The aberrant chromosomes were isolated by flow cytometry and used to map the chromosome 14 deletion or translocation breakpoints. (nih.gov)
Furthermore, a compilation of other human chromosome 14q proximal deletion and translocation cases was obtained from a search on cytogenetic databases. (nih.gov)
A translocation involves the mechanical breakage and reconnection between different chromosomes (Obata 1999). (sarcomahelp.org)
Frequency of chromosome2
We examined the intakes of these B vitamins and their food sources in relation to the frequency of chromosome translocations as a biomarker of cumulative DNA damage, in eighty-two male airline pilots. (cambridge.org)
These were characterized by striking morphological aberrations such as elongation and despiralization (uncoiling or incomplete contraction), increased frequency of chromosome breakage and centromere spreading. (karger.com)
Dicentric chromosomes1
Breakage-fusion-bridge creates several identifiable cytogenetic abnormalities, such as anaphase bridges and dicentric chromosomes, which can be seen in progress using methods that have been available for decades. (wikipedia.org)
Copies of each chromosome2
When a cell prepares to divide to form two cells, the DNA that makes up the chromosomes is copied so that each new cell will have two copies of each chromosome, one from each parent. (medlineplus.gov)
Almost all humans have two copies of each chromosome and therefore have two copies of each gene, one inherited from the mother and the other from the father. (healthywomen.org)
Chromosomal8
Breakage-fusion-bridge (BFB) cycle (also breakage-rejoining-bridge cycle) is a mechanism of chromosomal instability, discovered by Barbara McClintock in the late 1930s. (wikipedia.org)
Chromosomal breakage syndromes are a group of genetic disorders that are typically transmitted in an autosomal recessive mode of inheritance. (medscape.com)
In culture, cells from affected individuals exhibit elevated rates of chromosomal breakage or instability, leading to chromosomal rearrangements. (medscape.com)
most practicing physicians may never see a patient with a chromosomal breakage syndrome. (medscape.com)
Table 1 provides a summary outline of the gene symbols, chromosomal locations, radiation sensitivity characteristics, immunodeficiencies, chromosome breakage characteristics, and major cancer risk for each of these disorders. (medscape.com)
Centromere loss and relocation in chromosome regions with otherwise conserved collinearity can be explained by conventional mechanisms of chromosome rearrangements or, as newly available phylogenomic and cytogenomic data suggest, by centromere inactivation through epigenetic chromatin modifications and/or intra-and inter-chromosomal recombination. (muni.cz)
Some tests look at chromosomes for abnormalities such as extra, missing or transposed chromosomal material. (healthywomen.org)
The genetic controversy about LSD started in 1967 when Cohen, Marinello and Back (22) published a paper suggesting that LSD should be added to the list of substances capable of causing abnormalities in the chromosomes. (druglibrary.net)
Centromere1
This assay discerns the presence of centromere within the MN to distinguish the MN containing centric chromosomes from those containing acentric fragments. (cdc.gov)
Gene5
With the draft genomic sequence for human chromosome 14 available, gene searches were performed on selected intervals of the 14q11.2-q21 region to identify candidate genes for the observed phenotype in some of those affected. (nih.gov)
Gain of function of the gene PAX9 on chromosome 14 is a possible candidate for a t(14;18) patient affected with mesomelic bone dysplasia. (nih.gov)
Exchange of DNA between chromosomes derived from the individual's mother and father are also increased in people with BLM gene mutations. (medlineplus.gov)
Also, sometimes pieces of chromosomes become switched, or transposed, so that a gene ends up in a location where it is permanently and inappropriately turned on or off. (healthywomen.org)
derived Sr gene, Sr61 (previously designated SrB ), was identified in South African wheat accession W3757, which carries a 6Ae#3 (6D) chromosome substitution 16 . (nature.com)
Instability2
Although BFB cycles are a major source of genome instability, the rearrangement signature predicted by this model is not commonly present in cancer genomes without other chromosome alterations like chromothripsis. (wikipedia.org)
The genes on the chromosomes are responsible for making proteins, which direct our biological development and the activity of about 100 trillion cells in our bodies. (healthywomen.org)
Chromosomes are the cellular storage units for genes contained within the nucleus (which is the genetic center) of the cell and are analogous to a spool with the DNA or genetic message being the thread on the spool. (sarcomahelp.org)
Here, we isolate from wheat, Sr26 and Sr61 , with both genes independently introduced as alien chromosome introgressions from tall wheat grass ( Thinopyrum ponticum ). (nature.com)
Syndromes1
The reviewer was disappointed that there was little or no discussion of the role of cytogenetic analysis in the diagnosis of "Breakage" syndromes. (bmj.com)
McClintock1
He has demonstrated the separation in time of DNA replication and crossing over by breakage-reunion, extending the classical work of Creighton and McClintock. (science.org.au)
Pair1
One of each chromosome pair is inherited from the mother and the other is inherited from the father. (healthywomen.org)
Bridges1
The low density and small size of these bridges, and aneuploid chromosome number biologically persistent particles makes respiratory were observed. (cdc.gov)
Mutational1
The chromosome bridge formation could trigger a mutational cascade through the accumulation of chromothripsis in each cell division. (wikipedia.org)
Radiation1
The possibility of inducing structural changes in the chromosomes by exogenous agents such as radiation, viruses, and a variety of chemicals, has been a subject of great scientific interest for a long time. (druglibrary.net)
Relation1
These sequences have a functional role, perhaps in relation to homologous chromosome recognition. (science.org.au)
The first group includes papers describing structural changes of the chromosomes produced by LSD in vitro , ** in these experiments various concentrations of LSD are added to cultures of cells from human, animal, or plant tissues in a test-tube. (druglibrary.net)
Functional1
Functional centromeres, ensuring regular chromosome segregation in mitosis and meiosis, are a prerequisite for the evolutionary success of pre-existing and new chromosome variants. (muni.cz)
White blood2
A research team led by St. Jude Children's Research Hospital scientists has discovered details of how the abnormal breakage and rearrangement of chromosomes in white blood cells triggers a particularly aggressive form of acute lymphoblastic leukemia (ALL). (news-medical.net)
22) * After my arrival in the United States, I participated in a major study concentrating on structural changes of the chromosomes in the white blood cells following LSD administration. (druglibrary.net)
Occur1
Peacock has established the basis of meiotic drive (segregation distortion) in terms of sperm morphogenesis in Drosophila and has shown that highly repeated DNA sequences occur in the centromeric regions of chromosomes, are chromosome-specific, and highly conserved. (science.org.au)
The conventional MN assay does not discriminate between MN produced by acentric chromosome fragments from those arising due to whole lagging chromosomes that were not incorporated into daughter nuclei at the time of cell division. (cdc.gov)
Form1
Long strings of DNA condense together, packaging the DNA in the form of a chromosome. (healthywomen.org)
Breaks1
The BFB cycle begins when the end region of a chromosome, called its telomere, breaks off. (wikipedia.org)
Includes2
It includes a small number of papers dealing with the detailed mechanism of the action of LSD on the deoxyribonucleic acid (DNA), the most important constituent of the chromosomes. (druglibrary.net)
This includes an account of Painter's understandable indecision in the 1920s as to whether to plump for 46 or 48 as the diploid chromosome number for man and a reminder that terms like "super-female" were common currency in papers of the late 1950s. (bmj.com)
Previously2
Although the investigators had previously identified an abnormal chromosome rearrangement in Ph-like ALL, little was known about the biological effects of that rearrangement. (news-medical.net)
The breakpoints of deletions and translocations in the proximal chromosome 14q region were defined in nine patients, four of whom have not been reported previously. (nih.gov)
Progress1
The rapid progress in plant comparative genomics and cytogenetics brings new insights into the evolutionary fate of centromeres and mechanisms of chromosome number reduction (descending dysploidy). (muni.cz)
Health1
Extra or missing pieces of chromosomes can have a significant impact on the health of an individual. (healthywomen.org)
A number of scientific papers have been published indicating that LSD might cause structural changes in the chromosomes, genetic mutations, disturbances of embryonic development, and malignant degeneration of cells. (druglibrary.net)