loss of chromosomal DNA. (glycemicindex.com)

Genomic DNA isolated from circulating leukocytes has been used to measure telomere lengths with a quantitative PCR assay. (nih.gov)
This leads to telomere shortening over time, which has been thought of as a time-delay "fuse" that can trigger cell death or genomic instability. (ascopost.com)

Dr Tan pointed out the importance of the interdisciplinary expertise: "It was serendipitous to be sandwiched between Professor Edward Louis's yeast genetics lab and the Children's Brain Tumour Research Centre, both University of Nottingham research centres with expertise in telomere biology. (sciencedaily.com)
Genetics and unhealthy lifestyle are important contributors to telomere shortening, along with psychological stress. (mpg.de)

Flow-FISH thus allows for a higher throughput analysis of telomere length in blood leukocytes, which are a readily available form of human tissue sample. (wikipedia.org)

Telomeres are the protective caps at the end of chromosomes. (health.am)
Telomeres are the protective caps of our chromosomes and play a central role in the ageing process. (mpg.de)

Without telomeres, our genome would be vulnerable to damage and dysfunction. (antiaging-systems.com)
They created a score based on a combination of genetic variants identified by prior genome-wide association studies as being associated with telomere length. (ascopost.com)
Using genome data from more than 50,000 cancer cases and 60,000 controls through the GAME-ON (Genetic Associations and Mechanisms in Oncology) network, the team compared telomere lengths with the risk of developing breast, lung, colorectal, ovarian, and prostate cancers, also including subtypes. (ascopost.com)
This set of genes underscores the central function performed by telomere biology in the fungus lifestyle routine, as ~7% from the genome impacts telomere length. (bioskinrevive.com)

To test this hypothesis, the rate of telomere shortening was compared with age in circulating lymphocytes harvested from smokers with and without COPD. (ersjournals.com)
In the new study, Whooley and colleagues asked whether the rate of telomere change - rather than absolute telomere length - might be a better predictor of health span in heart disease patients. (scienceblog.com)

Mutations in the telomerase accessory component, DKC1 , the dyskeratosis congenita 1 gene, can also manifest as IPF, underscoring the important role of telomere dysfunction in IPF pathogenesis [ 10 ]. (ersjournals.com)
Unravelling the role of telomere shortening with ageing and their potential association with diabetes, cancer, and related lifestyle factors. (glycemicindex.com)
This will help to elucidate the role of telomerase activity in tumorigenesis as well as the role of telomere shortening in aging. (lu.se)

For researchers who wish to convert T/S ratio to base pairs (bp), the formula is (3,274 + 2,413 * (T/S)). The conversion from T/S ratio to bp is calculated based on comparison of telomeric restriction fragment (TRF) length from Southern blot analysis and T/S ratios using DNA samples from the human diploid fibroblast cell line IMR90 at different population doublings. (cdc.gov)
The researchers also point out several limitations: Because telomere length was only assessed once, it was unable to determine whether changes over time increased dementia risk. (nepalnews.com)
Controlling for these and other factors, the researchers found that those whose telomeres shortened over five years were 32 percent more likely to die during the next four years than those whose telomeres stayed the same, and those who experienced telomere lengthening were 56 percent less likely to die. (scienceblog.com)
In a study published in the American Journal of Epidemiology , a team of American researchers presented evidence of a healthy diet's anti-aging benefits by examining the effects of four antioxidant and anti-inflammatory diets on telomere length . (naturalnews.com)
Researchers have long discovered that the shortening of telomeres is responsible for the aging-related degeneration of cells . (naturalnews.com)
The researchers found that people who eat antioxidant-rich, anti-inflammatory diets that emphasize plant-based foods and limit consumption of meat and sugary foods have longer telomeres than people who don't . (naturalnews.com)
The researchers believe that this can be explained by the fact that healthy diets create a biochemical environment that's favorable to telomeres. (naturalnews.com)
Telomere size wasn't the only difference the researchers identified. (smithsonianmag.com)
Based on this knowledge, researchers have examined how much lifestyle can influence telomere length. (mpg.de)
Researchers used Mendelian randomization, a method that calculates telomere length based on genetic factors, to compare the telomeric length of 50,000 cancer cases and 60,000 controls. (ascopost.com)
Surprisingly, the researchers found no associations between shortened telomeres and cancer risk. (ascopost.com)
All the siblings had abnormally short telomeres, but the researchers found that mice that had not inherited the gene to produce telomerase from their wild-type parent exhibited shorter lifespans, progressive tissue atrophy and spontaneous cancers. (sciencedaily.com)
What's more, the researchers found that as skin cells from non-telomerase-deficient mice approached critical telomere length, they naturally produced a burst of telomerase, which slowed the process of telomere shortening and reduced the amount of DNA damage that could lead to cancer. (sciencedaily.com)
The researchers found that human cells also expressed telomerase as they approached critical telomere length. (sciencedaily.com)
Cao said that the next step for researchers is to find out how telomerase expression is turned on as cells approach critical telomere length and to explore the underlying mechanisms by which telomerase acts as a buffer against the stresses of shortening telomeres. (sciencedaily.com)
Researchers, journalists, and inquiring minds want to know more about telomeres, which seem to hold clues to human aging and age-related diseases. (cdc.gov)

Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations. (nih.gov)
Family members without TERT mutations have a shorter mean telomere length than normal, demonstrating epigenetic inheritance of shortened telomere lengths in the absence of an inherited TERT mutation. (nih.gov)
A subset of pulmonary fibrosis, like dyskeratosis congenita, bone marrow failure, and liver disease, represents a "telomeropathy" caused by germline mutations in telomerase and characterized by short telomere lengths. (nih.gov)
Telomerase mutations are the most common identifiable genetic cause of IPF, and at times, the telomere defect manifests in extrapulmonary disease such as bone marrow failure. (ersjournals.com)
Mutations in telomerase cause its loss of function and mediate disease through abnormally shortened telomeres [ 11 ]. (ersjournals.com)
In a small number of individuals with dyskeratosis congenita, mutations in other genes involved with telomere maintenance have been identified. (medlineplus.gov)
The team suggests a potential explanation for this observation is that long telomeres enable more rounds of cell division than short telomeres, which could allow cells to live longer and have more opportunities to accumulate carcinogenic mutations. (ascopost.com)
Interestingly, specific mutations have been found, which independent the functions that Ku takes on in NHEJ and in telomere biology 44,45. (bioskinrevive.com)

Unlike Q-FISH, Flow-FISH utilizes the quantitative properties of telomere specific PNA probe retention to quantify median fluorescence in a population of cells, via the use of a flow cytometer, instead of a fluorescence microscope. (wikipedia.org)
Cawthon, R., Telomere measurement by quantitative PCR. (cdc.gov)
Patients and Methods: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. (aacrjournals.org)

To prevent degradation by exonucleases or processing as damaged DNA, the telomere 3′ single-strand overhang folds back into the D-loop of duplex telomeric DNA to form a protective 'T-loop', which is reinforced with TRF2 and other telomeric DNA-binding proteins named Shelterin ( de Lange, 2005 ). (nature.com)
The length of telomeric repeats is dynamically regulated and can be affected by changes in the telomere chromatin structure. (nih.gov)
DNA was extracted from each individual candida strain and telomere size was assessed by Southern blot, using as probes telomeric repeats that hybridize towards the terminal limitation fragment 82,83,84. (bioskinrevive.com)
This group studies the function of telomeres and the basic molecular mechanisms of telomerase, the enzyme catalyzing the synthesis of telomeric DNA. (lu.se)

Telomerase prevents the shortening of telomeres -- a specialized DNA-protein structure at the end of a cell's chromosomes that protect the chromosomes from damage. (sciencedaily.com)

The lab has generated telomerase null mice that are viable and show progressive telomere shortening for up to six generations. (hopkinsmedicine.org)

Telomeres help protect chromosomes from abnormally sticking together or breaking down (degrading). (medlineplus.gov)

of telomere dysfunction. (hopkinsmedicine.org)

These findings highlight telomere length as a potential biomarker of brain health. (nepalnews.com)
Telomere length has emerged as a leading biomarker of aging, and predicts early onset of cardiovascular disease. (scienceblog.com)
Is telomere length a biomarker for aging? (cdc.gov)

They found that longer telomeres were significantly associated with increased risk for lung cancer, specifically lung adenocarcinoma, which more than doubled in risk for every 1,000-base pair increase in telomere length. (ascopost.com)

Chronic stress can decrease your supply of telomerase, an enzyme that protects telomeres. (inverse.com)

Studies have shown taking telomerase activation supplements can help lengthen telomeres, which can help slow down the aging process and reduce the risk of age-related diseases [ 3 ]. (antiaging-systems.com)
By activating the enzyme telomerase to lengthen telomeres, we can support cellular health and age gracefully. (enzymedica.com)

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)
While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. (goodreads.com)
Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. (goodreads.com)
Our telomeres get shorter with every cell division until they eventually become too small to protect the chromosomes. (antiaging-systems.com)
Telomeres are 'caps' at the end of chromosomes that protect the chromosomes from degrading. (ktvu.com)
Fortunately there are multiple ways to protect telomere length throughout the lifespan. (scienceblog.com)
Among the research-vetted ways to protect telomeres, the authors cite avoiding smoking, getting at least 150 minutes of moderate exercise or 75 minutes of vigorous exercise per week, and maintaining a healthy, low-fat diet. (scienceblog.com)
Telomeres are nucleoprotein complexes that cap the end of chromosomes to protect DNA from degradation. (ukbiobank.ac.uk)
These are the enzymes that protect telomeres. (inverse.com)
While the study period wasn't long enough to see if telomere length changed, this effect on the enzymes indicates that CBT therapy can protect one from cellular aging . (inverse.com)
In more scientific terms, telomeres protect the integrity of information carrying throughout each cell cycle by serving as specialized DNA caps on chromosomes. (glycemicindex.com)
Telomeres also protect a chromosome's DNA sequence as it is being copied during cell division. (cdc.gov)

A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
Crosses of these telomerase null mice to other tumor prone mice show that tumor formation can be greatly reduced by short telomeres. (hopkinsmedicine.org)
Future work in the lab will focus on identifying genes that induce DNA damage in response to short telomeres, identifying how telomeres are processed and how telomere elongation is regulated. (hopkinsmedicine.org)
Telomerase helps to rebuild our telomeres and keep them from getting too short. (antiaging-systems.com)
The results show that geese, compared to short-lived bird species, have a better ability to preserve the length of their telomeres. (health.am)
After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). (medlineplus.gov)
The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship. (frontiersin.org)
The prevailing hypothesis has been that short telomeres are bad for health, but it appears that this does not necessarily translate to some types of cancer. (ascopost.com)
When telomeres become too short, cells can no longer divide, which can lead to a number of health problems. (vermontrepublic.org)
To understand what was going on, Cao and her colleagues compared the skin cells of the sibling mice and found that while both cell lines had comparably short telomeres, cells from telomerase-deficient mice stopped dividing sooner and had more malignant transformations than cells from siblings that produced telomerase. (sciencedaily.com)
Over time, telomere length decreases until the telomere becomes too short for the cell to divide, eventually resulting in the death of the cell. (glycemicindex.com)
Over time, telomeres become so short that cell division stops and the cell dies. (cdc.gov)
In some families, inheritance of exceptionally short telomeres is linked to specific diseases, such as pulmonary fibrosis or bone marrow failure. (cdc.gov)

Therefore, proper establishment, regulation, and maintenance of the telomere chromatin structure are required for cell homeostasis. (nih.gov)
Another gene implicated in DKC, TINF2 , encodes a key component of the protein shelterin, which plays a role in telomere homeostasis. (medscape.com)

Thus, even in stem cells, except for embryonal stem cells and cancer stem cells, telomere shortening occurs during replicative ageing, possibly at a slower rate than that in normal somatic cells. (nature.com)
Recently, the importance of telomere maintenance in human stem cells has been highlighted by studies on dyskeratosis congenital, which is a genetic disorder in the human telomerase component. (nature.com)
The regulation of telomere length and telomerase activity is a complex and dynamic process that is tightly linked to cell cycle regulation in human stem cells. (nature.com)
Here we review the role of telomeres and telomerase in the function and capacity of the human stem cells. (nature.com)
As stem cells have elongated proliferative capacity, they should have a mechanism that maintains telomere length through many cell divisions. (nature.com)
Germ cells (eggs and sperm) and stem cells contain an enzyme, telomerase, that restores telomere length. (cdc.gov)
With each round of cell division, the length of telomeres is shortened and the enzyme telomerase compensates by maintaining telomere length in germline and stem cells. (medscape.com)

Thus, telomerase activity and telomere maintenance are associated with the immortality of cancer cells, germ-line cells, and embryonic stem (ES) cells. (nature.com)
Basically, given the difference of telomere and telomerase activity in human and mouse cells, the telomere and telomerase status in stem cell populations is different between humans and mice ( Harrington, 2004 ). (nature.com)

Previous work, leading to the award of the 2009 Nobel Prize for Physiology or Medicine, had shown that telomeres could be maintained by the activity of an enzyme called telomerase. (sciencedaily.com)
Within our telomeres is an enzyme called telomerase. (antiaging-systems.com)
An enzyme called telomerase normally prevents this, but as we grow older, our ability to make telomerase decreases and the protective telomeres become shorter. (stress.org)

Nucleus with chromosomes, DNA molecule (double helix), telomere and gene (length of DNA that codes for a specific protein). (istockphoto.com)
In this study, we present a novel hybrid assembly pipeline that allowed for both mitogenome de novo assembly and telomere length de novo assembly of all 7 chromosomes of the model entomopathogenic fungus, Metarhizium brunneum.ResultsThe improved assembly allowed for better ab initio gene prediction and a more BUSCO complete proteome set has been generated in comparison to the eight current NCBI reference Metarhizium spp. (swan.ac.uk)
This resulted in reduced telomere length and proved it was the right gene. (sciencedaily.com)
As such, the mutant gene and mutation type are not the primary mediators of disease severity but the telomere length defect, as previously reviewed [ 11 ]. (ersjournals.com)
A heterozygous mutation was found on the conserved telomere maintenance component 1 gene ( CTC1 ). (medscape.com)
Besides recombinations with traces limited to the ospC gene itself, there was evidence of lateral gene transfers that involved (i) part of the ospC gene and one of the two flanks or (ii) the entire ospC gene and different lengths of both flanks. (cdc.gov)
Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)

The length of telomeres offers insight into mitotic cell and possibly organismal longevity. (yang-sheng.com)

In these cases, the cause of the disorder is unknown, but other unidentified genes related to telomere maintenance are likely involved. (medlineplus.gov)
The SIR complex: Due to the heterochromatic nature of telomeres, in many organisms genes located close to telomeres undergo silencing (also called mutants). (bioskinrevive.com)
Jointly, these papers discovered ~400 genes impacting telomere duration (either shorter or much longer than the outrageous type). (bioskinrevive.com)
To comprehend the effectiveness of this process, it suffices to say that just 30 roughly genes were recognized to have an effect on telomere KU-55933 supplier length at that time the displays were completed 82. (bioskinrevive.com)

In this study we used information contained in people's genetic profile to show that a faster walking pace is indeed likely to lead to a younger biological age as measured by telomeres. (ktvu.com)
In fact, telomere length is what some scientists have used to assess biological age.1 Therefore, it is critical that if we want to age well, we keep our telomeres as long as possible. (enzymedica.com)
Telomere length is therefore regarded as a marker for the biological age of a person - in contrast to their chronological age. (mpg.de)
In other words, the shorter your telomeres, the greater your biological age. (glycemicindex.com)
Last week, a company in the UK announced that it would soon be offering a test of "biological age" based on telomere length to the public for approximately $700 (US). (cdc.gov)

As we get older, our telomeres naturally get shorter, increasing the risk of age-related diseases and impacting overall wellness. (antiaging-systems.com)
The botanicals in Telomere Plus have been shown to increase the activity of telomerase, a naturally-occurring enzyme that lengthens telomeres and protects them from shortening. (enzymedica.com)
The naturally-occurring enzyme telomerase lengthens telomeres and keeps them from shortening, and the botanicals in Telomere Plus activate the telomerase in our bodies so that it can give us the whole-body benefits. (enzymedica.com)

However, it remains unclear if telomere elongation actually reflects any improvement in a person's overall health and aging trajectory. (mpg.de)
It is a suppressor of telomere elongation and may be involved in stabilization of telomere length. (bvsalud.org)

This cell line is characterised by a lack of telomere shortening (and hence, constant telomere length) during cell division due to overexpression of telomerase 4 . (ersjournals.com)
A portion of the telomere DNA is lost during cell division. (ascopost.com)
Inside each cell, telomeres at the end of our chromosomes contain genetic information that gets clipped away with each cell division. (thundercloud.net)

In observational studies conducted in Asia, Europe and North America, people with shorter telomeres are found to have an increased risk of developing type 2 diabetes, independent of other known diabetes risk factors. (glycemicindex.com)
In people with existing diabetes, observational studies also indicate that shorter telomeres are associated with common diabetes complications like heart disease and stroke. (glycemicindex.com)

In 2019, Månsson and colleagues published a paper specifically examining how mood and anxiety disorders affect telomeres . (inverse.com)

Dr Veryan Codd, Senior Research Associate at the University of Leicester who co-ordinated the study and carried out the majority of the telomere length measurements said: "The findings open of the possibility that manipulating telomere length could have health benefits. (medindia.net)
However, previous studies evaluating telomere length in white blood cells called leukocytes as a predictor of mortality have produced inconsistent findings, only sometimes predicting mortality. (scienceblog.com)
The telomeres returned to their pre-flight length shortly after Scott returned to Earth, but the findings were nevertheless surprising. (smithsonianmag.com)

Results: Currently holding a full-time job and years of full-time work were significantly associated with shorter telomere length (b =20.003 per year, p = 0.002) independent of the effects of age (b =20.006 per year, p,0.0001). (cdc.gov)

In Saccharomyces cerevisiae , the telomere-associated protein Ndj1 is required for bouquet formation. (biorxiv.org)
Moreover, the Ku heterodimer helps in anchoring the telomeres to the perinuclear space 28 by a still strange mechanism that involves the small protein modifier SUMO 40. (bioskinrevive.com)
A ubiquitously expressed telomere-binding protein that is present at TELOMERES throughout the cell cycle. (bvsalud.org)

It also demonstrates a dose-effect relationship between exposure to tobacco smoking and telomere length, but failed to show that this effect is amplified in smokers who develop chronic obstructive pulmonary disease. (ersjournals.com)
Since longer telomere length is also linked to a reduced risk of major chronic disease, eating antioxidant-rich, anti-inflammatory diets may be the key to good health and healthy aging. (naturalnews.com)
Shorter telomeres are associated with chronic diseases and high stress levels can contribute to their shortening. (mpg.de)
Telomere length has now been linked to chronic stress exposure and depression. (yang-sheng.com)
Shorter telomere length has been associated with chronic stress , age and obesity in women, and with metabolic and cardiovascular disease outcomes. (cdc.gov)

Telomeres are a protective nucleoprotein structure at each chromosome end. (cdc.gov)

The genetic information inside cells is arranged in twisted strands of DNA called chromosomes. (sciencedaily.com)
The research team measured telomere lengths in over 48,000 individuals and looked at their DNA and identified seven genetic variants that were associated with telomere length. (medindia.net)
As DNA cannot be changed by lifestyle or environmental factors, an association of these genetic variants which affect telomere length with a disease also would suggest a causal link between telomere length and that disease. (medindia.net)
A large-scale genetic study of the links between telomere length and risk for five common cancers found that long telomeres are associated with an increased risk of lung adenocarcinoma. (ascopost.com)
The study, led by scientists from the University of Chicago , used a novel method to measure genetic predisposition for telomere length, rather than physiologic measures, which are confounded by factors such as age and lifestyle. (ascopost.com)
To address this issue, Dr. Pierce and his colleagues used Mendelian randomization, a method that calculates telomere length based on genetic factors. (ascopost.com)
While their results shed light on the unclear role of telomeres in cancer biology, Dr. Pierce and his colleagues warn that Mendelian randomization produces estimates of causal relationships, but the estimates could be biased if the genetic variants measured in the study affect cancer risk and telomere length independently. (ascopost.com)

This mechanism is thought to restrict the lifespan of cells to a limited number of divisions, making telomere length a measure of aging at the cellular level. (cdc.gov)

We find that telomere lengths of TERT mutation carriers decrease in an age-dependent manner and show progressive shortening with successive generations of mutation inheritance. (nih.gov)

This decline has been shown to be a surrogate marker for the concomitant decline in the telomere length of the hematopoietic stem cell pool, with the granulocyte lineage giving the best indication, presumably due to the absence of a long lived memory subtype and comparatively rapid turnover of these cells. (wikipedia.org)
One of the events associated with aging cells is related to telomere length. (sciencedaily.com)
It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives. (goodreads.com)
Telomeres sit on the end of our chromosomes - the strands of DNA stored in the nucleus of cells. (medindia.net)
It's also essential to note telomerase is not found in all cells, so certain cells won't be able to rebuild or extend their telomeres at all. (antiaging-systems.com)
Briefly, a suspension containing a mixture of 2×10 6 lymphocytes and 2×10 6 of 1301 cells was denatured at 82°C for 10 min, with and without the fluorescein-conjugated PNA telomere probe in the hybridisation solution. (ersjournals.com)
In most cells, telomeres become progressively shorter as the cell divides. (medlineplus.gov)
They believe that measuring telomere length in glial cells (non-neuronal cells in the central nervous system) would have been more revealing, but this information was not available from the UK Biobank. (nepalnews.com)
The length of these end fragments, called telomeres, is an indicator of how quickly we age and our cells' ability to repair and regenerate. (morungexpress.com)
Telomere length in white blood cells (called leukocytes) has been linked previously to smoking, but, until now, there has been little research into whether smoking status and the quantity of cigarettes smoked actually caused the shortening in telomere length. (morungexpress.com)
Nup2 is a nonessential nucleoporin that functions in nuclear transport, boundary activity, and telomere silencing in mitotically dividing cells. (biorxiv.org)
At critical telomere length, cells stop dividing and either die or experience DNA damage that could cause malignancies. (sciencedaily.com)
Cao and her colleagues suspected telomerase may have a function in adult cells when they observed dramatic differences in the laboratory among sibling mice with shortened telomeres. (sciencedaily.com)
In addition, human skin cells that were unable to express telomerase reached critical telomere length more quickly and displayed significantly more DNA damage than those that did express telomerase. (sciencedaily.com)
But eventually, they run out of length, the information they held is lost and the cells can't divide anymore. (thundercloud.net)
these abnormal chromosomes are often observed in cancer cells. (cdc.gov)

Anatomy48

Organisms1

Diseases11

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes76

Information Science2

Health Care2

Leukocyte telomere length12

Shorten18

Time a cell divides4

Change in telomere length2

Leucocyte telomere length6

Sequences8

Eukaryotic2

Shorter telomere lengths2

Senescence8

Ends21

Replication9

Structures2

Changes in telomere length2

Oxidative5

Shortens3

Activity and resultin1

Average telomere length1

Relative telomere length2

Maintain telomere length3

Determine telomere length2

Chromosomal3

Genomic2

Genetics2

Analysis of telomere1

Protective caps2

Genome4

Rate of telomere2

Role of telomere3

Researchers16

Mutations8

Quantitative3

Telomeric4

Cell's chromosomes1

Progressive telomere1

Abnormally1

Dysfunction1

Biomarker3

Longer telomeres1

Protects telomeres1

Lengthen telomeres2

Protect12

Short13

Homeostasis2

Stem cells7

Telomerase activity2

Enzyme called telomerase3

Gene7

Organismal1

Genes4

Biological age5

Naturally3

Elongation2

Cell division3

Observational studies2

20191

Findings3

Significantly associated with shorter1

Protein3

Chronic5

Nucleoprotein1

Genetic7

Divisions1

Mutation1

Cells16