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  • Mapping
  • Cells were examined for cytopathology, evaluated by fluorescence in-situ hybridization (FISH) for the centromere of chromosome 3, analyzed by 250K whole genome Mapping Array and U133 plus 2.0 Expression Array, and placed in cell culture. (nih.gov)
  • At passage 3, the cell lines were analyzed by Mapping Array and Expression Array. (nih.gov)
  • This study was conducted, using a genetic complementation approach, with the aim of identifying and mapping the genes responsible for repressing telomerase and, simultaneously, to establish the effect of experimentally induced telomerase repression on human tumor cell growth. (brunel.ac.uk)
  • Instability
  • In addition, multiple studies have displayed a correlation between the location of segmental duplications and the regions of chromosome instability. (wikipedia.org)
  • EVI1
  • Some transcription factors that are predicted to bind to the promoter of LSMEM1 in humans are: SRF, EVI1, SOX, ETS, LTSM, and TALE transcription factors. (wikipedia.org)
  • Molecular
  • Human chorionic gonadotropin is glycoprotein composed of 237 amino acids with a molecular mass of 36.7 kDa, approximately 14.5 αhCG and 22.2kDa βhCG. (wikipedia.org)
  • The protein LSMEM1 encodes in humans is 131 amino acids long and has a molecular weight ranging from 14.2-14.5 kDal. (wikipedia.org)
  • Mutation
  • About 10% of Angelman syndrome cases are caused by a mutation in the UBE3A gene, and another 3% result from a defect in the DNA region that controls the activation of the UBE3A gene and other genes on the maternal copy of chromosome 15. (wikipedia.org)
  • cancer
  • BACKGROUND: Activation of the enzyme telomerase, which has been associated with cellular immortality, may constitute a key step in the development of human cancer. (brunel.ac.uk)
  • Analysis
  • Regions of the introduced chromosomes associated with telomerase repression were mapped using segregant hybrids and a deletion analysis that employed microsatellite DNA markers. (brunel.ac.uk)
  • Deletion analysis of nonrepressed segregant monochromosome 3 hybrids indicated two regions on the short arm of chromosome 3 (3p21.3-p22 and 3p12-21.1) where telomerase regulator genes may be located. (brunel.ac.uk)
  • Here, we report new genotyping of eight SNPs showing some evidence of association in combined analysis of Stage 1 and Stage 2 in an additional 2048 cases of TGCT and 3944 controls (Stage 3). (forskningsdatabasen.dk)
  • Chromosome analysis was performed by standard 24 h-cultured method and R banding. (elsevier.com)
  • in 1997 to map the RAB7A gene to chromosome 3 using PCR analysis. (wikipedia.org)
  • found
  • So far, they have found that this particular SNP is significantly correlated with the degree of atherosclerosis in human aortas, the large blood vessel that brings blood from the heart to all parts of the body. (science20.com)
  • The Cambridge scientists found that chromosome1 genes are associated with Alzheimer's and prostate ailments while chromosome 6 is linked to intelligence. (bio-medicine.org)
  • 3] Segmental duplications found in primate genomes fall under one of three classifications. (wikipedia.org)
  • The human gene CCDC37 is found on chromosome 3 at the band 3q21.3. (wikipedia.org)
  • There is only one paralog for CCDC37 found in humans, CCDC38. (wikipedia.org)
  • These 3 residues are known collectively as a catalytic triad, and are found in all enzymes belonging to the phosphoglyceromutase branch of the histidine phosphatase superfamily. (wikipedia.org)
  • trait
  • With the new knowledge, biologists believe it is possible to pre-programme every human trait from hair colour to sexuality. (bio-medicine.org)