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  • gene
  • Having been exposed to chromatin dynamics, I have been curious about alternative strategies (apart from RNAi methods) of knocking down a gene instead of the physical deletion of the same from the genome. (epigenie.com)
  • Since gene expression would be a function of both of these parameters, a method to decipher both DNA methylation and nucleosome occupancy simultaneously could lead to new ways to understand the relationship of mutations on chromatin remodeling enzymes and disease. (epigenie.com)
  • Two high-throughput (HT) experimental technologies, gene expression microarrays and Chromatin Immuno-Precipitation on Chip (ChIP-chip), are capable of producing data informative about expression regulatory mechanism on a genome scale. (biomedcentral.com)
  • dynamics
  • Chromatin dynamics play a central role in maintaining genome integrity, but how this is achieved remains largely unknown. (gwu.edu)
  • These findings suggest that the PAK1-MORC2 axis is critical for orchestrating the interplay between chromatin dynamics and the maintenance of genomic integrity through sequentially integrating multiple essential enzymatic processes. (gwu.edu)
  • To explore whether the various H1 subtypes have a differential role in the organization and dynamics of chromatin we have incorporated all of the somatic human H1 subtypes into minichromosomes and compared their influence on nucleosome spacing, chromatin compaction and ATP-dependent remodeling. (nih.gov)
  • cells
  • He argued that the analysis of about 7300 differentially methylated regions suggests that both the pattern of hypomethylated and bivalent chromatin states found in ES cells are quite similar to that found in sperms. (epigenie.com)
  • Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. (nih.gov)
  • Assay
  • D) ChIP-qPCR assay from mouse heart chromatin, showing p-RNAPII S2 at the ANP, β-MHC, actin and GAPDH exonic region in CaMKIIδ-WT or CaMKIIδ-KO animals, 21 days after sham operation or TAC. (nih.gov)
  • Nuclear
  • In addition, loss of the nuclear chromatin-remodeling factor SMARCB1 in rhabdoid tumors led to increased phosphorylation of eIF2α, a central cytoplasmic unfolded protein response (UPR) component, suggesting a role for the UPR in these tumors. (uni-regensburg.de)
  • promote
  • H1 subtypes exhibit different affinities for chromatin and different abilities to promote chromatin condensation, as studied with the Atomic Force Microscope. (nih.gov)