• Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive. (wikipedia.org)
  • If the patient is not losing weight, then you are clearly in a situation that is more severe, and augmentation of therapy with loop diuretics plus metolazone or Diuril (chlorothiazide) is indicated. (medscape.com)
  • hypokalemia / hypomagnesia) The research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. (wikipedia.org)
  • Like other thiazides, chlorothiazide promotes water loss from the body (diuretics). (ncats.io)
  • Loop diuretics, like furosemide, and thiazide diuretics like chlorothiazide and hydrochlorothizide increase urination and cause potassium loss. (livestrong.com)
  • Breazeale was originally scheduled to fight Stiverne on the undercard, but when Luis "King Kong" Ortiz was booted from the fight for coming up positive for two banned diuretics, chlorothiazide and hydrochlorothiazide, in a random urine test conducted by the Voluntary Anti-Doping Association on Sept. 22, Stiverne was tapped to replace Ortiz. (espn.com)
  • The most common examples are blood pressure medicines, specifically diuretics (such as chlorothiazide and furosemide) and beta-blockers (such as metoprolol and atenolol), which can decrease blood flow to the penis. (healthpartners.com)
  • In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). (wikipedia.org)
  • and renal tubular secretion of chlorothiazide and hydrochlorothiazide in the avian kidney ( Odlind and Lonnerholm, 1982 ). (aspetjournals.org)
  • Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. (ncats.io)
  • As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. (ncats.io)
  • Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. (ncats.io)
  • Chlorothiazide sodium for injection is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. (ndclist.com)
  • Chlorothiazide sodium for injection has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. (ndclist.com)
  • tell your doctor and pharmacist if you are allergic to chlorothiazide, sulfonamide antibiotic medications, penicillin, any other medications, or any of the ingredients in chlorothiazide tablets or suspension. (medlineplus.gov)
  • Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. (ncats.io)
  • The four medications reviewed in the study were chlorothiazide (a medication used to treat high blood pressure and address fluid retention), voriconazole (an anti-fungal), levetiracetam (to stop seizures) and pantoprazole (for acid reflux). (infectioncontroltoday.com)
  • Chlorothiazide comes as a tablet and suspension (liquid) to take by mouth. (medlineplus.gov)
  • For example, the wholesale cost of a 5-milligram tablet of chlorothiazide is $1.48. (infectioncontroltoday.com)
  • Chlorothiazide is a "water pill" ( diuretic ) that causes you to make more urine. (webmd.com)
  • The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. (ncats.io)
  • When used to treat hypertension, take chlorothiazide around the same time(s) every day. (medlineplus.gov)
  • If you are taking either of these drugs, take them at least 4 hours before or after taking chlorothiazide. (webmd.com)
  • Lau cautions, however, that doctors are already bombarded with reminders and it might be best to start with drugs with the highest savings per dose, such as levetiracetam and chlorothiazide. (infectioncontroltoday.com)
  • Chlorothiazide may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. (medlineplus.gov)
  • Cholestyramine and colestipol can decrease the absorption of chlorothiazide . (webmd.com)
  • Chlorothiazide is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
  • When used to treat edema, chlorothiazide may be taken daily or only on certain days of the week. (medlineplus.gov)
  • Thiazide is found in these medicines: Bendroflumethiazide Chlorothiazide Chlorthalidone Hydrochlorothiazide Hydroflumethiazide Indapamide Methyclothiazide Metolazone Other medicines may also contain thiazide. (nih.gov)
  • Chlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. (nih.gov)
  • Chlorothiazide inhibits the reabsorption of sodium in distal tubules, causing increased excretion of sodium and water as well as of potassium and hydrogen ions. (medscape.com)
  • Chlorothiazide Sodium for Injection, USP is a diuretic and antihypertensive. (nih.gov)
  • Chlorothiazide is a diuretic and antihypertensive. (nih.gov)
  • Following intravenous use of Chlorothiazide Sodium, onset of the diuretic action occurs in 15 minutes and the maximal action in 30 minutes. (nih.gov)
  • This was one of Freis's first attempts to evaluate chlorothiazide, a new diuretic that acted to increase the excretion of water and salt, and therefore reduced fluid in blood volume and decreased blood pressure. (nih.gov)
  • Chlorothiazide Sodium for Injection is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. (nih.gov)
  • Chlorothiazide Sodium for Injection has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. (nih.gov)
  • Chlorothiazide may also be used to treat patients with diabetes insipidus and certain electrolyte disturbances and to prevent kidney stones in patients with high levels of calcium in their blood. (medlineplus.gov)
  • Chlorothiazide comes as a tablet and suspension (liquid) to take by mouth. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to chlorothiazide, sulfonamide antibiotic medications, penicillin, any other medications, or any of the ingredients in chlorothiazide tablets or suspension. (medlineplus.gov)
  • Chlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk. (nih.gov)
  • Excretion of chlorothiazide in human breast milk. (nih.gov)
  • Sprague - who joined Sharpe & Dohme in 1937, then continued at Merck Sharpe & Dohme after the companies merged - developed chlorothiazide with fellow organic chemist Frederick Novello and pharmacologists Karl Beyer and John Baer . (invent.org)
  • Chlorothiazide is used alone or in combination with other medications to treat high blood pressure. (medlineplus.gov)
  • Here, along with several colleagues from the Veterans Administration and Georgetown University, he recognized the promise that this antihypertensive agent held, noting that chlorothiazide was an 'effective and well-tolerated' treatment. (nih.gov)
  • if you are taking cholestyramine or colestipol, take them 1 hour before or 4 hours after taking chlorothiazide. (medlineplus.gov)
  • On the hypocalciuric action of chlorothiazide. (nih.gov)
  • Relevant published information on chlorothiazide was not found as of the revision date. (nih.gov)