AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and Equipment
ColobomaChoroidal NeovascularizationChoroidChoroid NeoplasmsMicrophthalmosAnophthalmosChoroid DiseasesFluorescein AngiographyChoanal AtresiaFundus Oculi
HypoplasiaNeovascularizationOpticScleralCongenitalIris colobomasNeovascular membranesCataractsLesionsRuptureDetachmentBilateralMelanomaPosterior segmentHemorrhageGlaucomaRetinaAbnormalitiesMalformationsAnteriorResultsEyesDevelopmentLeadChoroidCongenitalFissure to closeInvolving the optic nerveIris colobomaOcular colobomaPolypoidal choroidal vasculopathyMicrophthalmiaOsteomaRetinochoroidal colobomaOptic fissureMaculaAbnormalEyelidChorioretinalUnilaterally or bilaterallyDefectHemangiomasSyndromeCNVMDiagnosisSyndromicLensAniridiaOccurCataractEyeballVesselsDevelopmentalAbnormalityGlasses or contact lensesGeneticAffecting the irisIntraocularPatientsDepending
Hypoplasia6
  • Generally speaking, most dogs with CEA have abnormal vision and their vision is affected by choroidal hypoplasia and colobomas (see below) in addition to the retinal detachments. (vin.com)
  • has been applied to cases where post-natal development obscures the choroidal hypoplasia which is the key diagnostic feature, so that adult dogs have ?normal? (dogwellnet.com)
  • Clinically, the two major lesions associated with CEA are choroidal hypoplasia (CH) and coloboma, and both lesions are diagnosed based on ophthalmological examination. (dogwellnet.com)
  • However, in addition to choroidal hypoplasia, colobomas and staphylomas of the optic nerve head and adjacent tissues are considered part of the extended phenotype and can be the only visible abnormality - particularly as the dog ages. (dogwellnet.com)
  • Named for its high prevalence in Collie dogs, Collie Eye Anomaly (CEA) is more correctly termed choroidal hypoplasia. (embarkvet.com)
  • Collie eye anomaly (CEA), also known as choroidal hypoplasia, is an inherited eye disease caused by a mutation in the canine NHEJ1 gene. (pawprintgenetics.com)
Neovascularization1
Optic6
  • Early in development the choroidal fissure is a groove that extends along the ventral aspect of the optic stalk. (wikipedia.org)
  • While optic neural components (e.g. axons arising from retinal ganglion cells in the sensory retina) do not lie in the groove that is the choroidal fissure, they do extend through the portions of the optic stalk that form the walls of the fissure. (wikipedia.org)
  • PURPOSE: The purpose of this study was to report a case of a chorioretinal coloboma mimicking a second optic disk in an asymptomatic 12-year-old boy. (sutterhealth.org)
  • RESULTS: An asymptomatic 12-year-old boy presented with a chorioretinal coloboma of the right eye giving the impression of a second optic disk. (sutterhealth.org)
  • CONCLUSION: True optic nerve duplication is a rare entity that can be mimicked by other etiologies, including choroidal colobomas and postinflammatory lesions, requiring careful examination by clinicians. (sutterhealth.org)
  • Brown, E.A., Thomasy, S.M., Murphy, C.J., Bannasch, D.L. :Genetic analysis of optic nerve head coloboma in the Nova Scotia Duck Tolling Retriever identifies discordance with the NHEJ1 intronic deletion (collie eye anomaly mutation). (dogwellnet.com)
Scleral1
  • Collie eye anomaly (CEA) is a congenital, inherited ocular disorder affecting retinal, choroidal, and scleral development, which is widespread in herding breeds. (dogwellnet.com)
Congenital3
  • He asked me how you can differentiate if this is congenital coloboma and not optical iridectomy? (mrcophth.com)
  • The most common congenital malformation is persistent pupillary membranes, more rarely iris colobomas. (vin.com)
  • The second volume of this set covers several choroid and retinal disorders including, commotio retinae, choroidal rupture and macular trauma, retinal breaks and detachment, and a variety of congenital / genetic eye diseases such as Best's disease and Stargardt disease. (benthambooks.com)
Iris colobomas2
  • In some cases, iris colobomas can cause blurred vision, decreased visual acuity, double vision and ghost images . (allaboutvision.com)
  • Often, people with iris colobomas choose to wear prosthetic contact lenses to improve the appearance of the eye and decrease any visual symptoms. (allaboutvision.com)
Neovascular membranes2
  • When the RPE is torn, it stimulates the growth of abnormal blood vessels called choroidal neovascular membranes that also spread to the retina. (occeyecare.ca)
  • The presence of myopic choroidal neovascular membranes is generally seen in patients who are highly near sighted. (occeyecare.ca)
Cataracts1
Lesions1
  • Choroidal lesions in NF1, although invisible to ophthalmoscopy, may be rather common when imaged with MSI. (retinarevealed.com)
Rupture3
  • 94 APRIL Choroidal Rupture. (slackbooks.com)
  • Intraoperatively, a severe choroidal rupture secondary to a suprchoroidal hemorrhage was found temporally and a separate rhegmatogenous retinal detachment was found nasally. (asrs.org)
  • Fortunately, not all patients who have myopic bleeding will develop a choroidal neovascular membrane, since they may have a small blood vessel rupture without the associated new blood vessel growth. (occeyecare.ca)
Detachment4
  • Dogs affected with this condition will exhibit some combination of the following: Microphthalmia, eccentric pupils, coloboma or other irregularities of the iris, lens luxation, cataract, retinal dysplasia or detachment, persistent pupillary membrane, equatorial staphyloma and lack of a tapetum. (workingaussiesource.com)
  • Pneumatic retinopexy for retinal detachment associated with choroidal coloboma. (giacomoabbruzzese.it)
  • Chitaranjan Mishra, Sundar T, Srinivas S, Naresh Babu K, Kim R. Hydrochlorothiazide Sensitised Acetazolamide induced Bilateral Angle Closure Glaucoma with Choroidal Detachment after Cataract Surgery. (org.in)
  • Choroidal Melanoma with Retinal Detachment 720 views 57 year old female who underwent proton beam therapy for Choroidal Melanoma. (retinagallery.com)
Bilateral1
  • esotropia, with the slit lamp examination I found bilateral iris coloboma and cataract the doctor asked me what is the cause of poor vision? (mrcophth.com)
Melanoma1
  • Variable Results for Uveal Melanoma-Specific Gene Expression Profile Prognostic Test in Choroidal Metastasis. (ucla.edu)
Posterior segment1
  • I said there may be posterior segment coloboma he agreed and asked me about the operation for the patient for cataract and which eye I will do and what are the precautions? (mrcophth.com)
Hemorrhage1
  • Severe choroidal blow out caused by a suprachoroidal hemorrhage. (asrs.org)
Glaucoma1
  • Other features linked to the port-wine stain and typical to all of the three conditions are glaucoma and choroidal alterations. (hindawi.com)
Retina1
Abnormalities2
  • MSI may uncover myriad other choroidal and RPE abnormalities which are invisible to ophthalmoscopy. (retinarevealed.com)
  • The complex microphthalmic eye is associated with anatomical abnormalities, such as iris or retinochoroidal colobomas, which should be evaluated carefully. (aao.org)
Malformations1
  • If there are concomitant anatomical malformations such as anterior segment dysgenesis, iris or chorioretinal colobomas, retinal dysplasia or persistent fetal vasculature, there is a complex microphthalmos. (aao.org)
Anterior1
  • Blood flows from the anterior to the posterior choroidal veins. (scopeheal.com)
Results1
Eyes1
  • Gupta C, Tan R, Chitaranjan Mishra, Khandelwal N, Raman R, Kim R, Agrawal R, Sen P. Choroidal structural analysis in eyes with diabetic retinopathy and diabetic macular edema-A novel OCT based imaging biomarker. (org.in)
Development1
  • During development it is through the choroidal fissure that the retinal vessels enter and leave the eye. (wikipedia.org)
Lead1
  • Furthermore, choroidal melanocytosis in the phakomatosis pigmentovascularis can lead to malignant transformation. (hindawi.com)
Choroid1
  • Chorioretinal colobomas result from a failure of the fetal fissure to close posteriorly, resulting in a defect in the retinal pigment epithelium or choroid. (medscape.com)
Congenital2
  • A coloboma is a congenital defect that results from a failure of an embryonic fissure to close during the fifth week of development. (reviewofoptometry.com)
  • Congenital anomalies, such as optic pits or colobomas, may respond to vitrectomy and endolaser techniques. (medscape.com)
Fissure to close2
Involving the optic nerve2
  • Refractive error and anisometropia are common in patients with colobomas involving the optic nerve, and these patients should therefore be closely followed and managed appropriately with refraction and amblyopia treatment as necessary. (medscape.com)
  • Retinochoroidal coloboma involving the optic nerve. (reviewofoptometry.com)
Iris coloboma1
Ocular coloboma2
Polypoidal choroidal vasculopathy2
  • 19. Improved visualization of polypoidal choroidal vasculopathy lesions using spectral-domain optical coherence tomography. (nih.gov)
  • The prominent cause of PCNVM include age related macular degeneration (AMD), angioid streaks, myopia, post laser scars, choroidal rupture, non-infective posterior uveitis, disc malformations, colobomas, choroidal tumours, polypoidal choroidal vasculopathy (PCV) and in many cases no obvious cause is found. (surajeyeinstitute.org)
Microphthalmia4
  • Some people with coloboma also have a condition called microphthalmia . (medlineplus.gov)
  • We report an epidemiological and genetic study attempting complete ascertainment of subjects with microphthalmia, anophthalmia, and coloboma (MAC) born in Scotland during a 16 year period beginning on 1 January 1981. (bmj.com)
  • Microphthalmia, anophthalmia, and coloboma (MAC) are major structural eye malformations. (bmj.com)
  • Anophthalmia is the complete absence of the eye, microphthalmia is a small eye usually defined in terms of corneal diameter or axial length, and coloboma is a segmental ocular defect, most commonly a "keyhole" deficiency in the iris. (bmj.com)
Osteoma2
  • 17. Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor. (nih.gov)
  • Padhy SK, Mandal S, Gagrani M. Bone inside eye: choroidal osteoma presenting as exudative retinal detachment: a challenge to diagnosis. (medscape.com)
Retinochoroidal coloboma7
Optic fissure4
  • During the second month of development before birth, a seam called the optic fissure (also known as the choroidal fissure or embryonic fissure) closes to form the structures of the eye. (medlineplus.gov)
  • When the optic fissure does not close completely, the result is a coloboma. (medlineplus.gov)
  • Because the optic fissure forms at the bottom of the eyeball during development, colobomas occur in the lower half of the eye. (medlineplus.gov)
  • The particular structure within the eye affected by the coloboma depends on the part of the optic fissure that failed to close. (medlineplus.gov)
Macula1
Abnormal3
  • This finding indicates early timing of the abnormal closure causing the coloboma and results in failure of development of the inferior retinal ganglion cells. (medscape.com)
  • Coloboma arises from abnormal development of the eye. (medlineplus.gov)
  • Coloboma is an ocular birth defect resulting from abnormal development of the eye during embryogenesis. (beds.ac.uk)
Eyelid1
  • While these eyelid gaps are also called colobomas, they arise from abnormalities in different structures during early development. (medlineplus.gov)
Chorioretinal3
  • Chorioretinal colobomas are typically asymptomatic, although patients can have large defects in their visual fields. (medscape.com)
  • Optic nerve colobomas are distinct in appearance from chorioretinal colobomas and involve only the nerve itself. (medscape.com)
  • The visual acuity outcomes of patients who present with chorioretinal colobomas are determined by the degree of foveal involvement by the coloboma, not by the size of the defect, color of the optic nerve, or presence of subfoveal pigmentary changes. (medscape.com)
Unilaterally or bilaterally1
Defect2
  • A simple, rational, and apparently robust classification of the eye phenotype was developed based on the presence or absence of a defect in closure of the optic (choroidal) fissure. (bmj.com)
  • 3 Due to an absence of the retinal layers, an absolute visual field defect will be present in a location consistent with the coloboma. (reviewofoptometry.com)
Hemangiomas1
  • Choroidal hemangiomas may respond to laser photocoagulation or plaque brachytherapy. (medscape.com)
Syndrome4
  • They are observed in renal coloboma syndrome, which results from an autosomal dominant mutation in the PAX2 gene. (medscape.com)
  • Some individuals have coloboma as part of a syndrome that affects other organs and tissues in the body. (medlineplus.gov)
  • Only 41% of children with cat eye syndrome present a classic combination of anomalies characterized by coloboma of the iris, anal anomalies, and anomalies in the region in front of the ears (pre-atrial). (doctoraotorrino.com)
  • Retinal Coloboma 720 views Young 19-year old female with Charge Syndrome comes in for eye exam. (retinagallery.com)
CNVM2
  • Peripapillary CNVM are defined as a collection of new choroidal blood vessels, any portion of which lies within one disc diameter of the nerve head. (surajeyeinstitute.org)
  • In peripapillary CNVM, choroidal vessels either traverse through breaks within Bruch's membrane or extend around the termination of the membrane adjacent to the disc. (surajeyeinstitute.org)
Diagnosis1
  • 15. [Optical coherence tomography in the diagnosis of retinal alterations in the presence of pigmented choroidal tumors]. (nih.gov)
Syndromic1
  • Given the patient did not have any other systemic pathology, any of the syndromic associations with coloboma, were excluded. (illinoisretina.com)
Lens1
  • Further examination under anaesthesia revealed lens coloboma in the inferonasal quadrant and presence of a choroidal coloboma in the left eye. (nih.gov)
Aniridia2
  • This case report presents a rare association of a complete aniridia with lenticular and choroidal coloboma. (nih.gov)
  • A single PAX6 homeodomain missense mutation was identified in a subject with partial aniridia that had been initially misclassified as coloboma. (bmj.com)
Occur1
  • Colobomas involving the eyeball should be distinguished from gaps that occur in the eyelids. (medlineplus.gov)
Cataract1
  • Treatment of coloboma of the eyes may include the use of glasses or contact lenses in cases that are not very severe, correcting other problems that may be present such as cataract or strabismus, and, recently, surgical procedures to implant artificial iris, or to correct the shape of the iris and make it rounder. (doctoraotorrino.com)
Eyeball1
  • Some dogs also have optic nerve coloboma, in which a portion of the optic nerve where it enters the back of the eyeball has failed to develop. (ashgi.org)
Vessels1
  • During development it is through the choroidal fissure that the retinal vessels enter and leave the eye. (wikipedia.org)
Developmental2
  • Microcornea, iris and choroidal coloboma, and global developmental delay caused by TENM3 pathogenic variants in a Chinese patient. (nih.gov)
  • Coloboma is also frequently associated with small (microphthalmic) or absent (anophthalmic) eyes as part of an interrelated spectrum of developmental eye anomalies, and can affect either one or both eyes (summary by Kelberman et al. (beds.ac.uk)
Abnormality1
Glasses or contact lenses1
  • Large retinal colobomas or those affecting the optic nerve can cause low vision, which means vision loss that cannot be completely corrected with glasses or contact lenses. (medlineplus.gov)
Genetic2
  • Another genetic association to consider in patients with ocular colobomas is CHARGE association, which was identified in this patient. (medscape.com)
  • Most genetic changes associated with coloboma have been identified only in very small numbers of affected individuals. (medlineplus.gov)
Affecting the iris1
  • Colobomas affecting the iris, which result in a "keyhole" appearance of the pupil, generally do not lead to vision loss. (medlineplus.gov)
Intraocular1
  • Anomalía congénita en la que faltan algunas estructuras del ojo debido a la fusión incompleta de la fisura intraocular fetal durante la gestación. (bvsalud.org)
Patients2
  • 13. Optical coherence tomography of choroidal nevus in 120 patients. (nih.gov)
  • 1 Retinal detachment, likely secondary to vitreoretinal traction along the edges of the coloboma, has been reported in up to 40% of affected patients. (reviewofoptometry.com)
Depending2
  • The incidence of ocular colobomas varies depending on the population being examined and ranges from 0.5 (per 10,000 births) in Spain, 2.6 in the United States, and 7.5 in China, accounting for 3.2%-11.2% of blindness in children worldwide. (medscape.com)
  • Colobomas may be present in one or both eyes and, depending on their size and location, can affect a person's vision. (medlineplus.gov)