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Cholesterol Ester Transfer ProteinsCholesterol EstersGlycoproteinsCarrier ProteinsLipoproteins, HDLCholesterol, HDLPhosphatidylcholine-Sterol O-AcyltransferaseApolipoprotein A-ILipoproteinsCholesterolApolipoproteinsLipoproteins, LDLEstersHyperlipoproteinemiasTriglyceridesLipoproteins, VLDLApolipoprotein C-IPhospholipid Transfer ProteinsQuinolinesApolipoprotein A-IISterol O-AcyltransferaseCholesterol, VLDLSterol EsteraseApolipoproteins BLipidsAnticholesteremic AgentsLipoproteins, HDL3LipaseLipoprotein LipaseEsterificationCholesterol, LDLLiverCholesterol, DietaryHigh-Density Lipoproteins, Pre-betaScavenger Receptors, Class BApolipoproteins COxazolidinonesApolipoproteins AHypertriglyceridemiaApolipoproteins EBiological TransportLipid Metabolism, Inborn ErrorsKineticsLipid MetabolismHypercholesterolemiaPhospholipidsOrganosilicon CompoundsHyperlipidemiasProbucolWolman DiseaseArteriosclerosisReceptors, LDLHypolipidemic AgentsCholesterol Ester Storage DiseaseAntigens, CD36Particle SizeEmulsionsMice, TransgenicChylomicronsRabbitsSulfhydryl CompoundsHeptanoic AcidsReceptors, LipoproteinOleic AcidReceptors, ScavengerMacaca fascicularisDyslipidemiasLipoproteins, HDL2MacrophagesApolipoprotein C-IIIReticulocytosisDietary FatsOxepinsAtherosclerosisPyrrolesPolymorphism, GeneticFoam CellsCricetinaeTritiumRNA, MessengerOleic AcidsCarboxylic Ester HydrolasesHyperlipoproteinemia Type IIMesocricetusBlood Protein ElectrophoresisFatty AcidsDiet, AtherogenicTrioleinCell LineATP Binding Cassette Transporter 1HomozygoteHydroxymethylglutaryl-CoA Reductase InhibitorsApolipoprotein E3GenotypeMolecular Sequence DataHydrolysisGene Transfer TechniquesCells, CulturedElectrophoresis, Polyacrylamide GelReference Values
CETPLipoproteinsProtein inhibitorsApolipoproteinLipoproteinInhibitionProteinsCholesterolPhospholipid transfer proteinAlzheimer'sSimilar
CETP26
  • Cholesteryl ester transfer protein (CETP), also called plasma lipid transfer protein, is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. (wikipedia.org)
  • Most of the time, however, CETP does a heteroexchange, trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride. (wikipedia.org)
  • Cholesteryl ester transfer protein (CETP) catalyzes the transfer of cholesteryl ester from high-density lipoprotein (HDL) to apolipoprotein B-containing lipoproteins in exchange for triglyceride, and thereby plays a major role in lipoprotein metabolism. (cims-ops.cz)
  • In vitro fluorogenic assays of CETP-mediated TG and CE transfer For perseverance of in vitro CETP transfer activity, a continuing fluorogenic assay defined previously (64) was utilized. (phytid.org)
  • The cholesteryl ester transfer protein (CETP) has a central role in the lipid metabolism and therefore may alter the susceptibility to atherosclerosis. (biomedcentral.com)
  • Since the discovery of cholesteryl ester transfer protein (CETP) and its identification as a modulator of HDL-C levels (mediates the exchange of lipids between lipoproteins), there has been much speculation about its role in CAD [ 17 ]. (biomedcentral.com)
  • Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. (uai.cl)
  • This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID). (biomedcentral.com)
  • The LDL:HDL ratio in humans is set mainly by CETP activity, which exchanges cholesteryl esters for triglycerides across lipoprotein fractions to raise LDL and lower HDL as CETP activity increases. (biomedcentral.com)
  • and 3) describing the functions of cholesteryl ester transfer protein (CETP) in regulating the LDL:HDL ratio in humans, including therapeutic strategies targeting CETP. (biomedcentral.com)
  • Cholesteryl ester transfer protein (CETP) DNA polymorphisms Population study Italians Greeks Original Paper Hum. (karger.com)
  • The scientists were interested in a gene that codes for the cholesteryl ester transfer protein (CETP). (iflscience.com)
  • This is a cholesteryl ester transfer protein (CETP) inhibitor, and I'd like to get your take on that as well. (medscape.com)
  • This CETP inhibition, which exchanges a triglyceride molecule for a cholesteryl ester molecule between HDL-C-containing and apolipoprotein B (ApoB)-containing particles, also this particular therapeutic has been shown in prior studies to decrease ApoB significantly and, actually, to even decrease Lp(a), which is interesting. (medscape.com)
  • CETP Inhibitors (cholesteryl ester transfer protein inhibitors) are still under development. (wikidoc.org)
  • The companies agreed to co-develop BMS-795311, BMS'preclinical small-molecule inhibitor of the Cholesteryl Ester Transfer Protein(CETP). (drugdiscoverynews.com)
  • Merck (NYSE: MRK), known as MSD outside the U.S. and Canada, today announced that the company will not submit applications for regulatory approval for anacetrapib, Merck's investigational cholesteryl ester transfer protein (CETP) inhibitor. (merck.com)
  • Moreover, thyroid hormones stimulate the cholesteryl ester transfer protein (CETP), an enzyme which transports cholesteryl esters from HDL2 to the very low density lipoproteins (VLDL) and triglycerides in the opposite direction 9 (figure). (hormones.gr)
  • Aloïs Dusuel and colleagues at the University of Burgundy recently published findings in the Journal of Lipid Research that a protein tightly related to key players of the RLT pathway, cholesteryl ester transfer protein, or CETP, does not contribute to the binding and transfer of LPS in plasma. (asbmb.org)
  • The adverse effects of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib on cardiovascular outcome, which were observed despite a substantial increase in HDL levels, have suggested that a better understanding of the vascular effects of HDL from patients with CAD is urgently required. (health.am)
  • Cholesteryl ester transfer protein (CETP) deficiency is a rare autosomal recessive disorder caused by a mutation of the CETP gene. (msdmanuals.com)
  • Because CETP helps in the transfer of cholesterol from HDL to other lipoproteins, CETP deficiency affects low-density lipoprotein (LDL) cholesterol levels and slows removal of HDL cholesterol from the blood. (msdmanuals.com)
  • With the trial meeting its primary and secondary endpoints, results provide evidence use of the once-daily, oral, low-dose cholesteryl ester transfer protein (CETP) inhibitor from NewAmsterdam Pharma Company, in combination with ezetimibe, was associated with statistically significant and clinically meaningful reductions in LDL-C and apolipoprotein B (ApoB). (consultantlive.com)
  • 2010). Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. (bvsalud.org)
  • Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction. (cdc.gov)
  • Increases in HDL-C levels may also be attributable to decreasing plasma cholesteryl ester transfer protein (CETP) activity by statins. (medscape.com)
Lipoproteins3
Protein inhibitors2
  • Raising high-density lipoprotein with cholesteryl ester transfer protein inhibitors. (cims-ops.cz)
  • Evacetrapib is the third drug in a group called cholesteryl ester transfer protein inhibitors meant to disrupt the process turning HDL cholesterol into LDL, or "bad," cholesterol. (upi.com)
Apolipoprotein1
  • 2004). Apolipoprotein e and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies . (up.pt)
Lipoprotein2
  • Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. (hjarta.is)
  • Phospholipid transfer protein: its impact on lipoprotein homeostasis and atherosclerosis. (nih.gov)
Inhibition1
  • Multiple linear regression analysis and optimal descriptors: predicting the Cholesteryl Ester Transfer Protein inhibition activity" QSAR & Combinatorial Science 2008 , 27 , 595-606. (jsums.edu)
Proteins2
  • The same fold is shared by Bacterial Permeability Inducing proteins (examples: BPIFP1 BPIFP2 BPIFA3 and BPIFB4), phospholipid transfer protein (PLTP), and long-Palate Lung, and Nasal Epithelium protein (L-PLUNC). (wikipedia.org)
  • The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. (nih.gov)
Cholesterol1
  • Despite cholesterol being delivered as cholesteryl ester in adipocytes, approximately 95% of cholesterol paradoxically exists as free cholesterol (FC) ( 7 ) and resides in the plasma membrane or the cytosolic interface of lipid droplets where it is readily available for mobilization ( 8 ). (diabetesjournals.org)
Phospholipid transfer protein2
  • Plasma Phospholipid Transfer Protein Promotes Platelet Aggregation. (nih.gov)
  • PhosphoLipid transfer protein (PLTP) exerts a direct pro-inflammatory effect on rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) independently of its lipid transfer activity. (nih.gov)
Alzheimer's1
Similar1
  • In short, this assay methods the CE or TG transfer half-reaction utilizing a artificial donor particle very similar in proportions and thickness to HDL-C, which bears a core of fluorescent TG or CE. (phytid.org)