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  • metaphase
  • The FRAP results, together with its mutant effects late in meiosis I, indicate that γTub37C may perform a role subsequent to metaphase I, rather than nucleating microtubules for meiosis I spindle formation. (biomedcentral.com)
  • meiosis
  • Weak binding to the meiosis I spindle could stabilize pre-existing microtubules or position γ-tubulin for function during meiosis II spindle assembly, which follows rapidly upon oocyte activation and completion of the meiosis I division. (biomedcentral.com)
  • dynein
  • Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. (icts.res.in)
  • processes
  • At the broadest level our lab is interested in understanding how the constituent parts of a genome, chromosomes, function and the dynamic processes that influence them. (unc.edu)
  • TPX2
  • Consistent with this possibility, we found that TPX2 reduced the velocity of Eg5-dependent microtubule gliding, inhibited microtubule sliding, and resulted in the accumulation of motor on microtubules. (rupress.org)
  • To address this problem and to specifically study TPX2-dependent activation of Aurora A during spindle assembly in HeLa cells, Bird and Hyman (2008) used bacterial artificial chromosome (BAC)-based recombineering. (rupress.org)
  • 2003). Additional regions in the C-terminus of TPX2 are involved in direct or indirect binding to microtubules in cells (Trieselmann et al. (atlasgeneticsoncology.org)
  • organisms
  • In this paper, we highlight mechanistic models and regulations of microtubule severing by Katanin in context of structure and various functions of Katanin in different organisms. (hindawi.com)
  • cytoplasmic
  • Immediately after the completion of cytokinesis, newly divided plant cells form cytoplasmic microtubules (MTs) that radiate from the nuclear envelope toward the plasma membrane, and generate dynamic MT arrays at the cell cortex, which persist during interphase ( Hashimoto, 2015 ). (biologists.org)
  • Regulation
  • Regulated by several factors, Katanin manifests connective crosstalks in network motifs in regulation of anisotropic severing pattern of microtubule protofilaments in cell type and stage dependent way. (hindawi.com)
  • Compared to the regulation of microtubule growth, the molecular mechanism underlying the regulation microtubule nucleation is poorly understood. (crick.ac.uk)