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  • genes
  • Comparing our results with published gene expression levels, we find that clones exhibiting extreme ratios reflecting low relative methylation are statistically enriched for genes with high expression ratios, and vice versa , in most pairs of tissues examined. (biomedcentral.com)
  • genetic
  • this person has the genetic pattern as XO (this possibility can be excluded to see a band after enzyme treatment because, if indeed XO is the genetic pattern of the sample, then, there will be NO methylation, therefore no band should be visible after digesting with the enzyme. (wikipedia.org)
  • CpGs
  • Imagine two different genomic regions, A and B. Region A has six CpGs (DNA methylation in mammalian somatic cells generally occurs at CpG dinucleotides), three of which are methylated. (wikipedia.org)
  • This does not give the full picture of methylation in these two regions (in region A only half the CpGs are methylated, whereas in region B all the CpGs are methylated). (wikipedia.org)
  • Therefore, to get the full picture of methylation for a given region you have to normalize the signal you get from the MeDIP experiment to the number of CpGs in the region, and this is what the Batman algorithm does. (wikipedia.org)
  • CpG methylation state is generally highly correlated over hundreds of bases, so CpGs grouped together in 50- or 100-bp windows would have the same methylation state. (wikipedia.org)
  • sequences
  • MeDIP (methylated DNA immunoprecipitation) is an experimental technique used to assess DNA methylation levels by using an antibody to isolate methylated DNA sequences. (wikipedia.org)