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  • Transcriptional
  • The precocious appearance of several cartilage marker gene transcripts prior to chondrogenesis suggests that multiple levels of gene regulation including alternative promoter use, alternative RNA splicing, alternative polyadenylation, and other post-transcriptional as well as translational mechanisms are active prior to, and during avian limb chondrogenesis. (biologists.org)
  • In developing mouse limbs, Yap was nuclear in the perichondrium while mostly phosphorylated and cytosolic in cells of the cartilage anlage, suggesting downregulation of Yap co-transcriptional activity during physiological chondrogenesis in vivo . (biomedcentral.com)
  • cartilage repair
  • While successful in vitro induction of chondrogenesis with improved biochemical characteristics were obtained from hiPS cells, the working mechanisms in the implantation of hiPS cells and strategies for further improvement of in vivo cartilage repair with hiPS cells should be investigated in future studies. (bmj.com)
  • synthesis
  • This suggests that the ATP-producing glycolysis and mitochondrial respiration oscillate in antiphase with the ATP-consuming PPRP/nucleotide synthesis pathway during chondrogenesis. (hindawi.com)
  • Synovial
  • PAI-2 alone, however, had no effect on the synovial-induced inhibition of chondrogenesis, but produced a pronounced inhibitory effect on matrix breakdown. (springer.com)
  • Thus
  • Therefore, comprehensive profiles of differential metabolite changes during metabolic oscillations can reveal the connection of biochemical networks during metabolic oscillations and thus provide a system-level understanding of metabolic oscillations during chondrogenesis. (hindawi.com)
  • human
  • In a previous study using transgenic mice ectopically expressing Hoxa2 during chondrogenesis, we associated the animal phenotype to human idiopathic proportionate short stature. (mdpi.com)
  • study
  • In the present study, it was investigated how changes in metabolites are implicated in ATP oscillations during chondrogenesis by using capillary electrophoresis time-of-flight mass spectrometry (CE-TOF-MS). CE-TOF-MS detected 93 cationic and 109 anionic compounds derived from known metabolic pathways. (hindawi.com)
  • This study demonstrated that the rhCII hydrogel functions as a xeno-free platform for BM-MSC chondrogenesis, although the process is delayed. (eur.nl)
  • model
  • Suprapatellar-derived ASC transplantation in a severe OA mouse model significantly diminished the OA-associated knee inflammation and cartilage degenerative grade, significantly increasing the production of glycosaminoglycan and inducing endogenous chondrogenesis in comparison with the control group. (hindawi.com)
  • method
  • This problem led researchers from the laboratories of Farshid Guilak (Washington University, St. Louis, Missouri) and Charles A. Gersbach (Duke University, Durham, North Carolina, USA) to combine a rapid and highly reproducible protocol for hiPSC chondrogenesis broadly applicable across various hiPSC lines with a method to purify chondroprogenitors (CPs). (stemcellsportal.com)