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  • Genes
  • Positional cloning of such genes is dependent on high-resolution methods that can detect losses and gains of chromosome segments. (biomedcentral.com)
  • We used these gene assignments to construct comparative maps between wallaby and opossum, which uncovered many intrachromosomal rearrangements, particularly for genes found on wallaby chromosomes X and 3. (beds.ac.uk)
  • The immense diversity of genes encoding the variable regions of antigen receptors is generated through rearrangement of component V, D, and J segments via a cut-and-paste mechanism known as V(D)J recombination. (bloodjournal.org)
  • Chromosomal rearrangements leading to gene breakage are frequent in high-grade serous ovarian carcinomas and have been reported as a common mechanism for inactivating tumor suppressor genes. (beds.ac.uk)
  • In the present study, we looked for fusion gene candidates and aberrantly expressed genes as well as the possible mechanisms behind such expression changes in a series of ovarian carcinomas with cytogenetically identified chromosome 19 changes. (beds.ac.uk)
  • We then performed comparative FISH mapping using 29 mouse complementary DNA (cDNA) clones of the 22 X-linked genes and the seven genes linked to mouse chromosome 11 (whose homologue had fused to the sex chromosomes), and FISH mapping using two T. muenninki cDNA clones of the Y-linked genes. (springer.com)
  • Whereas six of the mouse chromosome 11 genes were also mapped to Xp and Yp, in addition, one gene, CBX2 , was also mapped to Xp, Yp, and chromosome 14 in T. muenninki . (springer.com)
  • microdissection
  • In addition, a novel procedure for chromosome microdissection and in vitro amplification of dissected DNA was developed and applied to several areas. (arizona.edu)
  • Finally, a chromosome microdissection combining microcloning technique has been developed and used to generate chromosomal band-specific DNA libraries for physical mapping. (arizona.edu)
  • sequences
  • Differentiation and copy number of repetitive sequences affect directly chromosome structure which contributes to reproductive isolation and speciation. (semanticscholar.org)
  • The DNA sequences in the human chromosome are exactly as expected from this scenario. (wordpress.com)
  • While generally error-free, HR can occur between misaligned sequences, resulting in deleterious sequence rearrangements that can contribute to cancer and aging. (pubmedcentralcanada.ca)
  • The RAG1/2 endonuclease initiates programmed DNA rearrangements in progenitor lymphocytes by generating double-strand breaks at specific recombination signal sequences. (bloodjournal.org)
  • The procedure uses tandemly repeated DNA sequences to generate a distinctive banding pattern for each of the 10 chromosomes. (pnas.org)
  • homology
  • Kartavtseva, I. 2011-09-16 00:00:00 The homology of DNA of C-positive centromeric regions of chromosomes in wood mice of the genus Sylvaemus (S. uralensis, S. fulvipectus, S. sylvaticus, S. flavicollis, and S. ponticus) was estimated for the first time. (deepdyve.com)
  • Current methods perform best with at least 40x depth [ 12 ], and even then detection can be hampered by low mappability at repetitive regions, meaning that rearrangements involving centromeric, heterochromatic or regions of high homology are often indiscernible. (biomedcentral.com)
  • telomere repeats
  • TERT reiteratively copies a templating sequence embedded in TER to establish and maintain telomere repeats on chromosome ends. (frontiersin.org)
  • The consensus 5' to 3' telomere motif in humans, chimps, apes, and mammals in general, is (TTAGGG) n and typically occurs in perfect tandem for stretches of DNA from about 10 to 15 kb (10,000 to 15,000 bases) and contains 1,667 to 2,500 telomere repeats at each chromosome end. (wordpress.com)
  • complement
  • Benirschke K, Malouf N, Low RJ, Heck H (1965) Chromosome complement differences between Equus caballus and Equus przewalskii , Poliakoff. (springer.com)
  • somatic
  • Study of the maize ( Zea mays L.) somatic chromosomes (2 n = 20) has been difficult because of a lack of distinguishing characteristics. (pnas.org)
  • Thus, there would be advantages for the study of maize chromosomes if each of the 10 members of the karyotype could be identified in somatic cells. (pnas.org)
  • However, the identification of somatic chromosomes has been difficult because the highly condensed chromatin structure conceals the fine details that are used for chromosome identification at the pachytene stage, such as cytologically observable knobs, heterochromatic regions, arm ratios, and total chromosome length ( 5 ). (pnas.org)
  • Benirschke K, Brownhill LE, Beath MM (1962) Somatic chromosomes of the horse, the donkey and their hybrids, the mule and the hinny. (springer.com)
  • pairs
  • The linkage map incorporates 508 segregating loci and represents each of the 28 chromosome pairs of octoploid strawberry, spanning an estimated length of 2050 cM. (beds.ac.uk)