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DNA NucleotidylexotransferaseX ChromosomeY ChromosomeChromosomesDNAChromosome MappingChromosome BandingChromosome AberrationsSex ChromosomesChromosomes, Human, Pair 1Chromosomes, HumanChromosomes, BacterialChromosome SegregationChromosomes, Human, Pair 7Chromosomes, Human, Pair 11Chromosomes, Human, Pair 17Chromosomes, Human, Pair 6Chromosome DeletionChromosomes, Human, Pair 9Chromosomes, Human, Pair 21Chromosomes, PlantChromosomes, FungalChromosomes, Human, 6-12 and XChromosomes, Human, Pair 2Chromosomes, Human, Pair 16Chromosomes, Human, Pair 22Chromosome PairingChromosomes, MammalianChromosomes, Human, Pair 13Chromosomes, Human, Pair 4Chromosomes, Human, Pair 10Chromosomes, Human, YChromosomes, Human, Pair 8Chromosomes, Human, Pair 19Chromosome DisordersChromosomes, Artificial, BacterialChromosomes, Human, XChromosomes, Human, 1-3Chromosomes, Human, Pair 12Chromosome PaintingChromosomes, Human, Pair 5Chromosomes, Human, Pair 15KaryotypingChromosomes, Human, Pair 14Chromosomes, Human, Pair 18Chromosomes, Human, 16-18In Situ Hybridization, FluorescenceChromosomes, Human, Pair 20Chromosomes, Artificial, YeastChromosomes, Human, 13-15Genetic LinkageChromosome BreakageChromosomes, Human, 21-22 and YRing ChromosomesChromosome InversionGenetic MarkersChromosome PositioningChromosomes, Human, 4-5Molecular Sequence DataX Chromosome InactivationCentromereBase SequenceChromosomes, InsectTranslocation, GeneticMeiosisHybrid CellsChromosome StructuresChromosomes, Human, 19-20AneuploidyMetaphaseMitosisRecombination, GeneticLod ScorePedigreeCrosses, GeneticMutationMicrosatellite Repeats
DNTTTerminalPolymeraseMoleculePROTEINSBindEndsSpecificRepair
DNTT1
  • Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells. (wikipedia.org)
Terminal1
  • A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
Polymerase4
  • As a member of the X family of DNA polymerase enzymes, it works in conjunction with polymerase λ and polymerase μ, both of which belong to the same X family of polymerase enzymes. (wikipedia.org)
  • Further, TdT is the only polymerase that is known to catalyze the synthesis of 2-15nt DNA polymers from free nucleotides in solution in vivo. (wikipedia.org)
  • TdIF1 is another protein that interacts with TdT to inhibit its function by masking the DNA binding region of the TdT polymerase. (wikipedia.org)
  • A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. (lookformedical.com)
Molecule1
  • Generally, TdT catalyses the addition of nucleotides to the 3' terminus of a DNA molecule. (wikipedia.org)
PROTEINS2
  • Proteins which bind to DNA. (lookformedical.com)
  • The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
Bind1
  • The differences between TdTS and TdTL occur outside regions that bind DNA and nucleotides. (wikipedia.org)
Ends2
  • An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES . (nih.gov)
  • During DNA REPLICATION, chromosome ends loose some of their telomere sequence (TELOMERE SHORTENING. (lookformedical.com)
Specific1
  • In vitro, this behaviour catalyzes the general formation of DNA polymers without specific length. (wikipedia.org)
Repair1
  • The 2-15nt DNA fragments produced in vivo are hypothesized to act in signaling pathways related to DNA repair and/or recombination machinery. (wikipedia.org)