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  • Mapping
  • Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene. (ox.ac.uk)
  • Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. (nih.gov)
  • OTP was mapped to human chromosome 5q13.3 using radiation hybrid panel mapping and fluorescence in situ hybridization. (nih.gov)
  • Amino Acid Seq
  • The deduced amino acid sequence of the open reading frame of the human cDNA is 99% homologous to mouse Otp and demonstrates a high degree of conservation when compared to sea urchin and Drosophila. (nih.gov)
  • A single putative OTP gene product was found in 17-week human fetal brain tissue by Western blot analysis using a novel polyclonal antibody raised against a conserved 13-amino-acid sequence at the C-terminus of the OTP protein. (nih.gov)
  • Disease
  • Although far from complete, such maps have revealed global topological and dynamic features of interactome networks that relate to known biological properties, suggesting that a human interactome map will provide insight into development and disease mechanisms at a systems level. (genes2cognition.org)
  • Teleost fish provide many models for human disease but possess anciently duplicated genomes that sometimes obfuscate connectivity. (genetics.org)
  • Likewise, the output of genetic variants of human disease uncovered by the International HapMap Project [ 1 ] requires effective tools to accurately translate this growing knowledge to model systems for functional studies. (pubmedcentralcanada.ca)
  • genomic
  • We mapped two overlapping expressed sequence tag clones within a genomic contig on human chromosome 5, band q31. (nih.gov)
  • Human cDNA and genomic libraries were screened with probes derived from mouse Otp sequences to find the human homologue, OTP. (nih.gov)
  • tumor
  • Scatter factor stimulates tumor growth and tumor angiogenesis in human breast cancers in the mammary fat pads of nude mice. (naver.com)
  • Molecular
  • 1. Chromosome banding patterns provide independent confirmation of relationship in hominids, in addition to anatomical, physiological, genetic, and molecular evidence. (indiana.edu)
  • Myeloid
  • Thus, CDC23 is unlikely to be involved in the pathogenesis of myeloid leukemias characterized by abnormalities of chromosome 5. (nih.gov)
  • linkage
  • No evidence for linkage of MODY1 and MODY3 markers to NIDDM in African-American sib pairs was observed. (diabetesjournals.org)
  • A maximum LOD score of 1.48 was calculated for linkage to MODYl-linked loci and 1.45 to MODY3-linked loci in Caucasian sib pairs. (diabetesjournals.org)
  • Definition
  • HUMAN FACTORS & ERGONOMICS IN AVIATION HUMAN FACTORS After much study, this is the most appropriate definition of Human factors: That which is concerned to optimize the relationship and their activities by systematic application of the human sciences, integrated within the framework of systems engineering with the underlying objectives of the effectiveness of the system, Which includes safety, efficiency and the well being of the individual. (majortests.com)
  • cDNA
  • We have isolated the human CDC23 cDNA containing the full-length predicted open reading frame. (nih.gov)
  • homologue
  • The human ATX1 homologue (HAH1), encodes a copper-binding protein with a role in antioxidant defence. (ox.ac.uk)
  • receptor
  • This C-terminal anchored membrane protein has sequence similarity to both a yeast soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE), Use1p/Slt1p, and a recently identified human syntaxin 18-binding protein, p31. (genes2cognition.org)