Cholesterol atherosclerosis models cardiovascular. Medical search. Frequent questions

Low levels of habitual physical activity have been identified as a major risk factor for cardiovascular diseases. (cdc.gov)
Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. (frontiersin.org)
In the past decades, unambiguous evidence has been provided that heightened oxidative stress and vascular wall inflammation are the key mechanisms for initiation and progression of atherosclerosis and vascular diseases associated with the risk factors ( Hansson and Hermansson, 2011 ). (frontiersin.org)
Therefore, elucidation of mechanisms underlying oxidative stress and inflammations in the vascular wall will have important impact in understanding atherosclerosis and vascular diseases associated with cardiovascular risk factors and will eventually lead to novel and effective therapeutic modalities. (frontiersin.org)
The gene also likely has roles in related cardiovascular diseases, including high blood pressure and diabetes. (wustl.edu)
Their findings could lead to new therapies to treat or prevent heart disease - the leading cause of death in the United States - as well as answer key questions about other diseases associated with high cholesterol levels, including some types of cancer. (science20.com)
In addition, the findings also suggest answers to questions about other diseases associated with high blood cholesterol levels, including cancer. (science20.com)
According to a 2019 consensus report on periodontitis and cardiovascular diseases, CVD is responsible for 17.9 million deaths worldwide each year. (colgateprofessional.com)
The institute organised and was actively engaged in research in the field of hypertension, atherosclerosis, coronary diseases and impaired blood circulation regulation. (ikem.cz)
The first group of hypertension and renal disease was managed by Jan Brod, the group of coronary artery diseases was managed by Vilém Ganz, the group of atherosclerosis by Tibor Zemplényi, the group of circulatory regulation by Zdeněk Fejfar, and the group of higher nervous activity by Valtr Ehrlich. (ikem.cz)
Hyperlipidemia, characterized by the abnormal blood lipid profiles, is one of the dominant factors of many chronic diseases such as diabetes, obesity, and cardiovascular diseases (CVD). (hindawi.com)
Hyperglycemia significantly increases the risk of cardiovascular diseases development, and premature death in the population [ 1 ]. (medsci.org)
Obesity has been linked with cardiometabolic disorders such as insulin resistance, atherogenic dyslipidemia and hypertension as well as cardiovascular diseases [ 1 ]. (biomedcentral.com)
Recent findings suggest that DNA methylation changes are related to the development and progression of a group of human diseases including atherosclerosis. (biomedcentral.com)
The theoretical analysis on blood flow is very useful as it plays a significant role to diagnose and understand many cardiovascular diseases such as coronary thrombosis, angina, pectoris, strokes etc. (scirp.org)
Lipoprotein(a) and cardiovascular diseases. (cdc.gov)
Cardiovascular diseases (hereinafter CVD) are the main reason for early loss of work capacity (at an age below 65) and death in Estonia. (who.int)
The experience of other countries shows that cardiovascular diseases can be reduced by long-term programmes covering multiple disciplines and enlisting the population extensively. (who.int)
to provide the prerequisites and conditions for each child born in this millennium to enable him or her to live to at least an age of 65 without suffering from avoidable cardiovascular diseases. (who.int)
Cardiovascular diseases are the main cause of premature deaths and disability throughout the world. (who.int)

Work time was positively associated with accelerated progression of carotid atherosclerosis. (cdc.gov)
ii) There are reports of a correlation between carotid atherosclerosis and AD ( 7 ) as well as atherosclerosis of the circle of Willis and AD ( 8 , 9 ). (spandidos-publications.com)
Whereas visceral abdominal adipose tissue (VAT) is associated with cardiometabolic risk, there is debate regarding the role of subcutaneous abdominal adipose tissue (SAT). The aim of this study was to investigate the relationships of subcutaneous and visceral abdominal fat with carotid atherosclerosis in patients with type 2 diabetes mellitus (T2DM). (biomedcentral.com)
SFT assessed by US was inversely associated with carotid atherosclerosis in patients with T2DM, particularly men. (biomedcentral.com)
Moreover, no previously published studies investigated the effects of SFT on US to detect carotid atherosclerosis in T2DM. (biomedcentral.com)
Therefore, the aim of this study was to investigate and compare the relationships of SFT and VFT with carotid atherosclerosis and cardiovascular risk factors in patients with T2DM. (biomedcentral.com)
Among them, patients who had undergone thorough evaluations for carotid atherosclerosis and abdominal SFT and VFT were included in this study. (biomedcentral.com)
However, I expected a slower development of carotid atherosclerosis in the hormone users, whereas results were neutral in this respect, despite beneficial metabolic alterations in the HT arms (i.e. lower cholesterol and better glucose handling). (menopause.org.au)

In fact, several recent prospective studies linked higher levels of OPA with accelerated progression of atherosclerosis, cardiovascular morbidity, and increases in mortality. (cdc.gov)
Regardless of the specific occupational conditions that may constitute the pathways for the observed relationships between long work time and progression of atherosclerosis, findings suggest that reducing weekly and yearly work time could have significant cardiovascular and public health benefits, especially in the aging working population. (cdc.gov)
This progression to advanced lesions is largely dependent on diabetes-induced dyslipidemia, because hyperlipidemic diabetic and nondiabetic mice with similar plasma cholesterol levels show a similar extent of atherosclerosis. (jci.org)
stream Reductions in the expression levels of these receptors resulted in decreased cholesterol efflux to apoA-I and HDL.163 Further, consistent with other studies,165-169 it was found that diabetes mellitus enhanced both atherosclerosis progression and impaired regression and that global deletion of RAGE overcame these defects by restoration of ABCA1 and ABCG1, promoting macrophage CEC despite ongoing hyperglycemia.163,170. (skanestugan.se)
These findings suggested that CA is an effective treatment approach for preventing atherosclerotic lesion progression attributed to protection against oxidative stress and various enzymatic activities in the Ath model. (hindawi.com)
One of the most common causes of CVDs is hypercholesterolemia, and an increase in serum LDL-C and TC are the most important risk factors for the development of inflammatory insult, damage to the vessel wall, platelet activation, and subsequent progression of atherosclerosis [ 6 ]. (hindawi.com)
The model] suggests that there is an association between long-term exposure to ozone and progression of atherosclerosis," he goes on to report. (medicalnewstoday.com)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
During 48 months of treatment with either type of HT vs. placebo, there were no apparent effects, either beneficial or deleterious, on atherosclerosis progression assessed by carotid ultrasound and a non-significant trend toward less accumulation of coronary artery calcium. (menopause.org.au)
In the Q&A section, the goal is phrased a little differently - 'To learn whether menopausal hormone therapy given to healthy women early in menopause would have an effect on progression of atherosclerosis as indicated by changes over time in arterial imaging. (menopause.org.au)
Dr. Bornfeldt's laboratory has shown, using a mouse model of type 1 diabetes-accelerated atherosclerosis, that diabetes stimulates both initiation of lesions of atherosclerosis and progression to advanced lesions. (diabetescenters.org)
Using MESA (Multi-Ethnic Study of Atherosclerosis), Budoff et al [ 6 ] examined the relationship of CAC progression to CHD outcomes in a cohort of 6778 subjects with an interscan interval of 2.5 years. (medscape.com)
However, no data were provided regarding the incremental value of CAC progression to baseline CAC regarding metrics such as improvement in the C statistic of the model or net reclassification improvement. (medscape.com)
Although various measures of CAC progression were independently associated with outcomes, none of the 10 CAC progression algorithms demonstrated an improvement in the C statistic or net reclassification of risk for hard CHD or hard ASCVD compared with models including risk factors and baseline CAC score. (medscape.com)
The etiology of atherosclerosis is unknown, but there are multiple factors that contribute to atherosclerotic plaque progression. (medscape.com)

Mechanisms of pathogenesis of atherosclerosis are complex interplay between bloodstream cells and arterial wall components that leads to a chronic state of vascular oxidative stress and inflammation ( Hansson and Hermansson, 2011 ). (frontiersin.org)
We propose that racial residential segregation and discrimination increases tissue inflammation and cytokine production, resulting in dysregulated immune signaling, which promotes plaque formation and cardiovascular disease. (frontiersin.org)
Once advanced atherosclerotic plaques are established, the process by which they undergo a reduction in one or more standard parameters (size, lipid content, foam cell content, and macrophage inflammation) is termed atherosclerosis regression. (skanestugan.se)
KLK10 acts in a different way, not affecting cholesterol, but instead inhibiting inflammation in endothelial cells. (emoryhealthsciblog.com)
vi) APP transgenic mice with apolipoprotein E (ApoE) deficiency had increased atherosclerosis and vascular inflammation ( 16 ). (spandidos-publications.com)
Current research focuses on the role glucose and acyl-CoAs might play in endothelial dysfunction, inflammation and diabetes-accelerated atherosclerosis. (diabetescenters.org)
Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)

A secondary aim of this study was to investigate whether these occupational risk factors are more strongly associated with change in IMT among men with pre-existing ischemic heart disease (IHD) or carotid artery stenosis (CAS) compared to men without these conditions as would be expected according to the hemodynamic theory of atherosclerosis. (cdc.gov)
Risk factors for atherosclerosis alone aren't accurate enough in predicting cardiovascular disease in adults with no history of atherosclerosis disease. (escardio.org)
Multidetector computed tomography may be a useful non-invasive technique to detect silent coronary artery disease in patients with peripheral preclinical atherosclerosis. (escardio.org)
The presence of one or more risk factors for atherosclerosis (ATS) is associated with the development of cardiovascular disease (CVD). (escardio.org)
Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. (jci.org)
A new study from Washington University School of Medicine in St. Louis has identified a gene - called SVEP1 - that makes a protein that influences the risk of coronary artery disease independent of cholesterol. (wustl.edu)
But now, scientists at Washington University School of Medicine in St. Louis have identified a gene that likely plays a causal role in coronary artery disease independent of cholesterol levels. (wustl.edu)
Cardiovascular disease remains the most common cause of death worldwide," said cardiologist Nathan O. Stitziel, MD, PhD , an associate professor of medicine and of genetics. (wustl.edu)
A major goal of treatment for cardiovascular disease has appropriately been focused on lowering cholesterol levels. (wustl.edu)
But there must be causes of cardiovascular disease that are not related to cholesterol - or lipids - in the blood. (wustl.edu)
We can decrease cholesterol to very low levels, and some people still harbor residual risk of future coronary artery disease events. (wustl.edu)
This is not the first nonlipid gene identified that has been implicated in cardiovascular disease. (wustl.edu)
According to Stitziel, other genes previously identified as raising the risk of cardiovascular disease independent of cholesterol appear to have widespread roles in the body and are therefore more likely to have far-reaching undesirable side effects if blocked in an effort to prevent cardiovascular disease. (wustl.edu)
Similarly, the research found that statins, drugs that lower cholesterol levels, enhance the responsiveness of cardiovascular cells to the protective actions of TGF-beta, thus helping prevent the development of atherosclerosis and heart disease. (science20.com)
Atherosclerosis is a complex multifactorial disease, often preceding the development of diabetic macrovascular complications. (biomedcentral.com)
Some are responsible for new flavors and some, according to a new study published in the Journal of Dairy Science, may protect us against cardiovascular disease. (news-medical.net)
Obese children who begin a low-fat, plant-based vegan diet may lower their risk of heart disease through improvements in their weight, blood pressure, body mass index, cholesterol levels, insulin sensitivity, and high-sensitivity C-reactive, according to Cleveland Clinic research published online today by The Journal of Pediatrics. (news-medical.net)
In new findings led by researchers at Brigham and Women's Hospital in Boston and Johns Hopkins University in Baltimore, researchers looked at glycemic index' effect on cardiovascular disease (CVD) and diabetes and found that low glycemic diets did not improve insulin sensitivity or cardiovascular risk factors. (news-medical.net)
Our recent findings published in Circulation indicated an association between several inflammatory disorders with cardiovascular disease (CVD). (ukbiobank.ac.uk)
The findings will facilitate enhanced risk prediction modelling and identify potential therapeutic targets for inflammatory disease patients. (ukbiobank.ac.uk)
Racist and discriminatory federal, state, and local housing policies significantly contribute to disparities in cardiovascular disease incidence and mortality for individuals that self-identify as Black or African American. (frontiersin.org)
This framework has the power to link structural racism not only to cardiovascular disease, but also to cancer. (frontiersin.org)
In this address, the AHA declared structural racism a key cause of premature death from cardiovascular disease ( 3 ) and called for change through strategic goals and increased focus on health equity ( 3 ). (frontiersin.org)
Despite the significance of atherosclerotic cardiovascular disease to healthcare, the pathophysiology of atherosclerosis is not fully understood. (ulster.ac.uk)
Previously, computational models of disease pathways have aided in combinatorial drug discovery, and have led to the generation of therapeutic hypotheses. (ulster.ac.uk)
In this article, we discuss the growing body of evidence showing the link between cardiovascular disease (CVD) and periodontitis and how dental students can help to prevent and manage periodontitis in their patients. (colgateprofessional.com)
There is a positive association between periodontitis and higher cardiovascular mortality due to coronary heart disease and cerebrovascular disease. (colgateprofessional.com)
Some strains of oral bacteria associated with periodontal disease have been shown to accelerate atherosclerosis and induce arterial lesions in animal models. (colgateprofessional.com)
Deciphering the role of lipid droplets in cardiovascular disease: a report from the 2017 National Heart, Lung, and Blood Institute Workshop. (skanestugan.se)
HDL and cardiovascular-disease risk-time for a new approach? (skanestugan.se)
endobj The high concentration of low-density lipoprotein cholesterol (LDL-c) is an independent risk factor for coronary artery disease. (skanestugan.se)
High-density lipoprotein cholesterol and cardiovascular disease. (skanestugan.se)
Using a workhorse model of disturbed blood flow in atherosclerosis , his team has steadily identified a stream of genes involved in the disease process. (emoryhealthsciblog.com)
It could serve as a platform for cell-based therapy by avoiding the problems of current stem cell-based approaches, and for disease modeling and drug development. (emoryhealthsciblog.com)
Another example, Dr. Taylor adds, is that epidemiologic studies have shown that as women with endometriosis age, they have a higher incidence of cardiovascular disease, which was previously attributed to the medications used to treat endometriosis. (yalemedicine.org)
Another risk factor for cardiovascular disease, he says, is hysterectomy (the surgical removal of the uterus), which can be used to treat endometriosis. (yalemedicine.org)
At present, cardiovascular origin disorders such as atherosclerotic cardiovascular disease (ASCVD) are the chief reason of illness and death across the globe [ 1 ]. (hindawi.com)
A study of 2,500 people with diabetes, published in October 2016 in the journal Nutrition Metabolism Cardiovascular Disease , found that following nutritional recommendations to limit added sugar in the diet was linked to significantly higher HDL cholesterol levels. (healthycholesterolclub.com)
Over 2.3mmol/L, HDL may behave more like LDL cholesterol and raise the risk of disease, according to current research. (healthycholesterolclub.com)
Cholesterol is one of the most important risk factors for cardiovascular disease, says Indu Poornima, MD, a cardiologist with Allegheny Health Network in Pittsburgh. (healthycholesterolclub.com)
We aimed to evaluate sex differences in cardiorespiratory fitness in a relatively healthy population and its association with cardiovascular disease (CVD) events. (cardiologyonline.com)
Although plasma L-carnitine did not meet the P -value cutoff for association with cardiovascular disease (CVD) using strict criteria, evaluation with less stringent criteria identified L-carnitine as a compound that was associated with CVD. (naturalmedicinejournal.com)
Atherosclerosis and Alzheimer's disease (AD) are a major cause of morbidity and mortality in Western societies. (spandidos-publications.com)
Atherosclerosis is considered to be a risk factor for cognitive deterioration in the elderly, including Alzheimer's disease (AD) ( 3 , 4 ). (spandidos-publications.com)
Several findings suggest that atherosclerosis and AD are linked: i) Atherosclerotic vascular disease and AD share common risk factors, such as hypertension, diabetes, hypercholesterolemia, and apolipoprotein ε4 allele ( 5 ). (spandidos-publications.com)
The ε4 allele has been associated with a higher risk of cardiovascular disease and AD, while the ε2 allele has a protective effect against AD. (spandidos-publications.com)
In 1963, Dr. W. F. Coulson and colleagues found that 22 of 33 experimental copper-deficient pigs died of cardiovascular disease. (blogspot.com)
11 of 33 died of coronary heart disease, the quintessential modern human cardiovascular disease. (blogspot.com)
Since this time, a number of papers have been published on the relationship between copper intake and cardiovascular disease in animals, including several showing that copper supplementation prevents atherosclerosis in one of the most commonly used animal models of cardiovascular disease ( 6 , 7 , 8 ). (blogspot.com)
For more than three decades, Dr. Klevay has been a champion of the copper deficiency theory of cardiovascular disease. (blogspot.com)
Yet questions have been raised about the relevance of this method to human cardiovascular disease, because studies have shown that the amount of time it takes copper to oxidize LDL in a test tube doesn't predict how much oxidized LDL you'll actually find in the bloodstream of the person you took the LDL from ( 10 , 11 ). (blogspot.com)
Atherosclerosis can lead to more dangerous cardiovascular events, such as coronary heart disease or peripheral artery disease , as well as a heart attack or stroke . (medicalnewstoday.com)
Wang and colleagues clinically followed 6,619 adults, who were 45-84 years old and who did not have cardiovascular disease or any other conditions at the start of the study. (medicalnewstoday.com)
The Cardiovascular Research Group has a wide range of cardiovascular research interests covering many aspects of health and disease. (aru.ac.uk)
His interests encompass the impact that the food and gut microbiota can have on inflammatory signalling in health and disease, and novel approaches to the engineering of immune responses in the context of immunotherapies for various conditions, including atherosclerosis. (aru.ac.uk)
This essential oil can provide protection against cardiovascular disease. (naturalherbals.net)
Tangier disease, familial hypoalphalipoproteinemia and familial deficiency of lecithin cholesterol acyltransferase deficiency]. (medscape.com)
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor? (medscape.com)
Recently, the pathogenesis of coronary atherosclerosis - a primary cause of cardiovascular disease - studied in a swine model has been investigated by considering in particular the effects of a high cholesterol diet lasting 8 or 16 weeks. (annexpublishers.com)
A second use case aims to develop models that predict a person's risk of developing atherosclerosis, a cardiovascular disease caused by build-up of fats, cholesterol, and other substances in and on the artery walls. (dutchlifescience.com)
Cardiovascular disease (CVD), mainly caused by atherosclerosis, is the leading cause of death worldwide. (einthovenlaboratory.com)
Therefore, we aim to investigate the mechanisms by which FGF21 improves cholesterol metabolism and unravel its effect on atherosclerosis development by using APOE*3-Leiden.CETP mice, a well-established human-like model for studies on (V)LDL and HDL metabolism, aiming at providing further preclinical evidence for developing FGF21 as a therapeutic strategy for the treatment of cardiovascular disease. (einthovenlaboratory.com)
People with type 1 or type 2 diabetes/insulin resistance have a greater risk of developing cardiovascular disease (myocardial infarction, stroke, and peripheral cardiovascular disease that can lead to the necessity to amputate limbs). (diabetescenters.org)
The cardiovascular disease is caused primarily by atherosclerosis. (diabetescenters.org)
Risk factors for cardiovascular disease associated with diabetes include inflammatory changes, sub-optimal metabolic control and lipid abnormalities, such as increased levels of triglycerides and fatty acids, and decreased levels of HDL cholesterol. (diabetescenters.org)
are the main reasons for ED. They include atherosclerosis (which also causes heart disease and peripheral artery disease), high blood pressure, diabetes, neurological disorders, medication side effects, prostate surgery, radiation treatment to the pelvis, and other health conditions. (limamemorial.org)
Familial hypercholesterolemia (FH), a genetic disorder of cholesterol metabolism affecting millions of people, has emerged as public health genomics priority for preventing premature morbidity and mortality from heart disease. (cdc.gov)
In addition, elevated lipoprotein (a) (Lp(a)) increases the risk of coronary heart disease, occur in 1 in 5 people, have a strong genetic basis, and accentuate the cardiovascular risk from FH and other risk factors. (cdc.gov)
This seminar will explore advances in FH and Lp(a) and the emerging clinical and public health approaches to reducing the burden of cardiovascular disease using genetics and family history. (cdc.gov)
These properties also offer the allure of quantifying change in atherosclerosis to better pinpoint and personalize atherosclerotic cardiovascular disease (ASCVD) risk estimates. (medscape.com)
Coronary atherosclerotic disease is a leading cause of mortality and morbidity due to major cardiovascular events in the United States and abroad. (bvsalud.org)
Abdominal Aortic Calcification is significantly associated with both cardiovascular heart disease and stroke even after adjustment for the traditional risk factors of age, cigarette use, diabetes mellitus, high systolic blood pressure, left ventricular hypertrophy, body mass index, and cholesterol (Szulc 2016, Schousboe 2017). (cdc.gov)
The worldwide incidence of type 2 diabetes (T2D) in children and for cardiovascular disease in adults. (who.int)
12] Screening should commence at 2 years trial, small very low-density lipoprotein (VLDL), small high- of age if there is a family history of hypercholesterolaemia, early density lipoprotein (HDL), medium low-density lipoprotein (LDL) cardiovascular disease or if the family history is unknown. (who.int)
Many people with diabetes will die from cardiovascular disease. (cdc.gov)
Therefore, controlling the risk factors for cardiovascular disease is of the utmost importance in reducing the risk for developing cardiovascular disease in the diabetic population. (cdc.gov)
In the U.S., important strides have been made in reducing the impact of several key risk factors for cardiovascular disease. (cdc.gov)

SVEP1 induces proliferation of vascular smooth muscle cells in the development of atherosclerosis. (wustl.edu)
However, the exact role of glucose variability in the development of atherosclerosis remains unclear. (biomedcentral.com)

When these mice are fed a cholesterol-free diet, diabetes, in the absence of associated lipid abnormalities, causes both accelerated lesion initiation and increased arterial macrophage accumulation. (jci.org)
The researchers also selectively reduced the protein in the arterial walls of mice, and this further reduced the risk of atherosclerosis. (wustl.edu)
Secondly, in a subsample of participants (N=190,000) we will test the hypothesis that inflammatory biomarkers and regulatory factors are associated with markers of atherosclerosis (arterial stiffness) and clinical outcomes. (ukbiobank.ac.uk)
Gathering of lipids within arterial walls is the hallmark feature in atherosclerosis that leads to fatty streak and formation of lipid-foam cells in the intima of an artery, which ultimately gets hardened and forms plaque, thereby causing artery constriction and hardening resulting in full blockage in later stages [ 7 ]. (hindawi.com)
New research suggests that chronic exposure to ambient ozone may raise the risk of atherosclerosis and harm arterial health. (medicalnewstoday.com)
This may indicate that the association between long-term exposure to ozone and cardiovascular mortality that has been observed in some studies is due to arterial injury and acceleration of atherosclerosis," comments Wang. (medicalnewstoday.com)
This lack of effect on the pace of arterial plaque formation is disappointing in view of previous data in animal models and clinical studies, but we should wait for the publication of full results. (menopause.org.au)
If atherosclerosis is present, the examination may reveal findings consistent with the affected arterial bed. (medscape.com)

They followed the participants for a mean period of 6.5 years, as part of the Multi-Ethnic Study of Atherosclerosis in which the participants had enrolled. (medicalnewstoday.com)

By using data of large population studies the concept of "Global Cardiovascular Risk" (GCVR) was defined and it was rapidly applied in clinical practice with the elaboration of risk charts, through the development of algorithms for primary prevention of CVD based on the simultaneous analysis of a few main risk factors (age, gender, diabetes, smoking, systolic blood pressure values and total cholesterol). (escardio.org)
The relative contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes are not clear, largely because there is a lack of suitable animal models. (jci.org)
We therefore have developed a transgenic mouse model that closely mimics atherosclerosis in humans with type 1 diabetes by breeding low-density lipoprotein receptor-deficient mice with transgenic mice in which type 1 diabetes can be induced at will. (jci.org)
The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation, according to a study in the March 10 issue of JAMA. (news-medical.net)
Brown adipose tissue (BAT) activation is a promising strategy to reduce atherosclerosis and its risk factors, including dyslipidemia, obesity and diabetes. (einthovenlaboratory.com)
Dr. Bornfeldt frequently serves on study sections on cardiovascular biology and the complications of diabetes at the NIH and the American Heart Association. (diabetescenters.org)
She is a Fellow of the Council of Basic Cardiovascular Sciences, American Heart Association, is Consulting Editor for Arteriosclerosis, Thrombosis and Vascular Biology, Associate Editor for Circulation Research, and is or has been a member of the editorial boards of the Journal of Clinical Investigation, Circulation Research, Diabetes, and the Journal of Biological Chemistry. (diabetescenters.org)
These cardiovascular complications also develop earlier in life compared to people without diabetes. (diabetescenters.org)
Dr. Bornfeldt's research focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that cardiovascular complications can be treated or prevented. (diabetescenters.org)
More resent research by Dr. Bornfeldt's group has identified a key step in the mechanism of diabetes-induced inflammatory changes and atherosclerosis. (diabetescenters.org)
Clinicians should therefore emphasize strategies to reduce cardiovascular risk even further among low-risk adults by treating modifiable risk factors (smoking, diabetes, blood pressure, hyperlipidemia, overweight, and exercise). (medscape.com)
Studies have reported that there has been an increase of 2 - 5% suicide or homicide were associated with non-HDL cholesterol in the annual incidence of type 1 diabetes (T1D) worldwide. (who.int)
Estimated risk was calculated using risk prediction algorithms from the UK Prospective Diabetes Study (UKPDS), the Atherosclerosis Risk in Communities study, and the Framingham Heart Study. (cdc.gov)
Sustained efforts in improving risk factors should further benefit the cardiovascular health of people with diabetes. (cdc.gov)

High cholesterol is the most commonly understood cause of atherosclerosis, a hardening of the arteries that raises the risk of heart attack and stroke. (wustl.edu)
It has long been known that high blood cholesterol is a key risk factor for developing atherosclerosis - sometimes called hardening of the arteries. (science20.com)

The study used primary care data with incomplete information on traditional vascular risk factors (ie hypertension, cholesterol) and demographic characteristics. (ukbiobank.ac.uk)
His primary research area is on the innate immune system and the mechanisms by which pattern recognition receptors within this system are regulated in vascular inflammatory pathologies such as atherosclerosis. (aru.ac.uk)
The reason behind the malfunction of cardio-vascular system is the presence of fats, cholesterol and lipoproteins at the sites of atherosclerotic lesion in the artery. (scirp.org)

The presence of preclinical atherosclerosis increases global cardiovascular risk - preclinical atherosclerosis can be considered an emerging determinant in assessing global cardiovascular risk. (escardio.org)
Cholesterol contributes to atherosclerosis - a condition that greatly increases the risk of heart attack and stroke - by suppressing the activity of a key protein that protects the heart and blood vessels, researchers at the Saint Louis University School of Medicine have found. (science20.com)
Dallas, TX 75231 Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice. (skanestugan.se)
But, again, studies now show that endometriosis itself, without hormonal treatments or hysterectomy, increases rates of atherosclerosis [the buildup of cholesterol plaque in the artery walls]," Dr. Taylor says. (yalemedicine.org)
When HDL is too lowbelow 45 mg/dl in women and 40 mg/dl in menyour risk of atherosclerosis, heart attack, and stroke increases. (healthycholesterolclub.com)
In humans, FGF21 also decreases plasma total and LDL-cholesterol, and increases HDL-cholesterol. (einthovenlaboratory.com)

1.2 - Relative effects of simple, refined and unrefined carbohydrate on cardiometabolic risk factors, macrophage cholesterol homeostasis, subcutaneous adipose tissue macrophage infiltration/inflammatory gene expression, and intestinal microbiome. (usda.gov)
Atherosclerosis is an inflammatory disorder characterized by the formation of plaque inside an artery wall. (ulster.ac.uk)
1][2][3] The protective functions of HDL are due to its role in reverse cholesterol transport (RCT) but also may be related to antioxidant and anti-inflammatory activities. (skanestugan.se)
Nonsteroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are very widely prescribed, but they may cause increased blood pressure (BP) and adverse cardiovascular (CV) events. (cardiologyonline.com)

To gain insight into the role of glycemic variability in the different stages of atherosclerosis, we used both ultrasonography and MRA to determine preclinical atherosclerosis and plaque formation. (biomedcentral.com)

Imaging tests can detect subclinical coronary atherosclerosis and aid initiation of targeted preventative efforts based on patient risk. (bvsalud.org)

Determine the effect of diets differing in fat and carbohydrate type on cardiometabolic risk indicators, lipoprotein and fatty acid metabolism, response to lipid modifying therapy, and gene-nutrient interactions, using human, animal and in vitro models. (usda.gov)
LAB NAME: Cardiovascular Nutrition In the next 5 years the Cardiovascular Nutrition Laboratory (CNL) will investigate the effects of diets differing in fat type and carbohydrate type on cardiometabolic risk factors, fatty acid metabolism, response to lipid modifying therapy, and gene-nutrient interactions using human, animal and in vitro models. (usda.gov)
There is evidence that levels of total cholesterol, low-density lipoproteins (LDL), triglycerides, and other blood lipid markers associated with CVD are elevated in periodontitis, while levels of protective lipid markers like high-density lipoprotein (HDL) are lowered. (colgateprofessional.com)
This work is aimed to examine the outcome of CA in atherogenic diet- (Ath-) induced rat model on lipid profile changes and endothelium function. (hindawi.com)
Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
ApoE is the main lipid carrier protein in the brain, and it is released by astrocytes in order to supply neurons with cholesterol. (spandidos-publications.com)
ABCA1 regulates the formation of nascent high-density lipoprotein (HDL) via cholesterol efflux to lipid free apolipoprotein A-1, whereas ABCG1 mediates cholesterol transport to the HDL fraction [ 13 ]. (biomedcentral.com)
New ATP III lipid guidelines update for patients at high risk for cardiovascular events. (medscape.com)

Pigs on a severely copper-deficient diet showed weakened and ruptured arteries (aneurysms), while moderately deficient pigs "survived with scarred vessels but demonstrated a tendency toward premature atherosclerosis" including foam cell accumulation ( 2 ). (blogspot.com)

Atherosclerosis is a major cause of morbidity and mortality in Western societies ( 1 , 2 ). (spandidos-publications.com)
the total mortality regarding cardiovascular causes an outcome that was not observed with the use of ARBs. (intechopen.com)

Elder age, increased systolic blood pressure, increased MBG and elevated low density lipoprotein cholesterol were independent contributors to plaque formation. (biomedcentral.com)
Also, CAC change was only the fifth strongest risk marker for CHD, following after baseline CAC, male sex, systolic blood pressure, and total cholesterol. (medscape.com)
Significant improvements in mean HbA 1c concentrations, systolic blood pressure, and the ratio of total cholesterol to HDL cholesterol occurred. (cdc.gov)

in the heart, it protects the aorta and other vessels from damage caused by a variety of factors, including hypertension and high blood cholesterol levels. (science20.com)

This led us to investigate whether FXI deficiency in elderly ApoE knockout (KO) mice would decrease pathological alterations compatible with atherosclerosis and AD. (spandidos-publications.com)
However, neither atherosclerosis nor AD‑associated pathological alterations in the elderly mice brains were observed in either the DKO mice or the ApoE KO mice. (spandidos-publications.com)
Therefore, the ApoE KO and DKO mice cannot serve as mouse models for studying AD or pathological brain changes compatible with atherosclerosis. (spandidos-publications.com)

A computational model of atherosclerosis has been built to study the process of atheroma formation and to suggest therapeutic hypotheses. (ulster.ac.uk)
With population data available from the 1000 Genomes Project, these new parameters can be used to study population specific dynamics of atherosclerosis, and subsequently suggest new therapeutic responses. (ulster.ac.uk)
New models of atherosclerosis and multi-drug therapeutic interventions. (ulster.ac.uk)
Lipoprotein(a): a risk factor for atherosclerosis and an emerging therapeutic target. (cdc.gov)

The association between different measures of work time, energy expenditure, and work postures with 11-year change in maximum IMT was evaluated in regression models adjusting for 21 potential confounders including among other factors cholesterol, body mass index, leisure time physical activity, smoking, socio-economic status, and job stress. (cdc.gov)
In patients without stenosis ( n = 63), SDBG ( r = 0.412, P = 0.001) and MAGE ( r = 0.365, P = 0.005) were both correlated with carotid IMT and these relationships remained significant in multiple linear regression analysis (multiple R 2 = 0.314 for the model including SDBG and multiple R 2 = 0.268 for the model including MAGE). (biomedcentral.com)
MEASUREMENTS AND MAIN RESULTS: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. (surrey.ac.uk)
In this case, I am evaluating the regression of atherosclerosis. (ethz.ch)
much evidence shows that if cholesterol is lowered there could be regression of atherosclerosis. (ethz.ch)
If I want to make a meta-regression with the cholesterol variable and I have the difference in cholesterol in the two branches, should I put the two differences in the model? (ethz.ch)

TGF-beta, it turns out, is a well- known tumor suppressor, and loss of TGF-beta's protective effects - caused by high blood cholesterol - could thus increase formation of these cancers, the findings suggest. (science20.com)
Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). (medscape.com)

Higher total cholesterol (TC) levels and low-density lipoprotein cholesterol (LDL-C) help immensely foster an atherosclerotic plaque in the coronary artery. (hindawi.com)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
Our aim was to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients younger than 18 years enrolled in a large national registry. (revespcardiol.org)
and low-density lipoprotein cholesterol (LDL-C). (who.int)

In animal models, we found that the protein induced atherosclerosis and promoted unstable plaque," Jung said. (wustl.edu)
Magnetic resonance angiography (MRA) was used to detect cervical and/or intracranial plaque, and ultrasonography was used to quantify carotid intima-media thickness (IMT) as an index of subclinical atherosclerosis. (biomedcentral.com)
and (ii) to explore the role of glycemic variability in both the subclinical stage and plaque formation stage of atherosclerosis in this population. (biomedcentral.com)
Atherosclerosis, or arteriosclerosis, happens when plaque collects and causes the arteries to narrow and harden, affecting blood flow. (medicalnewstoday.com)
The term atherosclerosis is derived from the Greek "athero," meaning gruel, or wax, corresponding to the necrotic core area at the base of the atherosclerotic plaque, and "sclerosis" for hardening, or induration, referring to the fibrous cap of the plaque's luminal edge. (medscape.com)

A previous study in a sample of middle-aged men and women found that higher amounts of subcutaneous abdominal fat are associated with lower levels of subclinical atherosclerosis[ 9 ]. (biomedcentral.com)

However, it remains unclear to what extent n-3 PUFAs may impact Reverse Cholesterol Transport (RCT). (skanestugan.se)

iii) In a transgenic mouse model of AD (B6Tg2576), early atherosclerosis lesions were detected and were positively correlated with cerebral β amyloid deposits when mice were fed a normal diet ( 11 ) or atherogenic diets ( 12 ). (spandidos-publications.com)

3. Identify novel biomarkers for food and nutrient intake related to dietary patterns and cardiovascular health. (usda.gov)
Furthermore, identifying new biomarkers of cardiovascular risk has the potential to refine early-life prevention strategies, before atherosclerosis becomes established. (bmj.com)

stream endstream MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. (skanestugan.se)

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. (naturalmedicinejournal.com)
However, the mechanisms underlying the effect of FGF21 on cholesterol metabolism, and the consequence of such modulation of cholesterol metabolism for atherosclerosis development, still needed to be investigated. (einthovenlaboratory.com)

However, whether atherosclerosis contributes to AD or they just share similar epidemiology is still not known. (spandidos-publications.com)

When diabetic mice are fed cholesterol-rich diets, on the other hand, they develop severe hypertriglyceridemia and advanced lesions, characterized by extensive intralesional hemorrhage. (jci.org)

Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages. (skanestugan.se)
Whether apoB-containing lipoproteins, which can also serve as cholesterol acceptors to facilitate RCT depending on the gradient, also enter peripheral tissues and drain into the lymph to regulate RCT remains to be investigated. (skanestugan.se)
Reverse cholesterol transport (RCT): process whereby cholesterol of peripheral cells is ultimately disposed into the feces via passage through plasma, liver, and biliary tract. (skanestugan.se)

But there are steps you can take to elevate your levels of HDL cholesterol. (healthycholesterolclub.com)
Background- Metabolic syndrome is defined by increased levels of LDL cholesterol and triglycerides and decreased levels of HDL cholesterol. (cardiologyonline.com)

Until now, however, the process by which cholesterol contributes to atherosclerosis has not been well understood. (science20.com)
16 0 obj MiR-33 contributes to the regulation of cholesterol homeostasis. (skanestugan.se)

One group of diabetic mice was treated with an intense insulin therapy (intense insulin) and fed the cholesterol-free diet. (jci.org)
We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients. (biomedcentral.com)
Poor glycaemic control, dyslipidaemia and HT are common in diabetic children, putting them at risk of cardiovascular complications in adulthood. (who.int)

Atherosclerosis is the result of fatty deposits - such as cholesterol , fat, or cellular waste - accumulating inside a person's arteries. (medicalnewstoday.com)
There were also reductions in serum triglycerides, free fatty acids, serum total cholesterol, and low-density lipoprotein (LDL) cholesterol, while increasing high-density lipoprotein (HDL) cholesterol. (naturalherbals.net)
Vaccenic acid and trans fatty acid isomers from partially hydrogenated oil both adversely affect LDL cholesterol: a double-blind, randomized controlled trial. (medscape.com)
Atherosclerosis Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or. (msdmanuals.com)

Cardiovascular Computed Tomography. (bvsalud.org)
Cardiovascular Imaging, Naval Medical Center Portsmouth, Board of Di- go to the ACR website at www.acr.org/ac to confirm that you are accessing rectors, Society of Cardiovascular Computed Tomography. (bvsalud.org)

Intake of diets with high content of cholesterol and saturated fats (i.e. (hindawi.com)

The CNL will determine the relationship between food preferences, consumption patterns and dietary acculturation, and cardiovascular health using population-based datasets by assessing the impact of acculturation status on dietary patterns and health outcomes. (usda.gov)

We can compare KLK10 to PCSK9 inhibitors , which lower LDL cholesterol and have a proven ability to prevent cardiovascular events. (emoryhealthsciblog.com)

Hospital - at risk of cardiovascular complications? (who.int)

HDL or high density lipoprotein has long been thought to have a positive effect on cardiovascular health. (healthycholesterolclub.com)

endobj Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. (skanestugan.se)

[ 4 ] There has been growing interest in exploring whether repeat CAC scanning, thereby evaluating change in the CAC score, could enhance cardiovascular risk prediction. (medscape.com)

This study gives us new insight into how cholesterol promotes atherosclerosis - and in turn, how it leads to heart attack and stroke," Dr. Huang added. (science20.com)

I guess that, even though a secondary cardiovascular endpoint (carotid artery wall thickness) was chosen as the main study target, which should have allowed statistically significant results in this relatively small, young cohort, these assumptions unfortunately failed. (menopause.org.au)
Coronary artery atherosclerosis is the single largest killer of men and women in the United States. (medscape.com)

Recent findings from our group and others demonstrate the involvement of coagulation factors in both atherosclerosis ( 27 , 28 ) and AD ( 29 , 30 ). (spandidos-publications.com)

Anatomy17

Organisms4

Diseases17

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes8

Technology, Industry, Agriculture2

Health Care2

Geographicals1

Diseases20

Carotid atherosclerosis8

Progression15

Inflammation7

Disease77

Development of atherosclerosis2

Arterial8

Multi-Ethnic Study of Atherosclerosis1

Diabetes14

Hardening of the a2

Vascular3

Increases6

Inflammatory4

Preclinical atherosclerosis1

Coronary atherosclerosis1

Lipid8

Premature atherosclerosis1

Mortality2

Systolic blood pr3

Hypertension1

ApoE3

Therapeutic4

Regression6

High blood chole2

Lipoprotein cholesterol4

Plaque5

Subclinical1

Remains unclear1

Transgenic mouse model1

Biomarkers2

Genes1

Metabolism2

Epidemiology1

Lesions1

Peripheral3

Levels of HDL cholesterol2

Contributes2

Diabetic3

Fatty4

Computed tomography2

Saturated fats1

Outcomes1

Lower LDL cholesterol1

Complications1

Effect on cardiovascular1

Hyperglycemia1

Risk prediction1

Promotes1

Artery2

Coagulation1