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  • lipids
  • It is the densest because it contains the highest proportion of protein to lipids. (wikipedia.org)
  • Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). (wikipedia.org)
  • The three main purposes of metabolism are the conversion of food/fuel to energy to run cellular processes, the conversion of food/fuel to building blocks for proteins, lipids, nucleic acids, and some carbohydrates, and the elimination of nitrogenous wastes. (wikipedia.org)
  • Steroids such as cholesterol are another major class of lipids. (wikipedia.org)
  • coronary artery
  • Coronary artery disease Hypertension Loeys-Dietz Syndrome Hypercholesterolemia Hyperhomocysteinemia Elevated C-reactive protein Tobacco use Peripheral vascular disease Marfan syndrome Ehlers-Danlos type IV Bicuspid Aortic Valve Syphilis IgG4-related disease Pregnancy An aortic aneurysm can occur as a result of trauma, infection, or, most commonly, from an intrinsic abnormality in the elastin and collagen components of the aortic wall. (wikipedia.org)
  • hydrophobic
  • In addition it serves for long-range transport of hydrophobic intercellular messengers, like the morphogen Indian hedgehog (protein). (wikipedia.org)
  • liver
  • HDL transports cholesterol mostly to the liver or steroidogenic organs such as adrenals, ovary, and testes by both direct and indirect pathways. (wikipedia.org)
  • Clinically, the choice of an agent will depend on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of the patient, evaluated against the balancing of risks and benefits of the medications. (wikipedia.org)
  • plasma
  • Using exogenously radiolabeled 125 I-apoA-I and monoexponential analysis, they reported that niacin dose-dependently decreased the clearance of apoA-I from plasma (associated with reduced uptake by the kidney), but did not alter the hepatic secretion of apoA-I nor the biliary and fecal excretion of cholesterol. (ahajournals.org)
  • Lipoprotein(a) is not fully synthesized until the precursor protein is released from the cell, so the slower rate of production for the larger isoforms limits the plasma concentration. (wikipedia.org)
  • It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. (wikipedia.org)
  • metabolism
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • ACAT
  • The mechanism scheme is as follows: Acyl-CoA + Cholesterol ←→ CoA + Cholesteryl ester There are two isoforms of SOAT (also sometimes referred to as ACAT) that have been reported to date: SOAT1 and SOAT2. (wikipedia.org)
  • statins
  • Drugs that interfere with the action of these peptides would aid in lowering cholesterol levels by complementing the action of the statins that inhibit the endogenous production of cholesterol. (wikipedia.org)
  • Statins are particularly well suited for lowering LDL, the cholesterol with the strongest links to vascular diseases. (wikipedia.org)
  • good cholesterol
  • thus the cholesterol carried within HDL particles (HDL-C) is sometimes called "good cholesterol" (despite being the same as cholesterol in LDL particles). (wikipedia.org)
  • Level of the good cholesterol HDL is also increased. (wikipedia.org)
  • The drug was aimed at raising the blood levels of "good cholesterol" (cholesterol carried in HDL particles, aka HDL-C). Prevailing observations indicate that high HDL levels correlate with better overall cardiovascular health, though it remains unclear whether raising HDL levels consequently leads to an increase in cardiovascular health. (wikipedia.org)
  • cardiovascular
  • Torcetrapib (CP-529,414, Pfizer) was a drug being developed to treat hypercholesterolemia (elevated cholesterol levels) and prevent cardiovascular disease. (wikipedia.org)
  • Those with higher levels of HDL-C tend to have fewer problems with cardiovascular diseases, while those with low HDL-C cholesterol levels (especially less than 40 mg/dL or about 1 mmol/L) have increased rates for heart disease. (wikipedia.org)
  • transporter
  • the complexes are capable of picking up cholesterol, carried internally, from cells by interaction with the ATP-binding cassette transporter A1 (ABCA1). (wikipedia.org)