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  • cells
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. (duke.edu)
  • These observations point out to Chlamydia-mediated manipulation of LDs in infected cells, which may impact the function and thereby the protein composition of these organelles. (duke.edu)
  • We determined that LDs isolated from C. trachomatis-infected cells were enriched in proteins related to lipid metabolism, biosynthesis and LD-specific functions. (duke.edu)
  • inclusion
  • Previous studies have shown that LDs accumulate at the periphery of, and eventually translocate into, the chlamydial inclusion. (duke.edu)
  • pathogenesis
  • Due to the reduced availability of human genital tissues for research purposes, an alternative hormone-responsive model system was sought to study chlamydial pathogenesis. (jove.com)
  • These differing requirements for Src-family kinases would not be apparent in genomic comparisons and appear to be a previously unrecognized distinction that may provide insights to guide research in chlamydial pathogenesis. (asm.org)
  • vacuole termed
  • Following endocytosis by a host cell, chlamydiae reside within a vacuole termed an inclusion, which is nonfusogenic with the endosomal/lysosomal pathway but acquires sphingomyelin and cholesterol from the Golgi apparatus ( 6 - 8 ). (asm.org)
  • nonhuman
  • Nonhuman chlamydial species C. caviae and C. muridarum show none of these requirements and, instead, appear to be growth restricted by the activities of Src-family kinases. (asm.org)
  • 1997
  • Rivlin et al to indicate that treating chlamydia infection during pregnancy is effective in reducing the incidence of premature rupture of the membranes, preterm birth and low birth weight babies. (health.gov.au)
  • detect
  • Based on limited evidence, Gram staining (Asbill et al 2000) and Pap smear (Spence et al 1986) had insufficient accuracy to detect chlamydia. (health.gov.au)
  • interactions
  • There has been significant recent progress in understanding chlamydial plasmid participation in host-microbe interactions, disease, and immune responses. (rupress.org)
  • among
  • Several risk factors are already defined for Chlamydial infection, among them, age under 25 years old and sexual behavior of the risk. (unesp.br)
  • The rate of diagnosis of chlamydia among the Aboriginal and Torres Strait Islander population resident in major cities in SA, Victoria and WA in 2009 was 3.5 times that among non-Indigenous people. (health.gov.au)
  • Among Aboriginal and Torres Strait Islander people resident in remote and very remote areas in the NT, SA, Tasmania, Victoria and WA, the rate of diagnosis of chlamydia was at least 7 times that among non-Indigenous people (NCHECR 2010). (health.gov.au)
  • Risk factors - Chlamydia is highly prevalent among younger people, with around 80% of all diagnoses being in young people (NCHECR 2010). (health.gov.au)
  • relation
  • However, the NICE guidelines note that the causal link between chlamydia infection and adverse outcomes of pregnancy has not been established and the evidence remains difficult to evaluate in relation to neonatal morbidities (NICE 2008). (health.gov.au)
  • distribution
  • Geographical distribution - Diagnoses of chlamydia in 2009 (NNDSS 2010) varied considerably by State/Territory, ranging from 210.5 per 100,000 population in NSW to 940.6 per 100,000 in the NT. (health.gov.au)