• Do not receive live vaccine (such as measles, mumps, rubella and others) while using chlorambucil, and avoid contact with anyone who has recently received a live vaccine as there are chances that the virus could be passed on to you. (1mg.com)
  • Chlorambucil is used to treat some types of blood cancers like Hodgkin's disease (cancer that starts in blood cells that are part of immune system), certain forms of non-Hodgkin's lymphoma, chronic lymphocytic leukemia (disease where the bone marrow produces a large number of abnormal white cells. (1mg.com)
  • Feinerman B., Paul R.D., Feinerman G. (1983) Treatment of a Murine Leukemia with Chlorambucil Bound Monoclonal Antibodies. (springer.com)
  • The most common adverse reactions (greater than or equal to 5%) with Arzerra in combination with chlorambucil (greater than or equal to 2% more than in the control arm) were infusion reactions, neutropenia, asthenia, headache, leukopenia, herpes simplex, lower respiratory tract infection, arthralgia and upper abdominal pain. (unm.edu)
  • We are pleased to receive the positive opinion from the CHMP for Arzerra in combination with chlorambucil or bendamustine for first line CLL and look forward to a final decision from the European Commission in the next few months," said Jan van de Winkel, Ph.D., Chief Executive Officer of Genmab. (globenewswire.com)
  • Why don't more oncologists suggest Chlorambucil since we've heard it has fewer side effects (i.e. cystitis) than Cytoxan? (tripawds.com)
  • Both reversible and permanent sterility have been observed in both sexes receiving chlorambucil. (drugs.com)
  • Kidney stones, history of-Chlorambucil may increase levels of uric acid in the body, which can cause gout or kidney stones. (mayoclinic.org)
  • Tripawds members Sassy , Jill the Cat and Jackson have recently switched to chlorambucil for their own metronomic protocols. (tripawds.com)
  • Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, inducing DNA damage via three different methods of covalent adduct generation with double-helical DNA: Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA. (wikipedia.org)
  • Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. (vetcontact.com)
  • Like many alkylating agents , chlorambucil has been associated with the development of other forms of cancer. (wikipedia.org)
  • In the 1950s, aromatic mustards like chlorambucil were introduced as less toxic alkylating agents than the aliphatic nitrogen mustards, proving to be less electrophilic and react with DNA more slowly. (wikipedia.org)
  • Neurotoxicity as a common side effect like in human medicine has never been described - until this cat was treated with chlorambucil. (vetcontact.com)
  • A high incidence of sterility has been reported when chlorambucil has been administered to prepuberal and puberal males. (drugs.com)
  • This is important since chlorambucil, as an electrophile, is made less reactive by conjugation with glutathione, thereby making the drug less toxic to the cell. (wikipedia.org)
  • A chlorambucil (CLB)-resistant cell line, N50-4, was developed from the established mouse fibroblast cell line NIH 3T3, by multistep drug selection. (aspetjournals.org)