Chromosomes aurora kinases. Medical search. Frequent questions

The Xenopus, Drosophila, and Caenorhabditis elegans genomes, on the other hand, contain orthologues only to Aurora A and Aurora B. In all studied species, the three Aurora mitotic kinases localize to the centrosome during different phases of mitosis. (wikipedia.org)
Aurora A and Aurora B kinases play important roles in mitosis. (wikipedia.org)
Finally, Aurora A helps orchestrate an exit from mitosis by contributing to the completion of cytokinesis- the process by which the cytoplasm of the parent cell is split into two daughter cells. (wikipedia.org)
Though the exact mechanism by which Aurora A aids cytokinesis is unknown, it is well documented that it relocalizes to the mid-body immediately before the completion of mitosis. (wikipedia.org)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
We show that one such factor is the kinesin KIF4A, which is present along the chromosome axes throughout mitosis and the central spindle in anaphase. (ox.ac.uk)
Aurora kinases play an important role during mitosis for chromosome alignment, segregation, and cytokinesis. (cancer-research-network.com)
The Stukenberg Lab studies the mechanisms used by cells to segregate chromosomes to understand how tumor cells hijack mitosis. (virginia.edu)
The purple is Aurora B, a protein kinase involved in the polymerisation/depolymerisation of the microtubules during mitosis. (mitosispictures.com)
The inner centromere protein, INCENP, is crucial for correct chromosome segregation during mitosis. (h-its.org)
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. (uchicago.edu)
Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. (umn.edu)
In mitosis, ATR localizes to centromeres through Aurora A-regulated association with centromere protein F (CENP-F), allowing ATR to engage replication protein A (RPA)-coated centromeric R loops. (umn.edu)
Thus, a mitosis-specific and R loop-driven ATR pathway acts at centromeres to promote faithful chromosome segregation, revealing functions of R loops and ATR in suppressing chromosome instability. (umn.edu)
The dynamic crosstalk between kinases and phosphatases is essential to ensure faithful mitosis. (ed.ac.uk)
PP2A(B56), together with Shugoshin1 (Sgo1), opposes Aurora B during early mitosis to protect cohesin from being disassembled at the inner centromere. (ed.ac.uk)
Aurora A and B are essential in mitosis. (cogershop.com)
Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. (cogershop.com)
however, Aurora C can complement Aurora B kinase activity in mitosis. (cogershop.com)
Human cancer cells are usually seen as a changes in the amount or organization of DNA because of mistakes in mitosis, causing chromosome instability and aneuploidy. (survivinpathway.com)
Development through mitosis depends upon three major regulatory systems, each involving several serine/threonine kinases, referred to as mitotic kinases. (survivinpathway.com)
Within this review, we summarize the functions that all of the Aurora kinases has in cancer biology and mitosis, and discuss the binding modes of Aurora A kinase inhibitors, the spot elements in the binding sites and the fortunate inhibitor components. (survivinpathway.com)
Aurora kinase A (AURKA), which is a member of serine/threonine kinase family, plays a critical role in regulating mitosis. (encyclopedia.pub)
Along with Cdk1/cyclin N, members of the Aurora/Ipl1 kinase family are also crucial regulators of mitosis. (smadpathway.com)
Aurora B levels peak in early mitosis and then dramatically decline at mitotic exit. (smadpathway.com)
Remarkably, a current study contradicts these findings, indicating that p97 is needed for the disassociation of Aurora B from chromosomes, which will be in turn a requisite for nuclear envelope reformation at the end of mitosis. (smadpathway.com)
Progression through mitosis depends on a large number of protein complexes that regulate the major structural and physiological changes necessary for faithful chromosome segregation. (nih.gov)
Mitosis is usually a dynamic process controlled by the activity of multiple kinases with attendant modification of proteins facilitating rigid checkpoint control. (ap26113.com)
GSK1904529A Aurora A is found at centrosomes in early mitosis and controls centrosome maturation centriole separation and chromosome alignment (33) whereas accurate targeting of Aurora B to the chromosomes and then to the spindle midzone and midbody is essential for maintaining microtubule/kinetochore attachments and therefore faithful chromosomal segregation (34). (ap26113.com)
GR phosphorylation by an Aurora kinase-dependent pathway provides the mechanism explaining the tight coupling GSK1904529A of ligand-independent GR phosphorylation to cell cycle phase because the maximal activity of these kinases occurs in mitosis. (ap26113.com)
To examine the functional role of GR during mitosis we performed GR knockdown studies tracking cell division in real time and observed increased chromosome segregation errors with evidence of spindle defects. (ap26113.com)
Redox priming promotes Aurora A activation during mitosis. (cornell.edu)
The Aurora family of kinases and their downstream targets are key components of the cellular machinery that ensures the proper execution of mitosis and the accurate segregation of chromosomes to daughter cells. (cornell.edu)
These findings reveal a potential mechanistic link between Aurora A activation and changes in the intracellular redox state during mitosis and provide insights into how novel small-molecule inhibitors may be developed to target specific subpopulations of Aurora A. (cornell.edu)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)

Aurora kinase A also known as serine/threonine-protein kinase 6 is an enzyme that in humans is encoded by the AURKA gene. (wikipedia.org)
Aurora A is a member of a family of mitotic serine/threonine kinases. (wikipedia.org)
The mammalian Aurora kinase family contains three serine/threonine kinase members that participate in cell division. (rndsystems.com)
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. (cogershop.com)
Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. (cogershop.com)
These proteins, including Aurora A and B, are serine/threonine kinases that are essential for cell division activities such as spindle construction, chromosome segregation, and cytokinesis. (smadpathway.com)

Treatment of HeLa cells with paclitaxel induces phosphorylation of Aurora A at Thr288 while treatment with hydroxyurea ablates phosphorylation. (cellsignal.com)
Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
Abstract Aurora kinases create phosphorylation gradients within the spindle during prometaphase and anaphase. (ox.ac.uk)
Overall, we propose the disordered region of INCENP to act as a phosphorylation-regulated and length-variable component, within the previously defined "dog-leash" model, that thereby regulates how Aurora B reaches its targets for proper chromosome segregation. (h-its.org)
Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. (uchicago.edu)
As discussed in detail below, biochemical, biophysical, structural, and cellular evidences have shown that the redox modification of the cysteine residues of AURKA affects both the phosphorylation state of Thr288 and the conformation state of structural elements critical for the kinase activity, leading to the regulation of AURKA activity. (encyclopedia.pub)
Importantly, one other individual meats directly influence Aurora T localization, and phosphorylation of conserved residues in the C terminus of INCENP greatly raises Aurora B kinase activity. (smadpathway.com)
Modifications Inhibitors,Modulators,Libraries in the phosphorylation state of the DAT by kinases causes alterations in the function and location of the DAT. (inhibitorkit.com)
Most, if not all, of the mitotic processes are regulated by a set of mitotic protein kinases that control protein activity by phosphorylation. (nih.gov)
Although many mitotic phosphorylation events have been identified in proteome-scale mass spectrometry studies, information on how these phosphorylation sites are distributed within mitotic protein complexes and which kinases generate these phosphorylation sites is largely lacking. (nih.gov)
In many complexes, the phosphorylation sites were concentrated on a few subunits, suggesting that these subunits serve as "switchboards" to relay the kinase-regulatory signals within the complexes. (nih.gov)
In a subsequent in-depth analysis of key mitotic regulatory complexes with the Aurora kinase B (AURKB) inhibitor Hesperadin and a new Polo-like kinase (PLK1) inhibitor, BI 4834, we determined the kinase dependency for 172 phosphorylation sites on 41 proteins. (nih.gov)
We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)

Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. (fsu.edu)
Our ongoing work hints that this specificity is mediated by dynamic interactions between Sgo1 and the B56 subunits, and aims to decipher the functional contribution of these interactions in achieving faithful chromosome segregation My work also unveils a novel interaction between PP2A(B56) and the CPC. (ed.ac.uk)

The Aurora kinase B is a chromosome passenger protein and regulates chromosome segregation and cytokinesis. (wikipedia.org)
It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS. (lookformedical.com)
These locally regulate factors that promote spindle organisation, chromosome condensation and movement, and cytokinesis. (ox.ac.uk)
Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. (uchicago.edu)
Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. (uchicago.edu)
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. (uchicago.edu)
Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation. (uchicago.edu)
Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. (cogershop.com)

In yeast, the ortholog of the Aurora B-INCENP protein kinase complex (Ipl1-Sli15) may have a role in this crucial process, because it is necessary to prevent attachment of sister kinetochores to microtubules from the same spindle pole. (pasteur.fr)
The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)

We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)
The elevated incidence of aneuploidy in human oocytes warrants study from the molecular mechanisms regulating proper chromosome segregation. (bioinf.org)

A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. (cancer-research-network.com)
SNS-314 is an ATP-competitive, selective, and potent nanomolar inhibitor of aurora kinases in vitro. (cogershop.com)
SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent. (cogershop.com)
HDAC8 inhibitor Ufd1 was proved to be required for Survivin ubiquitination, and for the localization of Aurora and Survivin W to centromeres. (smadpathway.com)

The Aurora kinase A is associated with centrosome maturation and separation and thereby regulates spindle assembly and stability. (wikipedia.org)
The new grant will enable the lab to study how Aurora kinase regulates the dramatic changes to chromosomes and the cytoskeleton that are required to allow cells to divide. (virginia.edu)
As the spindle formation is the process that is mainly governed by the kinase activity of AURKA, these observations led to the hypothesis that H 2 O 2 regulates the activity of AURKA [ 27 ] [ 28 ] . (encyclopedia.pub)

Chromosome segregation errors during meiosis are the leading cause of birth defects and developmental delays in humans ( H assold and H unt 2001 ). (biorxiv.org)

This promotes relocalisation of Aurora B kinase, and other components of the chromosome passenger complex (CPC), from centromeres to the spindle midzone. (warwick.ac.uk)
The chromosomes are white (DAPI stain for DNA), and the centromeres are yellow. (mitosispictures.com)
The effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function at centromeres. (umn.edu)
As ATR is activated at centromeres, it stimulates Aurora B through Chk1, preventing formation of lagging chromosomes. (umn.edu)
Hence, this study concluded that p97/Ufd1/Npl4 is just a positive regulator of the CPC, as it is necessary for the localization of Aurora and Survivin W to metaphase centromeres. (smadpathway.com)
DesPlaines, Ill), which includes probes for the centromeres for chromosomes 3, 7, and 17 and has a locus-specific probe for 9p21, was developed to screen for recurrent urothelial carcinoma and was approved by the US Food and Drug Administration (FDA) in 2005. (medscape.com)

γ-tubulins, the base structure from which centrosomal microtubules polymerize, are also recruited by Aurora A. Without Aurora A the centrosome does not accumulate the quantity of γ-tubulin that normal centrosomes recruit prior to entering anaphase. (wikipedia.org)
Prior to the first meiotic division, homologous chromosomes pair, synapse, and recombine to ensure their proper disjunction at anaphase I. Additionally, telomeres tethered at the nuclear envelope cluster in the bouquet configuration where they are subjected to dramatic pulling forces acting from outside of the nucleus. (biorxiv.org)
Previous work has shown KIF4A is activated by Aurora B at the anaphase central spindle. (ox.ac.uk)
In vertebrates, this drop is mediated partly by Aurora B ubiquitination via the anaphase marketing complex, and subsequent destruction by the proteasome. (smadpathway.com)
Conversely, the deubiquitinating enzyme hFAM was required for the disassociation of Survivin and Aurora B from anaphase chromosomes. (smadpathway.com)
The distribution of GR through metaphase and anaphase overlaps with the spindle centrosome which plays a major role in coordinating accurate chromosome segregation (28-32). (ap26113.com)

They significantly increase chromosome instability and aneuploidy in a subset of hepatocellular carcinoma, resulting in growth inhibition. (carislifesciences.com)
Overexpression of Aurora-A, a mitotic kinase, results in chromosomal instability and cell transformation. (tmu.edu.tw)

The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation. (fsu.edu)

Aurora A also assures proper organization and alignment of the chromosomes during prometaphase. (wikipedia.org)
Aurora A influences centrosome maturation and spindle assembly, while Auroras B and C direct chromosome alignment and segregation. (rndsystems.com)

To determine the roles of the two different pools of KIF4A, we generated specific point mutants that are unable to interact with either condensin I or PRC1, or are deficient for Aurora kinase regulation. (ox.ac.uk)
So far, several lines of evidence have shown that H 2 O 2 -induced regulation of the AURKA activity, possibly through direct oxidation of Cys290 present in the activation segment of the kinase domain. (encyclopedia.pub)
The Cdc48/p97 AAA ATPase has been linked by recent reports with the regulation of Aurora B and the chromosomal passenger complex. (smadpathway.com)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)

As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)

In men with macrozoospermia, the sperm cell head contains extra chromosomes, usually four copies of each instead of the usual one. (medlineplus.gov)
As a result, affected sperm cells contain extra chromosomes, usually four copies of each instead of the usual one. (medlineplus.gov)
These types of sperm often carry extra chromosomes and have problems fertilizing the woman's egg. (airecu.pics)

Surprisingly, the nup2Δ ndj1Δ double mutant failed to segregate chromosomes, even though the meiotic program continued. (biorxiv.org)

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. (pasteur.fr)

Inhibiting MLL1 activity or mutating Borealin K143 to arginine perturbs CPC phase separation, reduces Aurora kinase B activity, and impairs the resolution of erroneous kinetochore-microtubule attachments and sister-chromatid cohesion. (carislifesciences.com)
Protein phosphatases PP2A(B55) and PP2A(B56), and the Chromosomal Passenger Complex -CPC, containing Aurora B kinase-, establish a signalling network that controls sister chromatid cohesion, kinetochore-microtubule attachments, and timely chromosome segregation. (ed.ac.uk)

The Aurora kinases really are a group of three highly homologous Ser/ Thr protein kinases, including Aurora A, B and C. (survivinpathway.com)

It connects the kinase Aurora B to the inner centromere allowing this kinase to dynamically access … its kinetochore targets. (h-its.org)

Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. (cornell.edu)

CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. (uchicago.edu)

Mouse model was utilized to confirm the relationship between arsenic and Aurora-A. Results: We reveal that low dosage of arsenic treatment increased cell proliferation is associated with accumulated cell population at S phase. (tmu.edu.tw)
We further disclosed that Aurora-A expression and cell proliferation were increased in bladder and uterus tissues of the BALB/c mice after long-term arsenic (1 mg/L) exposure for 2 months. (tmu.edu.tw)
Conclusion: We reveal that low dose of arsenic induced cell proliferation is through Aurora-A overexpression, which is transcriptionally regulated by E2F1 both in vitro and in vivo. (tmu.edu.tw)

Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)

Right chromosome segregation is closely controlled by mitotic kinases such as cyclin dependent NIMA related kinase 2, Pololike kinase, kinase 1 and Aurora kinases. (survivinpathway.com)
Preeminent among these proteins are the cyclin dependent kinases, which upon binding to cyclins, phosphorylate numerous targets to trigger cell cycle progression. (smadpathway.com)

The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)

Furthermore, Aurora A is necessary for the proper separation of the centrosomes after the mitotic spindle has been formed. (wikipedia.org)
In the case of the former, it has been suggested that Aurora A cooperates with the kinase Nek2 in Xenopus to dissolve the structure tethering the cell's centrosomes together. (wikipedia.org)
Therefore, without proper expression of Aurora A, the cell's centrosomes are never able to separate. (wikipedia.org)
For example, deletion of Aurora A in C. elegans results in an initial separation of the cell's centrosomes followed by an immediate collapse of the asters. (wikipedia.org)
While Aurora A localizes to mitotic centrosomes and is required for centrosome growth and the development of a functional bipolar mitotic spindle, Aurora W is the catalytic core of the highly conserved genetic individual complex. (smadpathway.com)

In the absence of Aurora A mad2, a protein that normally dissipates once a proper kinetochore-microtubule connection is made, remains present even into metaphase. (wikipedia.org)
By analysing these mutants, we show that Aurora kinases phosphorylate the condensin I dependent pool of KIF4A and thus actively promote chromosome congression from the spindle poles to the metaphase plate. (ox.ac.uk)
It shows the metaphase plate just about to separate the chromosomes. (mitosispictures.com)
B lymphocytes from a family with GR haploinsufficiency ( A ) were analyzed for chromosome complement by metaphase spread assay ( B ). Chromosome counts show counts for 150 cells from three impartial passages (p5-p8). (ap26113.com)
Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation. (bvsalud.org)

The lab recently found that many breast cancers dysregulate the important mitotic regulator Aurora B kinase. (virginia.edu)

Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)

Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION. (lookformedical.com)
Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. (cogershop.com)

Aurora A localizes next to the centrosome late in the G1 phase and early in the S phase. (wikipedia.org)
The CPC includes, as well as Aurora B, three regulatory subunits: the inner centromeric protein, Survivin, and Borealin/Dasra W. Beginning in prophase, the CPC localizes to condensing chromosomes and steadily concentrates at the internal centromere where one function would be to correct poor Infectious causes of cancer spindle kinetochore devices. (smadpathway.com)

Now our data identify a role in mitotic progression and chromosome segregation. (ap26113.com)

The kinase plays an indefensible role in cancer. (cancer-research-network.com)
There are a number of chemical inhibitors of Aurora kinases in clinical trials as cancer chemotherapeutics and the studies will provide important insight into effective use of these therapeutics and generate new targets to specifically kill cancer cells. (virginia.edu)

We showed in both egg extracts and mammalian cells that a conserved cysteine residue within the Aurora A activation loop is crucial for Aurora A activation by autophosphorylation. (cornell.edu)

Here we show that MLL1/KMT2A methylates Borealin K143 in the intrinsically disordered region essential for liquid-liquid phase separation of the chromosome passenger complex (CPC). (carislifesciences.com)
Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. (fsu.edu)
Finally, we evaluate a functional interaction between Fry and NDR1 kinase, providing evidence of an evolutionarily conserved complex required for morphogenesis. (nature.com)

PP2A(B56) and Aurora B also act antagonistically in controlling the processes of error correction and activation of the Spindle Assembly Checkpoint, both of which are essential to achieve chromosome biorientation. (ed.ac.uk)

The AURKC gene provides instructions for making a protein called aurora kinase C. This protein is abundant in male testes, which are the male reproductive organs in which sperm are produced and stored. (medlineplus.gov)
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. (antikoerper-online.de)
A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. (antikoerper-online.de)
The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. (lookformedical.com)
Macrocephalic sperm may be caused by homozygous mutation of the aurora kinase C gene . (airecu.pics)
is located on chromosome 11 (11q14.1) as a mirtron, a microRNA encoded within an intron of a protein-coding gene [38C40]. (ubatubasat.com)

However, how arsenic induces carcinogenesis through Aurora-A activation remaining unclear. (tmu.edu.tw)

Identification of a new recurrent aurora kinase C mutation in both European and African men with macrozoospermia. (medlineplus.gov)

It is directly involved in the interaction of the kinetochore, the part of the chromosome at which the mitotic spindle attaches and pulls, and the mitotic spindle's extended microtubules. (wikipedia.org)

We investigated IPL1 function in cells that cannot replicate their chromosomes but nevertheless duplicate their spindle pole bodies (SPBs). (pasteur.fr)

The aurora kinases were first identified in 1990 during a cDNA screen of Xenopus eggs. (wikipedia.org)

Although there is evidence to suggest that Aurora C might be a chromosomal passenger protein, the cellular function of it is less clear. (wikipedia.org)

As the cell cycle progresses, concentrations of Aurora A increase and the kinase associates with the mitotic poles and the adjacent spindle microtubules. (wikipedia.org)

Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)

Aurora A is activated by one or more phosphorylations and its activity peaks during the G2 phase to M phase transition in the cell cycle. (wikipedia.org)
The transcription factor of Aurora-A was investigated by promoter activity, chromosome immunoprecipitation (ChIP), and small interfering RNA (shRNA) assays. (tmu.edu.tw)
In this study, x-ray crystal structures of the Aurora A kinase domain delineate redox-sensitive cysteine residues that, upon covalent modification, can allosterically regulate kinase activity and oligomerization state. (cornell.edu)

Anatomy62

Organisms6

Diseases15

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes116

Disciplines and Occupations1

Information Science3

Mitosis38

Serine9

Phosphorylation13

Faithful chromosome segregation2

Cytokinesis8

Protein kinase2

Proper chromosome segregation2

Inhibitor4

Regulates3

Segregation Errors1

Centromeres6

Anaphase6

Instability2

Kinetochores1

Alignment2

Regulation4

AURKA1

Extra chromosomes3

Segregate chromosomes1

Promotes chromosome1

Sister-chromatid2

Homologous1

Inner centromere1

Phosphatases1

INCENP1

Cell proliferation3

Maturation1

Cyclin2

Binds2

Centrosomes5

Metaphase5

Regulator1

Oncogene1

Tumor2

Localizes2

Progression1

Cancer2

Mammalian cells1

Complex3

Biorientation1

Gene6

Induces1

Mutation1

Kinetochore1

IPL11

Xenopus1

Passenger1

Poles1

Regulatory1

Activity3