Loading...
  • Trisomy
  • Light micrograph of the chromosomes (karyotype, with G banding) of a male with trisomy 8 in acute myeloid leukaemia (AML). (sciencephoto.com)
  • Trisomy 8 is found in some cases of leukaemia, and has severe effects on the foetus. (sciencephoto.com)
  • Trisomy 1 and 8 occur frequently in hepatocellular carcinoma but not in liver cell adenoma and focal nodular hyperplasia. (naver.com)
  • Involvement and functional impairment of the CD34(+)CD38(-)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8. (ox.ac.uk)
  • Clonality studies of mature cells suggest that the primary transformation event in myelodysplastic syndrome (MDS) most frequently occurs in a myeloid-restricted progenitor, a hypothesis supported by recent studies of purified CD34(+)Thy1(+) hematopoietic stem cells (HSCs) in cases with trisomy 8 (+8). (ox.ac.uk)
  • differentiation
  • Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal. (nih.gov)
  • Human chorionic gonadotropin also plays a role in cellular differentiation/proliferation and may activate apoptosis. (wikipedia.org)
  • recombinant
  • A rearrangement of chromosome 8 causes recombinant 8 syndrome, a condition that involves heart and urinary tract abnormalities, moderate to severe intellectual disability, and a distinctive facial appearance. (nih.gov)
  • Recombinant human CCDC23 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. (acris-antibodies.com)
  • chromosomal
  • Those hosted by the Sanger Institute include: COSMIC, a catalogue of somatic mutations in cancer DECIPHER, a database of chromosomal imbalance and phenotype in humans, using Ensembl resources Ensembl, a genome browser co-hosted by the European Bioinformatics Institute. (wikipedia.org)
  • The most common chromosomal abnormalities in CMML patients involve chromosome 7 and chromosome 8. (lls.org)
  • Proteins
  • A chromosome is an entire chain of DNA along with a group of stabilizing proteins. (reference.com)
  • Chromosome 8 likely contains about 700 genes that provide instructions for making proteins. (nih.gov)
  • There was a site for serine phosphorylation on both the human and mouse proteins and two for tyrosine phosphorylation, amino acids 147, 159, and 170 respectfully. (wikipedia.org)
  • myeloid
  • No evidence of a Philadelphia chromosome (seen in a similar disease known as "chronic myeloid leukemia" (CML). (lls.org)
  • symptoms
  • The signs and symptoms of TRPS II are related to the loss of multiple genes from this part of the chromosome. (nih.gov)
  • In males, due to the hemizygousity of the X-chromosome, the symptoms and issues surrounding X-linked Charcot-Marie-Tooth disease are more prevalent. (wikipedia.org)
  • Species
  • The advances in technology allow the Sanger Institute to carry out sequencing of the genomes of individual humans, vertebrate species and pathogens, at an ever-increasing pace and reducing cost. (wikipedia.org)