• The early onset retinal dysplasias result from abnormal development of the photoreceptors and breeds so affected can start to show signs as early as 12 weeks of age. (malamute-health.org)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Tumor xenograft model and ocular pathological neovascularization model were constructed as well as Isolectin B4 (IsoB4) staining and immunofluorescence staining were used to assess the effects of AFAP1L1 on the progression of neoplasms and neovascular eye diseases in vivo. (biomedcentral.com)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • Research has shown that the signal molecule, sonic hedgehog, that is produced in retinal ganglion neurons plays a role in this development. (veteriankey.com)
  • Choroid plexus tumors are graded based on the World Health Organization (WHO) classification scheme and include choroid plexus papilloma (CPP) (WHO grade I) (see the following image), atypical choroid plexus papilloma (WHO grade II), and choroid plexus carcinoma (CPC) (WHO grade III). (medscape.com)
  • This coronal T1-weighted magnetic resonance image (MRI) following contrast administration shows a homogeneously enhancing choroid plexus papilloma within the right lateral ventricle of a 1-year-old boy. (medscape.com)
  • Seeding of the CSF may be seen even in benign choroid plexus papillomas, but leptomeningeal dissemination is much more common in choroid plexus carcinomas. (medscape.com)
  • Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). (bvsalud.org)
  • The extrinsic astrocytes arose from the ventral neuroepithelium of the third ventricle, dispersed bilaterally to the optic tract , and subsequently to the outer layer of optic tectum, indicating migration of astrocytes along retinal ganglion cell axons. (brainmaps.org)
  • Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract . (brainmaps.org)
  • Most probably, the retinal ganglion cells fail to develop properly. (clinicalgate.com)
  • The retinal ganglion cell layer is diminished or absent. (clinicalgate.com)
  • When present, the retinal ganglion cells appear undifferentiated, lacking axons or dendrites. (clinicalgate.com)
  • the increased width is mainly due to the addition of myelin (seen as white within the ON in A ). C and D, Cross-sections (low and medium magnification, respectively) of the ON show the central parenchyma that contains axons, central retinal artery and vein, other blood vessels, astrocytes, oligodendrocytes, and pial septa. (clinicalgate.com)
  • Choroid plexus neoplasms can produce hydrocephalus and increased intracranial pressure by a number of mechanisms, including obstruction of normal cerebrospinal fluid (CSF) flow, overproduction of CSF by the tumor itself, local expansion of the ventricles, or spontaneous hemorrhage. (medscape.com)
  • The most frequent route of choroid plexus tumor spread is via seeding of the CSF. (medscape.com)
  • Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. (nih.gov)
  • the other minor source is the perineural plexus in the most anterior portions of the subarachnoid space surrounding the optic nerve. (clinicalgate.com)
  • [ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
  • Choroid plexus carcinomas are also far more common in the pediatric population, with approximately 80% of choroid plexus carcinomas occurring in children. (medscape.com)
  • Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
  • Choroid plexus carcinomas occasionally arise in association with hereditary cancer predisposition syndromes, including the Li-Fraumeni and rhabdoid predisposition syndromes, with germline mutations of TP53 and hSNF5/INI1/SMARCB1, respectively. (medscape.com)
  • Differentiated thyroid cancer (DTC) is one of the most frequently observed neoplasms today. (baskent.edu.tr)
  • The intraocular portion is divided into three parts or layers: the inner retinal layer anteriorly, the middle choroidal layer where white myelination of the ON begins ( A ), and the outer scleral layer posteriorly. (clinicalgate.com)
  • AdvSM includes patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SM-AHN), and mast cell leukemia (MCL). (nih.gov)