• After the prespecified conditioning in the discovery cohort, the authors identified an association between a novel single nucleotide polymorphism (SNP) in the CYP2C cluster on chromosome 10 (rs12777823) and warfarin dose requirement that reached genome-wide significance (p = 1.51 × 10 -8 ). (acc.org)
  • However, with current technology, it is difficult to separate the two chromosomes within a pair and the assays produce the combined haplotype, called the genotype information at each nucleotide. (wikipedia.org)
  • Terminus, telomere Centromere Chromatid DNA packaging A chromosome contains a single, uninterrupted DNA molecule. (coursehero.com)
  • The end-to-end fusion of chromosomes due to gradual telomere shortening may lead to the formation of dicentric chromosomes, which mark a potential threat to cellular viability. (scirp.org)
  • Further, the chromosome is no longer able to bind shelterin or associated proteins, and thus telomere uncapping occurs. (scirp.org)
  • A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA. (nih.gov)
  • Chromosome walking using cloned single-copy DNA from this region enabled us to identify the antibody-binding domain of this centromere. (nih.gov)
  • Nonparametric analysis of chromosome 20 inheritance data collected with the MODYl-linked marker D20S197 provides evidence forlinkage to NIDDM with a P value of 0.005 in Caucasian sib pairs using affected sibpair (ASP) analyses. (diabetesjournals.org)
  • Marker assisted selection was then used to produce congenic lines of C57BL/6J that contain different CAST-derived segments of chromosome 10. (jax.org)
  • Duplicated chromosome segments suggest that a genome duplication occurred in ray-fin phylogeny, and comparative studies suggest that this event happened deep in the ancestry of teleost fish. (zfin.org)
  • 10(-6) and performed in silico association analyses in an independent sample of ≤1003 cases and 7745 controls. (ox.ac.uk)
  • Although far from complete, such maps have revealed global topological and dynamic features of interactome networks that relate to known biological properties, suggesting that a human interactome map will provide insight into development and disease mechanisms at a systems level. (genes2cognition.org)
  • It is the end of eukaryote linear chromosomes, consisting of tandem arrays of G-rich repeats that protect the genome from degradation. (scirp.org)
  • although 415 million common and rare genetic variants exist in the human genome,the current genotyping arrays such as Affymetrix and Illumina microarrays can only assay up to 2.5 million SNPs. (wikipedia.org)
  • This work represents an important step towards a systematic and comprehensive human interactome project. (genes2cognition.org)