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  • Aberrations
  • We show that a single, short exposure of cultured mammalian epithelial cells to live pks + E. coli at low infectious doses induced a transient DNA damage response followed by cell division with signs of incomplete DNA repair, leading to anaphase bridges and chromosome aberrations. (pnas.org)
  • sequence
  • We also acknowledge Genome Canada for support of EST library construction and sequencing through the Protist EST Project and grant RR-009231 to EO from the National Institutes of Health (the National Center for Research Resources) which supported the RAPD and Cbs work and an EO subcontract to NSF grant MCB-0132675 which supported sequence analyses related to number of chromosomes and their copy number. (blogspot.com)
  • SMC5
  • Whole exome sequencing revealed biallelic missense mutations in the NSMCE3 (also known as NDNL2 ) gene, which encodes a subunit of the SMC5/6 complex that is essential for DNA damage response and chromosome segregation. (jci.org)
  • severe
  • Affected individuals with NSMCE3 mutations with severe l ung disease i mmunodeficiency and c hromosome breakage s yndrome (LICS). (jci.org)
  • genetic map
  • Thomas Hunt Morgan's group conducted many pioneering genetic studies in the fruit fly model during this period, and Morgan's student Alfred Sturtevant published the first genetic map of a chromosome in 1913 ( 5 ). (pnas.org)
  • genes
  • For much of the 20th century, genes were considered to be stable entities arranged in an orderly linear pattern on chromosomes, like beads on a string ( 1 ). (pnas.org)
  • She also found that depending on where they inserted into a chromosome these mobile elements could reversibly alter the expression of other genes. (pnas.org)
  • cells
  • We have previously demonstrated that oxidative stress-induced apoptosis could be a potential mechanism mediating chromosome breakages in nasopharyngeal epithelial cells. (springer.com)
  • These results reaffirm our previous findings that oxidative stress-induced apoptosis could be one of the potential mechanisms underlying chromosome breakages in nasopharyngeal epithelial cells. (springer.com)
  • Patient cells exhibited deficiency in BRCA1 and RAD51 localization to DNA-damage sites, combined with radial chromosome formation and hypersensitivity to ICL-inducing agents. (aacrjournals.org)
  • current
  • A former Dow Chemical researcher has reported significant levels of chromosome damage among Dow workers exposed to less benzene than the current federal standard allows. (washingtonpost.com)
  • Picciano is the first scientist to report chromosome damage at levels below the current 10 ppm federal standard. (washingtonpost.com)
  • report
  • We report here the shotgun sequencing, assembly, and analysis of the MAC genome of T. thermophila , which is approximately 104 Mb in length and composed of approximately 225 chromosomes. (blogspot.com)
  • We report on two unrelated patients with a proximal deletion of the long arm of chromosome 21. (biomedsearch.com)
  • link
  • This will be done by induction of a Y-autosome translocation to link the wild-type allele to the Y chromosome in such manner that males are wild-type (temperature resistant) and females are mutant (temperature sensitive). (springer.com)