Chromogenic CompoundsSubstrate SpecificityAmyloid beta-Protein PrecursorKineticsMolecular Sequence DataAmino Acid SequenceBinding SitesAmyloid Precursor Protein SecretasesMolecular StructureModels, MolecularCatalysisStructure-Activity RelationshipProtein BindingHydrolysisAlzheimer DiseaseAmyloid beta-PeptidesAspartic Acid EndopeptidasesEscherichia coliHydrogen-Ion ConcentrationMutationRecombinant ProteinsProtein Structure, TertiaryCatalytic DomainCrystallography, X-RayStereoisomerismOxidation-ReductionBase SequenceChromatography, High Pressure LiquidCell LineSulfur CompoundsMagnetic Resonance SpectroscopyPhosphorylationProtein ConformationPresenilin-1Volatile Organic CompoundsEndopeptidases