• The aim of this study was to evaluate 3 new 99m Tc-labeled minigastrin analogs modified with open chain tetraamines at the N-terminus for their suitability in the CCK-2/gastrin-R-targeted imaging of tumors (CCK-2/gastrin-R = cholecystokinin subtype 2/gastrin receptor). (snmjournals.org)
  • 90%) and high-density expression of CCK-2/gastrin-R (CCK-2/gastrin-R = cholecystokinin subtype 2/gastrin receptor) in human medullary thyroid cancer (MTC), already suspected by the highly sensitive pentagastrin diagnostic test ( 5 - 7 ). (snmjournals.org)
  • These sphincters are highly sensitive to cholecystokinin and other gut hormones (eg, gastrin-releasing peptide) and to alterations in cholinergic tone (eg, by anticholinergic drugs). (merckmanuals.com)
  • A broad spectrum of radiolabeled peptides with high affinity for receptors expressed on tumor cells is currently under preclinical and clinical investigation for scintigraphic imaging and radionuclide therapy. (nih.gov)
  • The present paper evaluates two (99m)Tc-labeled forms of the C-terminal octapeptide of cholecystokinin (CCK8): sulfated (s)CCK8, with high affinity for CCK1 and CCK2 receptors, and nonsulfated (ns)CCK8, with high affinity for CCK2 receptors but low affinity for CCK1 receptors. (nih.gov)
  • The advent of radiolabeled somatostatin analogs in the targeted imaging and radionuclide therapy of tumors overexpressing somatostatin receptors has paved the way for other radiopeptides to target alternative cancer-associated peptide receptor systems ( 1 - 4 ). (snmjournals.org)
  • Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1," PNAS , 104:15069-74, 2007. (the-scientist.com)
  • Amylin is a 37-amino-acid peptide that activates its specific receptors, which are multisubunit G protein-coupled receptors resulting from the coexpression of a core receptor protein with receptor activity-modifying proteins, resulting in multiple receptor subtypes. (aspetjournals.org)
  • The crunchy textural property of whole nuts may also promote satiety as the mechanical act of mastication results in the secretion of appetitive hormones such as cholecystokinin and glucagon-like peptide-1 [ 28 , 40 - 44 ]. (hindawi.com)
  • Amylin acts principally in the circumventricular organs of the central nervous system and functionally interacts with other metabolically active hormones such as cholecystokinin, leptin, and estradiol. (aspetjournals.org)
  • Monitor peptide binds to intestinal epithelial cells and induces CCK-release, which enhances pancreatic secretion in the presence of nutritional protein in the duodenum. (wikipedia.org)
  • When all nutritional protein is digested, monitor peptide is bound by trypsin and subsequently degraded, resulting in decreasing CCK-release and a reduction of pancreatic secretion. (wikipedia.org)
  • Glycomacropeptide (GMP) is a milk-derived bioactive peptide that comprises 15-20% of proteins present in whey, being the third most abundant. (intechopen.com)
  • ITT, GTT, and MTT showed that CS rats were neither insulin resistant nor glucose intolerant, but mRNA expression of cholecystokinin (CCK) in the duodenum was higher and that of CPT1, PPARα, and PGC1α in liver were lower than in CR rats. (frontiersin.org)
  • The present study assessed the effects of the FFNS and RT on postprandial appetite sensations (hunger and fullness), endocrine responses (plasma insulin, cholecystokinin, ghrelin and glucagon-like peptide-1 (GLP-1)), metabolism (glucose, energy expenditure and RER) and food intake (satiation) in older adults. (purdue.edu)
  • [ 2 ] The patient is instructed to fast, and plasma glucose, insulin, proinsulin, and C-peptide levels are measured every 6 hours until the plasma glucose level is less than 65 mg/dL, after which the testing frequency is increased to every 1-2 hours. (medscape.com)
  • Monitor peptide is composed of 61 amino acids with a molecular weight of approximately 6500 daltons and is basic (PI = 9.0), acid stable, and heat resistant. (wikipedia.org)
  • A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. (bvsalud.org)
  • 4 In the ARC, there are two distinct neuronal populations: one group of neurons produces the orexigenic neuropeptides neuropeptide Y (NPY) and agouti-related peptide (AgRP), whereas the other subset of neurons expresses the anorexigenic neuropeptides proopiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript. (nature.com)
  • The first subset coexpresses the orexigenic (appetite-stimulating) agouti-related peptide and neuropeptide Y (NPY) neurotransmitters, acting as an accelerator in the brain to stimulate feeding. (medscape.com)
  • Appetite ratings, acylated ghrelin, cholecystokinin (CCK), glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and glucagon were assessed in the basal state and in response to meal and exercise challenges at baseline, 3, and 6 months. (ku.dk)
  • Monitor peptide, also known as pancreatic secretory trypsin inhibitor I (PSTI-I) or pancreatic secretory trypsin inhibitor 61 (PSTI-61), is a peptide that plays an important role in the regulation of the digestive system, specifically the release of cholecystokinin (CCK). (wikipedia.org)
  • It was purified from rat bile-pancreatic juice and the peptide sequence was elucidated. (wikipedia.org)
  • Saturation binding experiments were performed for (radio)metallated peptides [ 99m Tc/ 99g Tc]Demogastrin 1-3 in rat acinar pancreatic AR4-2J cell membranes. (snmjournals.org)
  • Cholecystokinin is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. (toppr.com)
  • Many ingredients work via the same mechanism, which involves boosting levels of appetite-related hormones like satiety hormone glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and cholecystokinin (CCK). (nutraingredients.com)
  • Given historical focus on the roles for cholecystokinin (CCK) as a peripheral hormone controlling gastrointestinal processes and a brainstem peptide regulating food intake, the study of CCK as a limbic neuromodulator coordinating reward-seeking and emotional behavior remains underappreciated. (stanford.edu)
  • Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor. (expasy.org)
  • The study 'Anatomical and molecular characterization of parvalbumin cholecystokinin co-expressing inhibitory interneurons: implications for neuropsychiatric conditions' was published in July in Molecular Psychiatry . (news-medical.net)
  • The model was used to estimate kinetic parameters of in vitro transport data from organic anion-transporting peptide model substrates (e.g., cholecystokinin octapeptide deltorphin II, fexofenadine, and pitavastatin). (aspetjournals.org)
  • Tissue distribution of the peptides was compared in healthy mice and athymic mice bearing AR4-2J tumors. (snmjournals.org)
  • Peptides represent over decades of innovative peptide synthesis expertise. (anaspec.com)
  • The synthesis and applications of the peptides are gaining increasing popularity as a result of the developments in biotechnology and bioengineering areas and for a number of research purposes including cancer diagnosis and treatment, antibiotic drug development, epitope mapping, production of antibodies, and vaccine design. (intechopen.com)
  • The aim of this chapter is to review some applications of synthetic peptides providing a brief knowledge about peptide synthesis. (intechopen.com)
  • In the first part, information about the peptide synthesis was given in a very simple and readable format under the title of solid-phase peptide synthesis including a brief history, solid supports, linkers, protecting groups, and analysis method sections. (intechopen.com)
  • The synthesis of the peptides may provide sufficient material to enable further studies and to determine the structure-activity relationships or may provide discovery of new analogues with improved properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. (intechopen.com)
  • These products increase the concentrations of the hormones glucagon-like peptide-1 and peptide YY, which signal to the brain that the stomach is full. (medicalnewstoday.com)
  • Pinolenic acid triggers the release of hunger-suppressant enzymes cholecystokinin and Glucagon-like peptide-1 (GLP-1) in the gut. (nutrition-and-you.com)
  • On the other hand, certain residues of protein digestion stimulate the production of anorectic hormones: cholecystokinin (CCK) and glucagon-like-peptide-1 (GLP-1). (familiprix.com)
  • These neurons are characterized by their chemical signature of expressing calcium binding protein parvalbumin and the cholecystokinin (CCK) peptide. (news-medical.net)
  • DANN, O. A subpopulation of mesencephalic dopamine neurons projecting to limbic area contains a cholecystokinin-like peptide, evidence from immunohisto-chemistry combined with retrograde tracing. (bvsalud.org)
  • One of the primary functions of monitor peptide is to stimulate the release of CCK from the enteroendocrine cells of the small intestine. (wikipedia.org)
  • In the last part, information about cell-penetrating peptides that can be used as molecular carries is mentioned with providing classification and cellular uptake mechanism of them. (intechopen.com)
  • The amylin-based peptide, pramlintide, is used clinically to treat type 1 and type 2 diabetes. (aspetjournals.org)
  • Cholecystokinin may be the mediator of satiety. (bvsalud.org)
  • In both cases uptake was significantly reduced by excess unlabeled peptide to 1.0% and 0.4% for sCCK8 and nsCCK8, respectively. (nih.gov)
  • The specific characters of peptides (high bioactivity, high specificity, and low toxicity) have made them attractive therapeutic agents. (intechopen.com)
  • Avoiders exhibited higher CRF peptide levels in CeA that did not appear to be locally synthesized. (nature.com)
  • Fasting cholecystokinin was higher in the RT v. Sed group ( P (purdue.edu)
  • GMP is also a peptide with promising use in food industry, due to its nutritional value and its emulsifying, foaming, and gelling properties. (intechopen.com)
  • With over 25 years of peptide manufacturing experience, AnaSpec is your trusted source of highly complex peptides. (anaspec.com)
  • The use of synthetic peptides approved by the health authorities for vaccine, for cancer, and in drug delivery systems is increasing with these developments. (intechopen.com)
  • The aim of this book chapter is to review the recent developments in the use of peptides in the diagnosis of drug and vaccine systems and to present them to the reader with commercially available illustrations. (intechopen.com)
  • Similar to CCK-releasing peptide (CCK-RP), it is trypsin sensitive and stimulates CCK release. (wikipedia.org)
  • Cholecystokinin B (CCK B ) agonists increase "anxiety" in laboratory animals and induce "panic" in humans. (jneurosci.org)
  • Purified peptide conjugates were labeled with 99m Tc under alkaline conditions. (snmjournals.org)