Chromosomal trait. Medical search. Frequent questions

Until now, any given sample could be tested for only one or two conditions, typically chromosomal abnormalities such as trisomy 21, the cause of Down's syndrome. (nature.com)
Six different chromosome activites introduce biology aces to heredity, chromosomal abnormalities, sex-linked traits, and the human genome. (lessonplanet.com)
Chromosomal abnormalities typically occur due to a problem with cell division. (medicinenet.com)

One possible clue: more than 40% of the suspect chromosomal sites contain regulators, called expression quantitative trait loci, or eQTLs, that govern the expression of multiple genes. (nih.gov)
The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
We have a major interest in identifying the genes and molecular polymorphisms that underpin variation in fitness components (so-called life-history traits), such as body size, reproduction and lifespan, and in determining how they contribute to adaptation. (unifr.ch)
Sterility can also be caused by selective breeding, where a selected trait is closely linked to genes involved in sex determination or fertility. (wikipedia.org)
QTLs and candidate genes detected in our study for yield-related traits under stripe rust stress will facilitate elucidating genetic basis of yield-related trait and could be used in marker-assisted selection in wheat yield breeding. (biomedcentral.com)
Other work suggests some chromosomal clustering of genes by expression pattern. (biomedcentral.com)
Affymetrix GeneChip oligonucleotide microarray analyses were conducted to examine ZnO- induced expression of genes up-and downstream in the toll-like receptor signaling pathway and identify candidate genes present in other chromosomal regions of interest. (cdc.gov)
As a result, the linkage between the autoimmune experimental arthritis phenotype and the genomic region, that is, the quantitative trait locus, can cover several hundred genes. (medscape.com)
To facilitate this kind of data mining, we have created a tool, the Candidate Gene Capture (CGC) application, that makes keyword-based searches on textual information for genes situated within selected human chromosomal intervals that are homologous to a given rat QTL. (medscape.com)

We investigated the regulatory roles of a high-confidence and reproducible set of 69 trait-relevant lincRNAs (TR-lincRNAs) in human lymphoblastoid cells whose biological relevance is supported by their evolutionary conservation during recent human history and genetic interactions with other trait-associated loci. (nih.gov)
The aims of quantitative trait loci detection is the potential use of these molecular markers to increase accuracy in predicting the genetic merit of breeding and its implementation in animal breeding schemes through marker-assisted selection. (cambridge.org)
2018). Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits. (harvard.edu)
Distinguishing genetic correlation from causation across 52 diseases and complex traits. (harvard.edu)
Checking for hundreds or thousands of traits with one blood test, early in pregnancy, could move prenatal genetic testing from uncommon to routine. (nature.com)
Examples of 2-omics analyses include expression quantitative trait locus eQTL (Franke & Jansen, 2009) and methylation quantitative trait locus meQTL (Smith, Kilaru, Kocak, Almli, & Mercer, 2014) that, respectively, assess the influence of genetic and epigenetic markers on gene expression. (researchgate.net)
The genetic abnormality can range from minuscule to major -- from a discrete mutation in a single base in the DNA of a single gene to a gross chromosomal abnormality involving the addition or subtraction of an entire chromosome or set of chromosomes. (medicinenet.com)
However, still little is known about the genetic basis of variation and evolutionary changes in such fitness-related traits. (unifr.ch)
Using a resource population of crossbred gilts developed at UNL, we explored genetic factors associated with reproductive traits and lifetime productivity. (unl.edu)
To investigate the genetic contribution to familial similarity in longevity, we set up a novel experimental design where cousin-pairs born from siblings who were concordant or discordant for the longevity trait were analyzed. (mpg.de)
In the United Kingdom, the Cogent PrecisionMATCH team of evaluators relies on the Chromosomal Mating program to provide unmatched genetic progress and enhance the overall efficiency of dairy and beef farming operations. (cogentuk.com)
Chromosomal breakage syndromes are a group of genetic disorders that are typically transmitted in an autosomal recessive mode of inheritance. (medscape.com)
Both alleles influence the genetic trait or determine the characteristics of the genetic condition. (medlineplus.gov)

Their enrichment in enhancer-like chromatin signatures, interactions with nearby trait-relevant protein-coding loci, and preferential location at topologically associated domain (TAD) boundaries provide evidence that TR-lincRNAs likely regulate proximal trait-relevant gene expression in cis by modulating local chromosomal architecture. (nih.gov)
This is a perfect illustration of the mutual influence between gene expression levels and chromosomal organization in bacteria. (biomedcentral.com)
But how prevalent is chromosomal organization by gene expression? (biomedcentral.com)
Chromosomal inactivation Many factors can affect gene expression (and thus phenotypes). (msdmanuals.com)

Multifactorial inheritance also is associated with heritable traits such as fingerprint patterns, height, eye color, and skin color. (medicinenet.com)
Retrieving was the most heritable behavior trait. (discovermagazine.com)
But this argument has never been substantiated, despite the fact that studies have shown that homosexuality is a heritable trait. (iflscience.com)

We study these questions, e.g., in the context of climate adaptation and life-history clines across latitudinal gradients, chromosomal inversion polymorphisms maintained by spatially varying selection and other forms of balancing selection, and the evolution of aging and trade-offs associated with longevity and other fitness traits. (unifr.ch)
These studies have led us to explore the role of natural variation in the insulin/insulin-like growth factor signaling (IIS) pathway and of chromosomal inversion polymorphisms in affecting fitness components. (unifr.ch)
BACKGROUND: Chromosomal inversion polymorphisms have been associated with adaptive behavioral, physiological, morphological and life history traits in the two main Afrotropical malaria vectors, Anopheles coluzzii and Anopheles gambiae. (cdc.gov)
The understanding of the adaptive value of chromosomal inversion systems is constrained by the feasibility of cytological karyotyping. (cdc.gov)

Chromosomal segments underlying quantitative trait. (cambridge.org)
These results show that the average size of the quantitative trait loci effect was 1.6 phenotypic standard deviations for different traits and families. (cambridge.org)
A total of 13 stable quantitative trait loci (QTLs) were found to be highly associating to yield-related traits, including 6 for spike length (SL), 3 for thousand-kernel weight (TKW), 2 for kernel weight per spike (KWPS), and 2 for both TKW and KWPS, in at least two test environments under stripe rust stress conditions. (biomedcentral.com)
Therefore, wheat yield is a complex quantitative trait contributed by many morphological, physiological and biochemical components, all of which can be improved to increase the yield directly or indirectly. (biomedcentral.com)
Quantitative trait locus analysis of the development of pulmonary tolerance to inhaled zinc oxide. (cdc.gov)
A genome-wide screen using 298 F2 mice (CByD2FlxCByD2FI) that were phenotyped for the development of pulmonary tolerance following 5X ZnO exposure identified a significant quantitative trait locus (QTL) for the BAL protein phenotype on chromosome 1. (cdc.gov)
Statistically valid linkage between such genomic regions and measurements of quantitative traits are called quantitative trait loci (QTLs). (medscape.com)

To address these longstanding problems we combine population genetics and population genomics, functional genetics, transcriptomics, physiology, and experimental evolution and apply them to natural and laboratory populations of D. melanogaster that are phenotypically differentiated for fitness-related traits. (unifr.ch)
Inbreeding depression is often measured in fitness-related traits of life history (e.g. fecundity, survival, morphological measurements) and often only in captive populations ( Hedrick and Kalinowski 2000 ). (biorxiv.org)

Since its market debut in October 2018, Chromosomal Mating® has made a significant impact in 48 countries, benefiting more than 1,800 farms and facilitating the mating of over 3.8 million females. (cogentuk.com)

Chromosomal segments that control these traits were identified on various genomic regions. (usda.gov)

Abnormal karyotype - approximately 95% of cases result from chromosomal non-disjunction of chromosome 21 (47,XX,+21 or 47,XY,+21) at conception. (cdc.gov)

In culture, cells from affected individuals exhibit elevated rates of chromosomal breakage or instability, leading to chromosomal rearrangements. (medscape.com)

Trisomy 21 can be strongly suspected or diagnosed clinically during the neonatal period by recognizing the typical physical traits. (cdc.gov)

However, some species, especially plants and animals with holocentric chromosomes, are known to tolerate chromosomal heterozygosity even for multiple rearrangements. (frontiersin.org)
Diseases may also occur because of chromosomal translocation in which portions of two chromosomes are exchanged. (medicinenet.com)

For diagnosis, consider physical traits with greatest discriminant diagnostic value. (cdc.gov)
Their paper notes that little is still known about the genetics underpinning the behavioural traits associated with canine domestication compared to, say, the genetics responsible for differences in physical traits like fur colour and size. (cosmosmagazine.com)

Traditional selection for sow reproductive longevity results is ineffective due to low heritability and late expression of the trait. (unl.edu)
Although no significant difference emerged between the two groups of cousin-pairs, our study gave new insights on the hindrances to recruiting a suitable sample to obtain significant IBD data on longevity-related chromosomal regions. (mpg.de)

Genome-wide association study (GWAS) is a powerful tool to identify loci associated to target traits based on linkage disequilibrium (LD) using natural populations. (biomedcentral.com)

In some cases, intersex traits are visible at birth while in others, they are not apparent until puberty. (ourbodiesourselves.org)
Some chromosomal intersex variations may not be physically apparent at all. (ourbodiesourselves.org)
According to experts, between 0.05% and 1.7% of the population is born with intersex traits - the upper estimate is similar to the number of red haired people. (ourbodiesourselves.org)
Individuals classified as intersex are people born with physical or biological sex characteristics such as sexual anatomy, reproductive organs, hormonal patterns and/or chromosomal patterns that do not fit the typical definitions for male or female bodies. (co.zm)
For some intersex people these traits are apparent at birth, while for others they emerge later in life, often at puberty. (co.zm)

In some species, males and females have different chromosome numbers, a trait unusual in mammals, though it is seen in other organisms. (wikipedia.org)

Although many have recently been linked to complex human traits, the underlying mechanisms for most of these transcripts remain undetermined. (nih.gov)
raising questions about additional mechanisms that may rescue fertility in chromosomal hybrids. (frontiersin.org)
A synthesis of approaches may provide new insight in to adaptive mechanisms in evolution and the population basis of complex traits. (biomedcentral.com)
The existence of FL lacking the t(14;18) chromosomal alteration highlights the complex pathogenesis of FL, and indicates that there are alternative pathogenetic mechanisms that can induce a neoplasm with follicular center B-cell phenotype. (bvsalud.org)

lt;p>Some of this research has gone so far as to suggest that the degree of differentiation relates to other behavioral traits. (scienceblogs.com)
lt;p>Regardless of any behavioral links, this sexually dimorphic trait could be used to sex individuals. (scienceblogs.com)
Scientists now have a clearer understanding of how breed types influence behavioral traits. (discovermagazine.com)

Here, we identified loci associated to multi-environmental yield-related traits under stripe rust stress in 244 wheat accessions from Sichuan Province through genome-wide association study (GWAS) using 44,059 polymorphic markers from the 55 K single nucleotide polymorphism (SNP) chip. (biomedcentral.com)

Some cause the expression of traits to deviate from the patterns predicted by Mendelian inheritance. (msdmanuals.com)

Synesthesia is a rare cognitive trait in which the stimulation of one sensory pathway leads to the involuntary stimulation of a second sensory pathway. (jax.org)

Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome-wide expression profiles of both RNA and protein. (biomedcentral.com)

Our results provide insights into the molecular mode of action by which TR-lincRNAs contribute to complex human traits. (nih.gov)

From all the traits recorded before breeding, age at puberty was the only one that significantly affected the chance of females would produce a first parity litter. (unl.edu)
DNA markers located on three different chromosomal regions were associated with early expression of puberty that led to up to 1.36 greater number of lifetime parities. (unl.edu)

most practicing physicians may never see a patient with a chromosomal breakage syndrome. (medscape.com)

Genome-wide association analyses uncovered several regions that have an effect across the reproductive traits. (unl.edu)
Genomic prediction values of reproductive traits explained an important proportion of the phenotypic differences when training and prediction was performed in the same data set but negligible for litter size traits when training and genomic prediction were performed in different data sets. (unl.edu)

With some traits, genetics do influence doggy behavior. (discovermagazine.com)

We argue that the observed process of chromosome sorting would, if continued, result in a new homozygous chromosomal race, i.e., in a new karyotype with intermediate chromosome number and, possibly, in a new incipient homoploid hybrid species. (frontiersin.org)
We also discuss the segregational model of karyotype evolution and the chromosomal model of homoploid hybrid speciation. (frontiersin.org)

Sterility can also be caused by chromosomal differences within an individual. (wikipedia.org)

Thus, identifying loci associated with yield-related traits under stripe rust stress may provide favourable alleles and their useful markers for breeding wheat cultivars with high yield in combination with stripe rust resistance. (biomedcentral.com)

A posteriori granddaughter design was applied to the entire genome to determine haplotype effects for 33 traits of Holsteins. (usda.gov)
To be sure, musical talent is not a very quantifiable trait, which can make for a lot of noise in genome-wide association studies looking for shared variants of significance. (jax.org)
Genome-wide association studies have revealed at least 143 chromosomal sites associated with risk for schizophrenia. (nih.gov)
We have explored the possible conservation of relationships between mRNA abundances and chromosomal organization in the highly reduced genome of Buchnera aphidicola , the primary endosymbiont of the aphids, and a close relative to Escherichia coli . (biomedcentral.com)
Despite an important reduction in its genome size and an apparent decay of its capacity for regulating transcription, this work reveals a significant correlation between mRNA abundances and chromosomal organization of the aphid-symbiont Buchnera . (biomedcentral.com)

This study reports the results obtained in the search of chromosomal regions affecting fleece traits in a population of Angora goats in the Argentinean Patagonia. (cambridge.org)
found 4 large chromosomal regions linked to AP, although none were strong enough to reach statistical significance among all the families. (jax.org)
In addition, we analyzed haplotype transmission from centenarians to offspring, and a statistically significant Transmission Ratio Distortion (TRD) was observed for both chromosomal regions in the discordant families (P¼0.007 for 6p21.3 and P¼0.015 for 11p15.5). (mpg.de)

Genomic studies on bacteria have clearly shown the existence of chromosomal organization as regards, for example, to gene localization, order and orientation. (biomedcentral.com)
Moreover, transcriptomic analyses have demonstrated that, in free-living bacteria, gene transcription levels and chromosomal organization are mutually influenced. (biomedcentral.com)

While rare, this is a quantifiable - and complex - trait. (jax.org)
The components of fitness, so-called life-history traits (e.g., growth, size, fecundity, survival, lifespan), are complex polygenic traits that are fundamentally important for adaptation because they represent the targets of selection at the phenotypic level. (unifr.ch)

Inbreeding can significantly impact the traits we aim to improve, making it essential to quantify its economic implications when making mating decisions. (cogentuk.com)

For some traits, such as paternally inherited dominant conditions, this can be done by looking for DNA variants - alleles - that the mother does not carry. (nature.com)
For other traits, the number of copies of each variant can be used to determine how many copies of a chromosome the fetus carries, as well as how many copies of which alleles. (nature.com)

Chromosomal Mating® stands out due to its unique approach, focusing on maximising economic traits while addressing the challenges of inbreeding depression. (cogentuk.com)
Chromosomal Mating® carefully accounts for and manages inbreeding depression, ensuring a healthier and more profitable next generation. (cogentuk.com)
For species of management concern, accurate estimates of inbreeding and trait depression are crucial for the species' future. (biorxiv.org)

Heterozygotes for major chromosomal rearrangements such as fusions and fissions are expected to display a high level of sterility due to problems during meiosis. (frontiersin.org)

A novel region on chromosome 2B was identified impacting the traits under study that could improve all disease related traits. (usda.gov)
For all traits, the haplotype effect was important in at least 1 chromosomal region. (usda.gov)
The DNA analysis focused on a specific chromosomal region that is positively selected for in domestic species of dog - ergo, it is passed on through the population as an evolutionary advantageous trait. (cosmosmagazine.com)
In 2014, researchers confirmed the association between same-sex orientation in men and a specific chromosomal region . (iflscience.com)

Analysis of variance showed significant genotype and genotype by environment effect on all traits. (usda.gov)

Can microbial functional traits predict the response and resilience of decomposition to global change? (powershow.com)
The recent advances in this field started with the theories of evolution, mathematical models to predict traits, and studies at cellular level. (bvsalud.org)

However, isolated AV septal defects can be transmitted in families as an autosomal dominant trait. (medscape.com)

In most cases of significant chromosomal aberration, AV septal defects are associated with other noncardiac congenital defects. (medscape.com)

Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
What is more often found within families are common traits. (todaysparent.com)
For the trait of biddability, the team found that breeds like the Belgian Malinois, vizsla and border collie were the most likely to respond to human direction in training scenarios. (discovermagazine.com)

That term "sex individuals" is a quaint way archaeologists say "determine the chromosomal sex of individuals using proxy methods such as brow ridges and stuff, like they do on the TV show Bones. (scienceblogs.com)

In contrast, incontinentia pigmenti is inherited as an X-linked dominant trait. (medscape.com)

a new species could evolve from the mutated offspring with the desirable trait. (powershow.com)

All have played a part in endearing dogs to humans, but a new study lends weight to the view that a hardwired personality trait - sociability, to be specific - has been the crucial factor in the domestication of man's best friend. (cosmosmagazine.com)

Although researchers can attach some traits to specific breeds, dogs are far more individual than previously realized. (discovermagazine.com)

Even a single heterozygous chromosomal rearrangement, such as a reciprocal translocation or chromosomal fusion, is expected to result in 50% reduction of fertility ( King, 1993 ). (frontiersin.org)

Anatomy20

Organisms41

Diseases11

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology30

Phenomena and Processes102

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture18

Information Science8

Named Groups5

Health Care30

Abnormalities3

Genes9

Genetic13

Gene expression4

Heritable3

Inversion4

Quantitative trait7

Fitness-related traits2

20181

Genomic regions1

Chromosome 211

Instability1

Trisomy 211

Chromosomes2

Physical traits2

Longevity2

Linkage1

Intersex5

Different chromosome1

Mechanisms4

Behavioral3

GWAS1

Patterns1

Pathway1

Variation1

Molecular1

Puberty2

Syndrome1

Reproductive2

Genetics1

Karyotype2

Differences1

Loci1

Genome5

Regions3

Organization2

Complex2

Implications1

Alleles2

Inbreeding3

Sterility1

Region4

Genotype1

Predict2

Autosomal1

Significant1

Found3

Individuals1

Dominant1

Species1

Crucial1

Specific1

Result1