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  • aneuploidy
  • Eventual errors in the distribution of the genetic material between the two daughter cells, phenomena known as aneuploidy, give rise to alterations of the number of chromosomes, which are the cause of many types of cancer and different congenital diseases, such as Down's syndrome (caused by an error in the chromosome 21 distribution during cell division). (sruk.org.uk)
  • viral
  • Rana R & Biegalke BJ Human cytomegalovirus UL34 early and late proteins are essential for viral replication. (abcam.com)
  • researchers
  • Using this approach, the researchers succeeded in distributing artificial minichromosomes between the two daughter cells during cell division. (redorbit.com)
  • Molecular
  • Here, we review the progress in centromere genomics spanning the discovery of the sequence to its molecular characterization and the work done during the Human Genome Project era to elucidate alpha satellite structure and sequence variation. (mdpi.com)
  • Assay
  • Using the HAC-based chromosome loss assay, we have analyzed several well-known anti-mitotic, spindle-targeting compounds, all of which have been reported to induce micronuclei formation and chromosome loss. (biomedcentral.com)
  • structures
  • However, when the cell starts the process of cell division, chromosomes condense generating the typical X-shaped structures that we are more familiar with ( Figure 1 , Prophase). (sruk.org.uk)
  • During the process of mitosis, DNA and its associated packing proteins are arranged into structures called chromosomes that are duplicated and then segregated. (scienceblog.com)
  • microtubules
  • The DNA is in blue and the network of microtubules in green, the machinery that helps the chromosomes to be distributed equally into the two identical daughter cells. (sruk.org.uk)
  • genetic
  • To ensure an equal distribution of genetic material and that every chromosome arm goes to a daughter cell, the centromeric region plays a fundamental role ( Figure 2 ). (sruk.org.uk)
  • proteins
  • Sensitization to taxol was achieved by reducing the levels of Mps1 or BubR1, proteins with dual roles in checkpoint activation and chromosome alignment. (biomedcentral.com)
  • sequence
  • Long and accurate polymerase chain reaction, sequencing, and in silico analyses facilitated the complete sequence annotation of a BAC harboring human SM-Calp (hSM-Calp). (physiology.org)
  • We discuss exciting recent advances in alpha satellite sequence assembly that have provided important insight into the abundance and complex organization of this sequence on human chromosomes. (mdpi.com)