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  • mRNA
  • This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. (cancerindex.org)
  • The protein appears to have important roles in neuronal development and mRNA transport. (wikipedia.org)
  • Let-7 inhibits production of specific proteins by complementary binding to their mRNA transcripts. (wikipedia.org)
  • Many of these cancers express the normal HMGA2 protein, but the mature mRNA transcript is truncated, missing a portion of the 3'UTR that contains the critical let-7 complementary regions. (wikipedia.org)
  • chromosome
  • This article on a gene on the human X chromosome and/or its associated protein is a stub . (wikipedia.org)
  • Here, we show that increased levels of heterochromatin in 3D cell cultures characterized by histone H3 deacetylation and induced heterochromatin protein 1alpha expression result in increased radiation survival and reduced numbers of DNA double strand breaks (DSB) and lethal chromosome aberrations. (biomedsearch.com)
  • vitro
  • In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. (wikipedia.org)
  • sequences
  • Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo. (naver.com)
  • Apart from their apparent molecular weights, all these proteins share many common structural features, as can be expected from their similar amino acid compositions and sequences. (springer.com)
  • The degradation process yields peptides of about seven to eight amino acids long, which can then be further degraded into shorter amino acid sequences and used in synthesizing new proteins. (wikipedia.org)
  • Homologous proteins with highly conserved sequences are found in other mammalian species, including lab mice (Mus musculus). (wikipedia.org)
  • Molecular
  • Publications] Mori K., 他: 'Molecular cloning of a novel mouse aspartic protease-like protein that is expressed abundantly in the kidney. (nii.ac.jp)
  • In the case of the latter, low molecular weight HMG proteins, there is considerable literature on their possible function, although firm conclusions are not yet available (see chapter by Goodwin et al. (springer.com)
  • The low molecular weight HMG proteins do not display any evidence of secondary or tertiary folding. (springer.com)
  • Preferential affinity of high molecular weight high mobility group non-histone chromatin proteins for single-stranded DNA. (springer.com)
  • The proteasome subcomponents are often referred to by their Svedberg sedimentation coefficient (denoted S). The proteasome most exclusively used in mammals is the cytosolic 26S proteasome, which is about 2000 kilodaltons (kDa) in molecular mass containing one 20S protein subunit and two 19S regulatory cap subunits. (wikipedia.org)
  • HMGN
  • The nuclei of most vertebrate cells contain members of the high mobility group N (HMGN) protein family, which bind specifically to nucleosome core particles and affect chromatin structure and function, including transcription. (nih.gov)
  • Here, we study the biological role of this protein family by systematic analysis of phenotypes and tissue transcription profiles in mice lacking functional HMGN variants. (nih.gov)
  • Diagrams detailing structural domains of HMGN proteins and the mutations in them used in this study are shown. (nih.gov)
  • identification
  • section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein. (uniprot.org)
  • Later work on modification of histones led to the identification of an unexpected covalent modification of the histone protein by a bond between a lysine side chain of the histone and the C-terminal glycine residue of ubiquitin, a protein that had no known function. (wikipedia.org)
  • mutations
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Small-scale mutations include point mutations, deletions, and insertions, which may occur in the promoter of a gene and affect its expression, or may occur in the gene's coding sequence and alter the function or stability of its protein product. (wikipedia.org)
  • high mobil
  • High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. (nih.gov)
  • High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene . (wikipedia.org)
  • These are the proteins of the high mobility group that have the lowest electrophoretic mobility in both SDS and acid/urea gels and they have therefore been called HMG-1 or 2 in most tissues. (springer.com)
  • Post-synthetic modification of high mobility group proteins. (springer.com)
  • High mobility group proteins are methylated. (springer.com)
  • Adenosine diphosphate ribosylation of chicken erythrocyte histones H1, H5, and high mobility group proteins by purified calf thymus poly(adenosinediphosphateribose) polymerase. (springer.com)
  • Carbo- hydrate modifications of the high mobility group proteins. (springer.com)
  • High-mobility group nucleosome-binding protein 1 is a novel clinical biomarker in non-small cell lung cancer. (nih.gov)
  • HMGN2 (High Mobility Group Nucleosomal Binding Domain 2) is a Protein Coding gene. (genecards.org)
  • High mobility group box 1 protein, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene. (wikipedia.org)
  • HMGB1 was first identified as the founding member of a family of DNA-binding proteins, termed high mobility group box (HMGB) proteins, which are critical for DNA structure and stability. (google.ca)
  • 1991). "Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. (wikipedia.org)
  • family of proteins
  • In this respect, the situation of our knowledge on the HMG-1 family of proteins is very different than that for HMG-14 and 17. (springer.com)
  • Their ubiquitous distribution and relative abundance, as well as the high evolutionary conservation of the DNA-binding domain of the HMG14 family of proteins, suggest that they may be involved in an important cellular function. (wikipedia.org)
  • expression
  • Publications] Mori K., 他: 'Kidney-specific expression of a novel mouse organic cation trasporter-like protein. (nii.ac.jp)
  • Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. (cancerindex.org)
  • Reduction or absence of let-7a miRNA allows high expression of the HMGA2 protein. (wikipedia.org)
  • ERCC1 protein expression is reduced or absent in 84% to 100% of human colorectal cancers. (wikipedia.org)
  • ERCC1 protein expression was also reduced in a diet-related mouse model of colon cancer. (wikipedia.org)
  • homologous
  • For historical reasons, homologous proteins from trout testis and chicken erythrocytes are called HMG-T and HMG-E, respectively. (springer.com)
  • human
  • ERP was first cloned as a transforming growth factor (TGF) beta1-inducible protein encoded by the TSC36 gene from a mouse osteoblastic cell line, and later human and rat homologues were cloned from glioma cell lines and named due to their similarity at the amino acid sequence level to follistatin (an inhibitor of activin), termed an FS module. (nii.ac.jp)
  • Human spleen histone H1. (wikipedia.org)
  • Human testis/sperm-specific histone H2B (hTSH2B). (wikipedia.org)
  • nucleus
  • When the protein is not acetylated, it stays in the nucleus, but hyperacetylation on lysine residues causes it to translocate into the cytosol. (wikipedia.org)
  • The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. (wikipedia.org)
  • Apart from its roles in the nucleus, histone H1.2 also participates in apoptosis. (wikipedia.org)
  • Translocation
  • The chimeric gene of AML1-MDS1-EVI1 (AME) formed by the chromosomal translocation (3;21)(q26;q22) has also been shown in vitro to upregulate the cell cycle and block granulocytic differentiation of murine hematopoietic cells, as well as to delay the myeloid differentiation of bone marrow progenitors. (wikipedia.org)
  • nucleic acids
  • The biophysicists participating in QBM (Braun, Jungmann, Rädler, Schwille) bring a wealth of advanced expertise and novel methodologies, permitting the high-resolution quantitative and dynamic analysis of regulatory processes, including protein folding/conformation and the interaction of proteins with small molecules, nucleic acids, or other proteins in different settings (single molecule, purified/crude extracts). (lmu.de)
  • It deals with the structure and function of cellular components such as proteins, carbohydrates, lipids, nucleic acids and other biomolecules. (wikipedia.org)
  • Apoptosis
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • In one such pathway, caspase-independent apoptosis, the E3 ligase C-terminal of Hsc-70 interacting protein (CHIP), a regulator of EndoG expression, functions as a protective mechanism against oxidative stress. (wikipedia.org)
  • TGF-β, along with other TGF-β family ligands such as bone morphogenic protein (BMP) and activin are involved in regulating important cellular functions such as proliferation, differentiation, apoptosis, and matrix production. (wikipedia.org)
  • replication
  • This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. (wikipedia.org)
  • DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. (wikipedia.org)
  • MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. (wikipedia.org)
  • The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. (wikipedia.org)
  • Human
  • Rabbit anti Human histone H2BJ antibody detects a band of 17 kDa. (bio-rad-antibodies.com)
  • NFIX protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)
  • Human spleen histone H1. (wikipedia.org)
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • cellular
  • However, the mechanisms linking protein aggregation to cellular toxicity and death remain poorly understood. (lmu.de)
  • amino
  • The DHRS7B gene has a predicted protein product that is 325 amino acids, a molecular weight of 35.1 kDa, and an isoelectric point of 9.867. (wikipedia.org)
  • regulatory
  • MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. (wikipedia.org)
  • MCM6 contains two of the regulatory regions for LCT, the gene encoding the protein lactase, located in two of the MCM6 introns, approximately 14 kb (-13910) and 22 kb (-22018) upstream of LCT. (wikipedia.org)
  • Structural
  • In genetics a gene is a fundamental unit of hereditary, in biochemical or structural terms it is a sequence of DNA which can manufacture a single protein or RNA sequence. (wikibooks.org)
  • endonuclease
  • The caspase-3 His-237 stabilizes the target Aspartate causing the break of the association of ICAD and CAD leaving the endonuclease CAD active allowing it to degrade chromosomal DNA. (wikipedia.org)
  • cells
  • To address this question, we study the detailed architecture of protein aggregates inside cells using advanced cryo electron microscopy techniques. (lmu.de)
  • In this study, we investigated PTTG1 gene and protein expression in MM plasma cells from newly diagnosed MM patients. (biomedcentral.com)