• Chlorprothixene is structurally related to chlorpromazine, with which it shares, in principle, all side effects. (wikipedia.org)
  • Chlorprothixene, sold under the brand name Truxal among others, is a typical antipsychotic of the thioxanthene group. (wikipedia.org)
  • For this reason, chlorprothixene has sometimes been described instead as an atypical antipsychotic. (wikipedia.org)
  • His most commonly-used drug to treat bedwetting was the antipsychotic chlorprothixene, which was neither the standard drug of choice among child psychiatrists, nor was it supported by contemporary evidence. (wikipedia.org)
  • citation needed] Chlorprothixene is sold mainly under the brand name Truxal. (wikipedia.org)
  • Direct immersion solid-phase microextraction has been optimized and applied to the simultaneous determination of the neutral and basic pharmaceuticals: caffeine, carbamazepine, clomipramine, chlorprothixene and clotrimazole at low concentrations in municipal wastewater. (degruyter.com)
  • The high values of distribution coefficient (K fs ) in PDMS/water and PA/water systems (log K fs between 3.05 and 4.23) indicates the very high applicability of these stationary phases for determination of carbamazepine, clomipramine, chlorprothixene and clotrimazole in water samples. (degruyter.com)
  • Chlorprothixene may increase the plasma-level of concomitantly given lithium. (wikipedia.org)
  • Chlorprothixene, methotrimeprazine, and piperacetazine were the three most potent FDA-approved drugs with anti-SARS-CoV-2 activities. (c19early.org)
  • Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side effects. (wikipedia.org)
  • High-level prescribing trends for Chlorprothixene (BNF code 0402010F0) across all GP practices in NHS England for the last five years. (openprescribing.net)
  • Taractan (chlorprothixene) is a small molecule pharmaceutical. (pharmakb.com)
  • Chlorprothixene was first approved as Taractan on 1982-01-01. (pharmakb.com)
  • citation needed] Chlorprothixene was the first of the thioxanthene antipsychotics to be synthesized. (wikipedia.org)
  • Also, like most antipsychotics, chlorprothixene has antiemetic effects. (wikipedia.org)
  • Lometraline, tametraline, and sertraline were reportedly derived via structural modification of chlorprothixene. (wikipedia.org)
  • The TREX1 catalytic sites Chlorprothixene accommodate four nucleotides of ssDNA, and additional structural elements are positioned adjacent to the active sites for potential DNA polynucleotide interactions. (citiesofdata.org)
  • If chlorprothixene is given concomitantly with opioids, the opioid dose should be reduced (by approx. (wikipedia.org)
  • 14. Identification of chlorprothixene as a potential drug that induces apoptosis and autophagic cell death in acute myeloid leukemia cells. (nih.gov)
  • Failure to clear DNA has long been linked to lupus in humans, and these data point to dsDNA as a key substrate Chlorprothixene for TREX1 and a major antigen source in mice with dysfunctional TREX1 enzyme. (citiesofdata.org)
  • The virtual screening methodology proved highly successful, as 13 of 23 top drugs tested selectively inhibited histamine-induced calcium release with the best being chlorprothixene (IC(50) 1 nM). (ox.ac.uk)
  • Imipramine and diethazine were moderately active, while chlorprothixene was ineffective relative to 5-fluorouracil as positive control. (unl.pt)
  • Chlorprothixene has a strong sedative activity with a high incidence of anticholinergic side effects. (wikipedia.org)
  • The elderly are particularly sensitive to anticholinergic side effects of chlorprothixene (precipitation of narrow angle glaucoma, severe obstipation, difficulties in urinating, confusional and delirant states). (wikipedia.org)
  • 50%), because chlorprothixene amplifies the therapeutic actions and side effects of opioids considerably. (wikipedia.org)
  • in the 1960s, large-scale investigations into chlorprothixene for bedwetting were conducted, and general practitioners began to use it. (wikipedia.org)