Over the past 10 years, Chesney's research group has discovered the roles of several metabolic enzymes in the development and progression of lung cancer, including 6-phosphofructo-2-kinase 3, choline kinase and cytochrome c oxidase. (uoflnews.com)
An alternative hypothesis implicates direct basal ganglia damage due to dysfunction of cytochrome-c oxidase. (medscape.com)
Accumulation of propionic acid apparently results in an abnormal cytochrome-c oxidase. (medscape.com)
Acetylcholinesterase-choline oxidase2
Quantitative screening and resolution of carbamic and organoposphate pesticides mixture in extra virgin olive oil by acetylcholinesterase-choline oxidase sensor. (springer.com)
Based on the acetylcholinesterase/choline oxidase dual enzyme-mediated cascade catalytic reactions of Fe(2+)/Fe(3+) transformation, a ratiometric fluorescence sensing scheme is developed. (inra.fr)
Enzyme4
In enzymology, a choline oxidase (EC 1.1.3.17) is an enzyme that catalyzes the chemical reaction choline + O2 ⇌ {\displaystyle \rightleftharpoons } betaine aldehyde + H2O2 Thus, the two substrates of this enzyme are choline and O2, whereas its two products are betaine aldehyde and H2O2. (wikipedia.org)
The systematic name of this enzyme class is choline:oxygen 1-oxidoreductase. (wikipedia.org)
For illustration, the enzyme cholinesterase and choline oxidase is used for the sensing of organophosphorous pesticides. (lyceecharlesdegaulle.eu)
For samples that contain choline, prepare a blank control reagent with no PLD Enzyme (i.e., 85 µL Assay Buffer, 1 µL Enzyme Mix and 1 µL Dye Reagent). (gentaur.nl)
Arthrobacter2
Moneymaker') was transformed with the choline oxidase gene codA from Arthrobacter globiformis, which was modified to allow for targeting to both chloroplasts and the cytosol. (oregonstate.edu)
LuxAB was used to screen the substrate scopes of three prokaryotic oxidoreductases: an alcohol dehydrogenase (Pseudomonas putida), a choline oxidase variant (Arthrobacter chlorophenolicus) and a carboxylic acid reductase (Mycobacterium marinum). (tuni.fi)
Choline dehydrogenase ( betA ) of E . coli catalyses the first step in glycine betaine biosynthesis, the oxidation of choline. (scialert.net)
It detects choline, the ChE reaction product, though a multi-step process in which the oxidation of choline by choline oxidase results in the formation of H202, which is detected though a horseradish peroxidase-coupled reaction with 10-acetyl-3,7- dihydroxyphenoxazine (Amplex Red). (cdc.gov)
Betaine10
In this study, choline dehydrogenase ( betA ) gene encoding for glycine betaine biosynthesis in Escherichia coli isolated from salted shark ( Scoliodon sp. (scialert.net)
betaine biosynthesis is catalyzed by choline monooxygenase in combination with betaine aldehyde dehydrogenase. (scialert.net)
In E . coli , the biosynthetic pathway for the production of glycine betaine from choline has been well characterized at the genetic level ( Landfald and Strom, 1986 ). (scialert.net)
In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyze the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine. (expasy.org)
We give a mechanistic understanding of observed concentration differences in one-carbon metabolism and explain why women have lower S-andenosylmethionine, lower homocysteine, and higher choline and betaine. (biomedcentral.com)
Betaine is obtained by humans from foods, either as betaine or choline-containing compounds. (chemeurope.com)
Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. (unl.edu)
Oxidoreductase3
Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve. (mpg.de)
Pyranose 2-oxidase (POx) belongs to the GMC (glucose-methanol-choline) oxidoreductase superfamily of flavoenzymes. (boku.ac.at)
This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. (unl.edu)
Reaction1
Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified [Cellular processes, Adaptations to atypical conditions]. (unl.edu)
Monoamine oxidase1
It is inactivated by reuptake in the presynaptic terminal and degraded by monoamine oxidase and catechol-O-methyltransferase. (medscape.com)
Catalytic mechanism1
15369826 10.1016/J.ABB.2004.07.011 4 'On the Catalytic Mechanism of Choline Oxidase' J.Am.Chem.Soc. (rcsb.org)
Biosensor1
Tsafack, V.C., Marquette, C.A. , Pizzolato, F. and Blum, L.J. Chemiluminescent choline biosensor using histidine-modified peroxidase immobilised on metal-chelate substituted beads and choline oxidase immobilised on anion-exchanger beads co-entrapped in a photocrosslinkable polymer. (univ-lyon1.fr)
Determination of glucose1
Marquette C.A. and L.J. Blum, Self-containing reactant Biochips for the electrochemiluminescent determination of glucose, lactate and choline. (univ-lyon1.fr)
Sequence analysis1
Moreover, the sequence analysis of choline dehydrogenase from our isolate shows several base substitutions with that of reported sequences in GenBank, resulting in the altered amino acid sequences of the translated proteins. (scialert.net)
Carboxylic acid1
TMG is related to choline (trimethylaminoethanol) has been reduced from a terminal carboxylic acid to a hydroxyl group. (chemeurope.com)
Substrate1
12637017 '10.1016/S1570-9639(03)00003-7' 3 'The Trimethylammonium Headgroup of Choline is a Major Determinant for Substrate Binding and Specificity in Choline Oxidase' Arch.Biochem.Biophys. (rcsb.org)
Metabolism2
effects of drugs on choline-containing phospholipid metabolism. (gentaur.nl)
Brain hippocampal oxidative metabolism was measured using cytochrome oxidase histochemistry (CO) in CA1, CA3 and dentate gyrus regions. (psicothema.com)
Peroxidase1
Molecular docking was adopted to predict the catalytic interaction of chosen toxic diazo colorant, Congo red (CR), with four dye-degrading enzymes (laccase, lignin peroxidase, azoreductase, and aryl alcohol oxidase). (bvsalud.org)
Alcohol1
Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. (unl.edu)