ApoptosisCaspasesApoptosis Regulatory ProteinsCaspase 3Proto-Oncogene Proteins c-bcl-2Checkpoint Kinase 2Inhibitor of Apoptosis ProteinsDNA FragmentationCell Line, TumorIn Situ Nick-End Labelingbcl-2-Associated X ProteinX-Linked Inhibitor of Apoptosis ProteinDNA DamageCell SurvivalProtein KinasesTumor Suppressor Protein p53Signal TransductionApoptosis Inducing FactorCASP8 and FADD-Like Apoptosis Regulating ProteinProtein-Serine-Threonine KinasesEnzyme ActivationCaspase 9Caspase InhibitorsCell CycleCaspase 8MitochondriaFas Ligand ProteinTumor Cells, CulturedCells, CulturedPhosphorylationCytochromes cbcl-X ProteinAtaxia Telangiectasia Mutated ProteinsCell LineCell Cycle ProteinsBlotting, WesternCell ProliferationAnnexin A5Antineoplastic AgentsFlow CytometryRNA, Small InterferingPoly(ADP-ribose) PolymerasesProto-Oncogene ProteinsAmino Acid Chloromethyl KetonesCysteine Proteinase InhibitorsG2 PhaseEnzyme InhibitorsStaurosporineTransfectionCell DivisionDown-RegulationTumor Suppressor ProteinsReactive Oxygen SpeciesCell DeathJurkat CellsTNF-Related Apoptosis-Inducing LigandCaspase 7HL-60 CellsDose-Response Relationship, DrugDNA-Binding ProteinsHeLa CellsMembrane Potential, MitochondrialTumor Necrosis Factor-alphacdc25 PhosphatasesGenes, bcl-2bcl-2 Homologous Antagonist-Killer ProteinTime FactorsRNA, MessengerRNA InterferenceUp-RegulationCell Cycle CheckpointsMembrane GlycoproteinsNecrosisProto-Oncogene Proteins c-aktCytochrome c GroupMyeloid Cell Leukemia Sequence 1 ProteinGene Expression Regulation, NeoplasticReverse Transcriptase Polymerase Chain ReactionBH3 Interacting Domain Death Agonist ProteinNF-kappa BMice, Inbred C57BLRadiation, IonizingMutationNuclear ProteinsAntineoplastic Agents, PhytogenicCarrier ProteinsDrug SynergismMice, KnockoutCaspase 2S PhaseModels, Biologicalbcl-Associated Death ProteinGene Expression RegulationNeoplasm ProteinsImmunohistochemistryCell NucleusCeramidesHCT116 CellsOxidative StressReceptors, TNF-Related Apoptosis-Inducing Ligand