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  • yeast
  • Newswise - An international team of scientists led by Jef Boeke, PhD, director of NYU Langone Medical Center's Institute for Systems Genetics, has synthesized the first functional chromosome in yeast, an important step in the emerging field of synthetic biology, designing microorganisms to produce novel medicines, raw materials for food, and biofuels. (newswise.com)
  • We have shown that yeast cells carrying this synthetic chromosome are remarkably normal. (newswise.com)
  • In this week's issue of Science online March 27, the team reports how, using computer-aided design, they built a fully functioning chromosome, which they call synIII, and successfully incorporated it into brewer's yeast, known scientifically as Saccharomyces cerevisiae. (newswise.com)
  • We have made over 50,000 changes to the DNA code in the chromosome and our yeast still live. (newswise.com)
  • It shows that our synthetic chromosome is hardy, and it endows the yeast with new properties. (newswise.com)
  • Yeast chromosome III was selected for synthesis because it is among the smallest of the 16 yeast chromosomes and controls how yeast cells mate and undergo genetic change. (newswise.com)
  • Yeast shares roughly a third of its 6,000 genes functional units of chromosomal DNA for encoding proteins with humans. (nanowerk.com)
  • Exploring genomes - frequently human, but often mouse and yeast genomes as well - fills his day as a National Human Genome Research Institute (NHGRI) investigator in the Genetics and Molecular Biology Branch and head of the Genome Instability Section. (genome.gov)
  • Cells
  • Over the last five years, scientists have built bacterial chromosomes and viral DNA, but this is the first report of an entire eukaryotic chromosome, the threadlike structure that carries genes in the nucleus of all plant and animal cells, built from scratch. (newswise.com)
  • On a grainy, gray backdrop, he points out the dark gray ovals marking the boundaries of three human cells. (genome.gov)
  • Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells. (ox.ac.uk)
  • HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. (nih.gov)
  • Importantly, HDAC8 inhibition induces apoptosis in inv(16)(+) AML CD34(+) cells, while sparing the normal hematopoietic stem cells. (nih.gov)
  • Researchers learned to treat cells with a hypotonic solution to swell them, spreading apart the tangle of chromosomes. (the-scientist.com)
  • PKD1
  • Using a positional cloning approach the major autosomal dominant polycystic kidney disease (ADPKD) gene (PKD1) has been identified on chromosome 16: a disease associated chromosome translocation was instrumental in its identification. (ox.ac.uk)
  • Study of the PKD1 gene has been complicated because most of the gene lies in a genomic region reiterated elsewhere on the same chromosome. (ox.ac.uk)
  • Major genes which cause tuberous sclerosis (TSC) and autosomal dominant polycystic kidney disease (ADPKD), known as TSC2 and PKD1 respectively, lie immediately adjacent to each other on chromosome 16p. (ox.ac.uk)
  • high-density
  • We performed a high-density screen of SLI1, a region of chromosome 16q that shows highly significant and consistent linkage to nonword repetition, a measure of phonological short-term memory that is commonly impaired in SLI. (ox.ac.uk)
  • The high density and uniform coverage of the fluorescent signals were a strong indication that we could use the library to construct a map of overlapping cloned fragments spanning the entire length of the chromosome. (imsa.edu)
  • Since human epidemiological studies have suggested an association between LCAT levels and variations of high density lipoprotein cholesterol, we examined LCAT gene polymorphisms in a mouse animal model. (jax.org)
  • alpha globin
  • Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster. (ox.ac.uk)
  • Nevertheless, they fail to direct alpha globin synthesis in an interspecific hybrid containing the abnormal (alpha alpha)RA chromosome. (ox.ac.uk)
  • We have characterized a newly identified 16.6 kb deletion which removes a significant proportion of the human alpha-globin cluster including the psizeta1, alpha(D), psialpha1 and alpha2-globin genes but leaves the duplicated alpha1 gene intact. (ox.ac.uk)
  • kidney
  • This band is rich in deletion mutants of genes involved in several human diseases, notably polycystic kidney disease, alpha-thalassemia, tuberous sclerosis, mental retardation, and cancer. (ox.ac.uk)
  • consists
  • An automatic karyotyper consists of a computerized video camera that digitizes, thereby enhancing and improving, images of chromosomes as seen in the field of a dissecting light microscope. (the-scientist.com)
  • strands
  • the strands of human genetic material tend to bunch together maddeningly, overlapping and intertwining like so much spaghetti. (the-scientist.com)
  • Developmental
  • A small amount of missing genetic material on the p arm of chromosome 16 causes a condition called 16p12.2 microdeletion, which is associated with physical and developmental abnormalities in some affected individuals. (nih.gov)
  • position
  • It seems probable that previously unidentified positive regulatory sequences analogous to those detected in a corresponding position of the human beta globin cluster are removed by this deletion. (ox.ac.uk)