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  • subunit
  • Chloramphenicol binds in a deep pocket located at the boundary between adjacent subunits of the trimer, such that the majority of residues forming the binding pocket belong to one subunit while the catalytically essential histidine belongs to the adjacent subunit. (wikipedia.org)
  • Diagnostic
  • Chloramphenicol has been used in the U.S. in the initial empirical treatment of children with fever and a petechial rash, when the differential diagnosis includes both Neisseria meningitidis sepsis and Rocky Mountain spotted fever, pending the results of diagnostic investigations. (wikipedia.org)
  • available
  • In low-income countries, the WHO no longer recommends oily chloramphenicol as first-line to treat meningitis, but recognises it may be used with caution if there are no available alternatives. (wikipedia.org)