• Gyrate atrophy of the choroid and retina is an inherited disorder of protein metabolism characterized by progressive vision loss. (nih.gov)
  • While most people with gyrate atrophy of the choroid and retina have no symptoms other than vision loss, neonatal hyperammonemia (excess ammonia in the blood in the newborn period), neurological abnormalities, intellectual disability, peripheral nerve problems, and muscle weakness may occur. (nih.gov)
  • When Do Symptoms of Gyrate atrophy of choroid and retina Begin? (nih.gov)
  • Gyrate atrophy of the choroid and retina, which is often shortened to gyrate atrophy, is an inherited disorder characterized by progressive vision loss. (medlineplus.gov)
  • This fellowship provides broad and extensive exposure to the management of diseases of the retina, as a basis for pursuing a subsequent career in academic medical retina or a medical retina practice. (masseyeandear.org)
  • Clinically, the fellow will be able to demonstrate competency in the evaluation and management of diseases of the retina, vitreous, and choroid. (masseyeandear.org)
  • The Retina Macula Conference is a cornerstone in the teaching of fellows, and aims to create a systematic approach towards the diagnosis and treatment of retinal disease. (masseyeandear.org)
  • In addition, medical retina patients are seen in every clinic, and the fellows gain extensive experience in the diagnosis and management of macular diseases. (masseyeandear.org)
  • On the right: layers within the retina and the adjacent choroid. (nih.gov)
  • This fluid often comes from the choroid, a blood vessel layer beneath the retina. (oomc.com)
  • The choroid is a tissue that supplies oxygen to the eyes' retina and it occurs in collie puppies up to about 2 years old. (collieslife.com)
  • Clearside's SCS injection platform, utilizing the Company's patented SCS Microinjector ® , enables an in-office, repeatable, non-surgical procedure for the targeted and compartmentalized delivery of a wide variety of therapies to the macula, retina, or choroid to potentially preserve and improve vision in patients with sight-threatening eye diseases. (wlns.com)
  • The fellow also has an opportunity to treat patients with a variety of posterior segment inflammatory disorders and pediatric retinal diseases. (masseyeandear.org)
  • Glycogen Storage Diseases Glycogen storage diseases are carbohydrate metabolism disorders. (msdmanuals.com)
  • Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea. (bvsalud.org)
  • The glymphatic system, a fluid-clearance pathway involved in brain waste clearance, is known to be impaired in neurological disorders, including Alzheimer's disease (AD). (isciii.es)
  • Likewise, there is now up-to-date evidence indicating that ABCA4 is also implicated in the pathogenesis of various other retinal diseases beyond Stargardt, and we now consider age-related macular degeneration (AMD), some cone-rod dystrophies and forms of retinitis pigmentosa, ABCA4 -related disorders as well. (eyewiki.org)
  • Many studies have also highlighted the importance of the choroid in the diagnosis, pathophysiology, and progression of the disease. (nih.gov)
  • In an important discovery, scientists have demonstrated that the progression of a type of genetic brain disease is slowed and symptoms are improved in mice that received cell transplants. (news-medical.net)
  • This landmark £6.9million research project has been designed to identify measurable characteristics, known as biomarkers, which can detect the occurrence of Alzheimer's disease very early on in the progression of the disease - when a person may have no obvious symptoms. (neurodegenerationresearch.eu)
  • Our goal is to find treatments that can slow down or even stop the progression of Alzheimer's disease. (neurodegenerationresearch.eu)
  • Routine structural neuroimaging evaluation has long been based on nonspecific features such as atrophy, which is a late feature in the progression of the disease. (medscape.com)
  • Determine how changes in the BBB contribute to the progression of disease using sequencing, mouse models, and blood-brain barrier assays. (curealz.org)
  • Glb1l3 was the only Glb-related member strongly downregulated in Rpe65 −/− retinas before the onset and during progression of the disease. (molvis.org)
  • The disease progression is slow, but ultimately all experience severe visual disability between the 4th and 7th decade. (eyewiki.org)
  • Nonetheless, it is important to note that the observed clinical phenotype of Stargardt patients is also significantly influenced by age at time of diagnosis and, accordingly, progression of the disease. (eyewiki.org)
  • Researchers have discovered that an organ in the brain called the choroid plexus apparently plays a critical role in preventing the accumulation of a protein associated with Alzheimer's disease. (news-medical.net)
  • Zinc may be a familiar dietary supplement to millions of health-conscious people, but it remains a mystery metal to scientists who study zinc's role in Alzheimer's disease, stroke and other health problems. (news-medical.net)
  • Oregon Health & Science University is participating in a national study of a drug that may prevent Alzheimer's disease by blocking an enzyme that produces plaques believed to trigger the disorder. (news-medical.net)
  • PHOENIX, Ariz. - February 24, 2023 - A grape-like structure in the brain called the choroid plexus becomes enlarged and shows increased accumulation of abnormal inflammatory molecular signaling in people with Alzheimer's disease, according to a new study published in the journal Alzheimer's & Dementia: The Journal of the Alzheimer's Association . (tgen.org)
  • The choroid plexus increases in volume with age and Alzheimer's disease. (tgen.org)
  • Dr. Pirrotte continues to work on potential external risk factors that might exacerbate these changes, "and could accelerate the development of Alzheimer's Disease," he said. (tgen.org)
  • The purpose of this study was to examine the levels of cerebrospinal fluid (CSF) apolipoprotein E (apoE) species in Alzheimer's disease (AD) patients. (biomedcentral.com)
  • Studies have reported higher plasma matrix metalloproteinase-9 (MMP-9) levels in mild cognitive impairment (MCI) and Alzheimer's disease (AD). (biomedcentral.com)
  • Carefully conducted systematic reviews (SRs) can provide reliable evidence on the effectiveness of treatment strategies for Alzheimer's disease (AD). (biomedcentral.com)
  • Alzheimer's disease (AD) is the most common form of dementia affecting the growing aging population today, with prevalence expected to rise over the next 35 years. (frontiersin.org)
  • The growth in life expectancy and the developing aging population has led to the increased prevalence of chronic diseases, such as Alzheimer's disease (AD). (frontiersin.org)
  • Alzheimer's disease is a heterogeneous disease and has multiple cognitive subtypes. (frontiersin.org)
  • The variant of AD in which visual symptoms are prominent due to the localized pathology in the parieto-occipital region is often referred to as visual variant Alzheimer's disease (VVAD) ( 13 ). (frontiersin.org)
  • A new multimillion pound study to detect Alzheimer's disease has been announced. (neurodegenerationresearch.eu)
  • The Deep and Frequent Phenotyping study is funded by the National Institute of Health Research and the MRC and hopes to dramatically improve the success rate of clinical trials for treatments in Alzheimer's disease. (neurodegenerationresearch.eu)
  • Between 2002 and 2012, 99% of clinical trials into treatments for Alzheimer's disease failed. (neurodegenerationresearch.eu)
  • Due to the complex pathological mechanisms of Alzheimer's disease (AD), its treatment remains a challenge. (frontiersin.org)
  • Taking Alzheimer's disease (AD) as an example, it is the most prevalent neurodegenerative disease, and its pathogenesis has not been fully elucidated ( 1 ). (frontiersin.org)
  • Alzheimer's disease (AD) is the most common form of dementia, and neuroinflammation is an important hallmark of the pathogenesis. (ugent.be)
  • Reduced microglial responses to persistent joint inflammation in a model of Alzheimer's disease. (keystonesymposia.org)
  • Despite evidence demonstrating that impairments in the clearance of toxic waste in the brain contribute to late-onset Alzheimer's disease, the science of lymphatic system dysfunction and the systems regulating entry and exit through the blood-brain barrier has been largely overlooked in Alzheimer's disease - until now. (curealz.org)
  • Characterize the blood-choroid plexus barrier in young, old, and Alzheimer's disease model mice. (curealz.org)
  • Explore how the blood-brain barrier changes during Alzheimer's disease. (curealz.org)
  • From The New York Times: Why Didn't She Get Alzheimer's Disease? (curealz.org)
  • Cure Alzheimer's Fund is a "doing business as" name for the Alzheimer's Disease Research Foundation, a 501(c)(3) public charity with federal tax ID #52-239-6428. (curealz.org)
  • Alzheimer's disease (AD) is a neurodegenerative disease and the most common form of dementia. (howest.be)
  • Alzheimer's disease (AD) is the most common cause of dementia and is a neurodegenerative disease in which changes occur in the brain. (howest.be)
  • Aquaporin 5 in Alzheimer's disease: a link between oral and brain pathology? (isciii.es)
  • The purpose of this review is to analyze the current diagnostic tools for choroidal evaluation and the extrapolation of useful data for ophthalmologists and researchers studying the disease. (nih.gov)
  • The odds of having a best corrected visual acuity worse than 20/25 were 38.3 times higher in patients with a macular choroidal thickness of 168.7 mcm or less than in those with a thicker macular choroid (p=0.004). (medscape.com)
  • 13. The seasick choroid: a finding on enhanced depth imaging spectral-domain optical coherence tomography of choroidal lymphoma. (nih.gov)
  • Additionally, he/she will be able demonstrate competency in laser treatment of retinal and choroidal diseases. (masseyeandear.org)
  • Choroidal metastases usually appear late and are generally a sign of advanced metastatic disease and poor prognosis [ 3 ]. (omicsonline.org)
  • The scientists compared the CSF choroid plexus in healthy individuals and people with Alzheimer's, as well as patients with other neurological diseases such as acute Lyme disease and amyotrophic lateral sclerosis or ALS. (tgen.org)
  • NEUROPROTECTIVE CNS BARRIERS IN NEUROLOGICAL DISEASES RELEASE DATE: August 28, 2003 PA NUMBER: PAS-03-165 March 2, 2006 (NOT-OD-06-046) - Effective with the June 1, 2006 submission date, all R03, R21, R33 and R34 applications must be submitted through Grants.gov using the electronic SF424 (R&R) application. (nih.gov)
  • This PAS encourages studies focused on improving our understanding of the neuroprotective CNS barriers and enhancing the effectiveness of drug and gene delivery strategies for treatment of neurological diseases. (nih.gov)
  • Also, research is needed on the role of the brain microvasculature in protecting the brain from toxic agents and how damage to the BBB leads to long-term neurological toxicity in the development of many neurological diseases. (nih.gov)
  • which is the specialized light-sensitive tissue that lines the back of the eye, and in a nearby tissue layer called the choroid. (medlineplus.gov)
  • Following up on studies that show the choroid plexus can be damaged in aging and Alzheimer's, Dr. Stokin and his colleagues wanted to focus more deeply on the role that this tissue may play in neuroinflammation in the disease. (tgen.org)
  • Improving our knowledge of the molecular and cellular biology of the brain microvasculature and their interactions with surrounding brain cells, which constitutes the BBB in vivo, could lead to innovative strategies for drug and gene targeting to injured or disease tissue. (nih.gov)
  • Here, we report that TNF is the main inflammatory upstream mediator in choroid plexus tissue in AD patients. (ugent.be)
  • Anterior uveitis (AU) inflammation from the iris choroid or ciliary body can cause significant eye morbidity including visual loss. (exposed-skin-care.net)
  • Introduction Anterior uveitis (AU) inflammation of the iris choroid and/or ciliary body can be idiopathic or secondary to an underlying autoimmune condition. (exposed-skin-care.net)
  • A search was further conducted specifically on eye diseases where active smoking has been proposed to be a risk factor, including age-related macular degeneration, Graves ophthalmology, glaucoma, uveitis, refractive errors, strabismus, tobacco-alcohol amblyopia, non-arteritic ischaemic optic neuropathy, Leber optic neuropathy and diabetic retinopathy. (bmj.com)
  • AD is a genetic and sporadic neurodegenerative disease that is a common cause of cognitive impairment acquired in midlife and in late life, but its clinical impact is modified by other neurodegenerative and cerebrovascular conditions. (medscape.com)
  • Patients with Meniere disease (MD) have a thicker choroid and Haller layer on the ipsilateral side than controls, according to a study published online Nov. (giachinoplasticsurgery.com)
  • We report a case of choroid metastasis which was the first sign of systemic dissemination of the disease. (omicsonline.org)
  • Systemic lupus erythematosus (SLE) is a chronic disease of unclear etiology, characterized by an overactive immune system and the production of antibodies that may target normal tissues of many organ systems, including the kidneys. (nih.gov)
  • Unique patterns are associated with underlying systemic diseases. (exposed-skin-care.net)
  • 04 alleles during systemic corticosteroid therapy in patients with VKH disease. (researchsquare.com)
  • Methods: This retrospective case series included 57 eyes from 29 consecutive patients with treatment-naïve VKH disease who received systemic corticosteroid therapy. (researchsquare.com)
  • Vogt-Koyanagi-Harada (VKH) disease is a systemic disorder that is considered to represent an autoimmune disease against melanocytes [1]. (researchsquare.com)
  • In the eye, the disease presents as acute bilateral granulomatous panuveitis, which responds to systemic corticosteroid therapy and generally shows good visual prognosis with relatively short follow-up [2]. (researchsquare.com)
  • HLA, and HLA-DRB1*04 in particular, therefore plays a key role in immune systemic function, as well as in the pathogenesis of autoimmune diseases, including VKH [5]. (researchsquare.com)
  • This retrospective case series included 57 eyes from 29 consecutive patients with treatment-naïve VKH disease who visited the ophthalmology department at Osaka City University Hospital between December 2009 and January 2019 and were followed up for more than 6 months after the start of systemic corticosteroid therapy. (researchsquare.com)
  • It also potentially improves disease management and quality of life for AD patients, as an earlier diagnosis allows initiation of medication and treatment. (frontiersin.org)
  • For quick diagnosis and early treatment, Vogt-Koyanagi-Harada (VKH) disease requires a multidisciplinary management strategy involving dermatologists and ophthalmologists. (medscape.com)
  • The diagnosis of VKH disease is based on a constellation of clinical signs and symptoms with no confirmatory tests. (medscape.com)
  • Other changes in the CSF include the presence of melanin-laden macrophages (specific for VKH disease and helpful in confirming the diagnosis), increased protein levels, and increased pressure. (medscape.com)
  • New neuroimaging methods not only facilitate diagnosis of the most common neurodegenerative conditions (particularly AD) after symptom onset but also show diagnostic promise even at very early or presymptomatic phases of the disease. (medscape.com)
  • In addition, misdiagnosis may result from attempts to classify a choroid plexus tumor as benign or malignant solely on the basis of imaging characteristics. (medscape.com)
  • C138190 CTS-API Disease Main Type Terminology C3088 Angiosarcoma A malignant tumor arising from the endothelial cells of the blood vessels. (nih.gov)
  • Neuroimaging is widely believed to be generally useful for excluding reversible causes of dementia syndrome such as normal-pressure hydrocephalus, brain tumor, and subdural hematoma, and for excluding other likely causes of dementia such as cerebrovascular disease. (medscape.com)
  • Pathologic hallmarks of the disease include beta-amyloid (Aβ) plaques, neurofibrillary tangles (NFTs), and reactive gliosis. (medscape.com)
  • Considerable overlap exists between the risk factors of dementia and cerebral small vessel disease (SVD). (biomedcentral.com)
  • According to the World Health Organization (WHO) Global Burden of Disease (2004), dementia is the second largest contributor leading to total number of years living with disability (YLD) in people aged 60 years or older at 13.5%, compared to heart disease (4.0%), stroke (4.4%), and cancer (2.2%) ( 1 ). (frontiersin.org)
  • It is likely that treatments will be more effective in slowing or stopping further at onset of dementia at earlier stages of the disease. (neurodegenerationresearch.eu)
  • Alzheimer disease is a progressive neurodegenerative disorder characterized by gradual onset of dementia . (medscape.com)
  • The dopamine transporter (DaTScan) is used to distinguish Lewy body dementia from Alzheimer disease. (medscape.com)
  • In an effort to understand why patients who appear virus free are afflicted with AIDS-related dementia and other illnesses, researchers have focused on disease-fighting cells, called macrophages and monocytes, as they traffic throughout the body and into the brain. (technologynetworks.com)
  • Choroid plexus papillomas (CPPs) are rare central nervous system tumors. (medscape.com)
  • 16. Review of spectral domain enhanced depth imaging optical coherence tomography of tumors of the choroid. (nih.gov)
  • The researchers found protein abnormalities and "an aberrant signaling of immune molecules" in the CSF and choroid plexus of people with Alzheimer's," said study author Patrick Pirrotte, Ph.D. , Director of TGen's Collaborative Center for Translational Mass Spectrometry. (tgen.org)
  • The main hallmarks that characterize the disease are neurodegeneration, amyloid beta plaques (Aß plaques) , neurofibrillary tangles (NFTs) and activation of microglia and astrocytes. (howest.be)
  • Fluorescein angiography of the left eye in a patient with Vogt-Koyanagi-Harada disease. (medscape.com)
  • The vision problems associated with ROP remain poorly understood, and little is known about the choroid's role in the disease, they note in JAMA Ophthalmology online September 26. (medscape.com)
  • The brain is comprised of multiple barriers including the blood-brain barrier, the blood- choroid plexus barrier, meningeal lymphatics, and the blood-meningeal barrier. (curealz.org)
  • Although a number of HLA associations with VKH disease have been documented, HLA typing is not diagnostic of the syndrome and is not routinely recommended. (medscape.com)
  • The disease goes by many names such as macaw wasting syndrome, myenteric ganglioneuritis, proventricular dilatation syndrome and more. (avianstudios.com)
  • The choroid is in an integral relationship with the retinal pigment epithelium and photoreceptors, and its possible involvement during the disease should be considered. (nih.gov)
  • RARe-SOURCE™ offers rare disease gene variant annotations and links to rare disease gene literature. (nih.gov)
  • 213 disease terms (MeSH) has been reported with TLR9 gene. (cdc.gov)
  • Choroideremia affects men more than women because the gene responsible for the disease is located on the X chromosome. (nih.gov)
  • Effect of mutations in the glucocerebrosidase-1 gene on iPS cell-derived neurons from Parkinson´s disease patients. (fundacionareces.es)
  • 17 disease terms (MeSH) has been reported with FBLN5 gene. (cdc.gov)
  • Stargardt-like macular dystrophies (STGD3, OMIM #600110) involving dominant mutations in the ELOVL4 gene (6q14.1) present with overlapping clinical features but are not currently classified as typical Stargardt disease. (eyewiki.org)
  • The ABCA4 gene maps to the short arm of chromosome 1 (1p22.1) and presents with extraordinary allelic heterogeneity, with over 490 disease-associated variants discovered thus far, most of which are missense mutations. (eyewiki.org)
  • We assessed the association between ambient levels of fine PM [median aerodynamic diameter ≤ 2.5 μm (PM 2.5 )] measured at fixed-site monitoring stations and SLE disease activity measured with the SLE Disease Activity Index, version 2000 (SLEDAI-2K), which includes anti-double-stranded DNA (anti-dsDNA) serum-specific autoantibodies and renal tubule cellular casts in urine, which reflects serious renal inflammation. (nih.gov)
  • They analyzed inflammatory signaling in the CSF, as well as structure and volume changes in the choroid plexus in postmortem brains and in patients using MRI. (tgen.org)
  • The changes in choroid plexus volume in this group could be related to the recruitment of more inflammatory cells," said Mária Čarná, Ph.D., of St. Ann's University Hospital Brno, and the papers first author. (tgen.org)
  • The bottom line is that the disease is characterized by a specific inflammatory pattern found around nerves that causes the target organ to fail. (avianstudios.com)
  • A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
  • Neurovascular dysfunction, including blood-brain barrier (BBB) breakdown and cerebral blood flow (CBF) dysregulation and reduction, is increasingly recognized as contributing to Alzheimer disease. (medscape.com)
  • More than 80% of patients with VKH disease exhibit a transient CSF pleocytosis, which consists primarily of lymphocytes during the first several weeks of the disease. (medscape.com)
  • This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
  • Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing plaques and tau-containing neurofibrillary tangles. (medscape.com)
  • Alzheimer disease is diagnosed via clinical, neuropsychological, and neuroimaging assessments. (medscape.com)
  • Alzheimer disease was first described in 1907 by Alois Alzheimer. (medscape.com)
  • Although it was regarded as a rare disease when it was first described, Alzheimer disease has become one of the most common diseases in the aging population, ranking as the fourth most common cause of death. (medscape.com)
  • Coronal, T1-weighted magnetic resonance imaging (MRI) scan in a patient with moderate Alzheimer disease. (medscape.com)
  • MRI can be considered the preferred neuroimaging examination for Alzheimer disease because it allows accurate measurement of the 3-dimensional (3D) volume of brain structures, especially the size of the hippocampus and related regions. (medscape.com)
  • 15. Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease. (nih.gov)
  • 04 in Vogt-Koyanagi-Harada (VKH) disease is well known. (researchsquare.com)
  • Amyotrophic Lateral Sclerosis (ALS) and Other Motor Neuron Diseases (MNDs) Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei. (msdmanuals.com)
  • An international team of researchers, including scientists from the Translational Genomics Research Institute (TGen), part of City of Hope , show that these changes appear to be a more extreme or perturbed version of changes seen in the choroid plexus-part of the blood-brain barrier-during normal aging. (tgen.org)
  • Understanding the basic biology of how the BBB works under normal and disease conditions across the lifespan may also provide insight on the integrative function of the brain. (nih.gov)
  • The brain Magnetic resonance imaging revealed a left choroid metastasis. (omicsonline.org)
  • A decrease in CSF production and clearance is thought to contribute to the dysregulation in the brain that arises with aging and neurodegenerative diseases. (curealz.org)
  • As infection progressed, the researchers found MAC387 macrophages accumulated in the meninges and choroid plexus in early-stage brain infection. (technologynetworks.com)
  • Parkinson Disease Parkinson disease is a slowly progressive, degenerative disorder characterized by resting tremor, stiffness (rigidity), slow and decreased movement (bradykinesia), and eventually gait and/or. (msdmanuals.com)
  • Neuropsychiatric Symptoms and Parkinson Disease Are We Looking Carefully Enough? (neurology.org)
  • The choroid plexus is a network of blood vessels and cells that produces cerebrospinal fluid (CSF) and creates a barrier between CSF and blood circulating throughout the body. (tgen.org)
  • The blood-cerebrospinal fluid (CSF) barrier consists of a monolayer of choroid plexus epithelial (CPE) cells, and AD is associated with changes in CPE cell morphology. (ugent.be)
  • Symptoms of this disease may start to appear as a Child. (nih.gov)
  • The age symptoms may begin to appear differs between diseases. (nih.gov)
  • The symptoms from some diseases may begin at any age. (nih.gov)
  • The types of symptoms experienced, and their intensity, may vary among people with this disease. (nih.gov)
  • If you're experiencing symptoms or have been diagnosed with a macular disease, such as macular edema or central serous retinopathy, eye experts at OOMC practices can help develop a personalized treatment plan for your condition. (oomc.com)
  • The disease probably starts twenty years before the first symptoms appear and occurs mainly in elderly people. (howest.be)
  • Conclusion: Alleles of HLA-DRB1*04 might affect visual prognosis and be related to early response after initiation of treatment in VKH disease. (researchsquare.com)
  • Indeed, different combinations of ABCA4 alleles are predicted to result in distinct phenotypes, in a continuum of retinal disease manifestations and it appears the severity of disease is deemed inversely proportional to the residual ABCA4 activity. (eyewiki.org)
  • We provide novel data that suggest that short-term variations in air pollution may influence disease activity in established autoimmune rheumatic disease in humans. (nih.gov)
  • Bornavirus is a RNA type virus and has previously been reported to cause, or is associated with, disease in rats, horses, primates, chickens, pigs, humans and now parrots and finches. (avianstudios.com)
  • One striking finding from the study was that "the larger the choroid plexus, the poorer the cognitive performance in those Alzheimer's patients," said Gorazd B. Stokin, M.D., Ph.D., principal investigator at the International Clinical Research Center of St. Ann's University Hospital Brno, Czech Republic, and senior author of the study. (tgen.org)
  • With the help of cognitive performance tests taken by some patients, the team also showed that increased choroid plexus volume was correlated with poorer cognitive performance. (tgen.org)
  • Diagnostic investigations are limited, and physicians rely on clinical examination and exclusion of differential diagnoses that may cause cognitive impairment, such as depression, Parkinson's disease (PD), hypothyroidism, drug interactions, and vitamin deficiencies ( 6 ). (frontiersin.org)
  • When disease relapses within 3 months of discontinuing treatment it is classified as chronic (1). (exposed-skin-care.net)
  • New research from UT Southwestern Medical Center indicates that lowering "bad" blood cholesterol earlier in life, even by a modest amount, confers substantial protection from coronary heart disease. (news-medical.net)