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  • infection
  • Chronic infection may lead to cholangiocarcinoma, a malignant cancer of the bile ducts. (wikipedia.org)
  • In addition, under experimental conditions, the short-term treatment of Opisthorchis viverrini-infected hamsters with praziquantel (400 mg per kg of live weight) induced a dispersion of parasite antigens, resulting in adverse immunopathological changes as a result of oxidative and nitrative stresses following re-infection with Opisthorchis viverrini, a process which has been proposed to initiate and/or promote the development of cholangiocarcinoma in humans. (wikipedia.org)
  • tumor
  • Cholangiocarcinoma is considered to be an incurable and rapidly lethal cancer unless both the primary tumor and any metastases can be fully removed by surgery. (wikipedia.org)
  • The most common physical indications of cholangiocarcinoma are abnormal liver function tests, jaundice (yellowing of the eyes and skin occurring when bile ducts are blocked by tumor), abdominal pain (30%-50%), generalized itching (66%), weight loss (30%-50%), fever (up to 20%), and changes in the color of stool or urine. (wikipedia.org)
  • Cholangiocarcinoma staging is a process used by physicians to describe bile duct cancer in standardized terms regarding the size of a tumor and the extent of its spread. (moffitt.org)
  • The tumor in this case was a type IV cholangiocarcinoma with multi-focal involvement extending from the confluence of the hepatic ducts to the common bile duct (Table 2). (appliedradiology.com)
  • In most cases of cholangiocarcinoma , these genetic changes are acquired during a person's lifetime and are present only in bile duct cells that give rise to the tumor. (nih.gov)
  • Cholangiocarcinoma can be detected with these commonly used tumor markers: carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125). (wikipedia.org)
  • symptoms
  • Cholangiocarcinoma screening cannot be performed with any degree of reliability in individuals who are not experiencing symptoms. (moffitt.org)
  • For these reasons, cholangiocarcinoma is usually found only after the cancer has advanced enough to cause symptoms. (moffitt.org)
  • Because early detection can result in a better outcome, and because cholangiocarcinoma does not usually produce symptoms until it reaches an advanced stage, it is vital to see a physician regarding any potential warning signs as soon as possible. (moffitt.org)
  • If a physician suspects that cholangiocarcinoma is the cause of a patient's symptoms, the physician will usually perform a physical examination and order a series of tests. (moffitt.org)
  • The three types of cholangiocarcinoma do not usually cause any symptoms in their early stages, and this cancer is usually not diagnosed until it has already spread beyond the bile ducts to other tissues. (nih.gov)
  • detection
  • Because there is currently no cholangiocarcinoma screening method recommended for routine use in the general population, early detection is vital to achieving the best possible outcome. (moffitt.org)
  • If you have questions about cholangiocarcinoma screening and early detection, contact the experts at Moffitt by calling 1-888-663-3488 or completing a new patient registration form online. (moffitt.org)
  • For all types of cholangiocarcinoma, early detection and appropriate treatment are essential to achieving the best possible outcome. (moffitt.org)
  • New data from two clinical trials presented at the International Liver Congress 2013 demonstrated substantial improvements in the detection of both HCC and cholangiocarcinoma using diagnostic urine tests. (oncologynurseadvisor.com)
  • Diseases
  • PJB is the Principal Investigator of the National Institute of Allergy and Infectious Diseases grant number 1UO1 AI065871, which deals with liver fluke-induced cholangiocarcinoma. (plos.org)
  • found
  • Epidemiologic studies have suggested that the lifetime risk of developing cholangiocarcinoma for a person with PSC is on the order of 10%-15%, although autopsy series have found rates as high as 30% in this population. (wikipedia.org)