• What are the treatment recommendations for Philadelphia chromosome-negative acute lymphoblastic leukemia (ALL) in adults 40 years or older? (medscape.com)
  • Clinical effect of imatinib added to intensive combination chemotherapy for newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia. (medscape.com)
  • Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study. (medscape.com)
  • Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate. (medscape.com)
  • First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. (medscape.com)
  • A pivotal phase 2 trial of ponatinib with chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) resistant or intolerant to dasatinib or nilotinib, or with the T315I BCR-ABL mutation: 12-month follow-up of the PACE trial. (medscape.com)
  • Adverse prognostic significance of CD20 expression in adults with Philadelphia chromosome-negative B-cell precursor acute lymphoblastic leukemia. (medscape.com)
  • Human artificial chromosome (HAC) vectors have some unique characteristics as compared with conventional vectors, carrying large transgenes without size limitation, showing persistent expression of transgenes, and existing independently from host genome in cells. (biomedcentral.com)
  • This technique can move the large intact genomic structures of natural chromosomes or artificially engineered chromosomes, and transferred chromosomes can be stably retained and freely segregate in recipient cells. (biomedcentral.com)
  • However, the method of introduction of HACs into target cells is confined to microcell-mediated chromosome transfer (MMCT), which is less efficient than other methods of vector introduction. (biomedcentral.com)
  • If both chromosomes of a pair have the same inversion, and there is no extra or missing genes, then there is no problem with meiosis. (wikipedia.org)
  • Chromosomes are thread-shaped structures that are found in cells of living organisms and that contain DNA , a nucleic acid that contains the genetic instructions for those organisms. (wisegeek.com)
  • When these abnormal sex cells are involved in fertilization, the resulting cell will have the wrong number of chromosomes. (wisegeek.com)
  • This research shows that the region of chromosome 9 that contains the FXN locus is intrinsically prone to breakage in vivo even in control cells. (curefa.org)
  • Sometimes, however, a pair will not separate - which is called nondisjunction - giving one gamete too many chromosomes and another too few. (wisegeek.com)
  • During an inversion, a portion of the chromosome breaks off and reattaches in the inverted position, causing the sequence of the genes on that portion to be reversed. (wisegeek.com)
  • These individuals are male, but the presence of an extra X chromosome causes body proportions that are female and smaller testes , with no sperm production. (wisegeek.com)
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