• This gene encodes a member of the highly conserved Aurora subfamily of serine/threonine protein kinases with two other members, Aurora A and Aurora B. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. (wikipedia.org)
  • Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)
  • A family of highly conserved serine-threonine kinases that are involved in the regulation of MITOSIS. (lookformedical.com)
  • An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE. (lookformedical.com)
  • An aurora kinase that is a component of the chromosomal passenger protein complex and is involved in the regulation of MITOSIS. (lookformedical.com)
  • We show that one such factor is the kinesin KIF4A, which is present along the chromosome axes throughout mitosis and the central spindle in anaphase. (ox.ac.uk)
  • Aurora kinases play an important role during mitosis for chromosome alignment, segregation, and cytokinesis. (cancer-research-network.com)
  • The purple is Aurora B, a protein kinase involved in the polymerisation/depolymerisation of the microtubules during mitosis. (mitosispictures.com)
  • The Stukenberg Lab studies the mechanisms used by cells to segregate chromosomes to understand how tumor cells hijack mitosis. (virginia.edu)
  • The inner centromere protein, INCENP, is crucial for correct chromosome segregation during mitosis. (h-its.org)
  • The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis. (uchicago.edu)
  • Human cancer cells are usually seen as a changes in the amount or organization of DNA because of mistakes in mitosis, causing chromosome instability and aneuploidy. (survivinpathway.com)
  • Development through mitosis depends upon three major regulatory systems, each involving several serine/threonine kinases, referred to as mitotic kinases. (survivinpathway.com)
  • Within this review, we summarize the functions that all of the Aurora kinases has in cancer biology and mitosis, and discuss the binding modes of Aurora A kinase inhibitors, the spot elements in the binding sites and the fortunate inhibitor components. (survivinpathway.com)
  • Aurora kinase A (AURKA), which is a member of serine/threonine kinase family, plays a critical role in regulating mitosis. (encyclopedia.pub)
  • Along with Cdk1/cyclin N, members of the Aurora/Ipl1 kinase family are also crucial regulators of mitosis. (smadpathway.com)
  • Aurora B levels peak in early mitosis and then dramatically decline at mitotic exit. (smadpathway.com)
  • Remarkably, a current study contradicts these findings, indicating that p97 is needed for the disassociation of Aurora B from chromosomes, which will be in turn a requisite for nuclear envelope reformation at the end of mitosis. (smadpathway.com)
  • The dynamic crosstalk between kinases and phosphatases is essential to ensure faithful mitosis. (ed.ac.uk)
  • PP2A(B56), together with Shugoshin1 (Sgo1), opposes Aurora B during early mitosis to protect cohesin from being disassembled at the inner centromere. (ed.ac.uk)
  • Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. (umn.edu)
  • In mitosis, ATR localizes to centromeres through Aurora A-regulated association with centromere protein F (CENP-F), allowing ATR to engage replication protein A (RPA)-coated centromeric R loops. (umn.edu)
  • Thus, a mitosis-specific and R loop-driven ATR pathway acts at centromeres to promote faithful chromosome segregation, revealing functions of R loops and ATR in suppressing chromosome instability. (umn.edu)
  • Progression through mitosis depends on a large number of protein complexes that regulate the major structural and physiological changes necessary for faithful chromosome segregation. (nih.gov)
  • Aurora A and B are essential in mitosis. (cogershop.com)
  • Perturbation of their activity leads to multiple defects in mitosis including aberrant centrosome duplication, misalignment of chromosomes, inhibition of cytokinesis, and disruption of the spindle checkpoint. (cogershop.com)
  • however, Aurora C can complement Aurora B kinase activity in mitosis. (cogershop.com)
  • The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
  • kinase in candida, is an important mitosis regulatory proteins encoded on human being chromosome 20q13.2 that induces oncogenic change followed with centrosome amplification and aneuploidy when over indicated SEMA3E in rodent cells and (6-8). (arcillaresearch.com)
  • Aurora kinase C, also Serine/threonine-protein kinase 13 is an enzyme that in humans is encoded by the AURKC gene. (wikipedia.org)
  • The mammalian Aurora kinase family contains three serine/threonine kinase members that participate in cell division. (rndsystems.com)
  • An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. (lookformedical.com)
  • Mammalian aurora-A belongs to a multigenic family of mitotic serine/threonine kinases comprising two other members: aurora-B and aurora-C. In this review we will focus on aurora-A that starts to localize to centrosomes only in S phase as soon as centrioles have been duplicated, the protein is then degraded in early G1. (lookformedical.com)
  • A family of serine/threonine kinase Aurora constitutes a key regulator in the orchestration of mitotic events. (lookformedical.com)
  • These proteins, including Aurora A and B, are serine/threonine kinases that are essential for cell division activities such as spindle construction, chromosome segregation, and cytokinesis. (smadpathway.com)
  • Aurora kinases constitute a family of serine-threonine kinases that are strongly associated with cancer. (cogershop.com)
  • Phosphorylation of Histone H3 on serine 10, a known Aurora B cellular target, is inhibited with an EC50 of ~9nM following treatment of cells with SNS-314. (cogershop.com)
  • Temporal expression patterns and subcellular localization of Aurora kinases in mitotic cells from G2 to cytokinesis indicate association with mitotic and meiotic structure. (wikipedia.org)
  • Aurora C localizes to the centrosome and then to the midzone of mitotic cells from anaphase to cytokinesis. (wikipedia.org)
  • While Aurora A and B are expressed in mitotic somatic cells, Aurora C is more often expressed during meiosis (spermatogenesis and oogenesis). (wikipedia.org)
  • found that they have overlapping functions and that Aurora C was able to rescue Aurora B-deficient mitotic cells from aneuploidy. (wikipedia.org)
  • Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
  • Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
  • Overexpression of Aurora-A, a mitotic kinase, results in chromosomal instability and cell transformation. (tmu.edu.tw)
  • The lab recently found that many breast cancers dysregulate the important mitotic regulator Aurora B kinase. (virginia.edu)
  • Current research suggests that mitotic kinases have a key role in regulating the cell cycle. (survivinpathway.com)
  • Right chromosome segregation is closely controlled by mitotic kinases such as cyclin dependent NIMA related kinase 2, Pololike kinase, kinase 1 and Aurora kinases. (survivinpathway.com)
  • While Aurora A localizes to mitotic centrosomes and is required for centrosome growth and the development of a functional bipolar mitotic spindle, Aurora W is the catalytic core of the highly conserved genetic individual complex. (smadpathway.com)
  • Most, if not all, of the mitotic processes are regulated by a set of mitotic protein kinases that control protein activity by phosphorylation. (nih.gov)
  • Although many mitotic phosphorylation events have been identified in proteome-scale mass spectrometry studies, information on how these phosphorylation sites are distributed within mitotic protein complexes and which kinases generate these phosphorylation sites is largely lacking. (nih.gov)
  • In a subsequent in-depth analysis of key mitotic regulatory complexes with the Aurora kinase B (AURKB) inhibitor Hesperadin and a new Polo-like kinase (PLK1) inhibitor, BI 4834, we determined the kinase dependency for 172 phosphorylation sites on 41 proteins. (nih.gov)
  • Treatment of HeLa cells with paclitaxel induces phosphorylation of Aurora A at Thr288 while treatment with hydroxyurea ablates phosphorylation. (cellsignal.com)
  • Abstract Aurora kinases create phosphorylation gradients within the spindle during prometaphase and anaphase. (ox.ac.uk)
  • Overall, we propose the disordered region of INCENP to act as a phosphorylation-regulated and length-variable component, within the previously defined "dog-leash" model, that thereby regulates how Aurora B reaches its targets for proper chromosome segregation. (h-its.org)
  • Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis. (uchicago.edu)
  • As discussed in detail below, biochemical, biophysical, structural, and cellular evidences have shown that the redox modification of the cysteine residues of AURKA affects both the phosphorylation state of Thr288 and the conformation state of structural elements critical for the kinase activity, leading to the regulation of AURKA activity. (encyclopedia.pub)
  • Importantly, one other individual meats directly influence Aurora T localization, and phosphorylation of conserved residues in the C terminus of INCENP greatly raises Aurora B kinase activity. (smadpathway.com)
  • In many complexes, the phosphorylation sites were concentrated on a few subunits, suggesting that these subunits serve as "switchboards" to relay the kinase-regulatory signals within the complexes. (nih.gov)
  • Modifications Inhibitors,Modulators,Libraries in the phosphorylation state of the DAT by kinases causes alterations in the function and location of the DAT. (inhibitorkit.com)
  • We herein demonstrated that CADM1 interacts with Hippo pathway core kinases and enhances the phosphorylation of YAP1, and also that the membranous co-expression of CADM1 and LATS2 predicts a favorable prognosis in lung adenocarcinoma. (cancerindex.org)
  • In yeast, the ortholog of the Aurora B-INCENP protein kinase complex (Ipl1-Sli15) may have a role in this crucial process, because it is necessary to prevent attachment of sister kinetochores to microtubules from the same spindle pole. (pasteur.fr)
  • The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters. (lookformedical.com)
  • Chromosome bipolar attachment is achieved when sister kinetochores are attached by microtubules emanating from opposite spindle poles, and this process is essential for faithful chromosome segregation during anaphase. (fsu.edu)
  • Our ongoing work hints that this specificity is mediated by dynamic interactions between Sgo1 and the B56 subunits, and aims to decipher the functional contribution of these interactions in achieving faithful chromosome segregation My work also unveils a novel interaction between PP2A(B56) and the CPC. (ed.ac.uk)
  • There are a number of chemical inhibitors of Aurora kinases in clinical trials as cancer chemotherapeutics and the studies will provide important insight into effective use of these therapeutics and generate new targets to specifically kill cancer cells. (virginia.edu)
  • Our report on the reported chemical scaffolds of Aurora A kinase inhibitors and their binding modes could give a of good use Letrozole ic50 framework from which new design strategies for inhibitors may be evaluated or produced. (survivinpathway.com)
  • In addition, we review the main pre-clinical and clinical studies concerning Aurora kinase inhibitors currently under investigation. (survivinpathway.com)
  • The extensive pre-clinical data supports the develop-ment of focused Aurora kinase inhibitors in certain tumefaction types. (survivinpathway.com)
  • TKIs, aurora kinase inhibitors and homoharringtonine. (rockstarsagainstliveearth.com)
  • Therapy with tyrosine kinase inhibitors (TKIs) has changed the natural history of CML, which has gone from a potentially fatal disorder to one that can be easily controlled [8]. (rockstarsagainstliveearth.com)
  • Aurora B kinase regulates kinetochore maturation, destabilization of improper kinetochore-microtubule attachments, and spindle assembly checkpoint (SAC), central spindle organization, and cytokinesis. (wikipedia.org)
  • It mediates proper CHROMOSOME SEGREGATION and contractile ring function during CYTOKINESIS. (lookformedical.com)
  • These locally regulate factors that promote spindle organisation, chromosome condensation and movement, and cytokinesis. (ox.ac.uk)
  • Polo-like kinase 1 triggers the initiation of cytokinesis in human cells by promoting recruitment of the RhoGEF Ect2 to the central spindle. (uchicago.edu)
  • Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. (uchicago.edu)
  • Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. (uchicago.edu)
  • Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation. (uchicago.edu)
  • Analysis of DNA content and indirect immunofluoresence demonstrates that SNS-314 induces defects in cytokinesis and spindle checkpoint that are consistent with Aurora kinase inhibition. (cogershop.com)
  • The chromosomal passenger complex (CPC), essential for chromosome segregation, contains the four subunits: the Aurora kinase, INCENP, survivin, and borealin (also known as dasra). (wikipedia.org)
  • The new grant will enable the lab to study how Aurora kinase regulates the dramatic changes to chromosomes and the cytoskeleton that are required to allow cells to divide. (virginia.edu)
  • As the spindle formation is the process that is mainly governed by the kinase activity of AURKA, these observations led to the hypothesis that H 2 O 2 regulates the activity of AURKA [ 27 ] [ 28 ] . (encyclopedia.pub)
  • To determine the roles of the two different pools of KIF4A, we generated specific point mutants that are unable to interact with either condensin I or PRC1, or are deficient for Aurora kinase regulation. (ox.ac.uk)
  • So far, several lines of evidence have shown that H 2 O 2 -induced regulation of the AURKA activity, possibly through direct oxidation of Cys290 present in the activation segment of the kinase domain. (encyclopedia.pub)
  • The Cdc48/p97 AAA ATPase has been linked by recent reports with the regulation of Aurora B and the chromosomal passenger complex. (smadpathway.com)
  • The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
  • Inhibiting MLL1 activity or mutating Borealin K143 to arginine perturbs CPC phase separation, reduces Aurora kinase B activity, and impairs the resolution of erroneous kinetochore-microtubule attachments and sister-chromatid cohesion. (carislifesciences.com)
  • Protein phosphatases PP2A(B55) and PP2A(B56), and the Chromosomal Passenger Complex -CPC, containing Aurora B kinase-, establish a signalling network that controls sister chromatid cohesion, kinetochore-microtubule attachments, and timely chromosome segregation. (ed.ac.uk)
  • This promotes relocalisation of Aurora B kinase, and other components of the chromosome passenger complex (CPC), from centromeres to the spindle midzone. (warwick.ac.uk)
  • The chromosomes are white (DAPI stain for DNA), and the centromeres are yellow. (mitosispictures.com)
  • HDAC8 inhibitor Ufd1 was proved to be required for Survivin ubiquitination, and for the localization of Aurora and Survivin W to centromeres. (smadpathway.com)
  • Hence, this study concluded that p97/Ufd1/Npl4 is just a positive regulator of the CPC, as it is necessary for the localization of Aurora and Survivin W to metaphase centromeres. (smadpathway.com)
  • The effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function at centromeres. (umn.edu)
  • As ATR is activated at centromeres, it stimulates Aurora B through Chk1, preventing formation of lagging chromosomes. (umn.edu)
  • DesPlaines, Ill), which includes probes for the centromeres for chromosomes 3, 7, and 17 and has a locus-specific probe for 9p21, was developed to screen for recurrent urothelial carcinoma and was approved by the US Food and Drug Administration (FDA) in 2005. (medscape.com)
  • Here we show that MLL1/KMT2A methylates Borealin K143 in the intrinsically disordered region essential for liquid-liquid phase separation of the chromosome passenger complex (CPC). (carislifesciences.com)
  • Both Aurora B and C interact with the inner centromere protein (INCENP) from the C-terminal to the conserved IN box domain, but Aurora B preferentially binds INCENP. (wikipedia.org)
  • Co-expression of Aurora B and C in vivo interferes with INCENP binding, localization, and stability. (wikipedia.org)
  • Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. (pasteur.fr)
  • CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1. (uchicago.edu)
  • They significantly increase chromosome instability and aneuploidy in a subset of hepatocellular carcinoma, resulting in growth inhibition. (carislifesciences.com)
  • The translocation occurs in a primitive hematopoietic stem cell and the gene encodes a fusion protein (Bcr-Abl) that has deregulated tyrosine kinase (TK) activity and activates intracellular pathways that lead to increased cellular proliferation, resistance to apoptosis and genetic instability [1,3]. (rockstarsagainstliveearth.com)
  • The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation. (fsu.edu)
  • As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)
  • Background Aurora kinase A (AURKA) is amplified with varying occurrence in multiple human being cancers including mind and throat squamous cell carcinoma (HNSCC). (arcillaresearch.com)
  • In men with macrozoospermia, the sperm cell head contains extra chromosomes, usually four copies of each instead of the usual one. (medlineplus.gov)
  • As a result, affected sperm cells contain extra chromosomes, usually four copies of each instead of the usual one. (medlineplus.gov)
  • These types of sperm often carry extra chromosomes and have problems fertilizing the woman's egg. (airecu.pics)
  • Surprisingly, the nup2Δ ndj1Δ double mutant failed to segregate chromosomes, even though the meiotic program continued. (biorxiv.org)
  • Prior to the first meiotic division, homologous chromosomes pair, synapse, and recombine to ensure their proper disjunction at anaphase I. Additionally, telomeres tethered at the nuclear envelope cluster in the bouquet configuration where they are subjected to dramatic pulling forces acting from outside of the nucleus. (biorxiv.org)
  • The Aurora kinases really are a group of three highly homologous Ser/ Thr protein kinases, including Aurora A, B and C. (survivinpathway.com)
  • The zinc finger domain of Tzfp binds to the tbs motif located at the upstream flanking region of the Aie1 (aurora-C) kinase gene. (lookformedical.com)
  • KIT is a receptor tyrosine kinase type III, which binds to stem cell factor. (inhibitorkit.com)
  • However, how arsenic induces carcinogenesis through Aurora-A activation remaining unclear. (tmu.edu.tw)
  • We investigated IPL1 function in cells that cannot replicate their chromosomes but nevertheless duplicate their spindle pole bodies (SPBs). (pasteur.fr)
  • Previous work has shown KIF4A is activated by Aurora B at the anaphase central spindle. (ox.ac.uk)
  • In vertebrates, this drop is mediated partly by Aurora B ubiquitination via the anaphase marketing complex, and subsequent destruction by the proteasome. (smadpathway.com)
  • Conversely, the deubiquitinating enzyme hFAM was required for the disassociation of Survivin and Aurora B from anaphase chromosomes. (smadpathway.com)
  • The AURKC gene provides instructions for making a protein called aurora kinase C. This protein is abundant in male testes, which are the male reproductive organs in which sperm are produced and stored. (medlineplus.gov)
  • The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. (antikoerper-online.de)
  • A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. (antikoerper-online.de)
  • The mouse Tzfp gene, mapped to chromosome 7 B2-B3, encodes a 465-amino acid transcription factor containing a conserved N-terminal BTB/POZ domain and three C-terminal PLZF-like C(2)H(2) zinc fingers. (lookformedical.com)
  • Macrocephalic sperm may be caused by homozygous mutation of the aurora kinase C gene . (airecu.pics)
  • is located on chromosome 11 (11q14.1) as a mirtron, a microRNA encoded within an intron of a protein-coding gene [38C40]. (ubatubasat.com)
  • Aurora Kinase-A gene is usually amplified and overexpressed in lots of human malignancies, including colorectal, breasts, ovarian, bladder, gastric and pancreatic malignancies. (arcillaresearch.com)
  • The Ph chromosome is present in 95% of cases of CML and it gives rise to the gene, with the remaining 5% of cases having an alternative or occult translocation [2,4]. (rockstarsagainstliveearth.com)
  • Chromosome segregation errors during meiosis are the leading cause of birth defects and developmental delays in humans ( H assold and H unt 2001 ). (biorxiv.org)
  • Preeminent among these proteins are the cyclin dependent kinases, which upon binding to cyclins, phosphorylate numerous targets to trigger cell cycle progression. (smadpathway.com)
  • SNS-314 is a potent small-molecule inhibitor of Aurora kinase that is being developed as a novel anti-cancer therapeutic agent. (cogershop.com)
  • Aurora A influences centrosome maturation and spindle assembly, while Auroras B and C direct chromosome alignment and segregation. (rndsystems.com)
  • Works in various organisms have revealed that the kinase is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability. (lookformedical.com)
  • The CPC includes, as well as Aurora B, three regulatory subunits: the inner centromeric protein, Survivin, and Borealin/Dasra W. Beginning in prophase, the CPC localizes to condensing chromosomes and steadily concentrates at the internal centromere where one function would be to correct poor Infectious causes of cancer spindle kinetochore devices. (smadpathway.com)
  • Although all of the Aurora kinases are overexpressed in many cancer cell lines, only Aurora A and C possess oncogenic activity, producing multinucleated cells and tumors in vivo when overexpressed. (wikipedia.org)
  • The kinase plays an indefensible role in cancer. (cancer-research-network.com)
  • Aneuploidy results from independent and simultaneous inhibition of Aurora B and Aurora C. Slattery et al. (wikipedia.org)
  • By analysing these mutants, we show that Aurora kinases phosphorylate the condensin I dependent pool of KIF4A and thus actively promote chromosome congression from the spindle poles to the metaphase plate. (ox.ac.uk)
  • Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint. (fsu.edu)
  • Finally, we evaluate a functional interaction between Fry and NDR1 kinase, providing evidence of an evolutionarily conserved complex required for morphogenesis. (nature.com)
  • Those transformed cells form tumours when implanted in immunodeficient mice, indicating that the kinase is an oncogene. (lookformedical.com)
  • Aurora A overexpression in many malignant tumor types suggests that it may be directly involved in NEOPLASTIC CELL TRANSFORMATION. (lookformedical.com)
  • Analysis of SNS-314 treated tumors confirms that the anti-tumor activity is consistent with Aurora kinase inhibition. (cogershop.com)
  • Mouse model was utilized to confirm the relationship between arsenic and Aurora-A. Results: We reveal that low dosage of arsenic treatment increased cell proliferation is associated with accumulated cell population at S phase. (tmu.edu.tw)
  • We further disclosed that Aurora-A expression and cell proliferation were increased in bladder and uterus tissues of the BALB/c mice after long-term arsenic (1 mg/L) exposure for 2 months. (tmu.edu.tw)
  • Conclusion: We reveal that low dose of arsenic induced cell proliferation is through Aurora-A overexpression, which is transcriptionally regulated by E2F1 both in vitro and in vivo. (tmu.edu.tw)
  • A study from Victoria K Woodcock suggested that AZD0424 is an inhibitor of the proto-oncogenic non-receptor tyrosine kinases Src and ABL1. (cancer-research-network.com)
  • PP2A(B56) and Aurora B also act antagonistically in controlling the processes of error correction and activation of the Spindle Assembly Checkpoint, both of which are essential to achieve chromosome biorientation. (ed.ac.uk)
  • When cells overexpressing Aurora C were treated with nocodazole to turn on the SAC, Aurora B protein stability and activity decreased. (wikipedia.org)
  • The transcription factor of Aurora-A was investigated by promoter activity, chromosome immunoprecipitation (ChIP), and small interfering RNA (shRNA) assays. (tmu.edu.tw)
  • However, whether or not chromosome-associated KIF4A bound to condensin I is regulated by Aurora kinases remain unclear. (ox.ac.uk)