Chromatin euchromatic regions. Medical search. Frequent questions

According to this model, the heterochromatin forces an altered chromatin conformation on the euchromatic region. (wikipedia.org)
In other words, the heterochromatin spreads and causes gene silencing by packaging the normally euchromatic region. (wikipedia.org)
In htz1Delta cells, Sir2 and Sir3 spread into flanking euchromatic regions, producing changes in histone H4 acetylation and H3 4-methylation indicative of ectopic heterochromatin formation. (sdbonline.org)
Htz1 is enriched in these euchromatic regions and acts synergistically with a boundary element to prevent the spread of heterochromatin. (sdbonline.org)
Thus, euchromatin and heterochromatin each contains components that antagonize switching to the opposite chromatin state (Meneghini, 2003). (sdbonline.org)
The periphery of the mammalian nucleus is delineated by the nuclear envelope and by subjacent domains of compact and repressed heterochromatin separated by more open and active regions in the vicinity of nuclear pores. (frontiersin.org)
The first genome-wide examination of the chromatin landscape at the periphery of the plant cell nucleus reveals substantial enrichment of heterochromatin and Polycomb -based repressive chromatin. (biomedcentral.com)
In Arabidopsis cells, most heterochromatin typically aggregates around the centromeric and peri-centromeric regions, forming conspicuous subnuclear foci referred to as chromocenters which are thought to tether transposable elements (TEs) from distant genomic domains [ 6 ] (Fig. 1a ). (biomedcentral.com)
The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions. (nel.edu)
Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons. (nel.edu)
The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)
Recently, several chromatin-related proteins have been shown to regulate ESC pluripotency and/or differentiation, yet the role of the major heterochromatin proteins in pluripotency is unknown. (biomedcentral.com)
Here we show, using a LacI-tethering system, that JIL-1 mediated ectopic histone H3S10 phosphorylation is sufficient to induce a change in higher-order chromatin structure from a condensed heterochromatin-like state to a more open euchromatic state. (silverchair.com)
Studies of position-effect variegation have revealed that heterochromatic and euchromatic domains are interspersed on chromosome 4, and both cytological and biochemical studies have demonstrated that chromosome 4 is associated with heterochromatic marks, such as heterochromatin protein 1 and histone 3 lysine 9 methylation. (wustl.edu)
Euchromatic breakpoint of In(2)A4 inversion was localized at 105 bp region (chr2L:21182214-21182318) of the second exon of the Mcm10 gene, the heterochromatic breakpoint is located at the block of dodecasatellite in 2L pericentromeric heterochromatin. (refine.bio)
In order to check the effects of heterochromatin on neighbor euchromatic genes and estimate the distance of inactivation spreading, we performed RNA-seq analysis of genes expression in larvae and adults females of genotypes A12/A12 (control) and In(2)A4/In(2)A4. (refine.bio)
2004). This conserved histone variant acts partly to antagonize the spread of silent heterochromatin into euchromatic regions (Meneghini et al. (irpa2006europe.com)
the pericentric heterochromatin area or a euchromatic area of chromosome. (bioxorio.com)
During chromatin silencing induced by H3-K9 methylation, HP1 is usually recruited as a component to establish heterochromatin (14, 25). (bioxorio.com)
Long before the identification of its molecular nature, it was recognized that chromatin exists in two main states: the densely stained heterochromatin contrasting with euchromatin ( Heitz, 1928 ). (biologists.com)
Observations of Drosophila salivary glands revealed that genomic regions could switch between states of euchromatin and heterochromatin (facultative heterochromatin), whereas others remain continuously condensed (constitutive heterochromatin). (biologists.com)
In general, Melipona species have 2n = 18 chromosomes, and the species of each subgenus share the same characteristics in relation to heterochromatin regions, DAPI/CMA 3 fluorophores, and the number and distribution of 18S rDNA sites. (karger.com)
Yeast heterochromatin regulators Sir2 and Sir3 act directly at euchromatic DNA replication origins. (yeastgenome.org)

Microscopy, biochemical fractionation and chromatin immunoprecipitation reveal a diffuse nucleoplasmic distribution, weak association with chromatin and high expression levels for HP1β in ESCs. (biomedcentral.com)
CUT&RUN is now being widely used for characterizing the epigenetic landscape in many cell types as it utilizes far less cell numbers when compared to Chromatin Immunoprecipitation-sequencing (ChIP-seq), thereby making it a powerful tool for researchers working with limited material. (bvsalud.org)
In this work, we integrated publicly available ChIP-seq and piRNA data with chromatin immunoprecipitation experiments to get a more comprehensive picture of Bari-Jheh molecular effects. (nature.com)
Chromatin immunoprecipitation analysis shows that in ovaries the trimethylated histone 3 lysine 9 (H3K9me3) mark associates with transgenes producing piRNAs. (refine.bio)
The researchers used chromatin immunoprecipitation and RNA-sequencing methods to identify binding regions and to quantify the effects of RBPs on transcription output. (abclonal.com)

These characteristics correlate with a distinct nuclear architecture, epigenetic signatures enriched for active chromatin marks and hyperdynamic binding of structural chromatin proteins. (biomedcentral.com)
During the meiotic prophase some modifications expected in active chromatin are not found or are found at low level. (biomedcentral.com)
Methylation of different part of the N-terminal of H3 and H4 histones is linked with both repressed and active chromatin, depends on the particular amino acid that is modified in the histone tail. (microbiologynotes.org)
Nuclear condensates may thus function as mechano-active chromatin filters, physically pulling in targeted genomic loci while pushing out non-targeted regions of the neighboring genome. (princeton.edu)
With ChiP sequencing, the scientists found that RNA-binding proteins were in fact predominantly (~60%) localized on active chromatin regions. (abclonal.com)

Molecular analysis suggested that Esc2p contributed to silencing in a manner similar to Sir1p and probably helped recruit or stabilize the other Sir proteins, while Htz1p present at HMR assembled a specialized chromatin structure necessary for silencing (Dhillon, 2000). (sdbonline.org)
In metazoans, a complex meshwork of intermediate filament proteins constitutes the so-called lamina at the inner nuclear membrane to which chromatin regions and associated factors are anchored [ 2 ]. (biomedcentral.com)
Cleavage Under Targets & Release Using Nuclease (CUT&RUN) has swiftly become the preferred procedure over the past few years for genomic mapping and detecting interactions between chromatin and its bound proteins. (bvsalud.org)
Histones are a collection of proteins that link with DNA in the nucleus and help to condense it into chromatin. (microbiologynotes.org)
All living organisms package their DNA with chromatin proteins. (biologists.com)
Recently, an international team of scientists from the United States, China, and Canada collaborated on an ENCODE project to survey RNA-binding proteins on the chromatin regions of the human genome. (abclonal.com)
The chromo and SET domains are conserved sequence motifs present in chromosomal proteins that function in epigenetic control of gene expression, presumably by modulating higher order chromatin. (embl-heidelberg.de)
However, this histone methyltransferase (HMTase) activity is probably restricted to a subset of SET domain proteins as it requires the combination of the SET domain with the adjacent cysteine-rich regions, one located N-terminally (pre-SET) and the other posterior to the SET domain (post-SET). (embl.de)
The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)

Condensation and decondensation of chromatin is to a large extent controlled or accompanied by both postranslational modifications of nucleosomal histones and sometimes by DNA methylation. (biomedcentral.com)
Modifications include methylation, acetylation and phosphorylation, preferentially in the N-terminal regions of histones H3 and H4, but also in histone H2A and H2B. (biomedcentral.com)
We observe preferential methylation of H3K9 in the Y chromosome chromatin whereas H3K27 methylation is more prominent in the X and autosomal chromatin. (biomedcentral.com)
methylation of lysine at 9th position of H3 is associated with gene silincing/ chromatin condensation whereas methylation of lysine at 4th position of H3 is associated with transcription activation. (microbiologynotes.org)
Methylation of histone H3-K4 triggers activation of the chromatin state into the euchromatin state, while histone H3-K9 methylation evokes a transition of the chromatin state from euchromatin into inactive chromatin (7, 24). (bioxorio.com)
The "Roadmap Epigenomics Project" is currently mapping DNA methylation, histone modifications, chromatin accessibility and small RNA transcripts in the human genome. (splice-bio.com)
Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. (embl-heidelberg.de)
Cheng X., Blumenthal R.M., Coordinated chromatin control: structural and functional linkage of DNA and histone methylation. (biologie-journal.org)

Typically, the barrier DNA sequences prevent the heterochromatic region from spreading into the euchromatin but they are no longer present in the flies that inherit certain chromosomal rearrangements. (wikipedia.org)
Euchromatin is a lightly packed form of chromatin (DNA, RNA, and protein) that is enriched in genes, and is often (but not always) under active transcription. (bcgsc.ca)
Microsatellites were observed only in euchromatin regions, whereas the (TTAGG) 6 repeats were found at telomeric sites in both groups. (karger.com)

When an autosomal region carrying a fur color gene is inserted onto the X chromosome, variable silencing of the allele is seen. (wikipedia.org)
The fourth chromosome of Drosophila melanogaster has a number of unique properties that make it a convenient model for the study of chromatin structure. (wustl.edu)
This domain has a repeat density of ~35%, comparable to some pericentric chromosome regions, while maintaining a gene density similar to that of the other euchromatic chromosome arms. (wustl.edu)
The centromere or kine-tochore is the con-stricted region present on the chromosome re-sponsible for mitotic spindle attachment during cell division. (preservearticles.com)
This region of the chromosome is without thymonucleic acid (Sine Acedo Thymonucleirico) and is called the SAT-Chromosome . (preservearticles.com)
It is generally the most active region of chromosome, as it harbours the functional genes. (preservearticles.com)

These results describe a novel pathway for regulating transcription using variant histones to modulate chromatin structure (Santisteban, 2000). (sdbonline.org)
Histones are subject to numerous post-translational modifications that correlate with the state of higher-order chromatin structure and gene expression. (silverchair.com)
H5 histones are individual protein involve in the packing of specific region of DNA. (microbiologynotes.org)
Acetylation reduces the affinity of the histones for DNA and possibly reduces the interaction between the individual nucleosomes that leads to formation of chromatin fibre. (microbiologynotes.org)
Therefore, these Head wear coactivators had been shown to be global coactivators that activated chromatin through hyperacetylation of histones (36, 48). (bioxorio.com)
Campos E.I., Reinberg D. Histones: annotating chromatin. (biologie-journal.org)

These findings provide direct evidence that the epigenetic histone tail modification of H3S10 phosphorylation at interphase can function as a causative regulator of higher-order chromatin structure in Drosophila in vivo. (silverchair.com)
Higher order chromatin structure is important for epigenetic regulation and control of gene activation and silencing. (silverchair.com)
These data indicate the existence of a mammalian SU(VAR) complex and define Suv39h1/SUV39H1 as novel components of mammalian higher order chromatin. (embl-heidelberg.de)

In Drosophila phosphorylation of histone H3S10 in euchromatic chromatin regions by the JIL-1 tandem kinase has been implicated in counteracting heterochromatization and gene silencing. (silverchair.com)
In the male germ line of Drosophila chromatin remains decondensed and highly transcribed during meiotic prophase until it is rapidly compacted. (biomedcentral.com)
During the first meiotic prophase, the chromatin of Drosophila male germ cells displays remarkable differences compared with most other organisms. (biomedcentral.com)
The meiotic prophase in Drosophila is also characterized by a high level of transcriptional activity which ceases shortly before the compaction of the chromatin and the entry into the first meiotic metaphase [ 3 ]. (biomedcentral.com)

In mitosis prophase chromatin typically condenses progressively into the microscopically visible individual chromosomes, which can be seen in their fully condensed state at metaphase. (biomedcentral.com)
We spatially resolved V. mungo chromosomes into euchromatic, transcriptionally active A compartment and heterochromatic, transcriptionally-dormant B compartment. (bvsalud.org)
Both DNA and histone are packed all together to form nucleosome, nucleosome are a pack which are called chromatin, 2 chromatin forms a chromosomes . (microbiologynotes.org)
Chromosomes are the condensed chromatin fibres formed during cell division. (preservearticles.com)
Fourteen short (1.5-5kb) sc and low copy (lc) FISH probes (from chromosomes 1, 5, 9, 11, 15, 16, 17, 22) targeting genic and non-genic regions with and without DA were developed and hybridized to cells from 10 individuals with cytogenetically-distinguishable homologs. (cytognomix.com)

The "Human Genome Project" (HGP) started in 1986 and delivered a first genome draft (90% completion) by 2001 and a "compete" sequence (99% of the euchromatic genome with 99.99% accuracy) by 2006. (splice-bio.com)
As a logical step following HGP, the "ENCODE" Project was started in 2003 and aimed to identify all functional elements in the human genome , e.g. transcripts, promoters and long-range regulatory regions. (splice-bio.com)
92% of the human genome is euchromatic. (bcgsc.ca)
For modeling and analysis - such as in cancer research, for example, which is what we do here - by far the most important parts of the human genome assembly are the parts that code for protein ( transcribed regions and their ORFs ), along with their adjacent regulatory sequences . (bcgsc.ca)

The hot-spot lamin A R482W mutation causing familial partial lipodystrophy of Dunnigan-type (FPLD2), affects lamin A association with chromatin at the nuclear periphery and in the nuclear interior, and is associated with 3-dimensional (3D) rearrangements of chromatin. (frontiersin.org)
SUMOylation influences Bonus's subnuclear localization, its association with chromatin and interaction with SetDB1. (elifesciences.org)

This may be in part due to postmeiotic transcription and in part to differential histone replacement during chromatin condensation. (biomedcentral.com)

A question mark indicates the potential existence of gradually enriched RNA polymerase II transcription microenvironments from the nuclear interior to peripheral regions where mRNA surveillance and export could be favored. (biomedcentral.com)
In some processes, chromatin modifications carry heritable regulatory information that is transmitted from mother to daughter cells, whereas in other cases, they are implicated in the execution of the information contained in the DNA sequence, or occur as a consequence of dynamic nuclear processes such as transcription. (plos.org)
Many processes in parasite biology involve changes at the chromatin level, including regulation of transcription along a complex life cycle, delimitation of functional elements in the genome, and antigenic variation. (plos.org)
Group A act on histone in chromatin and involved with control of transcription. (microbiologynotes.org)
Pioneer transcription factors (TFs) function as genomic first responders, binding to inaccessible regions of chromatin to promote enhancer formation. (elsevierpure.com)
PARP-1-dependent Sox2-binding sites reside in euchromatic regions of the genome with relatively high nucleosome occupancy and low co-occupancy by other transcription factors. (elsevierpure.com)
All of the nuclear ARPs that have been studied in detail are constituents of either ATP-dependent nucleosome remodeling complexes or histone acetyltransferase complexes, both of which are involved in the modification of chromatin structure and, thus, the regulation of transcription and other DNA transactions (Olave et al. (irpa2006europe.com)
In particular, all chromatin-associated RBPs had preference for binding to active gene promot ers, hinting at their potential involvement in transcription as previously hypothesized. (abclonal.com)

The rearrangements due to PEV places the reporter gene in a new compartment of the nucleus where the transcriptional machinery required is not available, thus silencing the gene and modifying the chromatin structure. (wikipedia.org)
A closely related debate around chromatin modifications is about causality: several histone PTMs correlate with specific transcriptional states, but in many cases they are not responsible for a transcriptional outcome but rather are a consequence of it [7] . (plos.org)
We report the presence of TAD-like-regions throughout the diagonal of the HiC matrix that resembled transcriptional quiescent centers based on their genomic and epigenomic features. (bvsalud.org)
Adenot P.G., Mercier Y., Renard J.P., Thompson E.M., Differential H4 acetylation of paternal, maternal chromatin precedes DNA replication, and differential transcriptional activity in pronuclei of 1-cell mouse embryos. (biologie-journal.org)

indicate that ARP6 acts in the nucleus to regulate plant development, and we propose that it does so through modulation of chromatin structure and Rabbit polyclonal to c Fos the control of gene expression. (irpa2006europe.com)
In addition, it has been reported that CBP (dCBP) may regulate the formation of the chromatin state through interactions with some chromatin-associated factors (4, 5) and through functions in DNA metabolic events (54). (bioxorio.com)
This talk will give an overview of the wide range of histone modifications that are now known to exist, and discuss the possibility that they might operate as an epigenetic code, something that works in parallel with the genetic code to regulate chromatin function. (hstalks.com)

These are interactions between the different heterochromatic regions and the global chromosomal organisation in the interphase nucleus. (wikipedia.org)
E , Left) Computational 3D model of the genome in a diploid human fibroblast nucleus taking into account genome-wide chromosomal interactions and interactions between chromatin and the nuclear periphery. (frontiersin.org)
The double-membrane nuclear envelope provides a physical interface that contributes to the compartmentalization of chromosomal domains that have distinct chromatin states and activities within the nuclear space. (biomedcentral.com)
2003). Until recently, our knowledge of ARP6 function lagged behind that of the other nuclear ARPs and was limited to a few qualitative observations in yeast and SWR1 chromatin remodeling complex that functions to replace histone H2A with the variant H2A.Z at specific chromosomal locations (Krogan et al. (irpa2006europe.com)
Along with co-ordinate (location) details of S/MARs, the dataset also revealed details of S/MAR features, namely, length, inter-SMAR length (the chromatin loop size), nucleotide repeats, motif abundance, chromosomal distribution and genomic context. (researchgate.net)

In the last few years, chromatin modifications have been extensively studied in the malaria parasite Plasmodium falciparum (for recent reviews, see [9] - [13] ). (plos.org)
We will not judge the use of the term epigenetic in different situations, but will rather attempt to clarify the roles of chromatin-based modifications in the different processes. (plos.org)
The majority of modifications persist until the early spermatid nuclei, and only a minority further persist until the final chromatin compaction stages before individualization of the spermatozoa. (biomedcentral.com)
High-content mapping uncovers confinement of cohesin and active histone modifications to surfaces and enrichment of repressive modifications toward the core of CDs in both hetero- and euchromatic regions. (ox.ac.uk)
The two major functions of NR coregulators/coregulator complexes are chromatin remodeling (3, 30, 35) and histone modifications (15). (bioxorio.com)
Histone modifications define the state of chromatin (32). (bioxorio.com)
Nucleosome arrays are rearranged through ATP-dependent chromatin remodeling in response to histone modifications. (bioxorio.com)
The roles of each of the histone-modifying enzymes in chromatin remodeling and how the numerous chromatin states impact histone modifications are not Slc2a4 completely understood. (bioxorio.com)
Characterization of histone modifications at subtelomeric regions revealed H3 trimethyl-K9, H3 trimethyl-K27, and H4 trimethyl-K20 enrichment. (biomedcentral.com)
Giraldo A.M., Hylan D.A., Ballard C.B., Purpera M.N., Vaught T.D., Lynn J.W., Godke R.A., Bondioli K.R., Effect of epigenetic modifications of donor somatic cells on the subsequent chromatin remodeling of cloned bovine embryos. (biologie-journal.org)

we also examine the impact of mutations causing muscle dystrophies on chromatin and gene regulation. (collaslab.org)
Chromatin-dependent gene regulation is demonstrated by the potential of human SUV39H1 to increase repression of the pericentromeric white marker gene in transgenic flies. (embl-heidelberg.de)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)

It is also associated with changes in chromatin conformation. (wikipedia.org)

Fulka H., St John J.C., Fulka J., Hozak P., Chromatin in early mammalian embryos: achieving the pluripotent state. (biologie-journal.org)

Thus, our findings suggest that the action of NR coregulators may depend on the state of chromatin at the target loci. (bioxorio.com)
This study describes differences in metaphase compaction between homologous euchromatic loci. (cytognomix.com)

Chromatin modifiers, such as the histone H3 lysine 9 (H3K9) methyltransferase G9a, histone deacetylases, and chromatin remodelers (e.g. (biomedcentral.com)

In a recent study, Bi and colleagues identified genomic regions that are associated with the Arabidopsis NUCLEOPORIN1 (NUP1) protein, an inner subunit of the nuclear pore complex (NPC) [ 5 ] responsible for mRNA export that protrudes out into the lamina-like matrix (Fig. 1 ). (biomedcentral.com)
A minimal physical model explains how this stiffness sensitivity arises from lower mechanical energy associated with deforming softer genomic regions. (princeton.edu)
Using an ensemble of computational strategies we found that the majority of genomic regions in iPS cells derived from human B cells was indistinguishable from that of human embryonic stem cells. (ca.gov)
Specifically, we found that approximately 700 genomic regions located throughout the genome showed differential nuclear positioning upon comparing iPS cells derived from human lymphoid cells to that of human embryonic stem cells. (ca.gov)
These data indicate that the majority of the genome derived from that of human embryonic stem cells shows a similar pattern in chromatin folding as compared to that of iPS cells derived from human B cells but that they differ from each other in a subset of genomic regions. (ca.gov)
We plan to scale up the in situ HiC described here to chart the 3D-genomes of human lymphoid and myeloid cells in order to more to determine genomic regions that are differentially localized in the heterochromatic versus euchromatic compartments. (ca.gov)
Reproducible DA was observed at ~10% of 450 distinct genomic regions mapped by single copy fluorescence in situ hybridization (scFISH). (cytognomix.com)
3D anaglyph videos showed genomic regions with DA having nearly 5-fold larger differences in volumetric integrated probe intensities between homologs. (cytognomix.com)
Interestingly, genomic regions without DA are enriched in epigenetic marks (DHS, H3K27Ac, H3K4me1) of accessible interphase chromatin to a greater extent than regions with DA, suggesting these differences may be correlated with epigenetic marks established during the previous interphase. (cytognomix.com)

In pluripotent and differentiated cells HP1β is differentially localized and differentially associated with chromatin. (biomedcentral.com)

The 3-dimensional layout of the genom e, including interactions of chromatin with the nuclear lamina at the nuclear periphery, plays an important role in the establishment of gene expression programs that govern lineage-specific differentiation and cell identity. (collaslab.org)
The structured post-SET region brings in the C-terminal residues that participate in S-adenosylmethine-binding and histone tail interactions. (embl-heidelberg.de)

Our knowledge of chromatin organization and function in plant systems is rapidly expanding, and the roles of different nuclear peripheral components in structuring chromatin are also beginning to emerge [ 1 ]. (biomedcentral.com)

A-type lamins also associate with chromatin in the nuclear interior, away from the peripheral nuclear lamina. (frontiersin.org)

a Artist impression representing Arabidopsis interphase nuclei and the potential links between nuclear pore complexes ( NPC ) and contrasting chromatin contexts. (biomedcentral.com)
On the other hand, the complexes made up of histone deacetylase (HDAC) are known to corepress non-ligand-bound NRs through hypoacetylation of chromatin areas around Masitinib cell signaling NR binding sites (45, 67). (bioxorio.com)

Chromatin arranges in chains of mesoscale domains with nanoscale functional topography independent of cohesin. (ox.ac.uk)
This nanoscale functional topography is temporarily relaxed in postreplicative chromatin but remarkably persists after ablation of cohesin. (ox.ac.uk)
Scaffold/matrix attachment regions (S/MARs) are DNA elements that serve to compartmentalize the chromatin into structural and functional domains. (researchgate.net)

Walter Flemming was at that time the one to introduce the designations "chromatin" and "mitosis" ( Flemming, 1879 ). (frontiersin.org)

This nucleoplasmic lamin A environment tends to be euchromatic, suggesting distinct roles of lamin A in the regulation of gene expression in peripheral and more central regions of the nucleus. (frontiersin.org)

However, it is not clear whether changes in these epigenetic marks are causative regulatory factors in chromatin structure changes or whether they play a mainly reinforcing or maintenance role. (silverchair.com)
We concluded that besides adding cis-regulatory sequences, Bari-Jheh influences gene expression by affecting the local chromatin state. (nature.com)

In January 2003, a workshop was held in Baltimore to discuss the therapeutic potential of several agents that can modify chromatin structure. (aacrjournals.org)
Instead, the `kinase dead' construct had a dominant-negative effect, leading to a disruption of chromatin structure that was associated with a global repression of histone H3S10 phosphorylation levels. (silverchair.com)
H2A plays a crucial role in determining the overall structure of chromatin. (microbiologynotes.org)
H4 is involves in the structure of chromatin in eukaryotes. (microbiologynotes.org)

Differential staining divides chro-mosome into heterochromatic and euchromatic regions. (preservearticles.com)

Cy-tologists observe the pres-ence of certain bid-like structures formed due to accumulation of chromatin material which are visible along the entire length of the chromonema. (preservearticles.com)
Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex. (yeastgenome.org)
Recruitment of Bonus to chromatin leads to silencing associated with accumulation of the repressive H3K9me3 mark. (elifesciences.org)

For many, the multi-billion endeavor was considered a "moonshot" for biology, but with its successful completion (99% of the euchromatic genome sequenced with 99.99% accuracy) came the launch of many other large-scale sequencing projects such as the Cancer Genome Atlas (2005) or more recently, the Earth Bio-genome Project (2018). (abclonal.com)

Association of A-type lamins with chromatin at the nuclear periphery and in the nuclear interior. (frontiersin.org)

The silencing of euchromatic genes occurs when the genes get placed into a new heterochromatic neighborhood. (wikipedia.org)

These advances establish a third mechanism of chromatin reconfiguration, raising fundamental questions about the stability of nucleosomes in nonreplicative phases of the cell cycle and the cellular machinery responsible for incorporating histone variants into nucleosomes (Mizuguchi, 2004). (sdbonline.org)
During dynamic developmental events, such as sexual reproduction, we propose that dramatic and rapid reconfiguration of source-sink relationships modifies chromatin states. (biologists.com)

Also, the austerity of the variegated phenotype can be altered by the distance of the heterochromatic region from the breakpoint. (wikipedia.org)

We identify chains of interlinked ~200- to 300-nm-wide chromatin domains (CDs) composed of aggregated nucleosomes that can overlap with individual topologically associating domains and are distinct from a surrounding RNA-populated interchromatin compartment. (ox.ac.uk)

(D) Nucleoplasmic lamin A interacts with chromatin in the nuclear interior. (frontiersin.org)

Here, we use CasDrop, a novel CRISPR-Cas9-based optogenetic technology, to show that various IDPs phase separate into liquid condensates that mechanically exclude chromatin as they grow and preferentially form in low-density, largely euchromatic regions. (princeton.edu)

In this work, we hypothesized that Bari-Jheh could also be affecting the expression of nearby genes by remodeling the local chromatin state. (nature.com)
To study the function of histone-modifying coregulators in modulation of sex hormone receptor transactivation during the chromatin state transition, we have developed a altered position effect variegation (PEV) experimental system connected with an androgen-dependent reporter transgene (flies by usage of a hereditary approach. (bioxorio.com)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)

2004). Another Ac-LEHD-AFC recent report Ac-LEHD-AFC indicates that ARP6 binds to telomeres and is required to maintain the silencing of transgenes inserted into heterochromatic regions in the telomere but not transgenes in the centromere (Ueno et al. (irpa2006europe.com)

Based on these findings, we propose a model where JIL-1 kinase activity functions to maintain euchromatic regions by antagonizing Su(var)3-9-mediated heterochromatization. (silverchair.com)

Anatomy8

Organisms1

Chemicals and Drugs16

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes16

Heterochromatin23

Immunoprecipitation5

Active chromatin5

Proteins9

Methylation8

Euchromatin3

Chromosome6

Histones6

Higher-order chromatin3

Drosophila4

Chromosomes5

Human genome4

Association with chromatin2

Condensation1

Transcription8

Transcriptional4

Regulate3

Chromosomal5

Modifications10

Gene regulation4

Conformation1

Mammalian1

Loci2

Lysine1

Genomic regions9

Differentially localized1

Interactions2

Organization1

Nuclear lamina1

Complexes2

Functional3

Mitosis1

Nucleus1

Regulatory2

Structure4

Differential1

Accumulation3

99.991

Lamins1

Genes occurs1

Reconfiguration2

Breakpoint1

Distinct1

Nucleoplasmic1

Preferentially1

State3

Heterochromatic regions1

Kinase1