Chromatin tumor cell nuclei. Medical search. Frequent questions

plump polyhedral nevus cells: Abundant cytoplasm is filled with pigment and has a small round to oval nucleus with bland appearance. (aao.org)
slender spindle nevus cells (Fig 12-16): The cytoplasm contains scant pigment and a small, dark, elongated nucleus. (aao.org)
balloon cells: Abundant, foamy cytoplasm lacks pigment and has a bland nucleus. (aao.org)
Histologically, a melanocytoma is composed of large polyhedral cells with small round to oval nuclei and abundant cytoplasm. (aao.org)
Epithelioid melanoma cells resemble epithelium because of their abundant eosinophilic cytoplasm and enlarged round to oval nuclei. (aao.org)
Note the balloon cells (arrowheads) with abundant foamy cytoplasm. (aao.org)
The tumor is made of sheets and nests of loosely cohesive, small, round or oval cells with very scant cytoplasm (see the image below). (medscape.com)
The nuclei had generally maintained their ovoid shapes, with stippled to hyperchromatic chromatin and fusiform piloid cytoplasm. (ajnr.org)
There were foci of eosinophilia, stellate cytoplasm, and occasional gemistocytic morphology, and many cells were positive for glial fibrillary acidic protein (GFAP). (ajnr.org)
Histologic sections show small nests of cytologically bland epithelial cells with abundant clear to eosinophilic cytoplasm distributed within a fibromatous stroma. (cap.org)
The epithelial cells have a urothelial cell-like appearance, with abundant clear to pale eosinophilic cytoplasm and small nucleoli. (cap.org)
As the peripheral nerves form, the Schwann cells migrate peripherally from the spinal ganglia, parallel to the axons, and encase them with their cytoplasm. (medscape.com)
Tumor cells contained scant eosinophilic cytoplasm and oval to elongate nuclei with finely stippled chromatin and inconspicuous nucleoli. (veterinaryscijournal.com)
Examined cytologically, squamous cell breast carcinoma will tend to show malignant squamous cells (cancer cells) with keratinising cytoplasm . (breast-cancer.ca)
Microscopically, some loosely cohesive epithelioid cells were uniform with abundant clear cytoplasm, showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
Distinct round nucleoli were visible in some cells, notably with numerous melanin pigments in the cytoplasm. (biomedcentral.com)
The cytologic characteristics of the tumor can provide sufficient clues for PEComa diagnosis, which includes loosely cohesive, epithelioid morphology with abundant clear or eosinophilic cytoplasm, low-grade nuclear atypia, cytoplasmic melanin pigments. (biomedcentral.com)
Microscopically, we observed some loosely cohesive atypical cells arranged in single or clusters and sheets, which exhibited epithelioid morphology with abundant clear cytoplasm. (biomedcentral.com)
Distinct round nucleoli were visible in some cells (Fig. 1 C), notably with numerous melanin pigments in the cytoplasm (Fig. 1 D). The primary diagnosis was atypical cells which were suspected to be melanoma. (biomedcentral.com)
The cell block section showed single or clusters of medium-sized epithelioid cells in a background of fibrinoid fluid, with abundant clear or granular eosinophilic cytoplasm. (biomedcentral.com)
The neoplastic cells contain abundant eosinophilic cytoplasm. (surgpath4u.com)
The tumor is predominantly comprised of large eosinophilic cells with abundant cytoplasm -- the nuclei contain vesicular chromatin and a single prominent nucleolus. (surgpath4u.com)
The high expressed CBY1 in non-BCSC interacts with 14-3-3 and β-catenin to form a ternary complex, which leads a translocation of the ternary complex into cytoplasm from nucleus and degradation of β-catenin in phosphorylation-dependent pattern. (nature.com)
The polygonal cells were characterized by indistinct borders, lightly eosinophilic cytoplasm with moderate amount of granules, round or oval central nuclei with stippled chromatin ("salt and pepper" appearance) and inconspicuous nucleoli. (unipr.it)
Maturation (decrease in nuclear size of melanocytes with chromatin becoming darker accompanied by reduction in the amount of cytoplasm) with depth is present in many cases (Requena et al. (atlasgeneticsoncology.org)
The cells are usually large and polygonal, containing abundant eosinophilic cytoplasm, a large nucleus with open chromatin, a prominent eosinophilic nucleolus, and an occasional intracellular lumina containing red blood cells 1,4-7 . (bvsalud.org)

Spindle-A melanoma cells have slender, elongated nuclei with small nucleoli. (aao.org)
Their nuclei have a conspicuous nuclear membrane, very coarse chromatin, and large nucleoli. (aao.org)
The tumor is composed of small spindle or polygonal epithelial cells with small round or oval nuclei, dispersed chromatin and inconspicuous nucleoli. (webpathology.com)
The larger vesicular epithelial cells with prominent nucleoli characteristic of type B2 thymomas are not seen. (webpathology.com)
Fig. 2A ]) Their nuclei were round to oval with inconspicuous nucleoli and finely dispersed chromatin. (thieme-connect.com)
The nuclei are small and slightly irregular, with small nucleoli. (cap.org)
Prominent nucleoli can be observed in some cells. (biomedcentral.com)
Their nuclei are relatively large, round to oval in shape, and show mild pleomorphism with mostly small, round, regular nucleoli. (atlasgeneticsoncology.org)
are large, noncleaved with vesicular chromatin and have membrane-bound nucleoli. (basicmedicalkey.com)

In a 1995 study, it was discovered by Swedish scientist Anders Håkansson (Anders Hakansson) that multimeric alpha-lactalbumin (MAL), a compound isolated from a fraction of human milk called casein, induced what appeared to be apoptosis in human lung carcinoma cells, pneumococcus bacteria, and other pathogens, while leaving healthy, differentiated cells unaffected. (wikipedia.org)
For more information, see Bladder Cancer , as well as Pathologic Findings in Squamous Cell Bladder Carcinoma and Cystoscopy in Bladder Cancer . (medscape.com)
Small cell carcinoma of the urinary bladder usually has a polypoid or nodular appearance and often has an ulcerated surface. (medscape.com)
Sixty-eight percent of small cell carcinoma of the urinary bladder cases are mixed with classic urothelial carcinomas or adenocarcinomas of the bladder. (medscape.com)
[ 9 ] The histologic features of small cell carcinoma are the same as those in other organs. (medscape.com)
Small cell carcinoma of the bladder. (medscape.com)
Urinary cytology often reveals single and loosely cohesive clusters of tumor cells with typical small cell carcinoma morphology. (medscape.com)
As in small cell carcinoma of other organs, that of the bladder tumor cell exhibits abundant genomic aberrations. (medscape.com)
It is also suggested that acquisitions of genomic alterations in typical invasive urothelial carcinoma lead to the development of small cell bladder carcinoma. (medscape.com)
More recent investigations indicate that patterns of gene expression in small cell bladder carcinoma are associated with distinct clinical phenotypes (ie, from more indolent to aggressive disease). (medscape.com)
Small-cell carcinoma of the bladder: 20-year single-institution retrospective review. (medscape.com)
Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
It should be noted that the vast majority of neoplasms of the upper aerodigestive tract are epithelial and that some of these can show a spindle cell phenotype, e.g., spindle cell or sarcomatoid carcinoma and myoepitheliomas. (basicmedicalkey.com)
Herein, we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma (collision tumor) in the ampulla of Vater, which has seldom been reported in the literature. (koreamed.org)
Succinate dehydrogenase-deficient (SDH-deficient) renal cell carcinoma (RCC) is a rare subtype of RCC. (sajo.org.za)
Succinate dehydrogenase- (SDH)-deficient renal cell carcinoma (RCC) is a rare subtype of RCC, estimated to comprise 0.05% - 0.2% of all cases of RCC globally. (sajo.org.za)
Merkel cell carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma. (springeropen.com)
Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
A month later, this mass was surgically excised and the histology examination showed a poorly differentiated small cell carcinoma, with histopathologic features of a Merkel cell carcinoma. (springeropen.com)
The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with Merkel cell carcinoma. (springeropen.com)
Ovarian Microcystic Stromal Tumor (MCST) is a newly recognized entity with only 19 reported cases, in which only 3 cases showed a solid growth pattern and 1 with concurrent endometrial carcinoma. (austinpublishinggroup.com)
To our knowledge, this is the first report to demonstrate the co-over expression of β-catenin and cyclin D1 in case with MCST and concurrent endometrial carcinoma, which may provide new insights to the tumor biology. (austinpublishinggroup.com)
Squamous cell carcinoma is form of epithelial cell carcinoma which may occur in many different places in the body, and it is also the most common form of skin cancer . (breast-cancer.ca)
Squamous-cell carcinoma is also a type of non-small cell lung cancer. (breast-cancer.ca)
Squamous cell carcinoma is a malignant tumor of squamous epithelial cells, and it does occur in the breast, but very rarely . (breast-cancer.ca)
Primary squamous cell carcinoma is very rare, and accounts for only about 0.1% of breast cancers. (breast-cancer.ca)
It is referred to as primary pure squamous cell carcinoma when the malignant cells are all of the squamous cell type, but there is no relation with the skin and no indications for a primary location somewhere else in the body. (breast-cancer.ca)
But go ahead and take a gander at our new and improved page which has more up-to-date information on Squamous Cell Carcinoma . (breast-cancer.ca)
When squamous cell carcinoma occurs in the breast, it typically originates either in the epidermis, the nipple, or perhaps as the malignant transformation of a deep-seated epidermal cyst . (breast-cancer.ca)
In most cases the squamous cell carcinoma is not pure. (breast-cancer.ca)
Squamous cell carcinoma can present in a very similar way to an adenocarcinoma so differential diagnosis is important. (breast-cancer.ca)
But otherwise, there does not seem to be any indication that squamous cell breast carcinoma or squamous cell differentiation in other breast cancers has any particular effect on behavior or survival rates. (breast-cancer.ca)
Generally speaking, the behavior of squamous cell breast carcinoma closely resembles that of pure adenocarcinoma of the breast . (breast-cancer.ca)
Generally speaking, squamous cell breast carcinoma has an aggressive clinical course, with an outcome about the same as that of poorly differentiated breast adenocarcinoma. (breast-cancer.ca)
Apocrine carcinoma is defined as cases with >90% apocrine differentiation of tumor cells. (surgpath4u.com)
Immunohistochemistry aided in the diagnostic discrimination of paraganglioma from neuroendocrine carcinoma and in the assessment of tumor differentiation. (unipr.it)
Genetic and epigenetic alterations have been identified as to contribute directly or indirectly to the generation of transitional cell carcinoma of the urinary bladder (TCC-UB). (oncotarget.com)
We found that amplification of chromosome 6p22.3 is significantly associated with the muscle-invasive transitional cell carcinoma of the urinary bladder (TCC-UB) (22%) in contrast to superficial TCC-UB (9%) (p=7.2-04). (oncotarget.com)
Moreover, the most common type of tumor was complex carcinoma - 33.3% (5 cases). (biomedcentral.com)
According to the degree of differentiation, NENs have been divided into well differentiated NENs and poorly differentiated NENs in the 2010 World Health Organization classification of tumors of the digestive system, with the former being termed a neuroendocrine tumor (NET), and the latter, a neuroendocrine carcinoma (NEC) [ 1 ]. (biomedcentral.com)

No evidence of tumor was identified in adnexa, uterus or omentum in microscopy, but only GCT metastasis was detected in Douglas space peritoneal nodules. (researchsquare.com)
Cancer cells that die via apoptosis (larger dark purple structures) expel their nuclear contents (orange and yellow stringy structures) to spur metastasis and growth of living cancer cells (smaller light blue structures). (cancer.gov)
The survival outcome in these patients is very poor due to the high rate of tumour recurrence and distant metastasis, and about two-third of the patients succumb to the disease within 2 years of the diagnosis 7 . (turkjpath.org)
This case report is of clinical significance indicating that by any abnormal finding in the thyroid gland in patients with a malignant disease, the diagnostic approach should always contain consideration of metastasis from the primary tumor. (springeropen.com)
Of the 19 cases, 7 cases with follow-up data (1.5 to 12 years) revealed that the tumors had no metastasis or recurrence [1]. (austinpublishinggroup.com)
Furthermore, the scracht assay result suggested that ATRA was a potential reagent to prevent the invasion or metastasis of GIST cells. (biomedcentral.com)
A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
This demonstrates that distant metastasis can occur during the early phase of tumor growth in these aggressive lesions. (biomedcentral.com)

They are composed of irregular nests of malignant cells with stromal invasion, often associated with a desmoplastic reaction. (cap.org)
Conclusion: Gross and histologic appearance, were consistent with a diagnosis of gastrointestinal stromal tumor. (veterinaryscijournal.com)
Malberg JA, Webb BT, Hackett E. Colonic gastrointestinal stromal tumor resulting in recurrent colic and hematochezia in a warmblood gelding. (veterinaryscijournal.com)
Gastrointestinal Stromal Tumors in Equids. (veterinaryscijournal.com)
Stephan S, Hug S, Hilbe M. Gastrointestinal Stromal Tumor in the Cecum of a Horse. (veterinaryscijournal.com)
Hafner S, Harmon BG, King T. Gastrointestinal stromal tumors of the equine cecum. (veterinaryscijournal.com)
Ovarian Microcystic Stromal Tumor (MCST) is a newly recognized entity with only 19 reported cases [1-3]. (austinpublishinggroup.com)
The specimens revealed FIGO grade I endometrioid adenocarcinoma with minimal myometrial invasion and focal cervical stromal involvement as well as a microcystic stromal tumor of the left ovary. (austinpublishinggroup.com)
Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST) patients. (biomedcentral.com)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms occurring throughout the entire region of the gastrointestinal tract and are considered to originate from intestitial cells of Cajal, the pacemaker cells of the gut [ 1 ]. (biomedcentral.com)
Intraventricular meningiomas probably arise from the meningothelial cells of the tela choroidea, where there is an arachnoidal invagination into the stromal base of the choroid plexus. (medscape.com)

SFTs of the pleura are localized mesenchymal neoplasms composed of fibroblastlike cells believed to arise from the subpleural connective tissue. (medscape.com)
While most tumors metastatic to the serous membranes are of epithelial origin, cytologists should be aware that non-epithelial neoplasms can also cause malignant effusions including sarcomas, melanomas, germ cell tumors, and, more rarely, brain tumors. (cytojournal.com)
Diagnosing non-epithelial malignancies in effusion specimens based entirely upon their cytomorphologic features is difficult because these neoplasms often exhibit considerable morphological overlap and their cytomorphology can differ from the original tumor. (cytojournal.com)
As malignant cells have a tendency to round up in body fluids these non-epithelial neoplasms can therefore mimic reactive mesothelial cells and metastatic adenocarcinoma. (cytojournal.com)
Common non-epithelial neoplasms that may cause malignant effusions include malignant melanoma, sarcomas, and other neoplasms including germ cell tumors [ Figure 1 ]. (cytojournal.com)
Pineal region tumors constitute a rare group of neoplasms. (thieme-connect.com)
Brenner tumors are commonly associated with other ovarian neoplasms, including mucinous-type tumors. (cap.org)
Histologically, these tumors resemble non-invasive, low-grade urothelial neoplasms. (cap.org)
Perivascular epithelioid cell tumors (PEComas) are a rare group of mesenchymal neoplasms characterized by the presence of histologically and immunohistochemically distinctive perivascular epithelioid cells [ 1 ], which can occur in any part of the body. (biomedcentral.com)
Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
Meningiomas , as defined by the 2016 World Health Organization (WHO), are "a group of mostly benign, slow-growing neoplasms that most likely derive from the meningothelial cells of the arachnoid layer. (medscape.com)

Microfollicular containing eosinophilic material, gland-like arrangement with pyknotic nuclei and resembling Call-Exner bodies were noted in tumor tissue in Figure 2b,c. (researchsquare.com)

Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way -- whole-genome profiling of open chromatin -- to identify the kind of cell that leads to a given case of leukemia, a valuable key to cancer prognosis and outcome. (news-medical.net)
Every type of cell has a characteristic chromatin structure that includes closed chromatin, which is tightly wound around nucleosomes and is relatively inactive, and open chromatin, looser stretches of the material that interact with regulatory elements encoded in DNA. (news-medical.net)
Trowbridge hypothesized that analyzing open chromatin in bulk tumor cells could provide a possible improved method to identify cancer cell of origin because of the cell-type specificity of chromatin structure. (news-medical.net)
To profile the open chromatin in these distinct AML samples, and compare them to open chromatin patterns in normal cells, Trowbridge collaborated with Duygu Ucar, Ph.D., an assistant professor at JAX who develops computational models to study gene regulation including chromatin structure. (news-medical.net)
Together they identified open chromatin signatures and gene expression patterns in AML samples that may allow stem cell-derived AML to be distinguished from progenitor cell of origin AML. (news-medical.net)
To identify what drives treatment resistance to standard therapy, as well as the cellular source of recurrent disease, UCSF researchers used single-nucleus RNA, open-chromatin, spatial profiling to analyze 86 primary-recurrent, patient-matched, paired GBM specimens. (ucsf.edu)

Most tumors are confined to the ovary at diagnosis, and malignant Brenner tumors have a better prognosis than other epithelial ovarian carcinomas. (cap.org)
It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
Chromatin organisation and cancer prognosis: a pan-cancer study. (ox.ac.uk)
Aberrant organisation of DNA has been correlated with cancer prognosis in analyses of the chromatin component of tumour cell nuclei using image texture analysis. (ox.ac.uk)
Glioblastomas (GBMs) are incurable brain tumors with a prognosis of about one-and-a half years on average. (ucsf.edu)
The human "Elston and Ellis grading method" was utilized in dogs with mammary tumor to examine its relation to prognosis in this species, based on a 2-year follow-up period. (biomedcentral.com)
Furthermore, this research will allow a more discriminating classification of mammary tumors and probably has a bearing on cytohistopathology, epidemiology, pathogenesis and prognosis. (biomedcentral.com)

The differential diagnosis of a malignant effusion is accordingly broad, especially for the small round blue cell tumors that includes not only mesenchymal tumors, but also non-mesenchymal tumors, such as neuroblastoma and Wilms tumor. (cytojournal.com)

Other rare non-epithelial malignancies that may be encountered in effusion cytology include neuroblastoma, Wilms tumor, and metastatic brain tumors. (cytojournal.com)
1 - 3 Intracranial brain tumors, most commonly medulloblastoma [ Figure 2 ], can metastasize to the peritoneal cavity via ventriculo-peritoneal shunts used to divert excess cerebrospinal fluid. (cytojournal.com)

The tumor cell nuclei are hyperchromatic with coarsely granular chromatin. (medscape.com)
DSRCT is composed of small cells with round hyperchromatic nuclei and a dense fibrous or spindle cell stroma. (medscape.com)
The cells are hyperchromatic, with pleomorphic nuclei and frequent mitotic figures. (cap.org)

1% proliferation index in tumor cells. (thieme-connect.com)
The patient underwent a second TSS, and histology of the specimen revealed neoplastic proliferation of astrocytes and spindle-shaped cells with fascicles. (ajnr.org)
Nests are large and crowded and may show fusion, as a result of epithelial proliferation that exceeds what is seen in benign Brenner tumor. (cap.org)
Recently, a unique form of plexiform schwannoma consisting of a proliferation of epithelioid and spindled cells positive for S-100, Melan-A, and HMB-45 but no obvious melanin pigmentation, called plexiform melanocytic schwannoma, has also been described. (medscape.com)
An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS. (harvard.edu)
Cell proliferation was determined by trypan blue dye exclusion test. (biomedcentral.com)
In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. (biomedcentral.com)
Thereafter, the downstream signaling pathways are activated promoting cell proliferation and/or survival. (biomedcentral.com)
Results suggest leukocyte and T-cell proliferation have improved predictability performance over tumour mutational burden ( Nature ). (frontlinegenomics.com)
In particular, knockdown of E2F3 inhibits cell proliferation in a 6p22.3-dependent manner, whereas knockdown of CDKAL1 and Sox4 has no effect on cell proliferation. (oncotarget.com)
In summary, our data indicate that E2F3 is a key regulator of cell proliferation in a subset of bladder cancer and the 6p22.3 amplicon is a biomarker of aggressive phenotype in this tumor type. (oncotarget.com)
Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth, proliferation, and survival. (mdpi.com)
10. Alters cell proliferation, cell death, or nutrient supply nomes with high accuracy. (who.int)

However, the presence of nevus cells contiguous with a choroidal melanoma on histologic examination provides evidence that melanomas may arise from choroidal nevi. (aao.org)
[ 11 ] Recently, there have also been reports of nerve sheath tumors exhibiting histologic hybrid features of schwannoma and soft-tissue perineurioma. (medscape.com)
The tumor was extensively sampled and multiple tissue blocks were submitted for histologic evaluation. (austinpublishinggroup.com)
Spitz tumors include a group of cutaneous melanocytic tumors that share certain histologic features. (atlasgeneticsoncology.org)
2004). Less common are histologic variants such as desmoplastic/sclerosing, angiomatoid, myxoid and plexiform Spitz nevi (Lyon, 2010), and pigmented spindle cell nevus (Ferrara et al. (atlasgeneticsoncology.org)
Our objectives in this study were to identify cytopathology criteria of malignancy for canine mammary tumors and the frequency of different types of mammary lesions and their relationship with histologic grade was investigated. (biomedcentral.com)
It is the most common primary intracranial neoplasm and the most diversified in histologic patterns among all primary tumors of the CNS. (medscape.com)
In meningiomas, one feature may be dominant over the other, and this phenomenon partly contributes to the rich diversification of histologic patterns in these tumors. (medscape.com)
Although some of the observed variants, such as chondroid meningiomas, clear-cell meningiomas, papillary meningiomas, and rhabdoid meningiomas, are associated with unfavorable prognoses, the other histologic patterns are not indicators of unfavorable biologic behavior. (medscape.com)
The histologic hallmark of AE is represented by the presence of sheets and groups of atypical endothelial cells with prominent epithelioid morphologies. (bvsalud.org)

To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. (mdpi.com)
They found that cells in this surgical margin acted as niches of recurrence where non-malignant glia were broadcasting pro-growth signals that influenced the tumor cells to regrow. (ucsf.edu)
These paracrine (cell extrinsic) signals stimulated the activator protein (AP1) pathway, leading to mesenchymal transition, therapy resistance and tumor recurrence. (ucsf.edu)

The epithelioid cells were uniform and approximately the same size as the parabasal cells (Fig. 1 A&B), showing predominantly round or oval nuclei with finely stippled chromatin. (biomedcentral.com)
3B-C) Lesion is composed of large epithelioid and oval cells admixed with abundant collagenous stroma. (atlasgeneticsoncology.org)

Only one month of disease-free after four cycles of postoperative chemotherapy was remained when metastatic tumor developed in liver. (researchsquare.com)
The patient remained only one month of disease free when metastatic tumor developed in liver. (researchsquare.com)
At 5-year follow-up, she was alive, without recurrent or metastatic tumor. (medscape.com)
No metastatic tumor was noted in axillary lymph node. (medscape.com)

[ 10 ] are often focal or diffusely positive for small cell bladder tumors by immunohistochemistry, and they are useful tools to help establish a diagnosis. (medscape.com)
Upon immunohistochemistry (IHC), the tumor cells were positive for HMB45 and TFE3, focally positive for MelanA, while negative for muscle marker. (biomedcentral.com)

In spindle-B melanoma cells, coarse, granular chromatin and plump, large nuclei are seen. (aao.org)
On low power, the possibility of granular cell tumor might be considered. (surgpath4u.com)

Small cysts are often present, but benign Brenner tumors are rarely predominantly cystic. (cap.org)
These tumors are predominantly cystic but may contain variable solid areas, often representing a coexisting benign Brenner component. (cap.org)
Grossly, MCST tumors were solid-cystic (14/19), solid (3/19), or predominantly cystic (2/19) [1-3]. (austinpublishinggroup.com)
Microscopically, at low power of view, the tumor consisted of predominantly lobulated, cellular nodules separated by hyalinized fibrous stroma (Figure 1B). (austinpublishinggroup.com)

Their neuropathological spectrum is divided into well-differentiated "pineocytoma" (World Health Organization [WHO] grade I), pineal parenchymal tumors of intermediate differentiation and papillary tumor of pineal region (WHO grades II and III), and poorly differentiated "pinealoblastoma" (WHO grade IV). (thieme-connect.com)
Only about 13% of squamous cell carcinomas are completely pure and without some kind of glandular cell differentiation . (breast-cancer.ca)

This case first appeared as Performance Improvement Program in Surgical Pathology (PIP) 2020, Case 31, and is benign Brenner tumor in the ovary. (cap.org)
The findings are consistent with a benign Brenner tumor. (cap.org)
Similar to other epithelial ovarian tumors, Benner tumors are classified as benign, borderline/atypical proliferative, or malignant. (cap.org)
Benign Brenner tumors account for approximately 5% of all benign ovarian epithelial tumors and are typically found incidentally in women in the 5th to 7th decades of life. (cap.org)
Grossly, benign Brenner tumors are small (typically less than 2 cm) and unilateral. (cap.org)
Borderline/atypical proliferative Brenner tumors are often larger than benign Brenner tumors, with an average diameter of 18 cm. (cap.org)
A benign Brenner tumor component is often present in the background. (cap.org)
Histologically, malignant Brenner tumors are associated with a benign or borderline/atypical proliferative Brenner tumor component. (cap.org)
A neurilemmoma is a benign, usually encapsulated neoplasm derived from Schwann cells and, along with neurofibroma, constitutes one of the 2 most common benign peripheral nerve sheath tumors. (medscape.com)
Of note, the benign nerve sheath tumors are classified as World Health Organization grade I on the basis of their benign cytologic features, in contrast to the malignant counterparts, which are World Health Organization grade III or IV. (medscape.com)
Fibroblastic or myofibroblastic tumors make up the majority of soft tissue tumors of the aerodigestive tract and range from nonneoplastic or benign proliferations (fibromas) to high-grade malignancies (undifferentiated high-grade pleomorphic sarcomas). (basicmedicalkey.com)
Classification of all canine mammary gland lesions revealed 13(86.7%) malignant and 2(13.3%) benign tumors. (biomedcentral.com)

Moreover, the fibrous nature of the tumor has given rise to various other names, such as pleural fibroma, submesothelial fibroma, and localized fibrous tumor. (medscape.com)
The currently accepted nomenclature is solitary fibrous tumor. (medscape.com)
Microscopically, the tumors are composed of solid to cystic nests of epithelial cells embedded in a fibrous stroma. (cap.org)

Yang says her team's findings highlight the fact that individual cancer cells are part of a community of cells whose members influence one another's behavior - even in their final moments. (cancer.gov)
A review of the literature reveals only a few reports of this tumor, and there has been scanty discussion of the imaging findings of posterior pituitary astrocytomas compared with lesions of the anterior pituitary gland. (ajnr.org)
There are no typical mammogram findings for squamous cell carcinomas. (breast-cancer.ca)
The cytopathological features were well correlated with cell block and histopathological findings. (biomedcentral.com)
Findings suggest therapeutic strategies should be aimed at interfering with cancer cell reprogramming of microenvironment cues ( Nature ). (frontlinegenomics.com)
In shortly, these findings highlight that the novel lnc408 functions as an oncogenic factor by recruiting SP3 to inhibit CBY1 expression and β-catenin accumulation in nucleus to maintain stemness properties of BCSCs. (nature.com)
Cancer has been in existence on Earth even before the appearance of man, as evidenced by paleontological findings of tumors in animals ( 1 , 2 ). (jcancer.org)

Nuclei are typically herpchromatic and dense , with coarse chromatin and thick nuclear membranes. (breast-cancer.ca)

On the basis of these facts, it is understandable that the hypophyseal stalk or posterior pituitary can be a host to all the neoplastic processes that originate from the glial cell series. (ajnr.org)
A small proportion of these tumors show large ducts lined by neoplastic cells, the so-called large-duct variant of adenocarcinoma. (coek.info)
First of all, no other neoplastic elements are to be present in the tumor. (breast-cancer.ca)
Both non-neoplastic meningothelial cells and meningiomas possess mixed features of epithelial and mesenchymal cells. (medscape.com)

Developmental lesions such as heterotopia of meningothelial cells in the scalp are believed to be the origin of meningiomas under the scalp and skin of the head. (medscape.com)

Although individualized targeted therapies are routinely used for patients with lung and breast tumors, personalized medicine has not achieved the same degree of success in the pancreas. (coek.info)
Squamous cell breast tumors are usually estrogen and progesterone receptor negative . (breast-cancer.ca)

Papillary tumor of the pineal region (PTPR) is a neuroectodermal tumor thought to originate from cells of the subcommissural organ. (thieme-connect.de)

Meningioma comprises about one fourth of all primary tumors of the central nervous system (CNS). (medscape.com)

The mechanism of its entry is poorly understood, but recent studies indicate that the oleic acid in the HAMLET complex interacts with phosphatidylserine and o-glycosylated mucin on the plasma membrane, both of which are expressed in greater amounts on the plasma membrane of tumor cells, possibly providing for HAMLET's specificity. (wikipedia.org)
Summary: Astrocytoma, or pituicytoma, of the posterior pituitary is a relatively rare entity consisting of poorly characterized glial tumor cells. (ajnr.org)
A proportion of tumors are poorly differentiated with little or no gland formation. (coek.info)

There are several variants of cutaneous melanocytic tumors, characterized by differing clinical and pathologic features. (atlasgeneticsoncology.org)

Only some of these characteristics are seen in atypical Spitz tumors and spitzoid melanomas. (atlasgeneticsoncology.org)

The narrow diame- association with cellular and mitotic tubulin as ter and great length of single-walled carbon nano- well as the chromatin. (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

Rather it might be considered a skin cancer, which sometimes happens in the squamous epithelial cells of the breast. (breast-cancer.ca)

Curiously, squamous cell breast carcinomas rarely metastasize to the axillary lymph nodes , or do so about 10% of the time. (breast-cancer.ca)
Rarely these tumors are found within the orbital region. (unipr.it)

Cell death is not prevented by caspase inhibitors, or by BCL-2 or p53 mutagenesis, indicating that the traditional apoptotic caspase cascade is not the ultimate cause of cell death. (wikipedia.org)
The team suspects apoptotic cells may also help drive the growth of metastatic tumors in humans. (cancer.gov)
In the current study, we tested the apoptotic effect of GLA on human chronic myelogenous leukemia K562 cells. (omega-research.com)
Typical apoptotic nuclei were shown by staining of K562 cells with DNA-binding fluorochrome Hoechst 33342, characterized by chromatin condensation and nuclear fragmentation. (omega-research.com)
Cell viability was detected by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay, and apoptotic rate was determined by flow cytometry. (zju.edu.cn)
GP73-SphK1sR-Ad5 transfection significantly decreased the viability and increased the apoptotic rate of Huh7 cells, but had no effect on HL7702 cells. (zju.edu.cn)

We aimed to define and validate a novel prognostic biomarker for the automatic detection of heterogeneous chromatin organisation. (ox.ac.uk)
Chromatin heterogeneity was a significant predictor of cancer-specific survival in microsatellite unstable (HR 2·9, 95% CI 1·0-8·4) and microsatellite stable (1·8, 1·2-2·7) stage II colorectal cancer, but microsatellite instability was not a significant predictor of outcome in chromatin homogeneous (1·3, 0·7-2·4) or chromatin heterogeneous (0·8, 0·3-2·0) stage II colorectal cancer. (ox.ac.uk)

On inspection, occult blood was detected in stool, while preoperatively electronic gastroscopy and colonoscopy revealed no tumor lesion. (researchsquare.com)
Characteristics of the cells may not be sufficient in many instances to yield a definitive diagnosis or indicate the probable behavior of the lesion. (merckvetmanual.com)

B ) Higher power view demonstrating the presence of pineocytomatous rosettes (marked with an arrow head) interspersed with bizarre pleomorphic cells and numerous mast cells (marked with a thick arrow). (thieme-connect.com)

Before surgical excision of the tumour, FNAC was performed using a 0.6 mm diameter needle attached to a 10 ml syringe held in a standard metal syringe holder. (biomedcentral.com)

Single cell RNA sequencing of endothelial cell heterogeneity in breast cancer identifies lipid-processing subtype that could offer a potential route for future treatment regimes ( Nature ). (frontlinegenomics.com)
INTERPRETATION: The consistent prognostic prediction of Nucleotyping in different biological and technical circumstances suggests that the marker of chromatin heterogeneity can be reliably assessed in routine clinical practice and could be used to objectively assist decision making in a range of clinical settings. (ox.ac.uk)

When this type of tumor grows to a significant size, it may extend beyond its site of origin (ie, from the choroid to the ciliary body and vice versa). (aao.org)

Neuroendocrine markers, such as chromogranin A, synaptophysin, CD56, and neuronal specific enolase, are often focal or diffusely positive for this tumor by immunohistochemical method and are useful to help establish a diagnosis. (medscape.com)
Mean age at diagnosis is in the early 6th decade, and most tumors are unilateral. (cap.org)
The presence of a noninvasive tumor next to a peripheral nerve suggests the diagnosis of neurilemmoma. (medscape.com)
With the clinical diagnosis on tumor of the ampulla of Vater, endoscopic retrograde cholangiopancreatography (ERCP) was performed, which revealed huge prominent papilla and dilated common bile duct with asymmetrically irregular structures ( Fig. 2 ). (koreamed.org)
A diagnosis of SDH-deficient RCC required loss of staining in all tumour cells in the presence of internal positive controls. (sajo.org.za)
To complicate issues further for diagnosis, some tumors are mixed that is there can be squamous cells (tumor cells) found in adenocarcinomas or from metastatic diseases elsewhere. (breast-cancer.ca)
The final pathological diagnosis was PEComa identified by the liquid-based cytology, cell block, cervical biopsy, IHC and FISH result. (biomedcentral.com)
This will help cytopathologists to recognize this rare tumor that occurred in the cervix, and the combination of predictive morphology evaluation, immunophenotype, and molecular testing can achieve the definitive diagnosis of PEComa. (biomedcentral.com)
Finally, a tentative diagnosis of PEComa was made by combining cell block and IHC, and with the statement that the final diagnosis will require more representative material. (biomedcentral.com)
The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)

Shrivelled nuclei"/"raisin" like nuclei, nuclei with a wavy ("textured", convoluted) nuclear membrane -- usu. (librepathology.org)

These results bear out indications in human data that the stage of a progenitor cell when it becomes transformed to leukemia has an impact on its clinical progression, with earlier-stage cell of origin cancers being more aggressive. (news-medical.net)
In terms of clinical presentation, squamous cell breast carcinomas usually present as a firm-to-hard painless breast lump . (breast-cancer.ca)
Clinical diagnostics led to full appreciation of the severe tumor invasiveness and to an informed decision by the owner for euthanasia. (unipr.it)

Granulosa cell tumors(GCTs) arising outside the ovary are extremely rare. (researchsquare.com)
Carcinoid , or well-differentiated neuroendocrine tumor, of the ovary is uncommon but may occur as a monodermal teratoma or a somatic-type malignancy arising from a teratoma or dermoid cyst. (cap.org)

Elongated nuclei (similar to colorectal adenocarcinoma) - key feature . (librepathology.org)
Pseudostratification of the nuclei (like in colorectal adenocarcinoma), differentiates from tall cell variant . (librepathology.org)
Another aim of this study was to differentiate the simple and adenocarcinoma tumors from the complex or mixed tumor described by Elston and Ellis grading method. (biomedcentral.com)

Because the nevus cells are so heavily pigmented, it is usually necessary to apply melanin bleaching techniques to sections to accurately study the cytologic features (see Chapter 15, Fig 15-12D). (aao.org)
The cytoplasmic melanin content in melanoma cells can vary considerably. (aao.org)
A few spindled nuclei and melanin pigments were also identified (Fig. 2 A). IHC demonstrated that the epithelioid cells were positive for HMB45 andTFE3 (Fig. 2 B&C), focally positive for Melan-A, while negative for S-100, SOX-10, AE1/AE3, EMA, Desmin, SMA, H-caldesmon. (biomedcentral.com)

In mice, Yang's team found that the contents released from burst nuclei triggered growth-promoting signaling in nearby mammary tumor cells and accelerated the growth of metastatic tumors. (cancer.gov)
Moreover, the most often tumors occur in inguinal mammary (60%) and abdominal (27%) glands. (biomedcentral.com)

The lobules were lined peripherally by spindle cells. (unipr.it)
They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. (bvsalud.org)

Histologically, posterior uveal melanomas are composed of spindle cells and/or epithelioid melanoma cells (Figs 12-17, 12-18, 12-19). (aao.org)
Perivascular epithelioid cell tumor (PEComa) occurring in the female genital tract are rare, and typically found in the uterine corpus. (biomedcentral.com)
Epithelioid angiosarcoma is a rare malignant neoplasm found in vascular endothelial cells. (bvsalud.org)

Owing to the scarcity of notochord progenitors and notochord cells, a comprehensive identification of regulatory elements driving notochord-specific gene expression has been lacking. (bvsalud.org)
Remarkably, EOMES antagonizes BRACHYURY gene regulatory functions in coexpressing cells during early gastrulation to ensure the proper sequence of early AM and DE lineage specification followed by posterior mesoderm derivatives. (bvsalud.org)
This gene is expressed in cells of the blastopore of late blastulae and the archenteron invagination region of gastrulae. (bvsalud.org)
GnRH Transactivates Human AMH Receptor Gene via Egr1 and FOXO1 in Gonadotrope Cells. (harvard.edu)
BACKGROUND: Chromatin organisation affects gene expression and regional mutation frequencies and contributes to carcinogenesis. (ox.ac.uk)
From each tumor biopsy, they performed single-nucleus RNA-seq which measures transcriptome-wide gene expression in individual cells, for thousands of cells at a time. (ucsf.edu)

Spindle cell melanoma consists primarily of spindle-B melanoma cells (see Fig 12-18). (aao.org)
Tumors composed of a mix of spindle-A and spindle-B melanoma cells are designated spindle cell melanomas . (aao.org)
The lncRNA SLNCR Recruits the Androgen Receptor to EGR1-Bound Genes in Melanoma and Inhibits Expression of Tumor Suppressor p21. (harvard.edu)
Single-cell and spatial transcriptomics reveals the hierarchical nature of tumour growth in metastatic melanoma. (frontlinegenomics.com)

These tumors may exhibit variable amounts of necrosis. (aao.org)
Tumor necrosis is often present. (medscape.com)
The tumor was highly vascular with blood-filled lacunae and multifocal to coalescing areas of liquefactive necrosis. (unipr.it)

Figure 12-16 Spindle-cell choroidal nevus (between arrows) is composed of slender spindle-shaped cells with thin, homogeneously staining nuclei. (aao.org)
Synovial sarcomas encompass both biphasic (epithelial and spindle cell components) and monophasic (purely spindle cell) variants. (medscape.com)
Pigmented spindle cell nevus from right thigh of 11 year old female, 7mm in diameter. (atlasgeneticsoncology.org)

Anatomy44

Organisms12

Diseases42

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Phenomena and Processes72

Disciplines and Occupations2

Information Science3

Health Care1

Cytoplasm26

Nucleoli9

Carcinoma42

Metastasis8

Stromal11

Neoplasms12

Eosinophilic1

Open chromatin6

Prognosis7

Mesenchymal tumors1

Brain tumors2

Hyperchromatic3

Proliferation13

Histologic10

Recurrence3

Oval2

Metastatic tumor4

Immunohistochemistry2

Granular2

Predominantly4

Differentiation2

Benign12

Fibrous3

Findings7

Coarse chromatin1

Neoplastic4

Lesions1

Breast tumors2

Papillary Tumor1

Primary tumors1

Poorly3

Melanocytic1

Atypical1

Mitotic2

Epithelial cells1

Rarely2

Apoptotic6

Heterogeneous2

Lesion2

Pleomorphic1

Excision1

Heterogeneity2

Type of tumor1

Diagnosis10

Nuclear membrane1

Clinical3

Ovary2

Adenocarcinoma3

Melanin3

Mammary2

Peripherally2

Epithelioid3

Gene6

Melanoma4

Necrosis3

Spindle cell3