• Even a single heterozygous chromosomal rearrangement, such as a reciprocal translocation or chromosomal fusion, is expected to result in 50% reduction of fertility ( King, 1993 ). (frontiersin.org)
  • Balanced translocation abnormalities lead to the generation of fusion oncogenes such as Bcr-Abl in chronic myelogenous leukemia (CML) and PML-Rar alpha in acute promyelocytic leukemia (APL). (medscape.com)
  • The translocation does not result in a fusion gene. (atlasgeneticsoncology.org)
  • Many, but not all, African gazelles possess a characteristic chromosomal translocation (fusion) of an autosome with the X chromosome. (ivis.org)
  • Synovial sarcoma is characterized by a specific chromosomal translocation, t(X;18)(p11;q11). (medscape.com)
  • This specific chromosomal translocation between chromosome X and chromosome 18 has been noted in more than 90% of cases. (medscape.com)
  • Diagnosis relies on identification of chromosomal translocation. (standardofcare.com)
  • These tumors have a similar cellular physiology, as well as a shared chromosomal translocation. (medscape.com)
  • A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. (enzolifesciences.com)
  • The process begins when the CIITA gene breaks off and fuses with another gene (a process called chromosomal translocation). (bccancerfoundation.com)
  • These drugs are associated with a high prevalence of chromosomal abnormalities in bone marrow-in particular, the -5, del(5q), -7, del(q) and complex karyotype. (medscape.com)
  • ETV6 is known to be involved in a large number of chromosomal abnormalities associated with leukemia and inborn fibrosarcoma. (atlasgeneticsoncology.org)
  • These abnormalities underlie the signs and symptoms of Saethre-Chotzen syndrome, including the premature fusion of certain skull bones. (medlineplus.gov)
  • They underlie genetic disease in roughly 15% of patients with multiple congenital abnormalities and/or mental retardation (MCA/MR). In genetic diagnostics, the pathogenicity of chromosomal aberrations in these patients is typically assessed based on criteria such as phenotypic similarity to other patients with the same or overlapping aberration, absence in healthy individuals, de novo occurrence, and protein coding gene content. (biomedcentral.com)
  • Mosaic) aneuploidies and chromosomal rearrangements are a frequent cause of idiopathic MCA/MR. Starting in 1959 with the identification of trisomy-21 as the genetic basis of Down syndrome [ 10 ], microscopic observation of metaphase chromosomes has for several decades been the method of choice for detecting chromosome abnormalities in MCA/MR patients. (biomedcentral.com)
  • In consecutive, unselected MCA/MR patients karyotyping enables the detection of pathogenic chromosomal abnormalities in about 4% of cases (excluding Down syndrome), despite its limited resolution to about 5-10 Mb. (biomedcentral.com)
  • The continuously updated material also makes it possible to address scientific questions related to the mechanisms through which chromosomal/genomic changes participate in the carcinogenic process by elucidating why, how and when chromosome abnormalities are formed, the chromosomal anatomy of cytogenetic changes and genes involved in fusions, the role chromosome aberrations play in the formation of fusion genes, and the mechanisms by which gene fusions exert their effects. (lu.se)
  • Mitelman F. Cancer: Chromosomal Abnormalities. (lu.se)
  • The chromosomal abnormalities commonly involve the MLL gene (11q23). (medscape.com)
  • RAS and MYC), whereas limited knowledge is available about the molecular genetic correlates of the unbalanced chromosomal abnormalities. (lu.se)
  • Human chromosome 2 appears to have resulted from the fusion of two ancestral chromosomes, and many of the genes of those two original chromosomes have been translocated to other chromosomes. (wikipedia.org)
  • 120 different translocations, resulting in the generation of MLL-fusion proteins encompassing more than 75 different partner genes 5 . (nature.com)
  • As the SEC can regulate the transcriptional activity of RNA polymerase II, it was hypothesized that these MLL-fusions induce aberrant regulation of transcriptional elongation on MLL-target genes 14 . (nature.com)
  • Thus, a precise characterization of KMT2A-r and the fusion partner genes, especially in CKs, is of interest for managing AML. (cancerindex.org)
  • The fusion proteins SYT-SSX1 and SYT-SSX2 are believed to function as aberrant transcriptional regulators, resulting in either activation of proto-oncogenes or inhibition of tumor suppressor genes. (medscape.com)
  • 1 ] The development of DFSP was associated with chromosome 17 and 22 translocations,[ 2 ] which resulted in the fusion of collagen type 1-α1 (COL1A1 at 17q22) and platelet-derived growth factor-β (PDGFB at 22q13) genes. (thieme-connect.de)
  • The applications of this technology are quite varied, from assembling chromosome-scale genomes, linking non-coding disease-associated risk variants to target genes, understanding the mechanisms of gene regulation in a wide variety of diseases, and detecting gene fusions in tumor samples that were missed by other technologies, to name a few. (arimagenomics.com)
  • A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. (proteopedia.org)
  • These rearrangements result in the fusion of two genes that are normally located on separate chromosomes. (pcf.org)
  • Dr. Tomlins proposes to work on developing tests for the early diagnosis of prostate cancer using these gene fusions as well as characterizing additional dysregulated genes in prostate cancer. (pcf.org)
  • Histologic and Genetic Features of 51 Melanocytic Neoplasms With Protein Kinase C Fusion Genes. (nih.gov)
  • In other cases, genes that aren't usually close to each other on the chromosome can suddenly be stitched together to produce a new oncogenic fusion protein. (worldpharmanews.com)
  • Chromosome aberrations can affect one or more genes in a complex manner, such as by changing the regulation of gene expression, by disrupting exons, and by creating fusion genes. (biomedcentral.com)
  • Chromosomal translocations creating fusion genes are common cancer drivers. (bvsalud.org)
  • Balanced secondary changes are rare in CML AP/BC, but it is not known whether cryptic chromosomal translocations, generating fusion genes, may be responsible for disease progression in a subgroup of CML. (lu.se)
  • CML is triggered by a chromosomal abnormality (an error during cell growth) in which the ABL gene is mistakenly joined to the BCR gene, forming a mutated BCR-ABL "fusion gene. (cancercare.org)
  • This chromosomal abnormality is called the Philadelphia (Ph) chromosome. (cancercare.org)
  • Families of related leukemia fusion proteins that share genomic and biological properties represent unique opportunities to study how the combination of distinct functional protein modules can drive oncogenic transformation. (nature.com)
  • The database represents a unique international resource that enables clinicians to quickly find relevant information on cytogenetic aberrations and gene fusions in cancer and relate the findings to clinical data, in particular the diagnostic and prognostic significance of specific cytogenetic/genomic changes. (lu.se)
  • such as to study chromosomal aberrations, cellular function, taxonomic relationships, medicine and to gather information about past evolutionary events (karyosystematics). (wikipedia.org)
  • In spite of the clear association between large ( de novo ) CNVs and other SVs (collectively known as chromosomal aberrations) with MCA/MR phenotypes [ 9 ], precise characterization of molecular mechanisms that cause disease in individual patients is often unknown. (biomedcentral.com)
  • In the following sections we first provide an overview of current methods for diagnostic detection and interpretation of chromosomal aberrations in MCA/MR patients. (biomedcentral.com)
  • Subsequently, the introduction and relevance of new methods for high-resolution dissection of breakpoints of chromosomal aberrations is discussed. (biomedcentral.com)
  • The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene fusions identified by cytogenetics or massively parallel sequencing, and studies pertaining to the clinical relevance of cytogenetic aberrations and/or gene rearrangements. (lu.se)
  • It has therefore been proposed that the oncogenic activity of MLL-fusion proteins depends on chromatin targeting functions exerted by the MLL N-terminus in combination with other functional properties encoded by the fusion partners 6 . (nature.com)
  • Numerous studies have established strong links between the molecular function of the fusion partner and the mechanistic basis of oncogenic transformation in MLL-fusion-induced leukemogenesis 4 . (nature.com)
  • Purpose: Gene fusions are important oncogenic drivers and many are actionable. (researchgate.net)
  • The oncogenic ETV6-NTRK3 (EN) gene fusion joins the sterile alpha domain of the ETV6 transcription factor with the tyrosine kinase domain of the neurotrophin-3 receptor NTRK3. (bvsalud.org)
  • We identify in total 237 high-confidence interactors, which link EN fusions to several key signaling pathways, including ERBB, insulin and JAK/STAT. We then assessed the effects of EN variants on these pathways, and showed that the pan NTRK inhibitor Selitrectinib (LOXO-195) inhibits the oncogenic activity of EN2, the most common variant. (bvsalud.org)
  • A correlation appears to exist between the histologic subtype of the tumor and either of these two fusion proteins. (medscape.com)
  • A round cell sarcoma marked by a gene fusion involving members of the FET family and a member of the Ewings tumor sarcoma family of transcription factors. (standardofcare.com)
  • These differences could have resulted from successive unequal translocations which removed all the essential genetic material from a chromosome, permitting its loss without penalty to the organism (the dislocation hypothesis) or through fusion. (wikipedia.org)
  • Here, we studied male meiotic chromosome behavior in four hybrid generations (F1-F4) between two chromosomal races of the Wood White butterfly Leptidea sinapis differentiated by at least 24 chromosomal fusions/fissions. (frontiersin.org)
  • We argue that the observed process of chromosome sorting would, if continued, result in a new homozygous chromosomal race, i.e., in a new karyotype with intermediate chromosome number and, possibly, in a new incipient homoploid hybrid species. (frontiersin.org)
  • These terms correspond to a fusion of the SYT gene (chromosome 18) with the SSX gene (chromosome X). (medscape.com)
  • Heterozygotes for major chromosomal rearrangements such as fusions and fissions are expected to display a high level of sterility due to problems during meiosis. (frontiersin.org)
  • However, some species, especially plants and animals with holocentric chromosomes, are known to tolerate chromosomal heterozygosity even for multiple rearrangements. (frontiersin.org)
  • The importance of chromosomal rearrangements for speciation can be inferred from studies of genetic exchange between hybridising chromosomal races within species. (conicet.gov.ar)
  • Importantly, we found that centromeric regions of some non-rearranged chromosomes also showed genetic differentiation between the hybridising groups, indicating a complex interplay between chromosomal rearrangements and other parts of the genome in maintaining or promoting differentiation and potentially driving speciation between chromosomal races. (conicet.gov.ar)
  • Specific chromosomal rearrangements in more than half of prostate cancers, using a novel analysis of DNA microarray data, were identified in 2005. (pcf.org)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • We are studying the effects and consequences of protein fusion on the transcriptional and transforming activities of these proteins using in vitro and animal models. (stanford.edu)
  • We describe the clinical and molecular features of a child who presented with a large abdominal mass, AML, and a new CK, involving chromosomes 11, 16, and 19 leading to a KMT2A-MLLT1 fusion and 2 extra copies of the ELL gene, thus resulting in the concurrent overexpression of MLLT1 and ELL. (cancerindex.org)
  • This fusion gene is called, in genetic terms, the SYT-SSX1 , SYT-SSX2 , or SYT-SSX4 . (medscape.com)
  • The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
  • The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
  • Saethre-Chotzen syndrome is a genetic condition characterized by the premature fusion of certain skull bones (craniosynostosis). (medlineplus.gov)
  • We studied genetic exchange between two hybridising groups of chromosomal races of house mouse in Upper Valtellina (Lombardy, Italy), using microsatellites. (conicet.gov.ar)
  • One question with high relevance to aging is whether or not cfDNA fragments can behave as mobile genetic elements, illegitimately integrating in the chromosomal DNA of healthy cells in its own host, thereby contributing to genome instability and possibly causing age-related functional decline and age-related pathophysiological processes. (fightaging.org)
  • Specifically, we focused on understanding the disease mechanisms and studied two of the most common chromosomal translocations, or genetic mutations, that lead to pediatric leukemia. (lu.se)
  • In order for the Giemsa stain to adhere correctly, all chromosomal proteins must be digested and removed. (wikipedia.org)
  • We present the first comprehensive survey of protein-protein interactions of seven distantly related MLL-fusion proteins. (nature.com)
  • MLL-fusion proteins are found in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) and are often associated with adverse prognosis, particularly in pediatric patients 3 . (nature.com)
  • For instance, the CxxC-domain is essential for DNA binding of MLL-fusion proteins 7 . (nature.com)
  • Furthermore, the MLL-interacting protein Menin links MLL-fusion proteins with LEDGF, and the H3K36me3-binding PWWP domain of LEDGF is critical for the function of MLL-fusions 8 . (nature.com)
  • However, it is unclear whether these molecular mechanisms pertain to the entire family of MLL-fusions or if they specifically affect the leukemogenicity of isolated MLL-fusion proteins. (nature.com)
  • Fusion proteins, which can occur when parts of different chromosomal regions are joined, may drive the development of many cancers in children. (cancer.gov)
  • Advances in chemical biology have expanded the universe of "druggable" protein targets in pediatric cancers and new technological approaches provide strategies for the direct targeting of fusion oncoproteins and the proteins with which they interact within complexes. (cancer.gov)
  • While directly targeting fusion oncoproteins would be ideal because of their exclusivity in tumors, other targets (e.g., interacting proteins, synthetic lethal partners, mediators of fusion oncoprotein function) may be more amenable to these strategies. (cancer.gov)
  • We also discuss the segregational model of karyotype evolution and the chromosomal model of homoploid hybrid speciation. (frontiersin.org)
  • However, for patients with a KMT2A rearrangement (KMT2A-r), the prognosis appears to depend on the fusion partner gene rather than the karyotype structure. (cancerindex.org)
  • These groups differ by Robertsonian fusions and/or whole-arm reciprocal translocations such that F1 hybrids have a chain-of- five meiotic configuration. (conicet.gov.ar)
  • Deletion of 6q , STIL/TAL1 fusion and NOTCH1 mutation. (atlasgeneticsoncology.org)
  • When Saethre-Chotzen syndrome is caused by a chromosomal deletion instead of a mutation within the TWIST1 gene, affected children are much more likely to have intellectual disability, developmental delay, and learning difficulties. (medlineplus.gov)
  • The World Health Organiztion (WHO) classifies secondary MDS as MDS or acute leukemia that develops years after known exposure to sources of chromosomal damage. (medscape.com)
  • MLL-fusions represent a large group of leukemia drivers, whose diversity originates from the vast molecular heterogeneity of C-terminal fusion partners of MLL. (nature.com)
  • Functional investigation of 128 conserved MLL-fusion-interactors identifies a specific role for the lysine methyltransferase SETD2 in MLL-leukemia. (nature.com)
  • The largest family of "multi-partner translocations" in acute leukemia comprises fusions involving the product of the KMT2A ( MLL) gene. (nature.com)
  • In line, many MLL-fusions can act as potent oncogenes in cell line models and animal models of leukemia 4 . (nature.com)
  • The presence of a congenital anomaly is associated with increased childhood cancer risk, likely due to large effects of Down syndrome and chromosomal anomalies for leukemia. (plos.org)
  • Chromosomal and immunophenotypic patterns in T cell acute lymphoblastic leukemia (T ALL) and lymphoblastic lymphoma (LBL). (atlasgeneticsoncology.org)
  • Note=A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). (abcam.com)
  • Secondary MDS describes the development of MDS or acute leukemia years after known exposure to sources of chromosomal damage. (medscape.com)
  • Some of these mutations, such as (mixed-lineage leukemia) MLL fusions, are highly aggressive and can generate leukemia very quickly. (lu.se)
  • A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). (proteopedia.org)
  • Chemoplexy, rather than simple reciprocal translocations define the gene fusions in about 42% of patients. (standardofcare.com)
  • In the resultant ETV6/FRK fusion protein, the entire PNT oligomerization domain of ETV6 and the kinase domain of FRK are fused in frame. (atlasgeneticsoncology.org)
  • Malignant transformation is usually the result of chromosomal translocations that activate proto-oncogenes or create a chimeric fusion protein. (oncolink.org)
  • Taken as a pill once or twice daily, TKIs target the protein made by the mutated BCR-ABL fusion gene. (cancercare.org)
  • As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. (proteopedia.org)
  • It involves fusions between EWSR1, a gene encoding an RNA-binding protein and E26 transformation-specific transcription factors. (standardofcare.com)
  • While studies of selected MLL-fusions have revealed critical molecular pathways, unifying mechanisms across all MLL-fusions remain poorly understood. (nature.com)
  • However, these chromosomal fusion events are poorly understood, as their functional significance and therapeutic potential remain unclear. (bmj.com)
  • Experimental design: Using WGS and RNA-seq, we reviewed the prevalence of fusions in a cohort of 570 patients with cancer, and compared prevalence. (researchgate.net)
  • Previous work showed that these hybrids were fertile, although their fertility was reduced as compared to crosses within chromosomal races. (frontiersin.org)
  • raising questions about additional mechanisms that may rescue fertility in chromosomal hybrids. (frontiersin.org)
  • The overall goal of the Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) Network is to form a dynamic and collaborative team of investigators to advance our understanding of the mechanisms of action of fusion oncoproteins in pediatric cancers and apply novel chemical strategies to accelerate innovative drug discovery and preclinical development of therapeutics for fusion oncoprotein-driven childhood cancers. (cancer.gov)
  • Researchers investigating the molecular mechanisms by which fusion oncoproteins drive childhood cancers. (cancer.gov)
  • This systems-level analysis defines the molecular framework in which EN oncofusions operate to promote cancer and provides some mechanisms for therapeutics. (bvsalud.org)
  • Less is known about associations with presence of non-chromosomal anomalies. (plos.org)
  • Increasing number of non-chromosomal anomalies was associated with a stronger risk of childhood cancer (OR for 3+ anomalies: 3.11, 95% CI: 1.54-6.11). (plos.org)
  • Although central nervous system (CNS) anomalies were associated with CNS tumors (OR: 6.05, 95% CI 2.75-13.27), there was no strong evidence of other non-chromosomal anomalies being specifically associated with cancer occurring in the same organ system or anatomic location. (plos.org)
  • Non-chromosomal anomalies increased risk of several cancer types. (plos.org)
  • Additionally, we found that increasing number of non-chromosomal anomalies was associated with a stronger risk of cancer. (plos.org)
  • Birth defects are generally categorized as chromosomal or non-chromosomal anomalies. (plos.org)
  • 1 ] The role of chromosomal anomalies on childhood cancer risk has been described. (plos.org)
  • 4 ] Four recent population-based registry linkage studies in the United States (U.S.)[ 2 , 5 - 7 ] suggest that children with non-chromosomal anomalies may also be more likely to develop cancer compared to their unaffected contemporaries. (plos.org)
  • RÉSUMÉ Afin d'estimer l'incidence des cas de fente labiale et de fente palatine chez les nourrissons jordaniens et de repérer les anomalies associées, nous avons mené une étude prospective en milieu hospitalier sur une période de cinq ans, de janvier 2000 à janvier 2005. (who.int)
  • Progress in our understanding of fusion oncoprotein-driven cancer biology through investigator-initiated research and the Cancer Moonshot -funded Fusion Oncoproteins in Childhood Cancers (FusOnC2) Consortium , along with recent technological developments, provides an opportunity for collaborative efforts towards the development of new treatment approaches for childhood cancers. (cancer.gov)
  • Targeting Fusion Oncoproteins in Childhood Cancers (TFCC) was originally published by the National Cancer Institute. (cancer.gov)
  • These gene fusions become rational targets for prostate cancer therapy and also can be used for diagnosis. (pcf.org)
  • The discovery of ETS gene fusions as common events in prostate cancer represents a paradigmatic shift in the significance attributed to chromosomal translocations as a key mechanistic player in carcinogenesis. (bmj.com)
  • The process of chromosomal care and repair contributes to cancer in many ways, so the more we understand how it works, the better we can fine-tune it to treat cancer," said Cleveland. (worldpharmanews.com)
  • The gene fusion creates a double-whammy for the immune system by a) knocking out a molecule that helps T-cells detect cancerous cells in the body - thereby allowing the cancerous cells to multiply unchecked - and b) increasing the expression of a second molecule that leads to the destruction of T-cells, which are important for attacking cancer cells. (bccancerfoundation.com)
  • Mitelman F. Cancer gene fusions detected by massive parallel sequencing. (lu.se)
  • Mertens F, Johansson B, Fioretos T, Mitelman F. The emerging complexity of gene fusions in cancer. (lu.se)
  • Expression of MLL-fusions enhances proliferation and blocks myeloid differentiation of hematopoietic progenitor cells, leading to their pathological accumulation. (nature.com)
  • This program aims to combine therapeutic approaches with continued mechanistic studies to reveal potential treatment targets and advance the development of therapeutic strategies for fusion oncoprotein-driven childhood cancers. (cancer.gov)
  • Thus, the potential roles of these ETS gene fusion events are being actively explored and are discussed in this review within the context of the existing scientific and clinical climates. (bmj.com)
  • The groundbreaking discovery, published today in the international science and medical journal Nature, identifies for the first time a commonly-occurring gene fusion as a cause in primary mediastinal B-cell lymphoma, and as one of only a handful of times a specific gene has been implicated in the development of Hodgkin lymphoma. (bccancerfoundation.com)
  • Ten-year survival for this group was 63.6 per cent versus 85 per cent for the group without the gene fusion. (bccancerfoundation.com)
  • Structure: the 3D structure of the Genome can be used to identify structural variants such as gene fusions as potential drivers of disease. (arimagenomics.com)
  • The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)
  • Enhanced the understanding of opportunities for targeting fusion oncoproteins through emerging chemoproteomic methods. (cancer.gov)
  • In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. (proteopedia.org)
  • To provide molecular level insight into EN oncogenesis, we employed a proximity labeling mass spectrometry approach to define the molecular context of the fusions. (bvsalud.org)
  • Complex karyotypes are the product of chemoplexy (a sudden burst of complex, loop like gene arrangements that give rise to a fusion gene), and these fusions arise early, giving rise to both primary and relapsed Ewing sarcoma tumors, which can continue to evolve in parallel. (standardofcare.com)
  • It is now known that there are multiple levels of chromatin organization in the nucleus of cells, including chromosomal territories, compartments, domains, and looping structures that coordinate regulatory interactions. (arimagenomics.com)
  • In any individual patient, t(11;22) fuses one of many observed combinations of exons from EWS and FLI1 to form the fusion message. (medscape.com)
  • Multidisciplinary research groups working at Next Generation Chemistry Centers that are focusing on innovative medicinal chemistry, chemical biology and chemoproteomic approaches to target fusion oncoprotein-driven cancers. (cancer.gov)
  • Progress in medicinal chemistry (such as PROTACs and molecular glues) provides a knowledge base for the design of new therapies for fusion-driven childhood cancers. (cancer.gov)
  • The TFCC aims to build on the progress of fusion oncoprotein research and translate preclinical discoveries into the development of effective treatments for fusion oncoprotein-driven childhood cancers. (cancer.gov)
  • This chromosomal shattering and rearranging is called "chromothripsis" and occurs in the majority of human cancers, especially cancers of the bones, brain and fatty tissue. (worldpharmanews.com)
  • Four EN variants with alternating break points have since been detected in a wide range of human cancers. (bvsalud.org)
  • One of the key findings from the study was that the fusion cells have the characteristics of human embryonic stem cells. (news-medical.net)
  • Chemoplexy results in the formation of functional EWSR1-FLI1 or ESWR1-ERG fusions that provide a selective growth or survival advantage. (standardofcare.com)
  • The long term goal for this experiment was to do cell fusion in a way that would allow the elimination of the embryonic stem cell nucleus to create an embryonic stem cell from the somatic cell," said Melton. (news-medical.net)
  • So, while this does not obviate the need for human oocytes, it demonstrates that this general approach of cell fusion is an interesting one that should be further explored. (news-medical.net)
  • The researchers were also able to further confirmed that fusion occurred by studying the chromosomal makeup of the fused cells. (news-medical.net)