Cholera pathogenesis. Medical search. Frequent questions

13% of cholera patients in Bangladesh are cholera, Vibrio cholerae , are only now being defi ned. (cdc.gov)
In Vibrio cholerae , infection by a bacterial virus (bacteriophage) results in the conversion of non-pathogenic strains to pathogenic strains and this can lead to cholera pandemics. (nature.com)
My current interests are directed towards large-scale sequencing and phylogenomic studies investigating major public health threats, such as the causative agents of plague and cholera, Yersinia pestis and Vibrio cholerae , and the dominant cause of food-borne disease in North America, Escherichia coli O157:H7. (utsa.edu)
Research is focused on studying the molecular mechanisms involved in the pathogenesis of Vibrio cholerae , the bacterium that causes cholera, and Francisella tularensis , the bacterium that causes tularemia. (utsa.edu)
The cholera toxin is a protein complex secreted by the bacterium Vibrio cholerae. (embs.org)
Followed by the discovery of Vibrio cholerae in 1884 by Robert Koch, many works have been carried out all over the world to answer many questions related with its pathogenesis and mode of transmission. (embs.org)
Of the isolates, Vibrio Cholera (84%), V. mimicus (73%), V. alginolyticus (91%) and V. parahaemolyticus (100%) isolates harboured at least one of the virulence-associated genes investigated. (biomedcentral.com)
The study affirms the relevancy of environmental Vibrio species to the epidemiology of vibriosis, cholera and cholera-like infections. (biomedcentral.com)
His lab developed the first genetically modified cholera vaccine, made by removing the gene for cholera toxin from the bacteria Vibrio cholerae. (umaryland.edu)
Here we investigate the phylogenetic relationships, pathogenesis and determinants of antimicrobial resistance by sequencing the genomes of Vibrio cholerae isolates from the epidemic in Yemen and recent isolates from neighbouring regions. (pasteur.fr)
Twenty-nine strains of Vibrio cholowe No type el for isolated from the cholera epidemic in Korea On September, 1969 were subjected to study on the production of vibriocin, employing ultraviolet-irradiated induction method. (medric.or.kr)
The pathogenic agent of cholera is Vibrio cholerae , a Gram-negative, curved-rod shaped bacterium (Figure 1). (kenyon.edu)
The N-terminal GAF domain of Rv3651 is structurally most similar to a sensor domain associated with a Vibrio cholera histidine kinase. (ssgcid.org)
Vibrio cholerae (V. cholerae) secreted an enterotoxin that induces acute diarrhea called cholera. (usim.edu.my)

Holmgren and colleagues first described the AB subunit structure and function of cholera toxin and identified the cholera toxin receptor, the GM1 gangliosideM1 then the first-ever structurally defined biologic receptor molecule. (wikipedia.org)
Interaction of cholera toxin and membrane GM! (wikipedia.org)
Cholera toxin was discovered rather recently, in 1959, by the Indian microbiologist Sambhu Nath De (Figure 2). (embs.org)
Lastly, but most important, is De's discovery of cholera toxin in 1959 in the cell-free culture filtrate of V. cholerae that stimulates a specific cellular response. (embs.org)
Pathogenesis varies based on the strain, but it can include toxin production, invasion of the mucosal surface, and adhesion with alteration of enterocyte structure. (lecturio.com)
However, those that survive travel to the small intestine where they begin to produce cholera toxin (CT), which is the main virulence factor of V. cholerae . (kenyon.edu)
The laboratory has ongoing collaborations with academic and biopharmaceutic partners to develop vaccines and monoclonal antibodies for human use against COVID-19, Lyme disease, pertussis, tetanus, Salmonella, cholera, and ricin toxin. (wadsworth.org)

Cholera : its pathology and pathogenesis / S. N. De. (who.int)

Holmgren's research has focused primarily on mucosal vaccine development as well as disease and immune mechanisms of cholera and other mucosal infections. (wikipedia.org)
In the 1980s and '90s, Dr. Holmgren and colleagues at the University of Gothenburg developed the Dukoral™ oral cholera vaccine, which became the first internationally licensed and World Health Organization (WHO) prequalified oral cholera vaccine. (wikipedia.org)
The vaccine, which was tested in large field trials in Bangladesh, Peru, Mozambique and Zanzibar, reduced cholera by 85 to 90 percent in the first six months after vaccination. (wikipedia.org)
Unlike previous injected cholera vaccines, which conferred weak protection for only a few months, Dukoral™ oral cholera vaccine continued to provide immune protection for three years after immunization. (wikipedia.org)
NIAID efforts to develop a preventive cholera vaccine have targeted two distinct but overlapping approaches: live and "killed" vaccines. (nih.gov)
An important re-analysis of a large study involving a vaccine containing inactivated cholera found that the incidence of cholera among the placebo recipients varied inversely with the level of vaccination in the community. (nih.gov)
In the case of cholera, one epidemiological model in Bangladesh showed that because of community immunity, a vaccine containing inactivated cholera conferring relatively short-lived immunity could eliminate cholera entirely if 70 percent of the population was vaccinated. (nih.gov)
The development of a vaccine containing live cholera involves reducing the bacteria's virulence and ability to cause diarrhea while preserving its ability to induce an immune response. (nih.gov)
The technology used to create Dukoral was later transferred to Vietnam and India, where a modified killed cholera vaccine is being produced as OCV-Vax in Vietnam and as Shanchol in India. (nih.gov)
and Karen Kotloff, MD, for helping to get the cholera vaccine developed and licensed. (umaryland.edu)
The oral vaccine is available for individuals travelling to countries where cholera is endemic, and has recently started to be used during outbreaks of the disease. (kenyon.edu)
The finding of this study could provide an insight on the V. cholerae O1 biovar El Tor N16961 mechanism of pathogenesis, which could be useful for target identification for vaccine or drug design in order to reduce the fatality of cholera disease. (usim.edu.my)
I thought my background in biochemistry could be useful for studying the chemical and immunologic processes of bacterial pathogenesis, and applying this knowledge to vaccine design. (jaapgoudsmit.nl)

Ongoing work in our lab seeks to understand the underlying pathogenesis of the diarrhea in MVID that leads to early death in newborns. (yale.edu)

setting of cholera outbreaks. (cdc.gov)
Five (sites SR, PA5, PA6, EL4 and EL6) out of the seventeen sampling sites were detected as the hotspots for potential cholera-like infection and vibriosis outbreaks. (biomedcentral.com)
In the first half of the 20th century, the country experienced numerous outbreaks of smallpox, cholera, plague, and typhoid fever - necessitating the arrangement of quarantine facilities by the British (7). (who.int)

In humans, 1%-64% of colonic of antimicrobial drug therapy) during the spring cholera specimens demonstrate intestinal spirochetosis, with the outbreak of 2006 in Dhaka, Bangladesh, at the Interna- highest prevalence in developing countries and immuno- tional Centre for Diarrheal Disease Research, Bangladesh, compromised populations ( 4 ). (cdc.gov)
If used on a broader scale, the vaccines could reduce global cholera rates, especially if antimicrobial and oral rehydration therapies are also available, and sanitation programs are supported by community education. (nih.gov)

The emphasis is on furthering understanding of the epidemiology and pathogenesis of microbial disease, with further consideration of how these relate to diagnosis, treatment and strategies for disease prevention. (northumbria.ac.uk)

Background: Practice of open defection has growing health concerns especially on rural dwellers and is among leading causes of diarrhea, typhoid fever, cholera, stunting and responsible for the death of children under 5 years in Nigeria. (bvsalud.org)

Cholera in humans results in profuse, watery diarrhea We defi ned the frequent presence of spirochetes in fe- that can lead to severe dehydration and death ( 1 ). (cdc.gov)
his was an independent discovery for studying cholera in a rabbit model demonstrating the association of some strains of E. coli with diarrhea. (embs.org)
To this end, we were the first to demonstrate a physiologic role for regulated traffic of CFTR in the pathogenesis of infectious ( Cholera and E.Coli) secretory diarrhea, and extended those studies to other ion transporters. (yale.edu)
These heightened cAMP levels cause the diarrhea that is characteristic of cholera. (kenyon.edu)

Heinrich Hermann Robert Koch (1843-1910), German physician and microbiologist, founder of modern bacteriology, identified the specific causative agents of TB, cholera, and anthrax and gave experimental support for the concept of infectious disease basing such discoveries on animal and human experimentation (Figure 1). (embs.org)

The potential for pathogenic study, spirochetes from the genus Brachyspira were identi- synergy between V . cholerae and other pathogens has been fi ed at high titers in more than one third of cholera patients in Bangladesh. (cdc.gov)
In this module you will learn about the molecular and cellular biology of the key pathogens (viral, prokaryotic and eukaryotic) which currently threaten human populations, and the mechanisms that account for the pathogenesis of many of these diseases. (le.ac.uk)

and this plays a crucial role in the pathogenesis of malaria and anemia. (bvsalud.org)

NIAID supports university-based and pharmaceutical and biotechnology researchers who are working to develop new cholera treatments and vaccines to prevent infection. (nih.gov)
The conclusion drawn was that vaccination reduced the amount of cholera in the environment, and therefore, the risk of infection to everyone in the community. (nih.gov)
Pathogenesis, gross and microscopic pathology of mycoplasma infection (contagious bovine pleuropneumonia, contagious caprine pleuropneumonia, porcine enzootic pneumonia), diseases of chlamydial group, Q-fever, anaplasmosis and ehrlichiosis. (arawaliveterinarycollege.com)
1). However, other medical conditions such as co-infection with parasites and Vitamin A deficiency increase susceptibility to cholera infection. (kenyon.edu)
Although the mechanism of cholera infection has been well-studied, it remains a problem, especially in developing countries. (kenyon.edu)
Immunological studies with blood samples from severe cases of adenovirus infection is necessary to understand the pathogenesis of the hybrid variant among children. (telegraphindia.com)

The bacterium responsible for cholera was isolated in pure culture by Robert Koch in 1850. (kenyon.edu)

A second candidate, CVD-103HgR, was licensed in Europe, but is not currently in production or slated for use in cholera-endemic regions. (nih.gov)
Cholera is endemic in 50 nations around the world (1). (kenyon.edu)

Funded since 1982 by the National Institutes of Health's (NIH) National Institute of Allergy and Infectious Diseases, Dr. Kaper's research on the pathogenesis of enteric disease has contributed to six books, 68 book chapters, and more than 300 articles published in peer-reviewed journals. (umaryland.edu)
As chair of UMSOM's Department of Microbiology and Immunology, Dr. Kaper has trained more than 60 graduate students and postdoctoral fellows in the area of enteric pathogenesis, many of whom now hold leadership positions in preeminent academic institutions. (umaryland.edu)
According to ICMR-National Institute of Cholera and Enteric Diseases, of the 1,708 samples tested between January 1 and March 9, 650 were positive for the adenovirus. (telegraphindia.com)
The hybrid type was detected earlier, too, but in much lesser percentage," said Shanta Dutta, director of ICMR-National Institute of Cholera and Enteric Diseases, Kolkata. (telegraphindia.com)

Killed" or inactivated vaccines are those that contain cholera bacteria that have been made harmless so as not to infect the vaccinated recipient. (nih.gov)

He made significant contributions to the understanding of cholera and related diarrheal diseases. (embs.org)
Cholera is a severe diarrheal disease with ancient origins, with Sanskrit accounts of the disease from the Indian subcontinent dating to the fifth century B.C. (1). (kenyon.edu)

The food and drink contaminated by cholera vibrios if ingested. (overallscience.com)

Pathogenicity islands encoded in the V. cholerae genome play an important role in pathogenesis. (nature.com)
Discussion: The moderate risk of RESTV recurring among humans in the Philippines and its potential pathogenicity in humans reinforces the need for early detection, surveillance and continued studies of RESTV pathogenesis and its health consequences. (who.int)

Genomic insights into the 2016-2017 cholera epidemic in Yemen. (pasteur.fr)
Yemen is currently experiencing, to our knowledge, the largest cholera epidemic in recent history. (pasteur.fr)

Here we survey the cable connections between VpsS and CqsR and QS in (VC1831 is normally renamed as CqsR hereafter predicated on P005672 HCl its function as Cholera Quorum Sensing Receptor). (bibf1120.com)

Left untreated, cholera can have a fatality rate of over fifty percent (1). (kenyon.edu)

Vaccination is an important way to protect vulnerable populations from cholera. (nih.gov)

Prevention of cholera is contingent on the availability of clean water and the development of sanitation facilities (4). (kenyon.edu)

Vaccines are usually evaluated in field studies by comparing the incidence of disease (in this case, cholera) in a vaccinated population to an unvaccinated placebo control population. (nih.gov)
Currently, two of these types of cholera vaccines are available and both are administered orally as opposed to injection. (nih.gov)

Current study was designed to evaluate the pathogenesis of Newcastle disease in domestic ducks through histopathology, immunohistochemistry (IHC) and serum biochemical changes. (bvsalud.org)
In the early 1850s, the British physician John Snow was the first to suggest that cholera was a communicable disease that was spread through a drinking supply contaminated with infected stools. (kenyon.edu)

As it is caused by this aquatic pathogen, cholera is most commonly spread by water supplies contaminated with stools infected with V. cholerae . (kenyon.edu)

One example is cholera, which specifically infect humans. (jaapgoudsmit.nl)

2003), indicating a specific role in pathogenesis. (ssgcid.org)

Furthermore additionally it is unknown if also to what level each one of these four histidine kinase receptors is normally individually adding to the global control of the QS response in pathogenesis also offers not been looked into. (bibf1120.com)

The ces of patients with cholera. (cdc.gov)

Cholera if left untreated, lead to renal failure, shock, hypokalemia and pulmonary edema, which can cause death within hours. (usim.edu.my)

Oral rehydration therapy (ORT), or the administration of an oral solution containing glucose and electrolytes, is currently the predominant treatment for cholera worldwide. (nih.gov)

Anatomy1

Organisms3

Diseases1

Chemicals and Drugs6

Geographicals2

Vibrio14

Toxin7

PATHOLOGY AND PATHOGENESIS1

Vaccine13

Understand the underlying p1

Outbreaks3

Antimicrobial2

Epidemiology1

Typhoid fever1

Diarrhea4

Causative agents1

Pathogens2

Malaria1

Infection6

Bacterium1

Endemic2

Enteric4

Bacteria1

Diarrheal2

Vibrios1

Pathogenicity2

Epidemic2

Receptor1

Fatality1

Populations1

Prevention1

Vaccines2

Disease2

Cholerae1

Humans1

Role1

Global1

Patients1

Left1

Treatment1