Chromosomal tandem repeat sequences. Medical search. Frequent questions

Minisatellites are small sequences of DNA that do not encode proteins but appear throughout the genome hundreds of times, with many repeated copies lying next to each other. (wikipedia.org)
MIRU-VNTR analysis, on the other hand, uses mini-satellite sequences (tandem repeats of 10-100 nucleotides) dispersed at multiple loci in the bacterial genome. (frontiersin.org)
In this study, the Illumina HiSeq 4000 and PacBio platforms were used to sequence and assemble the whole genome of Fusarium equiseti D25-1. (researchsquare.com)
The total repetitive sequence length was 1,713,918 bp, accounting for 4.2033% of the genome. (researchsquare.com)
Advances in whole-genome sequencing technologies have enabled numerous key discoveries. (researchsquare.com)
Short tandem repeats (STRs) compose approximately 3% of the genome, and mutations at STR loci have been linked to dozens of human diseases including amyotrophic lateral sclerosis, Friedreich ataxia, Huntington disease, and fragile X syndrome. (biomedcentral.com)
To estimate the genome-wide pattern of mutations at STR loci, we analyze blood-derived whole-genome sequencing data for 544 individuals from 29 three-generation CEPH pedigrees. (biomedcentral.com)
Some of these tools are designed to detect STR expansions at disease-related loci, while others detect expansions and contractions of STRs genome-wide but are constrained by sequencing read length and the STR motif size. (biomedcentral.com)
Holden MT , Lindsay JA , Corton C , Quail MA , Cockfield JD , Pathak S , Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus , sequence type 239 (TW). (cdc.gov)
This allowed the complete 'repeat' to be mapped in detail, further studies confirmed that the majority of clusters are tandemly repeated in the genome. (bl.uk)
Whole genome sequencing was utilized to investigate genomic alterations. (biomedcentral.com)
A variety of simple repeat sequences that are distributed throughout the GENOME. (lookformedical.com)
domesticus genome, of a family repeat which included the EcoRI GAATTC restriction sequence. (unipv.it)
Here, tandem repeat patterns and dynamics during pollen mother cell development were addressed, with a focus on the meiotic recombination that determines chromosome/genome repatterning and stabilization under cross-pollination and artificial hybridization in wild goatgrass, Aegilops speltoides. (haifa.ac.il)
Using long-read sequencing, we generated the first complete and well-annotated genome assemblies of large, highly diverged, non-recombining regions associated with meiotic drive elements. (nih.gov)
To create this benchmark for a broadly consented son in a Personal Genome Project trio with broadly available cells and DNA, the Genome in a Bottle Consortium integrated 19 sequence-resolved variant calling methods from diverse technologies. (nabsys.com)
And structural variation hotspots in the human genome are formed by single processes at each hotspot, that is the underlying sequence drives the kind of SV seen in a hotspot. (blogspot.com)
Fungtammasan, A., E. Walsh, F. Chiaromonte, K. A. Eckert, and K. D. Makova, 2012 A genome-wide analysis of widespread fragile sites: What attributes establish chromosomal instability inside the human genome? (caspase1inhibitor.com)
He was at the origins of the introduction of DNA analysis into forensic medical examination in our country, participated in the discovery of genes key to Alzheimer's disease, was one of the first in Russia to start working with ancient DNA and sequenced the mitochondrial genome of a mammoth. (vechnayamolodost.ru)
What exactly from the human genome have you sequenced?The role of our group's employees is to participate in the analysis of centromeric alpha-like DNA repeats. (vechnayamolodost.ru)
Most of the unread genome just belonged to centromeric regions, these are special sections of chromosomes that are necessary for cell division, and they usually consist of tandem repeating DNA sequence units. (vechnayamolodost.ru)
According to an approximate estimate, the version of the human nuclear genome, which has been constantly replenished and improved since 2001, did not contain about 8% of the genomic DNA sequence. (vechnayamolodost.ru)
While we were doing this article for two years, some of these genes were gradually added to the reference sequence of the genome, which confirmed the validity of our approach. (vechnayamolodost.ru)
Since 2001, the composition of the genome has been updated several times, most recently in 2019?Yes, but there were still pieces of genomic DNA sequences that could not be "stuck" into the whole sequence, into the contig. (vechnayamolodost.ru)
The frequencies of CNVs in these populations were analyzed by oligonucleotide array comparative genome hybridization, quantitative PCR, PCR, DNA sequencing across breakpoints, and single-worm PCR. (biomedcentral.com)

When telomeres are not properly controlled, the resulting chromosomal alterations can induce genomic instability and ultimately the development of human diseases, such as cancer. (nih.gov)
Chromosomal instability. (lookformedical.com)
Nevertheless, although ring chromosome 22 has been described in over 50 cases, 13 it remains uncertain whether the variable phenotype is caused by the loss of a variable amount of chromosomal material or by a cellular mosaicism arising from instability of the ring. (bmj.com)

Confusingly, minisatellites are often referred to as VNTRs, and microsatellites are often referred to as short tandem repeats (STRs) or simple sequence repeats (SSRs). (wikipedia.org)
Short tandem repeats (STRs), or microsatellites, are 1-6 base pair (bp) motifs of repeating units of DNA. (biomedcentral.com)
Due to the repetitive structure of STRs and their high mutability, sequencing and genotyping these loci is difficult, especially using short-read sequencing data. (biomedcentral.com)
To date, the Philippine databases housed at the DNA Analysis Laboratory, Natural Sciences Research Institute, University of the Philippines, Diliman consist of autosomal STRs, X-STR, and Y-STR data as well as mitochondrial sequences. (edu.ph)
NGS can now be utilized to advance the generation of DNA profiles consisting of autosomal and gonosomal short tandem repeats (STRs) and mtDNA sequences. (edu.ph)
They are also known as short tandem repeats (STRs). (lookformedical.com)
Microsatellite markers (loci), also known as short tandem repeats (STRs), are polymorphic DNA loci consisting of a repeated nucleotide sequence. (macrogen-europe.com)

citation needed] Minisatellites also constitute the chromosomal telomeres, which protect the ends of a chromosome from deterioration or from fusion with neighbouring chromosomes. (wikipedia.org)
for example, human telomeres are 2-20 kb of (TTAGGG) n repeats. (rupress.org)
Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. (arigobio.com)
Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. (arigobio.com)
Centromeres and telomeres are important chromosomal domains required for the proper separation of genetic material during both mitosis and meiosis. (scitusacademics.com)

The products of CSR are a erased chromosomal locus and looped-out circular DNA. (roma2024.com)

SNP typing takes advantage of nucleotide changes in specific single-copy genes-i.e., gyrA, gyrB, groEL1, sodA, rpsA , and hsp65 -( 10 - 12 ) or chromosomal loci-i.e., 16S−23S rDNA internal transcribed spacer (ITS)-( 13 ) to use them as biomarkers for subspecies differentiation. (frontiersin.org)
The researchers analyzed 1,705 haplotypes based on 9 short tandem repeat (STR) loci on the Y-chromosome from 9 to 11 groups each of African-Americans, European-Americans, and Hispanics in the United States. (ojp.gov)
Dupuy, B. M., M. Stenersen, T. Egeland, and B. Olaisen, 2004 Y-chromosomal microsatellite mutation prices: differences in mutation rate in between and within loci. (caspase1inhibitor.com)

The karyotype demonstrated tumor cell patterns with aneuploidy and complex chromosomal aberrations. (biomedcentral.com)
Applications include: Loss of heterozygosity (LOH) in tumor samples - Copy number variation (CNV) - Aneuploidy assays - Large chromosomal deletion detection. (macrogen-europe.com)

Since mutations at splicing donor sites of the transcripts reduce CSR,21),22) not only transcription but also splicing of transcripts appears to be important, which gives rise to germline transcripts comprising the I and CH exon sequences. (roma2024.com)
The first tumours they sequenced had mutational phenotypes that went against a gradual model of tumour evolution, no mutations on some chromosomes but massively instable (chromothriptic) chromosome 15. (blogspot.com)
Frameshifting events happening in short operates of pyrimidines (primarily C residues) in the repeats bring about mutations which might provide a system for escape of the LF3 function from sponsor surveillance. (molecularcircuit.com)
non-etheless like chromosomal recurring elements generally (21) by providing the chance of template-primer misalignments or era of template hairpin buildings during replication the viral repeats offer possibilities for replication infidelity or transcriptional variant and mutations. (molecularcircuit.com)

Minisatellites and their shorter cousins, the microsatellites, together are classified as VNTR (variable number of tandem repeats) DNA. (wikipedia.org)
Several molecular typing methods have been developed to differentiate between M. avium subspecies and strains, such as single nucleotide polymorphism (SNP) typing and mini-satellite sequence analysis-mycobacterial interspersed repetitive-unit variable-number tandem repeats (MIRU-VNTR) ( 5 ). (frontiersin.org)
Non-homologous recombination NAHR, Mobile element insertion (MEI), variable number of simple tandem repeats (VNTR) non-homologous rearrangement. (blogspot.com)
The variable number of tandem repeats (VNTR) typing method was employed, as previously described, to further investigate these strains ( 11 ). (cdc.gov)

Considerable analyses of switch recombination junctions have exposed no consensus sequences in the proximity of the HMN-176 breakpoints nor homologous sequences between two recombined parental sequences.23),53),54) These HMN-176 results indicate that CSR is a unique type of recombination that does not belong to either homologous or site-specific recombination but belongs HMN-176 rather to region-specific recombination. (roma2024.com)
Its sequence, when compared to those of members of the human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. (shengsci.com)
Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor. (shengsci.com)

have analyzed the tef-1α sequences of F. equiseti , as well as the toxin-related genes PKS13 , PKS4, and TRI5 [26], and Kari has successfully cloned a protease gene [27]. (researchsquare.com)
While whole gene duplications and deletions are relatively well-studied, the biology of subexonic ( i.e. , within coding exon sequences), copy number variation remains elusive. (nature.com)
The salivary MUC7 gene provides an opportunity for studying such variation, as it harbors copy number variable subexonic repeat sequences that encode for densely O-glycosylated domains (PTS-repeats) with microbe-binding properties. (nature.com)
Here, we focus on the salivary mucin-7 gene ( MUC7 ) to study the evolution and functional impact of subexonic repeats. (nature.com)
These repeats can be particularly well studied in this gene because the repeats are relatively short and few in number compared to other mucins. (nature.com)
Restriction site mapping and DMA sequencing of clone XbHW61 allowed the location polarity, and identity of an H3, H4, and an HI gene to be determined. (bl.uk)
Extensive DNA sequence comparisons between various Xenopus histone gene clusters were undertaken. (bl.uk)
The picture of histone gene cluster structure in X. borealis that emerges from these studies, is compared at the nucleotide, gene, and chromosomal levels with X. laevis. (bl.uk)
This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. (arigobio.com)
A protein consists of one or more chains of amino acids (called polypeptides) whose sequence is encoded in a gene. (genome.gov)
A test target is what the test interrogates ( e. g. the analyte, chromosomal region/mitochondrion, gene or protein). (nih.gov)
The mouse biliary glycoprotein gene (Bgp): partial nucleotide sequence, expression, and chromosomal assignment. (shengsci.com)
The locus control region (LCR) of mammalian beta-globin genes covers at least 17 kb at the 5' end of the gene cluster and has been implicated in chromatin domain opening, enhancement, and insulation from neighboring sequences. (shengsci.com)
The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. (shengsci.com)
Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. (shengsci.com)
Is it possible to move the goal-posts and say that a clinical "test" no longer revolves around the actual sequencing of a cancer gene, as in the case of BRCA1/2 screening, but is now more about the algorithm used to ask specific questions of what could be a lifetime stored data set? (blogspot.com)
Sequence analysis showed that these "young" Alu insertions represented gene conversion events of pre-existing ancient Alu elements or independent parallel insertions of older Alu elements in the same genomic region. (ojp.gov)

The length of telomeric repeats is dynamically regulated and can be affected by changes in the telomere chromatin structure. (nih.gov)
Unique sequence DNA for each telomere is located 100-300 kilobases (kb) from the end of most chromosomes. (ox.ac.uk)
Previously it was thought that DNA replication began at an origin in chromosomal DNA adjacent to the telomere repeats, with the replication forks moving bidirectionally away from the subtelomeric origin ( Fig. 1 A ), thus replicating the telomere. (rupress.org)

The complete sequences of the galago and rabbit beta-globin locus control regions: extended sequence and functional conservation outside the cores of DNase hypersensitive sites. (shengsci.com)
It is interesting that such an essential and functionally conserved chromosomal locus has so rapidly evolved with regards to its structure, extension and DNA sequence composition. (scitusacademics.com)

All colonies, regardless of the nucleotide sequence of rpsA , were found to be sensitive to all of the drugs tested except for ethambutol. (frontiersin.org)

Microsatellites were observed only in euchromatin regions, whereas the (TTAGG) 6 repeats were found at telomeric sites in both groups. (karger.com)
Human chromosomes terminate with specialized telomeric structures including the simple tandem repeat (TTAGGG)n and additional complex subtelomeric repeats. (ox.ac.uk)

The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. (lookformedical.com)
The cell line was established and authenticated by assessing DNA microsatellite short tandem repeats. (cancer-genetics.org)

While other genomes (mouse, rat and pig) contain minisatellite-like sequences, none was found to be hypermutable. (wikipedia.org)
In order to better understand the genomic forces driving the evolution of Echinochloa species toward weed and crop characteristics, we assemble genomes of three Echinochloa species (allohexaploid E. crus-galli and E. colona , and allotetraploid E. oryzicola ) and re-sequence 737 accessions of barnyard grasses and millets from 16 rice-producing countries. (nature.com)
To further investigate the genomic diversity among this group and to help characterize lineages of the plague organism that have no sequenced members, we present here the genomes of two isolates of the "classical" antiqua biovar, strains Antiqua and Nepal516. (asm.org)
We compare all five currently sequenced Y. pestis genomes and the corresponding features in Yersinia pseudotuberculosis . (asm.org)
Cytogenetic analysis uncovered a wide spectrum of genotype- and cell-specific chromosomal rearrangements, suggesting intensive repatterning of both parental and hybrid genomes. (haifa.ac.il)
Centromeric DNA is composed of tandem repeats and/or transposable elements that have evolved fast and are therefore highly variable even among closely related species.Centromeric DNAs are one of the fastest evolving sequences in eukaryotic genomes. (scitusacademics.com)
Their proteins items however have got different sequences and antibodies to 1 usually do not cross-react using the various other (28 29 Although EBV IRs resemble in proportions the brief interspersed elements within eukaryotic genomes whereas brief interspersed elements are usually noncoding and will become retrotransposons there is absolutely no proof for retrotransposition from the EBV tandem repeats. (molecularcircuit.com)

The aim of this research study is to generate a frequency database of autosomal (aSTR), gonosomal STR makers, mitochondrial DNA (mtDNA) sequences and single nucleotide polymorphisms (SNPs) of representative Filipino populations utilizing DNA fragment analysis, capillary sequencing and next generation sequencing (NGS). (edu.ph)

We conclude that they have in a convergent manner accumulated similar patterns of tandem inversions and dense repeat clusters, presumably in response to similar needs to create linkage between genes causing drive and resistance. (nih.gov)
The repeats themselves are of various sizes ranging from about 100 to >3 0 bp but all reside within genes. (molecularcircuit.com)

The overall goal of this project is to generate frequency and sequence databases of autosomal, X- and Y- chromosomal Short Tandem Repeat (STR) markers, mitochondrial DNA sequences, and Single Nucleotide Polymorphism (SNPs) of representative Filipino populations utilizing DNA fragment analysis, capillary sequencing and next generation sequencing (NGS, also known as massively parallel sequencing). (edu.ph)

In chromosomal semiconservative replication, the short 5′ RNA primer is removed from the nascent strand and the gap is filled in by DNA that is ligated to the adjacent nascent DNA. (rupress.org)
A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
Sequence research web page link these frameshifts to PF-3644022 DNA replication mistakes. (molecularcircuit.com)
Nevertheless sequence alterations can and do occur because of RNA/DNA polymerase slippages during replication or transcription. (molecularcircuit.com)

Minisatellite variant repeat mapping by PCR (MVR-PCR) has been extensively used to chart the interspersion patterns of variant repeats along the array, which provides details on the structure of the alleles before and after mutation. (wikipedia.org)
Repeat turnover therefore appears to be controlled by recombinational activity in DNA that flanks the repeat array and results in a polarity of mutation. (wikipedia.org)

Single-nucleotide polymorphism (SNP) haplotype map showing position of methicillin-resistant Staphylococcus aureus sequence type 239-III (MRSA ST239-III) isolates, Ohio, USA, 2007-2009, within the global population structure of the MRSA ST239-III clonal group. (cdc.gov)
Wholegenome sequencing of deficient isolates revealed putative, underlying genetic changes. (nabsys.com)
Chromosomal DNA was extracted from the isolates with chloroform-isoamyl alcohol, and RFLP was performed according to international standards ( 7 ). (cdc.gov)

Several transcription regulatory sequences were identified in the promoter region. (elsevierpure.com)
Gemayel, R., M. D. Vinces, M. Legendre, and K. J. Verstrepen, 2010 Variable tandem repeats accelerate evolution of coding and regulatory sequences. (caspase1inhibitor.com)

DNA Short Tandem Repeats profiling was implemented for cell authorization. (biomedcentral.com)
They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. (lookformedical.com)
We demonstrate that the benchmark set reliably identifies false negatives and false positives in high-quality SV callsets from short-, linked- and long-read sequencing and optical mapping. (nabsys.com)
Garrison, E., and G. Marth, 2012 Haplotype-based variant detection from short-read sequencing. (caspase1inhibitor.com)
When we use modern sequencing methods to read short sequences (short reading), such sections are very difficult to orient. (vechnayamolodost.ru)

citation needed] It has been proposed that minisatellite sequences encourage chromosomes to swap DNA. (wikipedia.org)
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. (lookformedical.com)
The terminal regions of human chromosomes are known to contain specialised DNA sequences and may be vulnerable to rearrangements causing human genetic diseases and particularly idiopathic mental impairment. (bmj.com)
Centromeres in all chromosomes were considered homogeneous, consisting of identical repeats. (vechnayamolodost.ru)

However, there is no study to our knowledge that specifically investigated the evolution of copy number variable subexonic repeats from their initial emergence as functional units to the adaptive constraints and mutational properties that contributed to their extant variation in primates. (nature.com)

On a broader scale, our study highlights variable subexonic repeats as a primary source for modular evolutionary innovation that lead to rapid functional adaptation. (nature.com)
First, MUC7 carries subexonic repeats that are 69 bp (23 amino acids) long and are copy number variable in humans 5 . (nature.com)
The use of spoligotyping was based on the presence or absence of 43 variable spacers in the direct repeat (DR) region of M. tuberculosis . (cdc.gov)

In alternative models, it is the presence of neighbouring double-strand hotspots which is the primary cause of minisatellite repeat copy number variations. (wikipedia.org)
The use of variations in DNA fragment length as well as in actual DNA sequences significantly enhances the capacity of genetic tests to discriminate between two human persons and evaluate potential relationships. (edu.ph)
In the present study we used DYZ1, a satellite fraction present in the form of tandem arrays on the long arm of the human Y chromosome, as a tool to uncover sequence variations between the monozygotic males. (biomedcentral.com)
A Single Nucleotide Polymorphism (SNP) marker consists of a single base pair that varies in the known DNA sequence, creating up to four alleles or variations of the marker. (macrogen-europe.com)
The capability to effectively treat sufferers is rooted inside our mechanistic knowledge of genomic variations discovered via sequencing. (ipa2014.org)

The final benchmark set contains 12,745 isolated, sequence-resolved insertion (7,281) and deletion (5,464) calls ≥50 base pairs (bp). (nabsys.com)

In this study, the complete genomic sequence of Fusarium equiseti D25-1 was determined using multiple sequencing platforms. (researchsquare.com)
In this report, we present a corrected genomic sequence, genomic structure, and refined chromosomal location for KiSS-1. (shengsci.com)

Interestingly, my very first scientific work, my thesis, was devoted to cloning and sequencing the first fragment of a chromosome containing these alpha-like repeats of DNA centromeres. (vechnayamolodost.ru)

domesticus stDNA) with some endonucleases of which restriction sequences are present in the 230-240 bp repetitive unit of theM. (unipv.it)

Furthermore, insertion sequence disruption of fhaB was also detected in a previously identified pertussis toxin-deficient isolate that still produced normal levels of Fha. (nabsys.com)
The study identified just over 140 new L1 insertion polymorphisms and determined the chromosomal location and phylogenetic distribution of each L1 element. (ojp.gov)

A minisatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from 10-60 base pairs) are typically repeated two to several hundred times. (wikipedia.org)
The importance of structural variation in human disease and the difficulty of detecting structural variants larger than 50 base pairs has led to the development of several long-read sequencing technologies and optical mapping platforms. (nabsys.com)
As of 2003, 99% of the chemical base pairs that make up human DNA had been sequenced to within 99.99% accuracy. (medscape.com)

An anticodon is a trinucleotide sequence located at one end of a transfer RNA (tRNA) molecule, which is complementary to a corresponding codon in a messenger RNA (mRNA) sequence. (genome.gov)
In the RNA pathogen field items have been noticed with genetic modifications linked either with RNA polymerase slippages at PF-3644022 tandem repetitive sequences or mRNA editing and enhancing that creates frameshifts within an individual open reading body. (molecularcircuit.com)

A codon is a DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genetic information encoding a particular amino acid. (genome.gov)

We detected copy number variation, frequent insertions and deletions within the sequences of DYZ1 arrays amongst all the three sets of twins used in the present study. (biomedcentral.com)
DYZ1 showed both sequence and copy number variation between the MZT males. (biomedcentral.com)

To better understand the karyotype organization in Melipona and the relationship among the subgenera, we mapped repetitive sequences and analyzed previously reported cytogenetic data with the aim to identify cytogenetic markers to be used for investigating the phylogenetic relationships and chromosome evolution in the genus. (karger.com)
Phylogenetic analysis shows that, even though Sk-2 and Sk-3 are located in the same chromosomal region, they do not form sister clades, suggesting independent origins or at least a long evolutionary separation. (nih.gov)

Advances in DNA sequencing chemistries and technologies are currently being applied in large volume sequencing in molecular anthropology, medical genetics, and evolutionary biology. (edu.ph)
Advances in the understanding of may be more susceptible at a par- sembled for IARC Group 1 carcino- host susceptibility in tandem with the ticular site (i.e. the mammary gland gens contains information on mecha- evolution of the knowledge on the in females). (who.int)

We identified in-frame recently, tandem duplication of exons 18 - 25, which in turn causes EGFR Kinase Domains Duplication (EGFR-KDD). (ipa2014.org)
which has a tandem PM 102 in-frame duplication of exons 18C25 within an index individual with metastatic lung adenocarcinoma. (ipa2014.org)

These variant repeats are tandemly intermingled. (wikipedia.org)

Some minisatellites contain a central sequence (or "core unit") of nucleobases "GGGCAGGANG" (where N can be any base) or more generally consist of sequence motifs of purines (adenine (A) and guanine (G)) and pyrimidines (cytosine (C) and thymine (T)).[citation needed] Hypervariable minisatellites have core units 9-64 bp long and are found mainly at the centromeric regions. (wikipedia.org)
After Alu I digestion, the DNA was transferred to a nylon membrane for polymorphic guanine cytosine-rich repetitive sequence (PGRS) Southern blotting. (cdc.gov)

To help translate these methods to routine research and clinical practice, we developed a sequence-resolved benchmark set for identification of both false-negative and false-positive germline large insertions and deletions. (nabsys.com)
Sequence variation was also noticed between germline and blood DNA samples of the same individual as we observed at least in one set of sample. (biomedcentral.com)

NGS is unique in that it can provide both fragment length measurements and actual DNA sequences in a single analysis. (edu.ph)

They are composed of tandem arrays of repeated DNA sequences with a specific heterochromatic organization. (nih.gov)
Additional analyses of DNA sequences flanking human minisatellites have also revealed an intense and highly localized meiotic crossover hotspot that is centered upstream of the unstable side of minisatellite arrays. (wikipedia.org)

Since all hypermutable minisatellites contain internal variants, they provide extremely informative systems for analyzing the complex turnover processes that occur at this class of tandem repeat. (wikipedia.org)

Databases resulting from next generation sequencing will maximize the benefits of NGS in obtaining more genetic information from a very small amount of sample. (edu.ph)

The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. (shengsci.com)

Upon validation of the database for forensic applications, the database will be available to the scientific community and forensic DNA laboratories for statistical evaluation of matching DNA evidence using aSTR and gonosomal STR profiles, mtDNA sequences and SNP frequencies in forensic casework. (edu.ph)

Cosgrove SE , Sakoulas G , Perencevich EN , Schwaber MJ , Karchmer AW , Carmeli Y . Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. (cdc.gov)
In fact, several submicroscopic chromosomal abnormalities in patients with undiagnosed mental retardation or multiple congenital anomalies have been identified by other molecular methods such as DNA polymorphism analysis. (ox.ac.uk)
PCR (polymerase chain reaction) technique has achieved increased importance for post-mortem DNA analysis in forensic cases 8 because of the millions of copies amplified from one specific sequence of DNA. (bvsalud.org)

MUC7 provides an opportunity to assess the broader implications of subexonic repeat variation within the context of the functional evolution of the mucin functional group and primate salivary adaptation. (nature.com)

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes11

Information Science3

Genome25

Instability3

STRs7

Telomeres5

Erased chromosomal locus1

Loci3

Aneuploidy2

Mutations4

VNTR4

Homologous3

Gene17

Telomere3

Locus2

Nucleotide sequence1

Telomeric2

Microsatellite2

Genomes7

Single nucleotide po1

Genes2

Mitochondrial1

Replication4

Mutation2

Isolates3

Regulatory sequences2

Short5

Chromosomes4

Mutational1

Variable3

Variations5

DELETION1

Genomic sequence2

Centromeres1

Repetitive-unit1

Insertion2

Base pairs3

MRNA2

Nucleotides1

Copy number va2

Phylogenetic2

Advances2

Exons2

Tandemly1

Guanine2

Germline2

Fragment1

Arrays2

Variants1

Genetic1

Proteins1

Frequencies1

Analysis3

Functional1