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Cholesteatoma, Middle EarCholesteatomaMastoidTympanoplastyEar DiseasesEar OssiclesEar, MiddleEar CanalOtitis Media, SuppurativeOtoscopyTympanic MembraneOtologic Surgical ProceduresTemporal BoneImmunohistochemistryMastoiditisPetrous BoneHearing Loss, ConductiveCochlear DiseasesProflavineOssicular ReplacementSecond-Look SurgeryCerebrospinal Fluid OtorrheaEar NeoplasmsIncusEcho-Planar ImagingOtitis MediaCranial Fossa, MiddleMiddle Ear VentilationFistulaSkull NeoplasmsOptical ImagingDiffusion Magnetic Resonance Imaging

EpitheliumMiddle earExpressionImagingStudyRevealsHumanDifficultLesionTissuePatients

Epithelium2

• In cholesteatoma epithelium, we found a fragmented basement membrane with small amounts of laminin and HSPG showing only occasional positively stained fragments while Collagen IV was almost completely absent. (thieme-connect.com)
• Cholesteatoma is a cyst which coated by stratified squamous epithelium containing keratin epithelial desquamation. (balimedicaljournal.org)

Middle ear1

• Cholesteatoma specimens were obtained from six patients undergoing middle ear surgery. (thieme-connect.com)

Expression1

• The level of MMP-9 expression was assessed by immunohistochemical staining of cholesteatoma tissue. (balimedicaljournal.org)

Imaging1

• Imaging cholesteatoma. (nih.gov)

Study3

• The aim of this study is to determine the correlation between MMP-9 with bone destruction in CSOM with cholesteatoma patients. (balimedicaljournal.org)
• This study was conducted by using cross-sectional design to the 40 samples of cholesteatomas patients at Otorhinolaryngology Department of Adam Malik General Hospital in May 2016. (balimedicaljournal.org)
• Immunohistochemical staining and chromosomal study is useful to categorize these tumors. (ejao.org)

Reveals1

• An analysis of the basement membrane, which can modulate epithelial proliferation, reveals a dysfunction of this layer between cholesteatoma and stroma. (thieme-connect.com)

Human2

• This staining pattern resembles the initial rear-rangement of the epithelial basement membrane in human skin wounds and provides evidence for a lost contact inhibition on the provisional fibronectin-layer as a reason for the hyperproliferative nature of cholesteatoma lesions. (thieme-connect.com)
• Whereas autophagy has been linked to numerous human illnesses, whether or not it additionally performs a job in cholesteatoma is nearly unknown. (serpins.com)

Difficult2

• The recurrence and bone destruction arerelevant features in cholesteatoma pathophysiology, which makes cholesteatoma tend to be dangerous and difficult to treat. (balimedicaljournal.org)
• The remedy of center ear cholesteatoma has been difficult attributable to an inadequate understanding of the underlying illness mechanism. (serpins.com)

Lesion2

• Despite the misnomer, cholesteatomas cannot be considered a neoplastic lesion. (biomedcentral.com)
• Skull and plain radiographs demonstrate destructive osteolytic lesions of the temporal bone that are commonly mistaken for symptoms of suppurative mastoiditis, cholesteatoma, or a metastatic osteolytic lesion. (medscape.com)

Tissue1

• Immunohistochemical analysis revealed significantly reduced positive expression of SGK1, ENaC-a, ERß, and PR proteins in the decidual tissue of RSA patients (P (bvsalud.org)

Patients2

• The relationship was examined in these patients between the SUVmax value measured from the iliac bone region and the immunohistochemical and bone marrow fibrosis data of the biopsy taken from the iliac bone. (bvsalud.org)
• Patients may be at risk for developing secondary acquired cholesteatoma in the setting of Langerhans cell histiocytosis and should be managed surgically to rule out recurrent disease. (medscape.com)